Brief Report: Mediation of Treatment Effect in a Communication Intervention for Pre-School Children with Autism / Catherine ALDRED in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.447-454 Titre : Brief Report: Mediation of Treatment Effect in a Communication Intervention for Pre-School Children with Autism Type de document : texte imprimé Auteurs : Catherine ALDRED, Auteur ; Jonathan GREEN, Auteur ; Richard EMSLEY, Auteur ; Helen MCCONACHIE, Auteur Année de publication : 2012 Article en page(s) : p.447-454 Langues : Anglais (eng) Mots-clés : Pre-school child  Intervention trial  Parental synchrony  Mediation Index. décimale : PER Périodiques Résumé : Tests of mediation in treatment trials can illuminate processes of change and suggest causal influences in development. We conducted a mediation analysis of a previously published randomised controlled trial of parent-mediated communication-focused treatment for autism against ordinary care, with 28 children aged 2–5 years (Aldred et al. in J Child Psychol Psychiatr 45:1–11, 2004). The hypothesised mediating process, targeted by the intervention, was an increase in parental synchronous response within parent–child interaction. The results showed partial mediation, with change in synchrony accounting for 34% of the positive intervention effect on autism symptomatology (Autism Diagnostic Observation Schedule communication and social domain algorithm); the result was confirmed by bootstrap estimation. Improved parental synchronous response to child communication can alter short-term autism symptom outcome with targeted therapy. En ligne : http://dx.doi.org/10.1007/s10803-011-1248-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Brief Report: Mediation of Treatment Effect in a Communication Intervention for Pre-School Children with Autism [texte imprimé] / Catherine ALDRED, Auteur ; Jonathan GREEN, Auteur ; Richard EMSLEY, Auteur ; Helen MCCONACHIE, Auteur . - 2012 . - p.447-454. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.447-454 Mots-clés : Pre-school child  Intervention trial  Parental synchrony  Mediation Index. décimale : PER Périodiques Résumé : Tests of mediation in treatment trials can illuminate processes of change and suggest causal influences in development. We conducted a mediation analysis of a previously published randomised controlled trial of parent-mediated communication-focused treatment for autism against ordinary care, with 28 children aged 2–5 years (Aldred et al. in J Child Psychol Psychiatr 45:1–11, 2004). The hypothesised mediating process, targeted by the intervention, was an increase in parental synchronous response within parent–child interaction. The results showed partial mediation, with change in synchrony accounting for 34% of the positive intervention effect on autism symptomatology (Autism Diagnostic Observation Schedule communication and social domain algorithm); the result was confirmed by bootstrap estimation. Improved parental synchronous response to child communication can alter short-term autism symptom outcome with targeted therapy. En ligne : http://dx.doi.org/10.1007/s10803-011-1248-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Generalisation of Social Communication Skills by Autistic Children During Play-Based Assessments Across Home, School and an Unfamiliar Research Setting / Tony CHARMAN ; Kathy LEADBITTER ; Ceri ELLIS ; Lauren TAYLOR ; Heather L. MOORE ; Carol TAYLOR ; Kirsty JAMES ; Matea BALABANOVSKA ; Sophie LANGHORNE ; Catherine ALDRED ; Vicky SLONIMS ; Vicki GRAHAME ; Patricia HOWLIN ; Helen MCCONACHIE ; Jeremy R. PARR ; Richard EMSLEY ; Ann LE COUTEUR ; Jonathan GREEN ; Andrew PICKLES ; THE PACT-G. TRIAL GROUP in Journal of Autism and Developmental Disorders, 55-7 (July 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-7 (July 2025) . - p.2203-2216 Titre : Generalisation of Social Communication Skills by Autistic Children During Play-Based Assessments Across Home, School and an Unfamiliar Research Setting Type de document : texte imprimé Auteurs : Tony CHARMAN, Auteur ; Kathy LEADBITTER, Auteur ; Ceri ELLIS, Auteur ; Lauren TAYLOR, Auteur ; Heather L. MOORE, Auteur ; Carol TAYLOR, Auteur ; Kirsty JAMES, Auteur ; Matea