Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study / Carolyn MCCORMICK in Autism Research, 13-3 (March 2020)  

Public ISBD [article]  inAutism Research > 13-3 (March 2020) . - p.474-488 Titre : Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study Type de document : texte imprimé Auteurs : Carolyn MCCORMICK, Auteur ; Brian C. KAVANAUGH, Auteur ; Danielle SIPSOCK, Auteur ; Giulia RIGHI, Auteur ; Lindsay M. OBERMAN, Auteur ; Daniel MORENO DE LUCA, Auteur ; Ece D. GAMSIZ UZUN, Auteur ; Carrie R. BEST, Auteur ; Beth A. JERSKEY, Auteur ; Joanne G. QUINN, Auteur ; Susan B. JEWEL, Auteur ; Pei-Chi WU, Auteur ; Rebecca L. MCLEAN, Auteur ; Todd P. LEVINE, Auteur ; Hasmik TOKADJIAN, Auteur ; Kayla A. PERKINS, Auteur ; Elaine B. CLARKE, Auteur ; Brittany DUNN, Auteur ; Alan H. GERBER, Auteur ; Elena J. TENENBAUM, Auteur ; Thomas F. ANDERS, Auteur Article en page(s) : p.474-488 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  comorbidity  female autism  population study  registry Index. décimale : PER Périodiques Résumé : The objective of this study was to establish a large, densely sampled, U.S. population-based cohort of people with autism spectrum disorder (ASD). The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by ASD. Diagnosis was based on direct behavioral observation via the Autism Diagnostic Observation Schedule, Second Edition. For the first 1,000 participants, ages ranged from 21 months to 64 years. Using Geographic Information System and published prevalence rates, the overall cohort is estimated to represent between 20% and 49% of pediatric age persons in Rhode Island with ASD, with demographics representative of U.S. Census. We observed a high rate of co-occurring medical and psychiatric conditions in affected individuals. Among the most prominent findings of immediate clinical importance, we found that females received a first diagnosis of ASD at a later age than males, potentially due to more advanced language abilities in females with ASD. In summary, this is the first analysis of a large, population-based U.S. cohort with ASD. Given the depth of sampling, the RI-CART study reflects an important new resource for studying ASD in a representative U.S. population. Psychiatric and medical comorbidities in ASD constitute a substantial burden and warrant adequate attention as part of overall treatment. Our study also suggests that new strategies for earlier diagnosis of ASD in females may be warranted. Autism Res 2020, 13: 474-488. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by autism spectrum disorder (ASD). In this article, we provide results from the first 1,000 participants, estimated to represent >20% of affected families in the state. Importantly, we find a later age at first diagnosis of ASD in females, which potentially calls attention to the need for improved early diagnosis in girls. Also, we report a high rate of co-occurring medical and psychiatric conditions in affected individuals. En ligne : http://dx.doi.org/10.1002/aur.2261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study [texte imprimé] / Carolyn MCCORMICK, Auteur ; Brian C. KAVANAUGH, Auteur ; Danielle SIPSOCK, Auteur ; Giulia RIGHI, Auteur ; Lindsay M. OBERMAN, Auteur ; Daniel MORENO DE LUCA, Auteur ; Ece D. GAMSIZ UZUN, Auteur ; Carrie R. BEST, Auteur ; Beth A. JERSKEY, Auteur ; Joanne G. QUINN, Auteur ; Susan B. JEWEL, Auteur ; Pei-Chi WU, Auteur ; Rebecca L. MCLEAN, Auteur ; Todd P. LEVINE, Auteur ; Hasmik TOKADJIAN, Auteur ; Kayla A. PERKINS, Auteur ; Elaine B. CLARKE, Auteur ; Brittany DUNN, Auteur ; Alan H. GERBER, Auteur ; Elena J. TENENBAUM, Auteur ; Thomas F. ANDERS, Auteur . - p.474-488. Langues : Anglais (eng) in Autism Research > 13-3 (March 2020) . - p.474-488 Mots-clés : autism spectrum disorder  comorbidity  female autism  population study  registry Index. décimale : PER Périodiques Résumé : The objective of this study was to establish a large, densely sampled, U.S. population-based cohort of people with autism spectrum disorder (ASD). The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by ASD. Diagnosis was based on direct behavioral observation via the Autism Diagnostic Observation Schedule, Second Edition. For the first 1,000 participants, ages ranged from 21 months to 64 years. Using Geographic Information System and published prevalence rates, the overall cohort is estimated to represent between 20% and 49% of pediatric age persons in Rhode Island with ASD, with demographics representative of U.S. Census. We observed a high rate of co-occurring medical and psychiatric conditions in affected individuals. Among the most prominent findings of immediate clinical importance, we found that females received a first diagnosis of ASD at a later age than males, potentially due to more advanced language abilities in females with ASD. In summary, this is the first analysis of a large, population-based U.S. cohort with ASD. Given the depth of sampling, the RI-CART study reflects an important new resource for studying ASD in a representative U.S. population. Psychiatric and medical comorbidities in ASD constitute a substantial burden and warrant adequate attention as part of overall treatment. Our study also suggests that new strategies for earlier diagnosis of ASD in females may be warranted. Autism Res 2020, 13: 474-488. