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McGurk Effect by Individuals with Autism Spectrum Disorder and Typically Developing Controls: A Systematic Review and Meta-analysis / J. ZHANG in Journal of Autism and Developmental Disorders, 49-1 (January 2019)
[article]
Titre : McGurk Effect by Individuals with Autism Spectrum Disorder and Typically Developing Controls: A Systematic Review and Meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : J. ZHANG, Auteur ; Y. MENG, Auteur ; J. HE, Auteur ; Y. XIANG, Auteur ; C. WU, Auteur ; S. WANG, Auteur ; Z. YUAN, Auteur Article en page(s) : p.34-43 Langues : Anglais (eng) Mots-clés : Age Autism spectrum disorder McGurk effect Task scoring method Typically developing controls Index. décimale : PER Périodiques Résumé : By synthesizing existing behavioural studies through a meta-analytic approach, the current study compared the performances of Autism spectrum disorder (ASD) and typically developing groups in audiovisual speech integration and investigated potential moderators that might contribute to the heterogeneity of the existing findings. In total, nine studies were included in the current study, and the pooled overall difference between the two groups was significant, g = - 0.835 (p < 0.001; 95% CI - 1.155 to - 0.516). Age and task scoring method were found to be associated with the inconsistencies of the findings reported by previous studies. These findings indicate that individuals with ASD show weaker McGurk effect than typically developing controls. En ligne : http://dx.doi.org/10.1007/s10803-018-3680-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376
in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.34-43[article] McGurk Effect by Individuals with Autism Spectrum Disorder and Typically Developing Controls: A Systematic Review and Meta-analysis [Texte imprimé et/ou numérique] / J. ZHANG, Auteur ; Y. MENG, Auteur ; J. HE, Auteur ; Y. XIANG, Auteur ; C. WU, Auteur ; S. WANG, Auteur ; Z. YUAN, Auteur . - p.34-43.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.34-43
Mots-clés : Age Autism spectrum disorder McGurk effect Task scoring method Typically developing controls Index. décimale : PER Périodiques Résumé : By synthesizing existing behavioural studies through a meta-analytic approach, the current study compared the performances of Autism spectrum disorder (ASD) and typically developing groups in audiovisual speech integration and investigated potential moderators that might contribute to the heterogeneity of the existing findings. In total, nine studies were included in the current study, and the pooled overall difference between the two groups was significant, g = - 0.835 (p < 0.001; 95% CI - 1.155 to - 0.516). Age and task scoring method were found to be associated with the inconsistencies of the findings reported by previous studies. These findings indicate that individuals with ASD show weaker McGurk effect than typically developing controls. En ligne : http://dx.doi.org/10.1007/s10803-018-3680-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 22q11.2 duplication syndrome: elevated rate of autism spectrum disorder and need for medical screening / T. L. WENGER in Molecular Autism, 7 (2016)
[article]
Titre : 22q11.2 duplication syndrome: elevated rate of autism spectrum disorder and need for medical screening Type de document : Texte imprimé et/ou numérique Auteurs : T. L. WENGER, Auteur ; J. S. MILLER, Auteur ; L. M. DEPOLO, Auteur ; A. B. DE MARCHENA, Auteur ; Caitlin C. CLEMENTS, Auteur ; B. S. EMANUEL, Auteur ; E. H. ZACKAI, Auteur ; D. M. MCDONALD-MCGINN, Auteur ; Robert T. SCHULTZ, Auteur Article en page(s) : 27p. Langues : Anglais (eng) Mots-clés : Abnormalities, Multiple/diagnosis Adolescent Adult Analysis of Variance Autism Spectrum Disorder/complications/diagnosis/epidemiology Child Child, Preschool Chromosome Duplication Chromosomes, Human, Pair 22 DiGeorge Syndrome/complications/diagnosis Female Genetic Testing Humans Male Middle Aged Social Behavior Surveys and Questionnaires Young Adult 22q11.2 deletion syndrome 22q11.2 duplication syndrome Autism spectrum disorder Developmental delay Medical characterization Medical screening Neuropsychiatric functioning Syndromic autism Typically developing controls Index. décimale : PER Périodiques Résumé : BACKGROUND: Widespread use of microarray technology has led to increasing identification of 22q11.2 duplication syndrome (22q11.2DupS), the reciprocal syndrome of the well-characterized 