7 recherche sur le mot-clé 'Parental age'

Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population / Takafumi SHIMADA in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.500-507 Titre : Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population Type de document : Texte imprimé et/ou numérique Auteurs : Takafumi SHIMADA, Auteur ; Atsushi KITAMOTO, Auteur ; Ayako TODOKORO, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Hitoshi KAWAMURA, Auteur ; Soo-Yung KIM, Auteur ; Kei-ichiro WATANABE, Auteur ; Iwao MINOWA, Auteur ; Toshikazu SOMEYA, Auteur ; Hiroshi OHTSU, Auteur ; Yutaka OSUGA, Auteur ; Yukiko KANO, Auteur ; Kiyoto KASAI, Auteur ; Nobumasa KATO, Auteur ; Tsukasa SASAKI, Auteur Année de publication : 2012 Article en page(s) : p.500-507 Langues : Anglais (eng) Mots-clés : Autism  Attention deficit hyperactivity disorder  Tourette syndrome  Parental age  Assisted reproductive technology  Japanese population Index. décimale : PER Périodiques Résumé : We investigated whether advanced parental age and assisted reproductive technology (ART) are risk factors in autism spectrum disorders (ASDs), attention deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS). Clinical charts of Japanese outpatients with ASD (n = 552), ADHD (n = 87), and TS (n = 123) were reviewed. Parental age of individuals with ASD, ADHD, or TS was compared with parental age in the general population (GP) of Tokyo after adjusting for year of birth. Paternal and maternal ages were significantly higher in persons with ASD and ADHD, but not those with TS. In final steps of stepwise logistic regression analysis, both maternal and paternal age were associated with ASD after controlling for the other parent's age, gender, and birth order. In cases where the presence or absence of ART could be ascertained (ASD n = 467; ADHD n = 64; TS n = 83), the rate of ART in cases of persons with ASD (4.5%) was 1.8 times the frequency expected in the GP, while ART was not present in cases of persons with ADHD and TS. These preliminary results remain tentative pending replication with larger, community-based samples. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.07.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population [Texte imprimé et/ou numérique] / Takafumi SHIMADA, Auteur ; Atsushi KITAMOTO, Auteur ; Ayako TODOKORO, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Hitoshi KAWAMURA, Auteur ; Soo-Yung KIM, Auteur ; Kei-ichiro WATANABE, Auteur ; Iwao MINOWA, Auteur ; Toshikazu SOMEYA, Auteur ; Hiroshi OHTSU, Auteur ; Yutaka OSUGA, Auteur ; Yukiko KANO, Auteur ; Kiyoto KASAI, Auteur ; Nobumasa KATO, Auteur ; Tsukasa SASAKI, Auteur . - 2012 . - p.500-507. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.500-507 Mots-clés : Autism  Attention deficit hyperactivity disorder  Tourette syndrome  Parental age  Assisted reproductive technology  Japanese population Index. décimale : PER Périodiques Résumé : We investigated whether advanced parental age and assisted reproductive technology (ART) are risk factors in autism spectrum disorders (ASDs), attention deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS). Clinical charts of Japanese outpatients with ASD (n = 552), ADHD (n = 87), and TS (n = 123) were reviewed. Parental age of individuals with ASD, ADHD, or TS was compared with parental age in the general population (GP) of Tokyo after adjusting for year of birth. Paternal and maternal ages were significantly higher in persons with ASD and ADHD, but not those with TS. In final steps of stepwise logistic regression analysis, both maternal and paternal age were associated with ASD after controlling for the other parent's age, gender, and birth order. In cases where the presence or absence of ART could be ascertained (ASD n = 467; ADHD n = 64; TS n = 83), the rate of ART in cases of persons with ASD (4.5%) was 1.8 times the frequency expected in the GP, while ART was not present in cases of persons with ADHD and TS. These preliminary results remain tentative pending replication with larger, community-based samples. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.07.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study / B. C. KAVANAUGH in Autism Research, 15-1 (January 2022)  