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by autism spectrum disorder (ASD). In this article, we provide results from the first 1,000 participants, estimated to represent >20% of affected families in the state. Importantly, we find a later age at first diagnosis of ASD in females, which potentially calls attention to the need for improved early diagnosis in girls. Also, we report a high rate of co-occurring medical and psychiatric conditions in affected individuals. En ligne : http://dx.doi.org/10.1002/aur.2261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Brief Report: Factors Influencing Healthcare Satisfaction in Adults with Autism Spectrum Disorder / Alan H. GERBER in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1896-1903 Titre : Brief Report: Factors Influencing Healthcare Satisfaction in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alan H. GERBER, Auteur ; Carolyn MCCORMICK, Auteur ; Todd P. LEVINE, Auteur ; Eric M. MORROW, Auteur ; Thomas F. ANDERS, Auteur ; Stephen J. SHEINKOPF, Auteur Article en page(s) : p.1896-1903 Langues : Anglais (eng) Mots-clés : ASD  Autism  Adult  Healthcare  Satisfaction Index. décimale : PER Périodiques Résumé : The current study investigated healthcare satisfaction and factors related to satisfaction in 92 adults with Autism Spectrum Disorder (ASD). Participants or their caregiver completed a survey about their experiences with primary care and specialty physicians. Respondents reported a high level of satisfaction with their healthcare. The only factor significantly associated with satisfaction was age, with participants under age 26 reporting significantly higher levels of satisfaction than participants above age 26. Participants under age 26 also were significantly more likely to live at home, have private health insurance, and have others making their healthcare decisions than participants above age 26. Results indicate that healthcare satisfaction can be high for adults with ASD that have good family and community support. En ligne : http://dx.doi.org/10.1007/s10803-017-3087-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Brief Report: Factors Influencing Healthcare Satisfaction in Adults with Autism Spectrum Disorder [texte imprimé] / Alan H. GERBER, Auteur ; Carolyn MCCORMICK, Auteur ; Todd P. LEVINE, Auteur ; Eric M. MORROW, Auteur ; Thomas F. ANDERS, Auteur ; Stephen J. SHEINKOPF, Auteur . - p.1896-1903. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1896-1903 Mots-clés : ASD  Autism  Adult  Healthcare  Satisfaction Index. décimale : PER Périodiques Résumé : The current study investigated healthcare satisfaction and factors related to satisfaction in 92 adults with Autism Spectrum Disorder (ASD). Participants or their caregiver completed a survey about their experiences with primary care and specialty physicians. Respondents reported a high level of satisfaction with their healthcare. The only factor significantly associated with satisfaction was age, with participants under age 26 reporting significantly higher levels of satisfaction than participants above age 26. Participants under age 26 also were significantly more likely to live at home, have private health insurance, and have others making their healthcare decisions than participants above age 26. Results indicate that healthcare satisfaction can be high for adults with ASD that have good family and community support. En ligne : http://dx.doi.org/10.1007/s10803-017-3087-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Diminished respiratory sinus arrhythmia response in infants later diagnosed with autism spectrum disorder / Carolyn MCCORMICK in Autism Research, 11-5 (May 2018)  

Public ISBD [article]  inAutism Research > 11-5 (May 2018) . - p.726-731 Titre : Diminished respiratory sinus arrhythmia response in infants later diagnosed with autism spectrum disorder Type de document : texte imprimé Auteurs : Carolyn MCCORMICK, Auteur ; Stephen J. SHEINKOPF, Auteur ; Todd P. LEVINE, Auteur ; Linda L. LAGASSE, Auteur ; Ed TRONICK, Auteur ; Barry M. LESTER, Auteur Article en page(s) : p.726-731 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  infants  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : Indicators of risk for developing Autism Spectrum Disorder (ASD) are difficult to detect within the first year of life. In this study, infants who were originally followed prospectively to examine general developmental risks due to substance exposure interacted with their mother and an unfamiliar experimenter for 2 min episodes at 4 months of age. Electrocardiogram was collected to measure respiratory sinus arrhythmia (RSA) and the session was video recorded for behavioral coding. Two groups of infants were compared: infants with a diagnosed ASD outcome (N=8) and matched controls (N=186). Infants were compared on mean RSA and infant behavioral codes for each 2 min episode. No significant group differences were revealed on RSA or behavior during interactions between the infants and mothers. However, in response to play with a stranger, infants with an ASD outcome had lower RSA (M=2.49, 95% CI [2.30, 2.98]) than controls (M=3.12, 95% CI [3.06, 3.18]). During the interaction with a stranger, lower RSA response was associated with more protesting behaviors (P?