Autoimmunity in Autism Spectrum Disorders / Laila Y. AL-AYADHI  

Public ISBD in Autism - A Neurodevelopmental Journey from Genes to Behaviour / Valsamma EAPEN   Titre : Autoimmunity in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Laila Y. AL-AYADHI, Auteur Année de publication : 2011 Importance : p.299-318 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/17377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 in Autism - A Neurodevelopmental Journey from Genes to Behaviour / Valsamma EAPEN   Autoimmunity in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Laila Y. AL-AYADHI, Auteur . - 2011 . - p.299-318. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/17377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143

Exemplaires

Code-barres	Cote	Support	Localisation	Section	Disponibilité
aucun exemplaire

C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism / Mushtaq A. ANSARI in Research in Autism Spectrum Disorders, 71 (March 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 71 (March 2020) . - p.101500 Titre : C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Mushtaq A. ANSARI, Auteur ; Saleh A. BAKHEET, Auteur ; Laila Y. AL-AYADHI, Auteur ; Mohammad R. KHAN, Auteur ; Sabry M. ATTIA, Auteur ; Sheikh F. AHMAD, Auteur Article en page(s) : p.101500 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Typically developing controls  C-C motif chemokine receptor 6  Peripheral blood mononuclear cells  Pro-inflammatory mediators Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heterogeneous disorder associated with immune abnormalities. C-C motif chemokine receptor 6 (CCR6) has central roles in neuroinflammatory disorders. However, CCR6 expression in ASD is unclear. Here, we examined CCR6 expression in children with ASD. Children with ASD had significantly increased numbers of CCR6+/interferon-?+, CCR6+/tumor necrosis factor-?+, CCR6+/interleukin (IL)-9+, CCR6+/IL-22+, CCR6+/nuclear factor-?B p65+, and CCR6+/nitric oxide synthase 2+ cells compared with typically developing controls (TDs). Moreover, children with ASD showed increased CCR6 mRNA/protein levels compared with TDs. Thus, CCR6 upregulated pro-inflammatory mediators associated with immune dysfunction in children with ASD, suggesting contributions to ASD development. En ligne : https://doi.org/10.1016/j.rasd.2019.101500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism [Texte imprimé et/ou numérique] / Mushtaq A. ANSARI, Auteur ; Saleh A. BAKHEET, Auteur ; Laila Y. AL-AYADHI, Auteur ; Mohammad R. KHAN, Auteur ; Sabry M. ATTIA, Auteur ; Sheikh F. AHMAD, Auteur . - p.101500. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101500 Mots-clés : Autism spectrum disorder  Typically developing controls  C-C motif chemokine receptor 6  Peripheral blood mononuclear cells  Pro-inflammatory mediators Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heterogeneous disorder associated with immune abnormalities. C-C motif chemokine receptor 6 (CCR6) has central roles in neuroinflammatory disorders. However, CCR6 expression in ASD is unclear. Here, we examined CCR6 expression in children with ASD. Children with ASD had significantly increased numbers of CCR6+/interferon-?+, CCR6+/tumor necrosis factor-?+, CCR6+/interleukin (IL)-9+, CCR6+/IL-22+, CCR6+/nuclear factor-?B p65+, and CCR6+/nitric oxide synthase 2+ cells compared with typically developing controls (TDs). Moreover, children with ASD showed increased CCR6 mRNA/protein levels compared with TDs. Thus, CCR6 upregulated pro-inflammatory mediators associated with immune dysfunction in children with ASD, suggesting contributions to ASD development. En ligne : https://doi.org/10.1016/j.rasd.2019.101500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

Effectiveness of Auditory Integration Therapy in Autism Spectrum Disorders—Prospective Study / Laila Y. AL-AYADHI in Autism Insights, (April 2013)  