22q11.2 deletion syndrome (22q11.2DS). Individuals with 22q11.2DS have elevated rates of community diagnoses of autism spectrum disorder (ASD), schizophrenia, and a range of medical problems and birth defects that necessitate extensive medical screening. Case reports of 22q11.2DupS include patients with ASD, fewer medical problems, and no schizophrenia; however, no prospective cohort study has been reported. The goals of the study were to (1) characterize the neuropsychiatric functioning of a cohort of individuals with 22q11.2DupS in comparison to large samples of typically developing controls (TDCs), ASD and 22q11.2DS; (2) estimate the prevalence of ASD in 22q11.2DupS; (3) determine whether the indications that prompted the genetic testing in 22q11.2DupS differ from 22q11.2DS and (4) determine whether comprehensive medical screening should be recommended for those diagnosed with 22q11.2DupS. METHODS: Medical characterization was done by parental questionnaire and medical chart review of individuals with 22q11.2DupS (n = 37) and 22q11.2DS (n = 101). Neuropsychiatric characterization of children with 22.11.2DupS, 22q11.2DS, TDCs, and ASD was done by parent-report questionnaires; in addition, the ASD and 22q11.2DupS groups received the Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule. RESULTS: Individuals with 22q11.2DupS, 22q11.2DS, and ASD had significantly impaired social interaction and adaptive behavior skills compared to TDCs. Overall, 38% of children aged 2-18 with 22q11.2DupS had community diagnoses of ASD, but fewer (14-25%) met on the basis of best clinical judgment that included ADI-R and ADOS data. Indications for genetic testing were significantly different for 22q11.2DupS and 22q11.2DS, with the deletions more commonly tested because of birth defects or medical problems, and the duplications because of developmental delay. However, when the screening protocol for 22q11.2DS was applied to the 22q11.2DupS sample, several medical problems were identified that would pose significant risk if left undetected. CONCLUSIONS: 22q11.2DupS has a high rate of ASD at 14-25%, among the highest of any genetic disorder. Prospective medical screening should be done for all patients with 22q11.2DupS, including those diagnosed due to developmental delays and ASD alone. En ligne : http://dx.doi.org/10.1186/s13229-016-0090-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 27p.[article] 22q11.2 duplication syndrome: elevated rate of autism spectrum disorder and need for medical screening [Texte imprimé et/ou numérique] / T. L. WENGER, Auteur ; J. S. MILLER, Auteur ; L. M. DEPOLO, Auteur ; A. B. DE MARCHENA, Auteur ; Caitlin C. CLEMENTS, Auteur ; B. S. EMANUEL, Auteur ; E. H. ZACKAI, Auteur ; D. M. MCDONALD-MCGINN, Auteur ; Robert T. SCHULTZ, Auteur . - 27p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 27p.
Mots-clés : Abnormalities, Multiple/diagnosis Adolescent Adult Analysis of Variance Autism Spectrum Disorder/complications/diagnosis/epidemiology Child Child, Preschool Chromosome Duplication Chromosomes, Human, Pair 22 DiGeorge Syndrome/complications/diagnosis Female Genetic Testing Humans Male Middle Aged Social Behavior Surveys and Questionnaires Young Adult 22q11.2 deletion syndrome 22q11.2 duplication syndrome Autism spectrum disorder Developmental delay Medical characterization Medical screening Neuropsychiatric functioning Syndromic autism Typically developing controls Index. décimale : PER Périodiques Résumé : BACKGROUND: Widespread use of microarray technology has led to increasing identification of 22q11.2 duplication syndrome (22q11.2DupS), the reciprocal syndrome of the well-characterized 22q11.2 deletion syndrome (22q11.2DS). Individuals with 22q11.2DS have elevated rates of community diagnoses of autism spectrum disorder (ASD), schizophrenia, and a range of medical problems and birth defects that necessitate extensive medical screening. Case reports of 22q11.2DupS include patients with ASD, fewer medical problems, and no schizophrenia; however, no prospective cohort study has been reported. The goals of the study were to (1) characterize the neuropsychiatric functioning of a cohort of individuals with 22q11.2DupS in comparison to large samples of typically developing controls (TDCs), ASD and 22q11.2DS; (2) estimate the prevalence of ASD in 22q11.2DupS; (3) determine whether the indications that prompted the genetic testing in 22q11.2DupS differ from 22q11.2DS and (4) determine whether comprehensive medical