[article]
Titre : |
Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Takafumi SHIMADA, Auteur ; Atsushi KITAMOTO, Auteur ; Ayako TODOKORO, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Hitoshi KAWAMURA, Auteur ; Soo-Yung KIM, Auteur ; Kei-ichiro WATANABE, Auteur ; Iwao MINOWA, Auteur ; Toshikazu SOMEYA, Auteur ; Hiroshi OHTSU, Auteur ; Yutaka OSUGA, Auteur ; Yukiko KANO, Auteur ; Kiyoto KASAI, Auteur ; Nobumasa KATO, Auteur ; Tsukasa SASAKI, Auteur |
Année de publication : |
2012 |
Article en page(s) : |
p.500-507 |
Langues : |
Anglais (eng) |
Mots-clés : |
Autism Attention deficit hyperactivity disorder Tourette syndrome Parental age Assisted reproductive technology Japanese population |
Index. décimale : |
PER Périodiques |
Résumé : |
We investigated whether advanced parental age and assisted reproductive technology (ART) are risk factors in autism spectrum disorders (ASDs), attention deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS). Clinical charts of Japanese outpatients with ASD (n = 552), ADHD (n = 87), and TS (n = 123) were reviewed. Parental age of individuals with ASD, ADHD, or TS was compared with parental age in the general population (GP) of Tokyo after adjusting for year of birth. Paternal and maternal ages were significantly higher in persons with ASD and ADHD, but not those with TS. In final steps of stepwise logistic regression analysis, both maternal and paternal age were associated with ASD after controlling for the other parent's age, gender, and birth order. In cases where the presence or absence of ART could be ascertained (ASD n = 467; ADHD n = 64; TS n = 83), the rate of ART in cases of persons with ASD (4.5%) was 1.8 times the frequency expected in the GP, while ART was not present in cases of persons with ADHD and TS. These preliminary results remain tentative pending replication with larger, community-based samples. |
En ligne : |
http://dx.doi.org/10.1016/j.rasd.2011.07.010 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 |
in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.500-507
[article] Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population [Texte imprimé et/ou numérique] / Takafumi SHIMADA, Auteur ; Atsushi KITAMOTO, Auteur ; Ayako TODOKORO, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Hitoshi KAWAMURA, Auteur ; Soo-Yung KIM, Auteur ; Kei-ichiro WATANABE, Auteur ; Iwao MINOWA, Auteur ; Toshikazu SOMEYA, Auteur ; Hiroshi OHTSU, Auteur ; Yutaka OSUGA, Auteur ; Yukiko KANO, Auteur ; Kiyoto KASAI, Auteur ; Nobumasa KATO, Auteur ; Tsukasa SASAKI, Auteur . - 2012 . - p.500-507. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.500-507
Mots-clés : |
Autism Attention deficit hyperactivity disorder Tourette syndrome Parental age Assisted reproductive technology Japanese population |
Index. décimale : |
PER Périodiques |
Résumé : |
We investigated whether advanced parental age and assisted reproductive technology (ART) are risk factors in autism spectrum disorders (ASDs), attention deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS). Clinical charts of Japanese outpatients with ASD (n = 552), ADHD (n = 87), and TS (n = 123) were reviewed. Parental age of individuals with ASD, ADHD, or TS was compared with parental age in the general population (GP) of Tokyo after adjusting for year of birth. Paternal and maternal ages were significantly higher in persons with ASD and ADHD, but not those with TS. In final steps of stepwise logistic regression analysis, both maternal and paternal age were associated with ASD after controlling for the other parent's age, gender, and birth order. In cases where the presence or absence of ART could be ascertained (ASD n = 467; ADHD n = 64; TS n = 83), the rate of ART in cases of persons with ASD (4.5%) was 1.8 times the frequency expected in the GP, while ART was not present in cases of persons with ADHD and TS. These preliminary results remain tentative pending replication with larger, community-based samples. |
En ligne : |
http://dx.doi.org/10.1016/j.rasd.2011.07.010 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 |
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