A randomised controlled treatment trial of two forms of family therapy in adolescent anorexia nervosa: a five-year follow-up / Ivan EISLER in Journal of Child Psychology and Psychiatry, 48-6 (June 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-6 (June 2007) . - p.552–560 Titre : A randomised controlled treatment trial of two forms of family therapy in adolescent anorexia nervosa: a five-year follow-up Type de document : Texte imprimé et/ou numérique Auteurs : Ivan EISLER, Auteur ; Mima SIMIC, Auteur ; Gerald F.M. RUSSELL, Auteur ; Christopher DARE, Auteur Année de publication : 2007 Article en page(s) : p.552–560 Langues : Anglais (eng) Mots-clés : Family-therapy anorexia-nervosa adolescence Index. décimale : PER Périodiques Résumé : There is growing evidence that family therapy is an effective treatment for adolescent anorexia nervosa. This study aimed to ascertain the long-term impact of two forms of outpatient family intervention previously evaluated in a randomised controlled trial (RCT). Method: A five-year follow-up was conducted on a cohort of 40 patients who had received either ‘conjoint family therapy’ (CFT) or ‘separated family therapy’ (SFT). All patients were traced and 38 agreed to be reassessed (29 interviewed in person, 3 completed telephone interviews, 6 completed questionnaires and/or agreed for parents/GP to be interviewed). Results: Overall there was little to distinguish the two treatments at 5 years, with more than 75% of subjects having no eating disorder symptoms. There were no deaths in the cohort and only 8% of those who had achieved a healthy weight by the end of treatment reported any kind of relapse. Three patients developed bulimic symptoms but only one to a degree warranting a diagnosis of bulimia nervosa. The one difference between the treatments was in patients from families with raised levels of maternal criticism. This group of patients had done less well at the end of treatment if they had been offered conjoint family meetings. At follow-up this difference was still evident, as shown in the relative lack of weight gain since the end of outpatient treatment. Conclusions: This study confirms the efficacy of family therapy for adolescent anorexia nervosa, showing that those who respond well to outpatient family intervention generally stay well. The study provides further support for avoiding the use of conjoint family meetings at least early on in treatment when raised levels of parental criticism are evident. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01726.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=103 [article] A randomised controlled treatment trial of two forms of family therapy in adolescent anorexia nervosa: a five-year follow-up [Texte imprimé et/ou numérique] / Ivan EISLER, Auteur ; Mima SIMIC, Auteur ; Gerald F.M. RUSSELL, Auteur ; Christopher DARE, Auteur . - 2007 . - p.552–560. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-6 (June 2007) . - p.552–560 Mots-clés : Family-therapy anorexia-nervosa adolescence Index. décimale : PER Périodiques Résumé : There is growing evidence that family therapy is an effective treatment for adolescent anorexia nervosa. This study aimed to ascertain the long-term impact of two forms of outpatient family intervention previously evaluated in a randomised controlled trial (RCT). Method: A five-year follow-up was conducted on a cohort of 40 patients who had received either ‘conjoint family therapy’ (CFT) or ‘separated family therapy’ (SFT). All patients were traced and 38 agreed to be reassessed (29 interviewed in person, 3 completed telephone interviews, 6 completed questionnaires and/or agreed for parents/GP to be interviewed). Results: Overall there was little to distinguish the two treatments at 5 years, with more than 75% of subjects having no eating disorder symptoms. There were no deaths in the cohort and only 8% of those who had achieved a healthy weight by the end of treatment reported any kind of relapse. Three patients developed bulimic symptoms but only one to a degree warranting a diagnosis of bulimia nervosa. The one difference between the treatments was in patients from families with raised levels of maternal criticism. This group of patients had done less well at the end of treatment if they had been offered conjoint family meetings. At follow-up this difference was still evident, as shown in the relative lack of weight gain since the end of outpatient treatment. Conclusions: This study confirms the efficacy of family therapy for adolescent anorexia nervosa, showing that those who respond well to outpatient family intervention generally stay well. The study provides further support for avoiding the use of conjoint family meetings at least early on in treatment when raised levels of parental criticism are evident. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01726.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=103

Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls / Rozmin HALARI in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.307-316 Titre : Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls Type de document : Texte imprimé et/ou numérique Auteurs : Rozmin HALARI, Auteur ; Eric FOMBONNE, Auteur ; Mima SIMIC, Auteur ; Michael BRAMMER, Auteur ; Katya RUBIA, Auteur ; Carmine M. PARIANTE, Auteur ; Andrew S. PAPADOPOULOS, Auteur ; Anthony CLEARE, Auteur Année de publication : 2009 Article en page(s) : p.307-316 Langues : Anglais (eng) Mots-clés : Depression adolescent FMRI cognitive-control executive functions Index. décimale : PER Périodiques Résumé : Background: There is increasing recognition of major depressive disorder (MDD) in adolescence. In adult MDD, abnormalities of fronto-striatal and fronto-cingulate circuitries mediating cognitive control functions have been implicated in the pathogenesis and been related to problems with controlling negative thoughts. No neuroimaging studies of cognitive control functions, however, exist in paediatric depression. This study investigated whether medication-naïve adolescents with MDD show abnormal brain activation of fronto-striatal and fronto-cingulate networks when performing tasks of attentional and cognitive control. Methods: Event-related functional magnetic resonance imaging was used to compare brain activation between 21 medication-naïve adolescents with a first-episode of MDD aged 14–17 years and 21 healthy adolescents, matched for handedness, age, sex, demographics and IQ. Activation paradigms were tasks of selective attention (Simon task), attentional switching (Switch task), and motor response inhibition and error detection (Stop task). Results: In all three tasks, adolescents with depression compared to healthy controls demonstrated reduced activation in task-relevant right dorsolateral (DLPFC), inferior prefrontal cortex (IFC) and anterior cingulate gyrus (ACG). Additional areas of relatively reduced activation were in the parietal lobes during the Stop and Switch tasks, putamen, insula and temporal lobes during the Switch task and precuneus during the Simon task. Conclusions: This study shows first evidence that medication-naïve adolescents with MDD are characterised by abnormal function in ACG and right lateral prefrontal cortex during tasks of attention and performance monitoring, suggesting an early pathogenesis of these functional abnormalities attributed to MDD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01972.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719 [article] Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls [Texte imprimé et/ou numérique] / Rozmin HALARI, Auteur ; Eric FOMBONNE, Auteur ; Mima SIMIC, Auteur ; Michael BRAMMER, Auteur ; Katya RUBIA, Auteur ; Carmine M. PARIANTE, Auteur ; Andrew S. PAPADOPOULOS, Auteur ; Anthony CLEARE, Auteur . - 2009 . - p.307-316. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.307-316 Mots-clés : Depression adolescent FMRI cognitive-control executive functions Index. décimale : PER Périodiques Résumé : Background: There is increasing recognition of major depressive disorder (MDD) in adolescence. In adult MDD, abnormalities of fronto-striatal and fronto-cingulate circuitries mediating cognitive control functions have been implicated in the pathogenesis and been related to problems with controlling negative thoughts. No neuroimaging studies of cognitive control functions, however, exist in paediatric depression. This study investigated whether medication-naïve adolescents with MDD show abnormal brain activation of fronto-striatal and fronto-cingulate networks when performing tasks of attentional and cognitive control. Methods: Event-related functional magnetic resonance imaging was used to compare brain activation between 21 medication-naïve adolescents with a first-episode of MDD aged 14–17 years and 21 healthy adolescents, matched for handedness, age, sex, demographics and IQ. Activation paradigms were tasks of selective attention (Simon task), attentional switching (Switch task), and motor response inhibition and error detection (Stop task). Results: In all three tasks, adolescents with depression compared to healthy controls demonstrated reduced activation in task-relevant right dorsolateral (DLPFC), inferior prefrontal cortex (IFC) and anterior cingulate gyrus (ACG). Additional areas of relatively reduced activation were in the parietal lobes during the Stop and Switch tasks, putamen, insula and temporal lobes during the Switch task and precuneus during the Simon task. Conclusions: This study shows first evidence that medication-naïve adolescents with MDD are characterised by abnormal function in ACG and right lateral prefrontal cortex during tasks of attention and performance monitoring, suggesting an early pathogenesis of these functional abnormalities attributed to MDD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01972.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719

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