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Auteur Rozmin HALARI |
Documents disponibles écrits par cet auteur (3)



Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls / Rozmin HALARI in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)
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[article]
Titre : Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls Type de document : Texte imprimé et/ou numérique Auteurs : Rozmin HALARI, Auteur ; Eric FOMBONNE, Auteur ; Mima SIMIC, Auteur ; Michael BRAMMER, Auteur ; Katya RUBIA, Auteur ; Carmine M. PARIANTE, Auteur ; Andrew S. PAPADOPOULOS, Auteur ; Anthony CLEARE, Auteur Année de publication : 2009 Article en page(s) : p.307-316 Langues : Anglais (eng) Mots-clés : Depression adolescent FMRI cognitive-control executive functions Index. décimale : PER Périodiques Résumé : Background: There is increasing recognition of major depressive disorder (MDD) in adolescence. In adult MDD, abnormalities of fronto-striatal and fronto-cingulate circuitries mediating cognitive control functions have been implicated in the pathogenesis and been related to problems with controlling negative thoughts. No neuroimaging studies of cognitive control functions, however, exist in paediatric depression. This study investigated whether medication-naïve adolescents with MDD show abnormal brain activation of fronto-striatal and fronto-cingulate networks when performing tasks of attentional and cognitive control.
Methods: Event-related functional magnetic resonance imaging was used to compare brain activation between 21 medication-naïve adolescents with a first-episode of MDD aged 14–17 years and 21 healthy adolescents, matched for handedness, age, sex, demographics and IQ. Activation paradigms were tasks of selective attention (Simon task), attentional switching (Switch task), and motor response inhibition and error detection (Stop task).
Results: In all three tasks, adolescents with depression compared to healthy controls demonstrated reduced activation in task-relevant right dorsolateral (DLPFC), inferior prefrontal cortex (IFC) and anterior cingulate gyrus (ACG). Additional areas of relatively reduced activation were in the parietal lobes during the Stop and Switch tasks, putamen, insula and temporal lobes during the Switch task and precuneus during the Simon task.
Conclusions: This study shows first evidence that medication-naïve adolescents with MDD are characterised by abnormal function in ACG and right lateral prefrontal cortex during tasks of attention and performance monitoring, suggesting an early pathogenesis of these functional abnormalities attributed to MDD.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01972.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719
in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.307-316[article] Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls [Texte imprimé et/ou numérique] / Rozmin HALARI, Auteur ; Eric FOMBONNE, Auteur ; Mima SIMIC, Auteur ; Michael BRAMMER, Auteur ; Katya RUBIA, Auteur ; Carmine M. PARIANTE, Auteur ; Andrew S. PAPADOPOULOS, Auteur ; Anthony CLEARE, Auteur . - 2009 . - p.307-316.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.307-316
Mots-clés : Depression adolescent FMRI cognitive-control executive functions Index. décimale : PER Périodiques Résumé : Background: There is increasing recognition of major depressive disorder (MDD) in adolescence. In adult MDD, abnormalities of fronto-striatal and fronto-cingulate circuitries mediating cognitive control functions have been implicated in the pathogenesis and been related to problems with controlling negative thoughts. No neuroimaging studies of cognitive control functions, however, exist in paediatric depression. This study investigated whether medication-naïve adolescents with MDD show abnormal brain activation of fronto-striatal and fronto-cingulate networks when performing tasks of attentional and cognitive control.
Methods: Event-related functional magnetic resonance imaging was used to compare brain activation between 21 medication-naïve adolescents with a first-episode of MDD aged 14–17 years and 21 healthy adolescents, matched for handedness, age, sex, demographics and IQ. Activation paradigms were tasks of selective attention (Simon task), attentional switching (Switch task), and motor response inhibition and error detection (Stop task).
Results: In all three tasks, adolescents with depression compared to healthy controls demonstrated reduced activation in task-relevant right dorsolateral (DLPFC), inferior prefrontal cortex (IFC) and anterior cingulate gyrus (ACG). Additional areas of relatively reduced activation were in the parietal lobes during the Stop and Switch tasks, putamen, insula and temporal lobes during the Switch task and precuneus during the Simon task.
