Association between adolescent oral contraceptive use and future major depressive disorder: a prospective cohort study / Christine ANDERL in Journal of Child Psychology and Psychiatry, 63-3 (March 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.333-341 Titre : Association between adolescent oral contraceptive use and future major depressive disorder: a prospective cohort study Type de document : texte imprimé Auteurs : Christine ANDERL, Auteur ; Anouk E. DE WIT, Auteur ; Erik J. GILTAY, Auteur ; Albertine J. OLDEHINKEL, Auteur ; Frances S. CHEN, Auteur Article en page(s) : p.333-341 Langues : Anglais (eng) Mots-clés : Oral contraceptive use  adolescence  major depressive disorder  risk factors Index. décimale : PER Périodiques Résumé : BACKGROUND: Because of the widespread use of oral contraceptives (OCs) and the devastating effects of depression both on an individual and a societal level, it is crucial to understand the nature of the previously reported relationship between OC use and depression risk. Insight into the impact of analytical choices on the association is important when interpreting available evidence. Hence, we examined the association between adolescent OC use and subsequent depression risk in early adulthood analyzing all theoretically justifiable models. METHODS: Data from the prospective cohort study TRacking Adolescents' Individual Lives Survey, among women aged 13-25 years were used. Adolescent OC use (ages 16-19 years) was used as a predictor and major depressive disorder (MDD) in early adulthood (ages 20-25 years), as assessed by the Diagnostic and Statistical Manual of Mental Disorders-IV oriented Lifetime Depression Assessment Self-Report and the Composite International Diagnostic Interview, was used as an outcome. A total of 818 analytical models were analyzed using Specification Curve Analysis in 534 adolescent OC users and 191 nonusers. RESULTS: Overall, there was an association of adolescent OC use and an episode of MDD in early adulthood [median odds ratio (OR)(median)  = 1.41; OR(min)  = 1.08; OR(max)  = 2.18, p < .001], which was driven by the group of young women with no history of MDD (OR(median)  = 1.72; OR(min)  = 1.21; OR(max)  = 2.18, p < .001). CONCLUSIONS: In summary, adolescent OC use was associated with a small but robust increased risk for experiencing an episode of MDD, especially among women with no history of MDD in adolescence. Understanding the potential side effects of OCs will help women and their doctors to make informed choices when deciding among possible methods of birth control. En ligne : http://dx.doi.org/10.1111/jcpp.13476 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Association between adolescent oral contraceptive use and future major depressive disorder: a prospective cohort study [texte imprimé] / Christine ANDERL, Auteur ; Anouk E. DE WIT, Auteur ; Erik J. GILTAY, Auteur ; Albertine J. OLDEHINKEL, Auteur ; Frances S. CHEN, Auteur . - p.333-341. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.333-341 Mots-clés : Oral contraceptive use  adolescence  major depressive disorder  risk factors Index. décimale : PER Périodiques Résumé : BACKGROUND: Because of the widespread use of oral contraceptives (OCs) and the devastating effects of depression both on an individual and a societal level, it is crucial to understand the nature of the previously reported relationship between OC use and depression risk. Insight into the impact of analytical choices on the association is important when interpreting available evidence. Hence, we examined the association between adolescent OC use and subsequent depression risk in early adulthood analyzing all theoretically justifiable models. METHODS: Data from the prospective cohort study TRacking Adolescents' Individual Lives Survey, among women aged 13-25 years were used. Adolescent OC use (ages 16-19 years) was used as a predictor and major depressive disorder (MDD) in early adulthood (ages 20-25 years), as assessed by the Diagnostic and Statistical Manual of Mental Disorders-IV oriented Lifetime Depression Assessment Self-Report and the Composite International Diagnostic Interview, was used as an outcome. A total of 818 analytical models were analyzed using Specification Curve Analysis in 534 adolescent OC users and 191 nonusers. RESULTS: Overall, there was an association of adolescent OC use and an episode of MDD in early adulthood [median odds ratio (OR)(median)  = 1.41; OR(min)  = 1.08; OR(max)  = 2.18, p < .001], which was driven by the group of young women with no history of MDD (OR(median)  = 1.72; OR(min)  = 1.21; OR(max)  = 2.18, p < .001). CONCLUSIONS: In summary, adolescent OC use was associated with a small but robust increased risk for experiencing an episode of MDD, especially among women with no history of MDD in adolescence. Understanding the potential side effects of OCs will help women and their doctors to make informed choices when deciding among possible methods of birth control. En ligne : http://dx.doi.org/10.1111/jcpp.13476 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Brief Report: Broader