Public ISBD [article]  inAutism Insights > (April 2013) . - p.13-20 Titre : Effectiveness of Auditory Integration Therapy in Autism Spectrum Disorders—Prospective Study Type de document : Texte imprimé et/ou numérique Auteurs : Laila Y. AL-AYADHI, Auteur ; Abdul Majeed AL-DREES, Auteur ; Ahmed M. AL-ARFAJ, Auteur Année de publication : 2013 Article en page(s) : p.13-20 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Objectives: To determine the effectiveness of auditory integration training (AIT) in people with Autism Spectrum Disorders (ASD). Method: Seventy two subjects with ASD aged up to 17 years old (70 male and 2 females) were recruited for the study. All subjects were screened by Diagnostic and Statistical Manual of Mental Disorders, (DSM-IV), and assessed by CARS (Childhood Autism Rating Scale). Pre-intervention scores and post-intervention (3 and 6 months) scores were calculated for each child using CARS, Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Auditory integration training was performed over 2 week, 30 minutes, twice a day. Results: All subjects demonstrated improvement 3 and 6 months following the AIT. ASD subject showed 22% and 26% percentage improvement in SRS scoring 3 and 6 months respectively following the AIT intervention. Those changes were attributed to statistically significant changes in social awareness, social cognition, and social communication. Similar results were achieved with the ATEC check list: ASD subject showed 19.5% and 22.5% improvement 3 and 6 months following the AIT intervention, respectively. Those changes are due to statistically significant (P < 0.05) improvement in speech, communication and sociability only. Conclusions: The results of this study support the therapeutic effects of auditory integration training on social awareness, social cognition, and social communication, as well as speech and communication. En ligne : http://dx.doi.org/10.4137/AUI.S11463 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Effectiveness of Auditory Integration Therapy in Autism Spectrum Disorders—Prospective Study [Texte imprimé et/ou numérique] / Laila Y. AL-AYADHI, Auteur ; Abdul Majeed AL-DREES, Auteur ; Ahmed M. AL-ARFAJ, Auteur . - 2013 . - p.13-20. Langues : Anglais (eng) in Autism Insights > (April 2013) . - p.13-20 Index. décimale : PER Périodiques Résumé : Objectives: To determine the effectiveness of auditory integration training (AIT) in people with Autism Spectrum Disorders (ASD). Method: Seventy two subjects with ASD aged up to 17 years old (70 male and 2 females) were recruited for the study. All subjects were screened by Diagnostic and Statistical Manual of Mental Disorders, (DSM-IV), and assessed by CARS (Childhood Autism Rating Scale). Pre-intervention scores and post-intervention (3 and 6 months) scores were calculated for each child using CARS, Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Auditory integration training was performed over 2 week, 30 minutes, twice a day. Results: All subjects demonstrated improvement 3 and 6 months following the AIT. ASD subject showed 22% and 26% percentage improvement in SRS scoring 3 and 6 months respectively following the AIT intervention. Those changes were attributed to statistically significant changes in social awareness, social cognition, and social communication. Similar results were achieved with the ATEC check list: ASD subject showed 19.5% and 22.5% improvement 3 and 6 months following the AIT intervention, respectively. Those changes are due to statistically significant (P < 0.05) improvement in speech, communication and sociability only. Conclusions: The results of this study support the therapeutic effects of auditory integration training on social awareness, social cognition, and social communication, as well as speech and communication. En ligne : http://dx.doi.org/10.4137/AUI.S11463 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