Conclusions: This study shows first evidence that medication-naïve adolescents with MDD are characterised by abnormal function in ACG and right lateral prefrontal cortex during tasks of attention and performance monitoring, suggesting an early pathogenesis of these functional abnormalities attributed to MDD.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01972.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719 Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination / Anna B. SMITH in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)
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[article]
Titre : Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination Type de document : Texte imprimé et/ou numérique Auteurs : Anna B. SMITH, Auteur ; Michael BRAMMER, Auteur ; Eric TAYLOR, Auteur ; Rozmin HALARI, Auteur ; Katya RUBIA, Auteur Année de publication : 2008 Article en page(s) : p.977-985 Langues : Anglais (eng) Mots-clés : ADHD time-discrimination fMRI anterior-cingulate dorsolateral-prefrontal-cortex Index. décimale : PER Périodiques Résumé : Background: Patients with attention deficit hyperactivity disorder (ADHD) under-perform when discriminating between durations differing by several hundred milliseconds. This function involves right prefrontal and anterior cingulate (AC) brain regions, which are structurally and functionally compromised in this patient group during executive tasks. We investigated the neuro-anatomical substrates mediating fine temporal discrimination in adolescents with ADHD compared with controls, using functional magnetic resonance imaging (fMRI).
Methods: Twenty-one male medication-naïve adolescents aged 10–15 years with a DSM-IV diagnosis of ADHD (combined subtype) and without comorbid Axis I disorders (except conduct disorder) were compared to a group of 17 age- and IQ-matched healthy adolescents. Using fMRI on a 1.5T scanner, we compared brain activation and performance between adolescents with ADHD and controls during a time discrimination task contrasted with a temporal order task.
Results: Despite comparable performance, patients with ADHD showed decreased activation in right dorsolateral and inferior prefrontal cortex and AC during time discrimination compared with controls.
Conclusions: Right hemispheric fronto-cingulate abnormalities in ADHD, previously observed during inhibitory and executive functions, are also associated with temporal perception. Furthermore, recruitment of medication-naïve patients precludes the possibility that deficits are attributable to stimulant exposure.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01870.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558
in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.977-985[article] Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination [Texte imprimé et/ou numérique] / Anna B. SMITH, Auteur ; Michael BRAMMER, Auteur ; Eric TAYLOR, Auteur ; Rozmin HALARI, Auteur ; Katya RUBIA, Auteur . - 2008 . - p.977-985.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.977-985
Mots-clés : ADHD time-discrimination fMRI anterior-cingulate dorsolateral-prefrontal-cortex Index. décimale : PER Périodiques Résumé : Background: Patients with attention deficit hyperactivity disorder (ADHD) under-perform when discriminating between durations differing by several hundred milliseconds. This function involves right prefrontal and anterior cingulate (AC) brain regions, which are structurally and functionally compromised in this patient group during executive tasks. We investigated the neuro-anatomical substrates mediating fine temporal discrimination in adolescents with ADHD compared with controls, using functional magnetic resonance imaging (fMRI).
Methods: Twenty-one male medication-naïve adolescents aged 10–15 years with a DSM-IV diagnosis of ADHD (combined subtype) and without comorbid Axis I disorders (except conduct disorder) were compared to a group of 17 age- and IQ-matched healthy adolescents. Using fMRI on a 1.5T scanner, we compared brain activation and performance between adolescents with ADHD and controls during a time discrimination task contrasted with a temporal order task.
Results: Despite comparable performance, patients with ADHD showed decreased activation in right dorsolateral and inferior prefrontal cortex and AC during time discrimination compared with controls.
Conclusions: Right hemispheric fronto-cingulate abnormalities in ADHD, previously observed during inhibitory and executive functions, are also associated with temporal perception. Furthermore, recruitment of medication-naïve patients precludes the possibility that deficits are attributable to stimulant exposure.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01870.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocation / Katya RUBIA in Journal of Child Psychology and Psychiatry, 50-6 (June 2009)
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[article]
Titre : Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocation Type de document : Texte imprimé et/ou numérique Auteurs : Katya RUBIA, Auteur ; Michael BRAMMER, Auteur ; Stephen SCOTT, Auteur ; Anna B. SMITH, Auteur ; Rozmin HALARI, Auteur ; Majeed MOHAMMAD, Auteur Année de publication : 2009 Article en page(s) : p.669-678 Langues : Anglais (eng) Mots-clés : ADHD Conduct-disorder-(CD) fMRI interference-inhibition Simon-task oddball-task attention-allocation frontal-lobes Index. décimale : PER Périodiques Résumé : Background: Inhibitory and attention deficits have been suggested to be shared problems of disruptive behaviour disorders. Patients with attention deficit hyperactivity disorder (ADHD) and patients with conduct disorder (CD) show deficits in tasks of attention allocation and interference inhibition. However, functional magnetic resonance imaging (fMRI) of inhibitory and attention control has only been investigated in patients with ADHD, including comorbidity with CD, finding fronto-striatal and temporo-parietal dysfunction. This study investigates differences and commonalities in functional neural networks mediating interference inhibition and attention allocation between medication-naïve children and adolescents with pure CD and those with pure ADHD.