< 0.01), whereas higher RSA response was associated with more social monitoring (P=0.001). Lower RSA suggests that 4 month?old infants later diagnosed with ASD exhibited poorer autonomic regulation during interaction with an unfamiliar adult than did controls. Physiological regulation during interactions with a new social partner may be disrupted early in infancy in children with ASD, as indicated here by lower RSA, and therefore be a potential target for developing early risk screening tools for ASD. Autism Res 2018, 11: 726 731. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Autism Spectrum Disorder (ASD) emerges within the first years of life; however, it is difficult to identify children who will develop autism before 12 months of age based on behavioral measures. In a study of infants who were followed from birth, infants who were later diagnosed with ASD had poorer physiological regulation during play with a new adult. With additional evidence, poorer physiological regulation may function as an early sign of ASD risk. En ligne : https://doi.org/10.1002/aur.1929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Diminished respiratory sinus arrhythmia response in infants later diagnosed with autism spectrum disorder [texte imprimé] / Carolyn MCCORMICK, Auteur ; Stephen J. SHEINKOPF, Auteur ; Todd P. LEVINE, Auteur ; Linda L. LAGASSE, Auteur ; Ed TRONICK, Auteur ; Barry M. LESTER, Auteur . - p.726-731. Langues : Anglais (eng) in Autism Research > 11-5 (May 2018) . - p.726-731 Mots-clés : autism spectrum disorder  infants  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : Indicators of risk for developing Autism Spectrum Disorder (ASD) are difficult to detect within the first year of life. In this study, infants who were originally followed prospectively to examine general developmental risks due to substance exposure interacted with their mother and an unfamiliar experimenter for 2 min episodes at 4 months of age. Electrocardiogram was collected to measure respiratory sinus arrhythmia (RSA) and the session was video recorded for behavioral coding. Two groups of infants were compared: infants with a diagnosed ASD outcome (N=8) and matched controls (N=186). Infants were compared on mean RSA and infant behavioral codes for each 2 min episode. No significant group differences were revealed on RSA or behavior during interactions between the infants and mothers. However, in response to play with a stranger, infants with an ASD outcome had lower RSA (M=2.49, 95% CI [2.30, 2.98]) than controls (M=3.12, 95% CI [3.06, 3.18]). During the interaction with a stranger, lower RSA response was associated with more protesting behaviors (P?< 0.01), whereas higher RSA response was associated with more social monitoring (P=0.001). Lower RSA suggests that 4 month?old infants later diagnosed with ASD exhibited poorer autonomic regulation during interaction with an unfamiliar adult than did controls. Physiological regulation during interactions with a new social partner may be disrupted early in infancy in children with ASD, as indicated here by lower RSA, and therefore be a potential target for developing early risk screening tools for ASD. Autism Res 2018, 11: 726 731. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Autism Spectrum Disorder (ASD) emerges within the first years of life; however, it is difficult to identify children who will develop autism before 12 months of age based on behavioral measures. In a study of infants who were followed from birth, infants who were later diagnosed with ASD had poorer physiological regulation during play with a new adult. With additional evidence, poorer physiological regulation may function as an early sign of ASD risk. En ligne : https://doi.org/10.1002/aur.1929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Parasympathetic Response Profiles Related to Social Functioning in Young Children with Autistic Disorder / Stephen J. SHEINKOPF in Autism Research and Treatment, (November 2013)  

Public ISBD [article]  inAutism Research and Treatment > (November 2013) . - 7 p. Titre : Parasympathetic Response Profiles Related to Social Functioning in Young Children with Autistic Disorder Type de document : texte imprimé Auteurs : Stephen J. SHEINKOPF, Auteur ; A. Rebecca NEAL-BEEVERS, Auteur ; Todd P. LEVINE, Auteur ; Cynthia MILLER-LONCAR, Auteur ; Barry M. LESTER, Auteur Année de publication : 2013 Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Psychophysiology studies of heart rate and heart rate variability can be employed to study regulatory processes in children with autism. The objective of this study was to test for differences in respiratory sinus arrhythmia (RSA; a measure of heart rate variability) and to examine the relationship between physiologic responses and measures of social behavior. Participants included 2- to 6-year-old children with Autistic Disorder and children without autism. Heart rate and RSA were derived from ECG recordings made during a baseline period and then a stranger approach paradigm. Social and adaptive behavior was assessed by parent report. Groups did not differ in mean heart rate or RSA at baseline or in response to social challenge. However, children with autism were more likely to show a physiologic response to intrusive portions of the stranger approach than to less intrusive portions of this procedure. Nonautistic children were equally likely to respond to intrusive and less intrusive social events. Within the autistic group, physiologic response to the