Mechanism of nitrogen metabolism-related parameters and enzyme activities in the pathophysiology of autism / G. A. ABU SHMAIS in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.4 Titre : Mechanism of nitrogen metabolism-related parameters and enzyme activities in the pathophysiology of autism Type de document : Texte imprimé et/ou numérique Auteurs : G. A. ABU SHMAIS, Auteur ; Laila Y. AL-AYADHI, Auteur ; A. M. AL-DBASS, Auteur ; A. K. EL-ANSARY, Auteur Article en page(s) : p.4 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: There is evidence that impaired metabolism play an important role in the etiology of many neuropsychiatric disorders. Although this has not been investigated to date, several recent studies proposed that nitrogen metabolism-related parameters may have a pathophysiological role in autism. METHODS: The study enrolled 20 Saudi boys with autism aged 4 to 12 years and 20 healthy controls matched for age and gender. Levels of creatine, urea, ammonia, gamma-aminobutyric acid (GABA), glutamate:glutamine (Glu:Gln) ratio, and enzymatic activities of glutamate dehydrogenase, 5'-nucleotidase, and adenosine deaminase (ADA) were determined in plasma samples from both groups. RESULTS: We found a significant elevation of creatine, 5'-nucleotidase, GABA, and glutamic acid and a significant decrease in the enzymatic activity of ADA and glutamine level in patients with autism compared with healthy controls. The most significant variation between the two groups was found in the Glu:Gln ratio. CONCLUSION: A raised Glu:Gln ratio together with positive correlations in creatine, GABA, and 5'-nucleotidase levels could contribute to the pathophysiology of autism, and might be useful diagnostic markers. The mechanism through which these parameters might be related to autism is discussed in detail. En ligne : http://dx.doi.org/10.1186/1866-1955-4-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Mechanism of nitrogen metabolism-related parameters and enzyme activities in the pathophysiology of autism [Texte imprimé et/ou numérique] / G. A. ABU SHMAIS, Auteur ; Laila Y. AL-AYADHI, Auteur ; A. M. AL-DBASS, Auteur ; A. K. EL-ANSARY, Auteur . - p.4. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.4 Index. décimale : PER Périodiques Résumé : BACKGROUND: There is evidence that impaired metabolism play an important role in the etiology of many neuropsychiatric disorders. Although this has not been investigated to date, several recent studies proposed that nitrogen metabolism-related parameters may have a pathophysiological role in autism. METHODS: The study enrolled 20 Saudi boys with autism aged 4 to 12 years and 20 healthy controls matched for age and gender. Levels of creatine, urea, ammonia, gamma-aminobutyric acid (GABA), glutamate:glutamine (Glu:Gln) ratio, and enzymatic activities of glutamate dehydrogenase, 5'-nucleotidase, and adenosine deaminase (ADA) were determined in plasma samples from both groups. RESULTS: We found a significant elevation of creatine, 5'-nucleotidase, GABA, and glutamic acid and a significant decrease in the enzymatic activity of ADA and glutamine level in patients with autism compared with healthy controls. The most significant variation between the two groups was found in the Glu:Gln ratio. CONCLUSION: A raised Glu:Gln ratio together with positive correlations in creatine, GABA, and 5'-nucleotidase levels could contribute to the pathophysiology of autism, and might be useful diagnostic markers. The mechanism through which these parameters might be related to autism is discussed in detail. En ligne : http://dx.doi.org/10.1186/1866-1955-4-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study / Manan AL-HAKBANY in Autism Research and Treatment, (February 2014)  

Public ISBD [article]  inAutism Research and Treatment > (February 2014) . - 6 p. Titre : The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study Type de document : Texte imprimé et/ou numérique Auteurs : Manan AL-HAKBANY, Auteur ; Sitalbanat AWADALLAH, Auteur ; Laila Y. AL-AYADHI, Auteur Année de publication : 2014 Article en page(s) : 6 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Earlier reports showed the relationship between autism and immune genes located in the human leukocyte antigen (HLA). In this current study, we compared the HLA class I and class II alleles and haplotypes in 35 autistic children with 100 control subjects from Saudi Arabia, using PCR-SSP method and Luminex technology. In class I the HLA-A*01 ( En ligne : http://dx.doi.org/10.1155/2014/242048 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study [Texte imprimé et/ou numérique] / Manan AL-HAKBANY, Auteur ; Sitalbanat AWADALLAH, Auteur ; Laila Y. AL-AYADHI, Auteur . - 2014 . - 6 p. Langues : Anglais (eng) in Autism Research and Treatment > (February 2014) . - 6 p. Index. décimale : PER Périodiques Résumé : Earlier reports showed the relationship between autism and immune genes located in the human leukocyte antigen (HLA). In this current study, we compared the HLA class I and class II alleles and haplotypes in 35 autistic children with 100 control subjects from Saudi Arabia, using PCR-SSP method and Luminex technology. In class I the HLA-A*01 ( En ligne : http://dx.doi.org/10.1155/2014/242048 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

---

1 (1 - 5 / 5)