BALABANOVSKA, Auteur ; Sophie LANGHORNE, Auteur ; Catherine ALDRED, Auteur ; Vicky SLONIMS, Auteur ; Vicki GRAHAME, Auteur ; Patricia HOWLIN, Auteur ; Helen MCCONACHIE, Auteur ; Jeremy R. PARR, Auteur ; Richard EMSLEY, Auteur ; Ann LE COUTEUR, Auteur ; Jonathan GREEN, Auteur ; Andrew PICKLES, Auteur ; THE PACT-G. TRIAL GROUP, Auteur Article en page(s) : p.2203-2216 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We investigated autistic children s generalisation of social communication over time across three settings during a play-based assessment with different adults and explore the potential moderating effects on generalisation of age, nonverbal IQ and level of restricted and repetitive behaviours. The social communication abilities of 248 autistic children (2-11 years, 21% female, 22% single parent, 60% white) from three UK sites were assessed from 1984 video interactions in three contexts with three different interaction partners (parent/home, teaching assistant/school, researcher/clinic) at baseline, midpoint (+ 7m) and endpoint (+ 12m) within the Paediatric Autism Communication Trial-Generalised (PACT-G), a parent-mediated social communication intervention. Children s midpoint social communication at home generalised to school at midpoint and to clinic at endpoint. Generalisation was stronger from home to school and clinic than school to home and clinic. Generalisation was not moderated by age, nonverbal IQ or restricted and repetitive behaviour. Broader child development did not explain the pattern of results. The current study is the largest study to date to explore generalisation with autistic children and provides novel insight into their generalisation of social communication skills. Further research is needed to gain a more comprehensive understanding of facilitators of generalisation across settings and interaction partners in order to develop targeted strategies for interventions to enhance outcomes for young autistic children. En ligne : https://doi.org/10.1007/s10803-024-06370-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Generalisation of Social Communication Skills by Autistic Children During Play-Based Assessments Across Home, School and an Unfamiliar Research Setting [texte imprimé] / Tony CHARMAN, Auteur ; Kathy LEADBITTER, Auteur ; Ceri ELLIS, Auteur ; Lauren TAYLOR, Auteur ; Heather L. MOORE, Auteur ; Carol TAYLOR, Auteur ; Kirsty JAMES, Auteur ; Matea BALABANOVSKA, Auteur ; Sophie LANGHORNE, Auteur ; Catherine ALDRED, Auteur ; Vicky SLONIMS, Auteur ; Vicki GRAHAME, Auteur ; Patricia HOWLIN, Auteur ; Helen MCCONACHIE, Auteur ; Jeremy R. PARR, Auteur ; Richard EMSLEY, Auteur ; Ann LE COUTEUR, Auteur ; Jonathan GREEN, Auteur ; Andrew PICKLES, Auteur ; THE PACT-G. TRIAL GROUP, Auteur . - p.2203-2216. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-7 (July 2025) . - p.2203-2216 Index. décimale : PER Périodiques Résumé : We investigated autistic children s generalisation of social communication over time across three settings during a play-based assessment with different adults and explore the potential moderating effects on generalisation of age, nonverbal IQ and level of restricted and repetitive behaviours. The social communication abilities of 248 autistic children (2-11 years, 21% female, 22% single parent, 60% white) from three UK sites were assessed from 1984 video interactions in three contexts with three different interaction partners (parent/home, teaching assistant/school, researcher/clinic) at baseline, midpoint (+ 7m) and endpoint (+ 12m) within the Paediatric Autism Communication Trial-Generalised (PACT-G), a parent-mediated social communication intervention. Children s midpoint social communication at home generalised to school at midpoint and to clinic at endpoint. Generalisation was stronger from home to school and clinic than school to home and clinic. Generalisation was not moderated by age, nonverbal IQ or restricted and repetitive behaviour. Broader child development did not explain the pattern of results. The current study is the largest study to date to explore generalisation with autistic children and provides novel insight into their generalisation of social communication skills. Further research