Methods: Event-related fMRI was used to compare brain activation of 13 boys with non-comorbid CD, 20 boys with non-comorbid ADHD and 20 healthy comparison boys during a Simon task that measures interference inhibition and controls for attention allocation, thus tapping into interference inhibition and selective attention networks.
Results: During interference inhibition, both patient groups shared reduced activation compared to controls in right superior temporal lobe and in predominantly right precuneus. During the oddball condition, both patient groups showed reduced activation compared to healthy control children in right medial prefrontal lobe. However, only ADHD patients showed a disorder-specific under-activation compared to the other two groups in an extensive activation cluster in left inferior prefrontal cortex.
Conclusions: This study shows shared dysfunction in both patients groups in right hemispheric temporal and parietal brain regions during interference inhibition and in right dorsolateral prefrontal cortex during attention allocation. Ventrolateral prefrontal dysfunction, however, was specific to ADHD and not observed in patients with CD in the context of attention allocation. The findings suggest that the typically reduced functional activation in patients with ADHD in ventrolateral prefrontal cortex may be specific to the disorder, at least when compared to patients with CD.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02022.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=755
in Journal of Child Psychology and Psychiatry > 50-6 (June 2009) . - p.669-678[article] Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocation [Texte imprimé et/ou numérique] / Katya RUBIA, Auteur ; Michael BRAMMER, Auteur ; Stephen SCOTT, Auteur ; Anna B. SMITH, Auteur ; Rozmin HALARI, Auteur ; Majeed MOHAMMAD, Auteur . - 2009 . - p.669-678.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-6 (June 2009) . - p.669-678
Mots-clés : ADHD Conduct-disorder-(CD) fMRI interference-inhibition Simon-task oddball-task attention-allocation frontal-lobes Index. décimale : PER Périodiques Résumé : Background: Inhibitory and attention deficits have been suggested to be shared problems of disruptive behaviour disorders. Patients with attention deficit hyperactivity disorder (ADHD) and patients with conduct disorder (CD) show deficits in tasks of attention allocation and interference inhibition. However, functional magnetic resonance imaging (fMRI) of inhibitory and attention control has only been investigated in patients with ADHD, including comorbidity with CD, finding fronto-striatal and temporo-parietal dysfunction. This study investigates differences and commonalities in functional neural networks mediating interference inhibition and attention allocation between medication-naïve children and adolescents with pure CD and those with pure ADHD.
Methods: Event-related fMRI was used to compare brain activation of 13 boys with non-comorbid CD, 20 boys with non-comorbid ADHD and 20 healthy comparison boys during a Simon task that measures interference inhibition and controls for attention allocation, thus tapping into interference inhibition and selective attention networks.
Results: During interference inhibition, both patient groups shared reduced activation compared to controls in right superior temporal lobe and in predominantly right precuneus. During the oddball condition, both patient groups showed reduced activation compared to healthy control children in right medial prefrontal lobe. However, only ADHD patients showed a disorder-specific under-activation compared to the other two groups in an extensive activation cluster in left inferior prefrontal cortex.
Conclusions: This study shows shared dysfunction in both patients groups in right hemispheric temporal and parietal brain regions during interference inhibition and in right dorsolateral prefrontal cortex during attention allocation. Ventrolateral prefrontal dysfunction, however, was specific to ADHD and not observed in patients with CD in the context of attention allocation. The findings suggest that the typically reduced functional activation in patients with ADHD in ventrolateral prefrontal cortex may be specific to the disorder, at least when compared to patients with CD.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02022.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=755