Age-related changes of gene expression in the neocortex: Preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas / Oksana Yu NAUMOVA in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1427-1442 Titre : Age-related changes of gene expression in the neocortex: Preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas Type de document : Texte imprimé et/ou numérique Auteurs : Oksana Yu NAUMOVA, Auteur ; Dean PALEJEV, Auteur ; Natalia V. VLASOVA, Auteur ; Maria LEE, Auteur ; Sergei Yu RYCHKOV, Auteur ; Olga N. BABICH, Auteur ; Flora M. VACCARINO, Auteur ; Elena L. GRIGORENKO, Auteur Année de publication : 2012 Article en page(s) : p.1427-1442 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of understanding developmental (age-related) changes in the brain using different technologies (e.g., DNA-Microarray) and the new and increasingly popular RNA-Seq. We focus on advancements in studies of gene expression in the human brain, which have provided data on the structure and age-related variability of the transcriptome in the brain. We present data on RNA-Seq of the transcriptome in three distinct areas of the neocortex from different ages: mature and elderly individuals. We report that most age-related transcriptional changes affect cellular signaling systems, and, as a result, the transmission of nerve impulses. In general, the results demonstrate the high potential of RNA-Seq for the study of distinctive features of gene expression among cortical areas and the changes in expression through normal and atypical development of the central nervous system. En ligne : http://dx.doi.org/10.1017/S0954579412000818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Age-related changes of gene expression in the neocortex: Preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas [Texte imprimé et/ou numérique] / Oksana Yu NAUMOVA, Auteur ; Dean PALEJEV, Auteur ; Natalia V. VLASOVA, Auteur ; Maria LEE, Auteur ; Sergei Yu RYCHKOV, Auteur ; Olga N. BABICH, Auteur ; Flora M. VACCARINO, Auteur ; Elena L. GRIGORENKO, Auteur . - 2012 . - p.1427-1442. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1427-1442 Index. décimale : PER Périodiques Résumé : The study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of understanding developmental (age-related) changes in the brain using different technologies (e.g., DNA-Microarray) and the new and increasingly popular RNA-Seq. We focus on advancements in studies of gene expression in the human brain, which have provided data on the structure and age-related variability of the transcriptome in the brain. We present data on RNA-Seq of the transcriptome in three distinct areas of the neocortex from different ages: mature and elderly individuals. We report that most age-related transcriptional changes affect cellular signaling systems, and, as a result, the transmission of nerve impulses. In general, the results demonstrate the high potential of RNA-Seq for the study of distinctive features of gene expression among cortical areas and the changes in expression through normal and atypical development of the central nervous system. En ligne : http://dx.doi.org/10.1017/S0954579412000818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

Childhood adversity and DNA methylation of genes involved in the hypothalamus–pituitary–adrenal axis and immune system: Whole-genome and candidate-gene associations / Johanna BICK in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1417-1425 Titre : Childhood adversity and DNA methylation of genes involved in the hypothalamus–pituitary–adrenal axis and immune system: Whole-genome and candidate-gene associations Type de document : Texte imprimé et/ou numérique Auteurs : Johanna BICK, Auteur ; Oksana Yu NAUMOVA, Auteur ; Scott HUNTER, Auteur ; Baptiste BARBOT, Auteur ; Maria LEE, Auteur ; Suniya S. LUTHAR, Auteur ; Adam RAEFSKI, Auteur ; Elena L. GRIGORENKO, Auteur Année de publication : 2012 Article en page(s) : p.1417-1425 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In recent years, translational research involving humans and animals has uncovered biological and physiological pathways that explain associations between early adverse circumstances and long-term mental and physical health outcomes. In this article, we summarize the human and animal literature demonstrating that epigenetic alterations in key biological systems, the hypothalamus–pituitary–adrenal axis and immune system, may underlie such disparities. We review evidence suggesting that changes in DNA methylation profiles of the genome may be responsible for the alterations in hypothalamus–pituitary–adrenal axis and immune system trajectories. Using some preliminary data, we demonstrate how explorations of genome-wide and candidate-gene DNA methylation profiles may inform hypotheses and guide future research efforts in these areas. We conclude our article by discussing the many important future directions, merging perspectives from developmental psychology, molecular genetics, neuroendocrinology, and immunology, that are essential for furthering our understanding of how early adverse circumstances may shape developmental trajectories, particularly in the areas of stress reactivity and physical or mental health. En ligne : http://dx.doi.org/10.1017/S0954579412000806 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Childhood adversity and DNA methylation of genes involved in the hypothalamus–pituitary–adrenal axis and immune system: Whole-genome and candidate-gene associations [Texte imprimé et/ou numérique] / Johanna BICK, Auteur ; Oksana Yu NAUMOVA, Auteur ; Scott HUNTER, Auteur ; Baptiste BARBOT, Auteur ; Maria LEE, Auteur ; Suniya S. LUTHAR, Auteur ; Adam RAEFSKI, Auteur ; Elena L. GRIGORENKO, Auteur . - 2012 . - p.1417-1425. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1417-1425 Index. décimale : PER Périodiques Résumé : In recent years, translational research involving humans and animals has uncovered biological and physiological pathways that explain associations between early adverse circumstances and long-term mental and physical health outcomes. In this article, we summarize the human and animal literature demonstrating that epigenetic alterations in key biological systems, the hypothalamus–pituitary–adrenal axis and immune system, may underlie such disparities. We review evidence suggesting that changes in DNA methylation profiles of the genome may be responsible for the alterations in hypothalamus–pituitary–adrenal axis and immune system trajectories. Using some preliminary data, we demonstrate how explorations of genome-wide and candidate-gene DNA methylation profiles may inform hypotheses and guide future research efforts in these areas. We conclude our article by discussing the many important future directions, merging perspectives from developmental psychology, molecular genetics, neuroendocrinology, and immunology, that are essential for furthering our understanding of how early adverse circumstances may shape developmental