Public ISBD [article]  inAutism Research > 15-1 (January 2022) . - p.86-92 Titre : Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study Type de document : Texte imprimé et/ou numérique Auteurs : B. C. KAVANAUGH, Auteur ; T. GABERT, Auteur ; R. N. JONES, Auteur ; S. J. SHEINKOPF, Auteur ; E. M. MORROW, Auteur Article en page(s) : p.86-92 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Female  Humans  Mothers  Parents  Rhode Island  neuropsychiatric disorders  parental age  repetitive behaviors  restricted Index. décimale : PER Périodiques Résumé : Advanced parental age at offspring birth has been associated with autism spectrum disorder (ASD). The objective of the current study was to investigate associations between parental age at birth and autism severity. The Rhode Island Consortium for Autism Research and Treatment (RI-CART) study represents a community-based sample with a range of autism severity, including participants with and without ASD. This study involved participants (n = 1178) enrolled in RI-CART with available mother and father ages at birth. Primary data points included the age of mother and father at the participant's birth and results from the Autism Diagnostic Observation Schedule - Second Edition (ADOS-2). Mothers were 1.7?years older at the time of birth of the child with ASD, as compared to mothers of offspring without ASD. Fathers of children with ASD were 1.6?years older at the time of birth than fathers of children without ASD. The age of both parents at offspring birth displayed a positive, statistically significant association with overall ASD severity and the severity of restricted/repetitive behaviors. This finding was driven by the association between parental age and the severity of compulsions or rituals. Intelligence and adaptive functioning did not moderate the relationship between parental age and ASD severity. This study extends prior research to show that advanced parental age at birth is associated with the severity as well as the presence of ASD in offspring. En ligne : http://dx.doi.org/10.1002/aur.2648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study [Texte imprimé et/ou numérique] / B. C. KAVANAUGH, Auteur ; T. GABERT, Auteur ; R. N. JONES, Auteur ; S. J. SHEINKOPF, Auteur ; E. M. MORROW, Auteur . - p.86-92. Langues : Anglais (eng) in Autism Research > 15-1 (January 2022) . - p.86-92 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Female  Humans  Mothers  Parents  Rhode Island  neuropsychiatric disorders  parental age  repetitive behaviors  restricted Index. décimale : PER Périodiques Résumé : Advanced parental age at offspring birth has been associated with autism spectrum disorder (ASD). The objective of the current study was to investigate associations between parental age at birth and autism severity. The Rhode Island Consortium for Autism Research and Treatment (RI-CART) study represents a community-based sample with a range of autism severity, including participants with and without ASD. This study involved participants (n = 1178) enrolled in RI-CART with available mother and father ages at birth. Primary data points included the age of mother and father at the participant's birth and results from the Autism Diagnostic Observation Schedule - Second Edition (ADOS-2). Mothers were 1.7?years older at the time of birth of the child with ASD, as compared to mothers of offspring without ASD. Fathers of children with ASD were 1.6?years older at the time of birth than fathers of children without ASD. The age of both parents at offspring birth displayed a positive, statistically significant association with overall ASD severity and the severity of restricted/repetitive behaviors. This finding was driven by the association between parental age and the severity of compulsions or rituals. Intelligence and adaptive functioning did not moderate the relationship between parental age and ASD severity. This study extends prior research to show that advanced parental age at birth is associated with the severity as well as the presence of ASD in offspring. En ligne : http://dx.doi.org/10.1002/aur.2648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort / Katja M. LAMPI in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2526-2535 Titre : Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort Type de document : Texte imprimé et/ou numérique Auteurs : Katja M. LAMPI, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Venla LEHTI, Auteur ; Hans HELENIUS, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur Article en page(s) : p.2526-2535 Langues : Anglais (eng) Mots-clés : Epidemiology  Autism spectrum disorders  Parental age Index. décimale : PER Périodiques Résumé : Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger’s syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35–49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger’s syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1801-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort [Texte imprimé et/ou numérique] / Katja M. LAMPI, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Venla LEHTI, Auteur ; Hans HELENIUS, Auteur ; Mika GISSLER, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur . - p.2526-2535. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2526-2535 Mots-clés : Epidemiology  Autism spectrum disorders  Parental age Index. décimale : PER Périodiques Résumé : Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger’s syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35–49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger’s syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring. En ligne : http://dx.doi.org/10.1007/s10803-013-1801-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children / Ashley Y. SONG in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2359-2370 Titre : Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children Type de document : Texte imprimé et/ou numérique Auteurs : Ashley Y. SONG, Auteur ; Kelly BAKULSKI, Auteur ; Jason I. FEINBERG, Auteur ; Craig NEWSCHAFFER, Auteur ; Lisa A. CROEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Homayoon FARZADEGAN, Auteur ; Kristen LYALL, Auteur ; M Daniele FALLIN, Auteur ; Heather E. VOLK, Auteur ; Christine LADD-ACOSTA, Auteur Article en page(s) : p.2359-2370 Langues : Anglais (eng) Mots-clés : Child  Male  Pregnancy  Female  Humans  Autism Spectrum Disorder/epidemiology/genetics  Prospective Studies  Parents  Cognition  Biological Products  Epigenesis, Genetic  DNA methylation  age acceleration  autism spectrum disorder  autism-related traits  biologic age  epigenetic age  parental age Index. décimale : PER Périodiques Résumé : Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, "epigenetic clock" algorithms have been developed to estimate biologic age and to evaluate how the epigenetic aging impacts health and disease. In this study, we examined the relationship between parental epigenetic aging and their child's prospective risk of ASD and autism related quantitative traits in the Early Autism Risk Longitudinal Investigation study. Estimates of epigenetic age were computed using three robust clock algorithms and DNA methylation measures from the Infinium HumanMethylation450k platform for maternal blood and paternal blood specimens collected during pregnancy. Epigenetic age acceleration was defined as the residual of regressing chronological age on epigenetic age while accounting for cell type proportions. Multinomial logistic regression and linear regression models were completed adjusting for potential confounders for both maternal epigenetic age acceleration (n = 163) and paternal epigenetic age acceleration (n = 80). We found accelerated epigenetic aging in mothers estimated by Hannum's clock was significantly associated with lower cognitive ability and function in offspring at 12 months, as measured by Mullen Scales of Early Learning scores (Î2 = -1.66, 95% CI: -3.28, -0.04 for a one-unit increase). We also observed a marginal association between accelerated maternal epigenetic aging by Horvath's clock and increased odds of ASD in offspring at 36 months of age (aOR = 1.12, 95% CI: 0.99, 1.26). By contrast, fathers accelerated aging was marginally associated with decreased ASD risk in their offspring (aOR = 0.83, 95% CI: 0.68, 1.01). Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. En ligne : http://dx.doi.org/10.1002/aur.2822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children [Texte imprimé et/ou numérique] / Ashley Y. SONG, Auteur ; Kelly BAKULSKI, Auteur ; Jason I. FEINBERG, Auteur ; Craig NEWSCHAFFER, Auteur ; Lisa A. CROEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Homayoon FARZADEGAN, Auteur ; Kristen LYALL, Auteur ; M Daniele FALLIN, Auteur ; Heather E. VOLK, Auteur ; Christine LADD-ACOSTA, Auteur . - p.2359-2370. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2359-2370 Mots-clés : Child  Male  Pregnancy  Female  Humans  Autism Spectrum Disorder/epidemiology/genetics  Prospective Studies  Parents  Cognition  Biological Products  Epigenesis, Genetic  DNA methylation  age acceleration  autism spectrum disorder  autism-related traits  biologic age  epigenetic age  parental age Index. décimale : PER Périodiques Résumé : Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, "epigenetic clock" algorithms have been developed to estimate biologic age and to evaluate how the epigenetic aging impacts health and disease. In this study, we examined the relationship between parental epigenetic aging and their child's prospective risk of ASD and autism related quantitative traits in the Early Autism Risk Longitudinal Investigation study. Estimates of epigenetic age were computed using three robust clock algorithms and DNA methylation measures from the Infinium