is needed to gain a more comprehensive understanding of facilitators of generalisation across settings and interaction partners in order to develop targeted strategies for interventions to enhance outcomes for young autistic children. En ligne : https://doi.org/10.1007/s10803-024-06370-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA) / Stavros STIVAROS in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 12 p. Titre : Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA) Type de document : texte imprimé Auteurs : Stavros STIVAROS, Auteur ; Shruti GARG, Auteur ; Maria TZIRAKI, Auteur ; Ying CAI, Auteur ; Owen THOMAS, Auteur ; Joseph MELLOR, Auteur ; Andrew A. MORRIS, Auteur ; Carly JIM, Auteur ; Karolina SZUMANSKA-RYT, Auteur ; Laura M. PARKES, Auteur ; Hamied A. HAROON, Auteur ; Daniela MONTALDI, Auteur ; Nicholas WEBB, Auteur ; John KEANE, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Alcino J. SILVA, Auteur ; Sue HUSON, Auteur ; Simon WILLIAMS, Auteur ; D. GARETH EVANS, Auteur ; Richard EMSLEY, Auteur ; Jonathan GREEN, Auteur Article en page(s) : 12 p. Langues : Anglais (eng) Mots-clés : Autism  Neurofibromatosis type 1  Neuroimaging  Randomised controlled trial  Simvastatin  Statin Index. décimale : PER Périodiques Résumé : Background: Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects for the first time in younger children with NF1 and co-morbid autism and by using multiparametric imaging outcomes. Methods: A single-site triple-blind RCT of simvastatin vs. placebo was done. Assessment (baseline and 12-week endpoint) included peripheral MAPK assay, awake magnetic resonance imaging spectroscopy (MRS; GABA and glutamate+glutamine (Glx)), arterial spin labelling (ASL), apparent diffusion coefficient (ADC), resting state functional MRI, and autism behavioural outcomes (Aberrant Behaviour Checklist and Clinical Global Impression). Results: Thirty subjects had a mean age of 8.1 years (SD 1.8). Simvastatin was well tolerated. The amount of imaging data varied by test. Simvastatin treatment was associated with (i) increased frontal white matter MRS GABA (t(12) = - 2.12, p = .055), GABA/Glx ratio (t(12) = - 2.78, p = .016), and reduced grey nuclei Glx (ANCOVA p < 0.05, Mann-Whitney p < 0.01); (ii) increased ASL perfusion in ventral diencephalon (Mann-Whitney p < 0.01); and (iii) decreased ADC in cingulate gyrus (Mann-Whitney p < 0.01). Machine-learning classification of imaging outcomes achieved 79% (p < .05) accuracy differentiating groups at endpoint against chance level (64%, p = 0.25) at baseline. Three of 12 (25%) simvastatin cases compared to none in placebo met 'clinical responder' criteria for behavioural outcome. Conclusions: We show feasibility of peripheral MAPK assay and autism symptom measurement, but the study was not powered to test effectiveness. Multiparametric imaging suggests possible simvastatin effects in brain areas previously associated with NF1 pathophysiology and the social brain network. Trial registration: EU Clinical Trial Register (EudraCT) 2012-005742-38 (www.clinicaltrialsregister.eu). En ligne : http://dx.doi.org/10.1186/s13229-018-0190-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA) [texte imprimé] / Stavros STIVAROS, Auteur ; Shruti GARG, Auteur ; Maria TZIRAKI, Auteur ; Ying CAI, Auteur ; Owen THOMAS, Auteur ; Joseph MELLOR, Auteur ; Andrew A. MORRIS, Auteur ; Carly JIM, Auteur ; Karolina SZUMANSKA-RYT, Auteur ; Laura M. PARKES, Auteur ; Hamied A. HAROON, Auteur ; Daniela MONTALDI, Auteur ; Nicholas WEBB, Auteur ; John KEANE, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Alcino J. SILVA, Auteur ; Sue HUSON, Auteur ; Simon WILLIAMS, Auteur ; D. GARETH EVANS, Auteur ; Richard EMSLEY, Auteur ; Jonathan GREEN, Auteur . - 12 p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 12 p. Mots-clés : Autism  Neurofibromatosis type 1  Neuroimaging  Randomised controlled trial  Simvastatin  Statin Index. décimale : PER Périodiques Résumé : Background: Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects for the first time in younger children with NF1 and co-morbid autism and by using multiparametric imaging outcomes. Methods: A single-site triple-blind RCT of simvastatin vs. placebo was