[article]
| Titre : |
Brief Report: “Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye? |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Asimenia ANGELIDOU, Auteur ; Konstantinos-Dionysios ALYSANDRATOS, Auteur ; Shahrzad ASADI, Auteur ; Bodi ZHANG, Auteur ; Konstantinos FRANCIS, Auteur ; Magdalini VASIADI, Auteur ; Dimitrios KALOGEROMITROS, Auteur ; Theoharis THEOHARIDES, Auteur |
| Année de publication : |
2011 |
| Article en page(s) : |
p.1579-1585 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Allergy Autism Brain Food intolerance Inflammation Mast cells |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of “allergic symptomatology”, often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut–blood–brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-010-1171-z |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 |
in Journal of Autism and Developmental Disorders > 41-11 (November 2011) . - p.1579-1585
[article] Brief Report: “Allergic Symptoms” in Children with Autism Spectrum Disorders. More than Meets the Eye? [Texte imprimé et/ou numérique] / Asimenia ANGELIDOU, Auteur ; Konstantinos-Dionysios ALYSANDRATOS, Auteur ; Shahrzad ASADI, Auteur ; Bodi ZHANG, Auteur ; Konstantinos FRANCIS, Auteur ; Magdalini VASIADI, Auteur ; Dimitrios KALOGEROMITROS, Auteur ; Theoharis THEOHARIDES, Auteur . - 2011 . - p.1579-1585. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 41-11 (November 2011) . - p.1579-1585
| Mots-clés : |
Allergy Autism Brain Food intolerance Inflammation Mast cells |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of “allergic symptomatology”, often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut–blood–brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-010-1171-z |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 |
|
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