Autism Phenotype Predicts Spontaneous Reciprocity of Direct Gaze / Frances S. CHEN in Journal of Autism and Developmental Disorders, 41-8 (August 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1131-1134 Titre : Brief Report: Broader Autism Phenotype Predicts Spontaneous Reciprocity of Direct Gaze Type de document : texte imprimé Auteurs : Frances S. CHEN, Auteur ; Jennifer M.D. YOON, Auteur Année de publication : 2011 Article en page(s) : p.1131-1134 Langues : Anglais (eng) Mots-clés : Eye contact  Direct gaze  Broader autism phenotype  Autism-Spectrum Quotient Index. décimale : PER Périodiques Résumé : We report evidence for a relationship in the general population between self-reported autism-associated traits and the spontaneous reciprocation of direct gaze, a behavior that we propose may reflect a tendency to synchronize with social partners. Adults viewed videos of actors whose gaze was either directed towards or averted from them. Individuals with lower scores on four subscales of the Autism-Spectrum Quotient (AQ) scale showed a greater tendency to look at directed relative to averted eyes; individuals with higher scores on the AQ did not. This relationship was specific to autism-associated traits and to gaze towards the eyes; it did not generalize to a social anxiety measure or to gaze towards the mouth. We discuss implications for our understanding of the broader autism phenotype. En ligne : http://dx.doi.org/10.1007/s10803-010-1136-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Brief Report: Broader Autism Phenotype Predicts Spontaneous Reciprocity of Direct Gaze [texte imprimé] / Frances S. CHEN, Auteur ; Jennifer M.D. YOON, Auteur . - 2011 . - p.1131-1134. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1131-1134 Mots-clés : Eye contact  Direct gaze  Broader autism phenotype  Autism-Spectrum Quotient Index. décimale : PER Périodiques Résumé : We report evidence for a relationship in the general population between self-reported autism-associated traits and the spontaneous reciprocation of direct gaze, a behavior that we propose may reflect a tendency to synchronize with social partners. Adults viewed videos of actors whose gaze was either directed towards or averted from them. Individuals with lower scores on four subscales of the Autism-Spectrum Quotient (AQ) scale showed a greater tendency to look at directed relative to averted eyes; individuals with higher scores on the AQ did not. This relationship was specific to autism-associated traits and to gaze towards the eyes; it did not generalize to a social anxiety measure or to gaze towards the mouth. We discuss implications for our understanding of the broader autism phenotype. En ligne : http://dx.doi.org/10.1007/s10803-010-1136-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Early adversity and internalizing symptoms in adolescence: Mediation by individual differences in latent trait cortisol / Catherine B. STROUD in Development and Psychopathology, 31-2 (May 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-2 (May 2019) . - p.509-524 Titre : Early adversity and internalizing symptoms in adolescence: Mediation by individual differences in latent trait cortisol Type de document : texte imprimé Auteurs : Catherine B. STROUD, Auteur ; Frances S. CHEN, Auteur ; Leah D. DOANE, Auteur ; Douglas A. GRANGER, Auteur Article en page(s) : p.509-524 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Research suggests that early adversity places individuals at risk for psychopathology across the life span. Guided by concepts of allostasis and allostatic load, the present study examined whether early adversity contributes to the development of subsequent internalizing symptoms through its association with traitlike individual differences in hypothalamic–pituitary–adrenal axis regulation. Early adolescent girls (n = 113; M age = 12.30 years) provided saliva samples at waking, 30 min postwaking, and bedtime over 3 days (later assayed for cortisol). Objective contextual stress interviews with adolescents and their mothers were used to assess the accumulation of nine types of early adversity within the family environment. Greater early adversity predicted subsequent increases in internalizing symptoms through lower levels of latent trait cortisol. Traitlike individual differences in hypothalamic–pituitary–adrenal axis activity may be among the mechanisms through which early adversity confers risk for the development of psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579418000044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Early adversity and internalizing symptoms in adolescence: Mediation by individual differences in latent trait cortisol [texte imprimé] / Catherine B. STROUD, Auteur ; Frances S. CHEN, Auteur ; Leah D. DOANE, Auteur ; Douglas A. GRANGER, Auteur . - p.509-524. Langues : Anglais (eng) in Development and Psychopathology > 31-2 (May 2019) . - p.509-524 Index. décimale : PER Périodiques Résumé : Research suggests that early adversity places individuals at risk for psychopathology across the life span. Guided by concepts of