screening should be recommended for those diagnosed with 22q11.2DupS. METHODS: Medical characterization was done by parental questionnaire and medical chart review of individuals with 22q11.2DupS (n = 37) and 22q11.2DS (n = 101). Neuropsychiatric characterization of children with 22.11.2DupS, 22q11.2DS, TDCs, and ASD was done by parent-report questionnaires; in addition, the ASD and 22q11.2DupS groups received the Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule. RESULTS: Individuals with 22q11.2DupS, 22q11.2DS, and ASD had significantly impaired social interaction and adaptive behavior skills compared to TDCs. Overall, 38% of children aged 2-18 with 22q11.2DupS had community diagnoses of ASD, but fewer (14-25%) met on the basis of best clinical judgment that included ADI-R and ADOS data. Indications for genetic testing were significantly different for 22q11.2DupS and 22q11.2DS, with the deletions more commonly tested because of birth defects or medical problems, and the duplications because of developmental delay. However, when the screening protocol for 22q11.2DS was applied to the 22q11.2DupS sample, several medical problems were identified that would pose significant risk if left undetected. CONCLUSIONS: 22q11.2DupS has a high rate of ASD at 14-25%, among the highest of any genetic disorder. Prospective medical screening should be done for all patients with 22q11.2DupS, including those diagnosed due to developmental delays and ASD alone. En ligne : http://dx.doi.org/10.1186/s13229-016-0090-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism / Mushtaq A. ANSARI in Research in Autism Spectrum Disorders, 71 (March 2020)
[article]
Titre : C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Mushtaq A. ANSARI, Auteur ; Saleh A. BAKHEET, Auteur ; Laila Y. AL-AYADHI, Auteur ; Mohammad R. KHAN, Auteur ; Sabry M. ATTIA, Auteur ; Sheikh F. AHMAD, Auteur Article en page(s) : p.101500 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Typically developing controls C-C motif chemokine receptor 6 Peripheral blood mononuclear cells Pro-inflammatory mediators Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heterogeneous disorder associated with immune abnormalities. C-C motif chemokine receptor 6 (CCR6) has central roles in neuroinflammatory disorders. However, CCR6 expression in ASD is unclear. Here, we examined CCR6 expression in children with ASD. Children with ASD had significantly increased numbers of CCR6+/interferon-?+, CCR6+/tumor necrosis factor-?+, CCR6+/interleukin (IL)-9+, CCR6+/IL-22+, CCR6+/nuclear factor-?B p65+, and CCR6+/nitric oxide synthase 2+ cells compared with typically developing controls (TDs). Moreover, children with ASD showed increased CCR6 mRNA/protein levels compared with TDs. Thus, CCR6 upregulated pro-inflammatory mediators associated with immune dysfunction in children with ASD, suggesting contributions to ASD development. En ligne : https://doi.org/10.1016/j.rasd.2019.101500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416
in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101500[article] C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism [Texte imprimé et/ou numérique] / Mushtaq A. ANSARI, Auteur ; Saleh A. BAKHEET, Auteur ; Laila Y. AL-AYADHI, Auteur ; Mohammad R. KHAN, Auteur ; Sabry M. ATTIA, Auteur ; Sheikh F. AHMAD, Auteur . - p.101500.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101500
Mots-clés : Autism spectrum disorder Typically developing controls C-C motif chemokine receptor 6 Peripheral blood mononuclear cells Pro-inflammatory mediators Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a heterogeneous disorder associated with immune abnormalities. C-C motif chemokine receptor 6 (CCR6) has central roles in neuroinflammatory disorders. However, CCR6 expression in ASD is unclear. Here, we examined CCR6 expression in children with ASD. Children with ASD had significantly increased numbers of CCR6+/interferon-?+, CCR6+/tumor necrosis factor-?+, CCR6+/interleukin (IL)-9+, CCR6+/IL-22+, CCR6+/nuclear factor-?B p65+, and CCR6+/nitric oxide synthase 2+ cells compared with typically developing controls (TDs). Moreover, children with ASD showed increased CCR6 mRNA/protein levels compared with TDs. Thus, CCR6 upregulated pro-inflammatory mediators associated with immune dysfunction in children with ASD, suggesting contributions to ASD development. En ligne : https://doi.org/10.1016/j.rasd.2019.101500 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416