trajectories, particularly in the areas of stress reactivity and physical or mental health. En ligne : http://dx.doi.org/10.1017/S0954579412000806 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents / Oksana Yu NAUMOVA in Development and Psychopathology, 24-1 (January 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-1 (January 2012) . - p.143-155 Titre : Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents Type de document : Texte imprimé et/ou numérique Auteurs : Oksana Yu NAUMOVA, Auteur ; Maria LEE, Auteur ; Roman A. KOPOSOV, Auteur ; Moshe SZYF, Auteur ; Mary DOZIER, Auteur ; Elena L. GRIGORENKO, Auteur Année de publication : 2012 Article en page(s) : p.143-155 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous studies with nonhuman species have shown that animals exposed to early adversity show differential DNA methylation relative to comparison animals. The current study examined differential methylation among 14 children raised since birth in institutional care and 14 comparison children raised by their biological parents. Blood samples were taken from children in middle childhood. Analysis of whole-genome methylation patterns was performed using the Infinium HumanMethylation27 BeadChip assay (Illumina), which contains 27,578 CpG sites, covering approximately 14,000 gene promoters. Group differences were registered, which were characterized primarily by greater methylation in the institutionalized group relative to the comparison group, with most of these differences in genes involved in the control of immune response and cellular signaling systems, including a number of crucial players important for neural communication and brain development and functioning. The findings suggest that patterns of differential methylation seen in nonhuman species with altered maternal care are also characteristic of children who experience early maternal separation. En ligne : http://dx.doi.org/10.1017/S0954579411000605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents [Texte imprimé et/ou numérique] / Oksana Yu NAUMOVA, Auteur ; Maria LEE, Auteur ; Roman A. KOPOSOV, Auteur ; Moshe SZYF, Auteur ; Mary DOZIER, Auteur ; Elena L. GRIGORENKO, Auteur . - 2012 . - p.143-155. Langues : Anglais (eng) in Development and Psychopathology > 24-1 (January 2012) . - p.143-155 Index. décimale : PER Périodiques Résumé : Previous studies with nonhuman species have shown that animals exposed to early adversity show differential DNA methylation relative to comparison animals. The current study examined differential methylation among 14 children raised since birth in institutional care and 14 comparison children raised by their biological parents. Blood samples were taken from children in middle childhood. Analysis of whole-genome methylation patterns was performed using the Infinium HumanMethylation27 BeadChip assay (Illumina), which contains 27,578 CpG sites, covering approximately 14,000 gene promoters. Group differences were registered, which were characterized primarily by greater methylation in the institutionalized group relative to the comparison group, with most of these differences in genes involved in the control of immune response and cellular signaling systems, including a number of crucial players important for neural communication and brain development and functioning. The findings suggest that patterns of differential methylation seen in nonhuman species with altered maternal care are also characteristic of children who experience early maternal separation. En ligne : http://dx.doi.org/10.1017/S0954579411000605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Epigenetic regulation of cognition: A circumscribed review of the field / Elena L. GRIGORENKO in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1285-1304 Titre : Epigenetic regulation of cognition: A circumscribed review of the field Type de document : Texte imprimé et/ou numérique Auteurs : Elena L. GRIGORENKO, Auteur ; Sergey A. KORNILOV, Auteur ; Oksana Yu NAUMOVA, Auteur Article en page(s) : p.1285-1304 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The last decade has been marked by an increased interest in relating epigenetic mechanisms to complex human behaviors, although this interest has not been balanced, accentuating various types of affective and primarily ignoring cognitive functioning. Recent animal model data support the view that epigenetic processes play a role in learning and memory consolidation and help transmit acquired memories even across generations. In this review, we provide an overview of various types of epigenetic mechanisms in the brain (DNA methylation, histone modification, and noncoding RNA action) and discuss their impact proximally on gene transcription, protein synthesis, and synaptic plasticity and distally on learning, memory, and other cognitive functions. Of particular importance are observations that neuronal activation regulates the dynamics of the epigenome's functioning under precise timing, with subsequent alterations in the gene expression profile. In turn, epigenetic regulation impacts neuronal action, closing the circle and substantiating the signaling pathways that underlie, at least partially, learning, memory, and other cognitive processes. En ligne : http://dx.doi.org/10.1017/s0954579416000857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Epigenetic regulation of cognition: A circumscribed review of the field [Texte imprimé et/ou numérique] / Elena L. GRIGORENKO, Auteur ; Sergey A. KORNILOV, Auteur ; Oksana Yu NAUMOVA, Auteur . - p.1285-1304. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1285-1304 Index. décimale : PER Périodiques Résumé : The last decade has been marked by an increased interest in relating epigenetic mechanisms to complex human behaviors, although this interest has not been balanced, accentuating various types of affective and primarily ignoring cognitive functioning. Recent animal model data support the view that epigenetic processes play a role in learning and memory consolidation and help transmit acquired memories even across generations. In this review, we provide an overview of various types of epigenetic mechanisms in the brain (DNA methylation, histone modification, and noncoding RNA action) and discuss their impact proximally on gene transcription, protein synthesis, and synaptic plasticity and distally on learning, memory, and other cognitive functions. Of particular importance are observations that neuronal activation regulates the dynamics of the epigenome's functioning under precise timing, with subsequent alterations in the gene expression profile. In turn, epigenetic regulation impacts neuronal action, closing the circle and substantiating the signaling pathways that underlie, at least partially, learning, memory, and other cognitive processes. En ligne : http://dx.doi.org/10.1017/s0954579416000857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

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