HumanMethylation450k platform for maternal blood and paternal blood specimens collected during pregnancy. Epigenetic age acceleration was defined as the residual of regressing chronological age on epigenetic age while accounting for cell type proportions. Multinomial logistic regression and linear regression models were completed adjusting for potential confounders for both maternal epigenetic age acceleration (n = 163) and paternal epigenetic age acceleration (n = 80). We found accelerated epigenetic aging in mothers estimated by Hannum's clock was significantly associated with lower cognitive ability and function in offspring at 12 months, as measured by Mullen Scales of Early Learning scores (Î2 = -1.66, 95% CI: -3.28, -0.04 for a one-unit increase). We also observed a marginal association between accelerated maternal epigenetic aging by Horvath's clock and increased odds of ASD in offspring at 36 months of age (aOR = 1.12, 95% CI: 0.99, 1.26). By contrast, fathers accelerated aging was marginally associated with decreased ASD risk in their offspring (aOR = 0.83, 95% CI: 0.68, 1.01). Our findings suggest epigenetic aging could play a role in parental age risks on child brain development. En ligne : http://dx.doi.org/10.1002/aur.2822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Brief Report: No Association Between Parental Age and Extreme Social-Communicative Autistic Traits in the General Population / Elise B. ROBINSON in Journal of Autism and Developmental Disorders, 41-12 (December 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1733-1737 Titre : Brief Report: No Association Between Parental Age and Extreme Social-Communicative Autistic Traits in the General Population Type de document : Texte imprimé et/ou numérique Auteurs : Elise B. ROBINSON, Auteur ; Kerim M. MUNIR, Auteur ; Marie C. MCCORMICK, Auteur ; Karestan C. KOENEN, Auteur ; Susan L. SANTANGELO, Auteur Année de publication : 2011 Article en page(s) : p.1733-1737 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Autistic traits  Parental age  ALSPAC Index. décimale : PER Périodiques Résumé : This is the first investigation of the relationship between parental age and extreme social-communicative autistic traits in the general population. The parents of 5,246 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) completed the Social and Communication Disorders Checklist (SCDC). The association between parental age and SCDC scores was assessed in the full sample and among high scoring individuals (e.g. top 5%, 1%). There was no association between parental age and social-communicative autistic traits in the general population. Neither maternal nor paternal age was associated with extreme scores. These findings suggest that advanced parental age does not confer increased risk for extreme social and communication impairment assessed quantitatively. En ligne : http://dx.doi.org/10.1007/s10803-011-1202-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 [article] Brief Report: No Association Between Parental Age and Extreme Social-Communicative Autistic Traits in the General Population [Texte imprimé et/ou numérique] / Elise B. ROBINSON, Auteur ; Kerim M. MUNIR, Auteur ; Marie C. MCCORMICK, Auteur ; Karestan C. KOENEN, Auteur ; Susan L. SANTANGELO, Auteur . - 2011 . - p.1733-1737. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1733-1737 Mots-clés : Autism spectrum disorders  Autistic traits  Parental age  ALSPAC Index. décimale : PER Périodiques Résumé : This is the first investigation of the relationship between parental age and extreme social-communicative autistic traits in the general population. The parents of 5,246 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) completed the Social and Communication Disorders Checklist (SCDC). The association between parental age and SCDC scores was assessed in the full sample and among high scoring individuals (e.g. top 5%, 1%). There was no association between parental age and social-communicative autistic traits in the general population. Neither maternal nor paternal age was associated with extreme scores. These findings suggest that advanced parental age does not confer increased risk for extreme social and communication impairment assessed quantitatively. En ligne : http://dx.doi.org/10.1007/s10803-011-1202-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148

The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism / Kristen LYALL in Autism Research, 13-6 (June 2020)  

Permalink

Autism Spectrum Disorder Risk Factors and Autistic Traits in Gender Dysphoric Children / Doug P. VANDERLAAN in Journal of Autism and Developmental Disorders, 45-6 (June 2015)  

Permalink