intrusive stranger approach corresponded to higher ratings of social adaptive behaviors. These results suggest that physiologic responses to social challenge may help understand differences in social behavioral outcomes in children with autism. En ligne : http://dx.doi.org/10.1155/2013/868396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Parasympathetic Response Profiles Related to Social Functioning in Young Children with Autistic Disorder [texte imprimé] / Stephen J. SHEINKOPF, Auteur ; A. Rebecca NEAL-BEEVERS, Auteur ; Todd P. LEVINE, Auteur ; Cynthia MILLER-LONCAR, Auteur ; Barry M. LESTER, Auteur . - 2013 . - 7 p. Langues : Anglais (eng) in Autism Research and Treatment > (November 2013) . - 7 p. Index. décimale : PER Périodiques Résumé : Psychophysiology studies of heart rate and heart rate variability can be employed to study regulatory processes in children with autism. The objective of this study was to test for differences in respiratory sinus arrhythmia (RSA; a measure of heart rate variability) and to examine the relationship between physiologic responses and measures of social behavior. Participants included 2- to 6-year-old children with Autistic Disorder and children without autism. Heart rate and RSA were derived from ECG recordings made during a baseline period and then a stranger approach paradigm. Social and adaptive behavior was assessed by parent report. Groups did not differ in mean heart rate or RSA at baseline or in response to social challenge. However, children with autism were more likely to show a physiologic response to intrusive portions of the stranger approach than to less intrusive portions of this procedure. Nonautistic children were equally likely to respond to intrusive and less intrusive social events. Within the autistic group, physiologic response to the intrusive stranger approach corresponded to higher ratings of social adaptive behaviors. These results suggest that physiologic responses to social challenge may help understand differences in social behavioral outcomes in children with autism. En ligne : http://dx.doi.org/10.1155/2013/868396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Perception of Cry Characteristics in 1-Month-Old Infants Later Diagnosed with Autism Spectrum Disorder / M. Samantha ENGLISH in Journal of Autism and Developmental Disorders, 49-3 (March 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.834-844 Titre : Perception of Cry Characteristics in 1-Month-Old Infants Later Diagnosed with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : M. Samantha ENGLISH, Auteur ; Elena J. TENENBAUM, Auteur ; Todd P. LEVINE, Auteur ; Barry M. LESTER, Auteur ; Stephen J. SHEINKOPF, Auteur Article en page(s) : p.834-844 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Communication & language  Cry  Infancy Index. décimale : PER Périodiques Résumé : This study investigates parental perceptions of cries of 1-month-old infants later diagnosed with autism spectrum disorder (ASD) and non-ASD controls. Parents of children with and without ASD listened to cry recordings of infants later diagnosed with ASD and comparison infants and rated them on cry perception scales. Parents completed the Broad Autism Phenotype Questionnaire (BAPQ) to assess the potential relations between traits associated with autism and cry perception. Across parents, ASD infant cries were rated as more distressed, less typical, and reflecting greater pain, with no significant differences between parent groups. Parents of children with ASD scored higher on the BAPQ compared to parents of children without ASD. Follow up analyses explored the relations between BAPQ score and cry ratings. En ligne : http://dx.doi.org/10.1007/s10803-018-3788-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Perception of Cry Characteristics in 1-Month-Old Infants Later Diagnosed with Autism Spectrum Disorder [texte imprimé] / M. Samantha ENGLISH, Auteur ; Elena J. TENENBAUM, Auteur ; Todd P. LEVINE, Auteur ; Barry M. LESTER, Auteur ; Stephen J. SHEINKOPF, Auteur . - p.834-844. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.834-844 Mots-clés : Autism spectrum disorders  Communication & language  Cry  Infancy Index. décimale : PER Périodiques Résumé : This study investigates parental perceptions of cries of 1-month-old infants later diagnosed with autism spectrum disorder (ASD) and non-ASD controls. Parents of children with and without ASD listened to cry recordings of infants later diagnosed with ASD and comparison infants and rated them on cry perception scales. Parents completed the Broad Autism Phenotype Questionnaire (BAPQ) to assess the potential relations between traits associated with autism and cry perception. Across parents, ASD infant cries were rated as more distressed, less typical, and reflecting greater pain, with no significant differences between parent groups. Parents of children with ASD scored higher on the BAPQ compared to parents of children without ASD. Follow up analyses explored the relations between BAPQ score and cry ratings. En ligne : http://dx.doi.org/10.1007/s10803-018-3788-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Physiologic arousal to social stress in children with Autism Spectrum Disorders: A pilot study / Todd P. LEVINE in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

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