allostasis and allostatic load, the present study examined whether early adversity contributes to the development of subsequent internalizing symptoms through its association with traitlike individual differences in hypothalamic–pituitary–adrenal axis regulation. Early adolescent girls (n = 113; M age = 12.30 years) provided saliva samples at waking, 30 min postwaking, and bedtime over 3 days (later assayed for cortisol). Objective contextual stress interviews with adolescents and their mothers were used to assess the accumulation of nine types of early adversity within the family environment. Greater early adversity predicted subsequent increases in internalizing symptoms through lower levels of latent trait cortisol. Traitlike individual differences in hypothalamic–pituitary–adrenal axis activity may be among the mechanisms through which early adversity confers risk for the development of psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579418000044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Oral contraceptive use in adolescence predicts lasting vulnerability to depression in adulthood / Christine ANDERL in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.148-156 Titre : Oral contraceptive use in adolescence predicts lasting vulnerability to depression in adulthood Type de document : texte imprimé Auteurs : Christine ANDERL, Auteur ; Gu LI, Auteur ; Frances S. CHEN, Auteur Article en page(s) : p.148-156 Langues : Anglais (eng) Mots-clés : Nhanes  Oral contraceptive use  adolescence  depression  sensitive period Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous evidence suggests that use of oral contraceptives (OCs), especially during adolescence, may increase women's vulnerability to depression in the short term. Here, we investigate whether women who had first used OC in adolescence show an increased prevalence of depression in the long term. METHODS: We examined 1,236 women in the United States National Health and Nutrition Examination Survey for whom information on depression and age at first OC use was publicly available. We compared women who reported first use of OCs in adolescence to women who had never used OCs and women who had first used OCs in adulthood on 1-year prevalence of major depressive disorder (MDD) assessed by trained interviewers. RESULTS: Compared with women who had used OCs during adolescence, women who had never used OCs were less likely to meet the criteria for MDD within the past year in adulthood [odds ratio (OR) = 0.31, 95% CI = 0.16-0.60], and so were women who only started using OCs in adulthood (OR = 0.54, 95% CI = 0.30-0.95). Third factors that have previously been proposed to explain the relationship between OC use and depression risk such as age at sexual debut, and, importantly, current OC use, did not account for the results in propensity score analyses. CONCLUSIONS: We show a long-term association between adolescent OC use and depression risk in adulthood regardless of current OC use. Our findings suggest that adolescence may be a sensitive period during which OC use could increase women's risk for depression, years after first exposure. En ligne : http://dx.doi.org/10.1111/jcpp.13115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Oral contraceptive use in adolescence predicts lasting vulnerability to depression in adulthood [texte imprimé] / Christine ANDERL, Auteur ; Gu LI, Auteur ; Frances S. CHEN, Auteur . - p.148-156. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.148-156 Mots-clés : Nhanes  Oral contraceptive use  adolescence  depression  sensitive period Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous evidence suggests that use of oral contraceptives (OCs), especially during adolescence, may increase women's vulnerability to depression in the short term. Here, we investigate whether women who had first used OC in adolescence show an increased prevalence of depression in the long term. METHODS: We examined 1,236 women in the United States National Health and Nutrition Examination Survey for whom information on depression and age at first OC use was publicly available. We compared women who reported first use of OCs in adolescence to women who had never used OCs and women who had first used OCs in adulthood on 1-year prevalence of major depressive disorder (MDD) assessed by trained interviewers. RESULTS: Compared with women who had used OCs during adolescence, women who had never used OCs were less likely to meet the criteria for MDD within the past year in adulthood [odds ratio (OR) = 0.31, 95% CI = 0.16-0.60], and so were women who only started using OCs in adulthood (OR = 0.54, 95% CI = 0.30-0.95). Third factors that have previously been proposed to explain the relationship between OC use and depression risk such as age at sexual debut, and, importantly, current OC use, did not account for the results in propensity score analyses. CONCLUSIONS: We show a long-term association between adolescent OC use and depression risk in adulthood regardless of current OC use. Our findings suggest that adolescence may be a sensitive period during which