1 recherche sur le mot-clé 'Pro-inflammatory mediators'

C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism / Mushtaq A. ANSARI in Research in Autism Spectrum Disorders, 71 (March 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 71 (March 2020) . - p.101500 Titre : C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism Type de document : texte imprimé Auteurs : Mushtaq A. ANSARI, Auteur ; Saleh A. BAKHEET, Auteur ; Laila Y. AL-AYADHI, Auteur ; Mohammad R. KHAN, Auteur ; Sabry M. ATTIA, Auteur ; Sheikh F. AHMAD, Auteur Article en page(s) : p.101500 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Typically developing controls  C-C motif chemokine receptor 6  Peripheral blood mononuclear cells  Pro-inflammatory mediators Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heterogeneous disorder associated with immune abnormalities. C-C motif chemokine receptor 6 (CCR6) has central roles in neuroinflammatory disorders. However, CCR6 expression in ASD is unclear. Here, we examined CCR6 expression in children with ASD. Children with ASD had significantly increased numbers of CCR6+/interferon-γ+, CCR6+/tumor necrosis factor-α+, CCR6+/interleukin (IL)-9+, CCR6+/IL-22+, CCR6+/nuclear factor-κB p65+, and CCR6+/nitric oxide synthase 2+ cells compared with typically developing controls (TDs). Moreover, children with ASD showed increased CCR6 mRNA/protein levels compared with TDs. Thus, CCR6 upregulated pro-inflammatory mediators associated with immune dysfunction in children with ASD, suggesting contributions to ASD development. En ligne : https://doi.org/10.1016/j.rasd.2019.101500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism [texte imprimé] / Mushtaq A. ANSARI, Auteur ; Saleh A. BAKHEET, Auteur ; Laila Y. AL-AYADHI, Auteur ; Mohammad R. KHAN, Auteur ; Sabry M. ATTIA, Auteur ; Sheikh F. AHMAD, Auteur . - p.101500. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101500 Mots-clés : Autism spectrum disorder  Typically developing controls  C-C motif chemokine receptor 6  Peripheral blood mononuclear cells  Pro-inflammatory mediators Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heterogeneous disorder associated with immune abnormalities. C-C motif chemokine receptor 6 (CCR6) has central roles in neuroinflammatory disorders. However, CCR6 expression in ASD is unclear. Here, we examined CCR6 expression in children with ASD. Children with ASD had significantly increased numbers of CCR6+/interferon-γ+, CCR6+/tumor necrosis factor-α+, CCR6+/interleukin (IL)-9+, CCR6+/IL-22+, CCR6+/nuclear factor-κB p65+, and CCR6+/nitric oxide synthase 2+ cells compared with typically developing controls (TDs). Moreover, children with ASD showed increased CCR6 mRNA/protein levels compared with TDs. Thus, CCR6 upregulated pro-inflammatory mediators associated with immune dysfunction in children with ASD, suggesting contributions to ASD development. En ligne : https://doi.org/10.1016/j.rasd.2019.101500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416