Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder / Kari L. HANSON in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) Titre : Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder Type de document : texte imprimé Auteurs : Kari L. HANSON, Auteur ; Thomas AVINO, Auteur ; Sandra L. TAYLOR, Auteur ; Karl D. MURRAY, Auteur ; Cynthia M. SCHUMANN, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Neuronal connectivity is refined throughout development by the proliferation and pruning of axons in cerebral white matter, and progressive axon myelination that enables rapid communication across brain regions. Differences in connectivity have been observed in autism spectrum disorder (ASD), including changes in white matter volume and connectivity. In the prefrontal cortex, this includes imbalances between short- and long-ranging axons, consistent with a pattern of local hyperconnectivity, and long-range hypoconnectivity. Alterations in temporal lobe white matter development—critical for social behavior—may contribute to atypical neural connectivity. En ligne : https://doi.org/10.1186/s13229-025-00684-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder [texte imprimé] / Kari L. HANSON, Auteur ; Thomas AVINO, Auteur ; Sandra L. TAYLOR, Auteur ; Karl D. MURRAY, Auteur ; Cynthia M. SCHUMANN, Auteur. Langues : Anglais (eng) in Molecular Autism > 16 (2025) Index. décimale : PER Périodiques Résumé : Neuronal connectivity is refined throughout development by the proliferation and pruning of axons in cerebral white matter, and progressive axon myelination that enables rapid communication across brain regions. Differences in connectivity have been observed in autism spectrum disorder (ASD), including changes in white matter volume and connectivity. In the prefrontal cortex, this includes imbalances between short- and long-ranging axons, consistent with a pattern of local hyperconnectivity, and long-range hypoconnectivity. Alterations in temporal lobe white matter development—critical for social behavior—may contribute to atypical neural connectivity. En ligne : https://doi.org/10.1186/s13229-025-00684-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

Amygdale et Autisme: apport des études chez le primate non humain / David G. AMARAL

Public ISBD contenu dans L'autisme / Alain BERTHOZ Titre : Amygdale et Autisme: apport des études chez le primate non humain Type de document : texte imprimé Auteurs : David G. AMARAL, Auteur ; Margaret L. BAUMAN, Auteur ; Cynthia MILLS-SCHUMANN, Auteur Année de publication : 2005 Importance : p.321-342 Langues : Français (fre) Mots-clés : Amygdales Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=193 contenu dans L'autisme / Alain BERTHOZ Amygdale et Autisme: apport des études chez le primate non humain [texte imprimé] / David G. AMARAL, Auteur ; Margaret L. BAUMAN, Auteur ; Cynthia MILLS-SCHUMANN, Auteur . - 2005 . - p.321-342. Langues : Français (fre) Mots-clés : Amygdales Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=193

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Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders / Bradley P. ANDER in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-13 Titre : Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders Type de document : texte imprimé Auteurs : Bradley P. ANDER, Auteur ; Nicole BARGER, Auteur ; Boryana STAMOVA, Auteur ; Frank R. SHARP, Auteur ; Cynthia M. SCHUMANN, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microRNA (miRNA), could have profound effects upon multiple functional pathways. We assessed whether a brain region associated with core social impairments in ASD, the superior temporal sulcus (STS), would evidence greater transcriptional dysregulation of sncRNA than adjacent, yet functionally distinct, primary auditory cortex (PAC). En ligne : http://dx.doi.org/10.1186/s13229-015-0029-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders [texte imprimé] / Bradley P. ANDER, Auteur ; Nicole BARGER, Auteur ; Boryana STAMOVA, Auteur ; Frank R. SHARP, Auteur ; Cynthia M. SCHUMANN, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-13 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microRNA (miRNA), could have profound effects upon multiple functional pathways. We assessed whether a brain region associated with core social impairments in ASD, the superior temporal sulcus (STS), would evidence greater transcriptional dysregulation of sncRNA than adjacent, yet functionally distinct, primary auditory cortex (PAC). En ligne : http://dx.doi.org/10.1186/s13229-015-0029-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder / Julia A. SCOTT in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.246-257 Titre : A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder Type de document : texte imprimé Auteurs : Julia A. SCOTT, Auteur ; David G. AMARAL, Auteur ; Cynthia MILLS-SCHUMANN, Auteur ; Beth GOODLIN-JONES, Auteur Année de publication : 2009 Article en page(s) : p.246-257 Langues : Anglais (eng) Mots-clés : Asperger MRI developmental-delays vermis neurodevelopmental-disorder Index. décimale : PER Périodiques Résumé : Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to plane of section artifacts may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.97 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder [texte imprimé] / Julia A. SCOTT, Auteur ; David G. AMARAL, Auteur ; Cynthia MILLS-SCHUMANN, Auteur ; Beth GOODLIN-JONES, Auteur . - 2009 . - p.246-257. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.246-257 Mots-clés : Asperger MRI developmental-delays vermis neurodevelopmental-disorder Index. décimale : PER Périodiques Résumé : Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to plane of section artifacts may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.97 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

From Toddlers to Adults: The Changing Landscape of the Brain in Autism / Eric COURCHESNE

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : From Toddlers to Adults: The Changing Landscape of the Brain in Autism Type de document : texte imprimé Auteurs : Eric COURCHESNE, Auteur ; Sara Jane WEBB, Auteur ; Cynthia M. SCHUMANN, Auteur Année de publication : 2011 Importance : p.611-631 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL From Toddlers to Adults: The Changing Landscape of the Brain in Autism [texte imprimé] / Eric COURCHESNE, Auteur ; Sara Jane WEBB, Auteur ; Cynthia M. SCHUMANN, Auteur . - 2011 . - p.611-631. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome / Claudia M. GRECO in Molecular Autism, (February 2011)  

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Neuropathology of Autism Spectrum Disorders: Postmortem Studies / Cynthia M. SCHUMANN

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Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain / Cynthia M. SCHUMANN in Molecular Autism, 8 (2017)  

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Rigor in science and science reporting: updated guidelines for submissions to Molecular Autism / Joseph D. BUXBAUM in Molecular Autism, 10 (2019)  

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Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome / C.H. LEW in Molecular Autism, 11 (2020)  

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The Amygdala in Autism Spectrum Disorders / John T. MORGAN

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