OC use could increase women's risk for depression, years after first exposure. En ligne : http://dx.doi.org/10.1111/jcpp.13115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Research Review: Are sampling biases masking long-term effects of hormonal contraceptive use in adolescence on risk for depression? / Frances S. CHEN in Journal of Child Psychology and Psychiatry, 66-12 (December 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1889-1903 Titre : Research Review: Are sampling biases masking long-term effects of hormonal contraceptive use in adolescence on risk for depression? Type de document : texte imprimé Auteurs : Frances S. CHEN, Auteur ; Bita ZAREIAN, Auteur ; Marisa A. NELSON, Auteur ; Nina EDWARDS, Auteur ; Christine ANDERL, Auteur Article en page(s) : p.1889-1903 Langues : Anglais (eng) Mots-clés : Mental health  mood disorder  sex hormones  oral contraceptives  puberty Index. décimale : PER Périodiques Résumé : Background Growing evidence suggests that the use of hormonal contraceptives (HCs) during adolescence may be linked to an increased risk for depression. This review examines major inconsistencies that have been reported regarding this relationship, and in particular, how the common practice of combining ?never users? and ?former users? of HCs in analyses obscures patterns that are detectable when these groups are analyzed separately. Methods A review was conducted of research examining the relationship between HC use and depression to determine what data-analytic choices were commonly made by individual researchers. Specifically, we assessed whether the past history of HC use had been accounted for in each reported analysis. Results The majority of papers published between 2013 and 2022 did not account for the former use of HCs. These papers reported mixed findings regarding the relationship between HC use and depression. In contrast, the subset of papers that did account for former use of HCs, or otherwise explicitly addressed common biases affecting the interpretation of observational data, revealed a more consistent relationship between HC use and depression, particularly for those who began using HCs during adolescence. Conclusion We conclude that there is consistent evidence of a relationship between adolescent HC use and long-term risk for depression and offer several recommendations to help ensure that future work in this area will yield consistent, interpretable findings. Although this paper focuses primarily on HCs and depression, many of the analytical approaches and recommendations outlined within it are also relevant to research on the side effects of other drugs and medications. En ligne : https://doi.org/10.1111/jcpp.14180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Research Review: Are sampling biases masking long-term effects of hormonal contraceptive use in adolescence on risk for depression? [texte imprimé] / Frances S. CHEN, Auteur ; Bita ZAREIAN, Auteur ; Marisa A. NELSON, Auteur ; Nina EDWARDS, Auteur ; Christine ANDERL, Auteur . - p.1889-1903. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1889-1903 Mots-clés : Mental health  mood disorder  sex hormones  oral contraceptives  puberty Index. décimale : PER Périodiques Résumé : Background Growing evidence suggests that the use of hormonal contraceptives (HCs) during adolescence may be linked to an increased risk for depression. This review examines major inconsistencies that have been reported regarding this relationship, and in particular, how the common practice of combining ?never users? and ?former users? of HCs in analyses obscures patterns that are detectable when these groups are analyzed separately. Methods A review was conducted of research examining the relationship between HC use and depression to determine what data-analytic choices were commonly made by individual researchers. Specifically, we assessed whether the past history of HC use had been accounted for in each reported analysis. Results The majority of papers published between 2013 and 2022 did not account for the former use of HCs. These papers reported mixed findings regarding the relationship between HC use and depression. In contrast, the subset of papers that did account for former use of HCs, or otherwise explicitly addressed common biases affecting the interpretation of observational data, revealed a more consistent relationship between HC use and depression, particularly for those who began using HCs during adolescence. Conclusion We conclude that there is consistent evidence of a relationship between adolescent HC use and long-term risk for depression and offer several recommendations to help ensure that future work in this area will yield consistent, interpretable findings. Although this paper focuses primarily on HCs and depression, many of the analytical approaches and recommendations outlined within it are also relevant to research on the side effects of other drugs and medications. En ligne : https://doi.org/10.1111/jcpp.14180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

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