done. Assessment (baseline and 12-week endpoint) included peripheral MAPK assay, awake magnetic resonance imaging spectroscopy (MRS; GABA and glutamate+glutamine (Glx)), arterial spin labelling (ASL), apparent diffusion coefficient (ADC), resting state functional MRI, and autism behavioural outcomes (Aberrant Behaviour Checklist and Clinical Global Impression). Results: Thirty subjects had a mean age of 8.1 years (SD 1.8). Simvastatin was well tolerated. The amount of imaging data varied by test. Simvastatin treatment was associated with (i) increased frontal white matter MRS GABA (t(12) = - 2.12, p = .055), GABA/Glx ratio (t(12) = - 2.78, p = .016), and reduced grey nuclei Glx (ANCOVA p < 0.05, Mann-Whitney p < 0.01); (ii) increased ASL perfusion in ventral diencephalon (Mann-Whitney p < 0.01); and (iii) decreased ADC in cingulate gyrus (Mann-Whitney p < 0.01). Machine-learning classification of imaging outcomes achieved 79% (p < .05) accuracy differentiating groups at endpoint against chance level (64%, p = 0.25) at baseline. Three of 12 (25%) simvastatin cases compared to none in placebo met 'clinical responder' criteria for behavioural outcome. Conclusions: We show feasibility of peripheral MAPK assay and autism symptom measurement, but the study was not powered to test effectiveness. Multiparametric imaging suggests possible simvastatin effects in brain areas previously associated with NF1 pathophysiology and the social brain network. Trial registration: EU Clinical Trial Register (EudraCT) 2012-005742-38 (www.clinicaltrialsregister.eu). En ligne : http://dx.doi.org/10.1186/s13229-018-0190-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

Research Reviews: Advances in methods for evaluating child and adolescent mental health interventions / Danielle EDWARDS ; Levente HORVATH ; Richard EMSLEY in Journal of Child Psychology and Psychiatry, 64-12 (December 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-12 (December 2023) . - p.1765-1775 Titre : Research Reviews: Advances in methods for evaluating child and adolescent mental health interventions Type de document : texte imprimé Auteurs : Danielle EDWARDS, Auteur ; Levente HORVATH, Auteur ; Richard EMSLEY, Auteur Article en page(s) : p.1765-1775 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Backround The evidence base for interventions for child mental health and neurodevelopment is weak and the current capacity for rigorous evaluation limited. We describe some of the challenges that make this field particularly difficult and expensive for evaluation studies. Methods We describe and review the use of novel study designs and analysis methodology for their potential to improve this situation. Results While several novel designs appeared ill-suited to our field, systematic review found others that offered potential but had yet to be widely adopted, some not at all. Conclusions While funding is inevitably a constraint, we argue that improvements in the evidence base of both current and new treatments will only be achieved by the adoption of a number of these new technologies and study designs, the consistent application of rigorous constructive but demanding standards, and the engagement of the public, patients, clinical and research services to build a design, recruitment, and analysis infrastructure. En ligne : https://doi.org/10.1111/jcpp.13892 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Research Reviews: Advances in methods for evaluating child and adolescent mental health interventions [texte imprimé] / Danielle EDWARDS, Auteur ; Levente HORVATH, Auteur ; Richard EMSLEY, Auteur . - p.1765-1775. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-12 (December 2023) . - p.1765-1775 Index. décimale : PER Périodiques Résumé : Backround The evidence base for interventions for child mental health and neurodevelopment is weak and the current capacity for rigorous evaluation limited. We describe some of the challenges that make this field particularly difficult and expensive for evaluation studies. Methods We describe and review the use of novel study designs and analysis methodology for their potential to improve this situation. Results While several novel designs appeared ill-suited to our field, systematic review found others that offered potential but had yet to be widely adopted, some not at all. Conclusions While funding is inevitably a constraint, we argue that improvements in the evidence base of both current and new treatments will only be achieved by the adoption of a number of these new technologies and study designs, the consistent application of rigorous constructive but demanding standards, and the engagement of the public, patients, clinical and research services to build a design, recruitment, and analysis infrastructure. En ligne : https://doi.org/10.1111/jcpp.13892 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Restricted and Repetitive Behaviors in Autism Spectrum Disorders and Typical Development: Cross-Sectional and Longitudinal Comparisons / Clare HARROP in Journal of Autism and Developmental Disorders, 44-5 (May 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-5 (May 2014) . - p.1207-1219 Titre : Restricted and Repetitive Behaviors in Autism Spectrum Disorders and Typical Development: Cross-Sectional and Longitudinal Comparisons Type de document : texte imprimé Auteurs : Clare HARROP, Auteur ; Helen MCCONACHIE, Auteur ; Richard EMSLEY, Auteur ; Kathy LEADBITTER, Auteur ; Jonathan GREEN, Auteur Année de publication : 2014 Article en page(s) : p.1207-1219 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Repetitive behaviors  Measurement longitudinal Index. décimale : PER Périodiques Résumé : Restricted and repetitive behaviors (RRBs) are characteristic of autism spectrum disorders (ASD). However, compared to social and communicative impairments, less is known about their development, trajectory and etiology. This study explored RRBs in young children with ASD matched to typically developing (TD) children on non-verbal development. RRBs were coded from direct observation at three time points within 13 months of development. Children with ASD displayed higher frequency and greater diversity of RRBs at all time points, however RRBs were not unique to ASD and evident in the TD control group albeit at a reduced frequency. RRBs did not correlate with social and communicative impairments in the ASD group, suggesting dissociation between these domains. En ligne : http://dx.doi.org/10.1007/s10803-013-1986-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] Restricted and Repetitive Behaviors in Autism Spectrum Disorders and Typical Development: Cross-Sectional and Longitudinal Comparisons [texte imprimé] / Clare HARROP, Auteur ; Helen MCCONACHIE, Auteur ; Richard EMSLEY, Auteur ; Kathy LEADBITTER, Auteur ; Jonathan GREEN, Auteur . - 2014 . - p.1207-1219. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-5 (May 2014) . - p.1207-1219 Mots-clés : Autism spectrum disorder  Repetitive behaviors  Measurement longitudinal Index. décimale : PER Périodiques Résumé : Restricted and repetitive behaviors (RRBs) are characteristic of autism spectrum disorders (ASD). However, compared to social and communicative impairments, less is known about their development, trajectory and etiology. This study explored RRBs in young children with ASD matched to typically developing (TD) children on non-verbal development. RRBs were coded from direct observation at three time points within 13 months of development. Children with ASD displayed higher frequency and greater diversity of RRBs at all time points, however RRBs were not unique to ASD and evident in the TD control group albeit at a reduced frequency. RRBs did not correlate with social and communicative impairments in the ASD group, suggesting dissociation between these domains. En ligne : http://dx.doi.org/10.1007/s10803-013-1986-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

The Autism Family Experience Questionnaire (AFEQ): An Ecologically-Valid, Parent-Nominated Measure of Family Experience, Quality of Life and Prioritised Outcomes for Early Intervention / Kathy LEADBITTER in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

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The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting / Gauri DIVAN in Autism Research, 12-2 (February 2019)  

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