Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders / Dario SINISCALCO in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2686-2695 Titre : Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Anna SAPONE, Auteur ; Catia GIORDANO, Auteur ; Alessandra CIRILLO, Auteur ; Laura MAGISTRIS, Auteur ; Francesco ROSSI, Auteur ; Alessio FASANO, Auteur ; James Jeffrey BRADSTREET, Auteur ; Sabatino MAIONE, Auteur ; Nicola ANTONUCCI, Auteur Article en page(s) : p.2686-2695 Langues : Anglais (eng) Mots-clés : Autistic disorders  Cannabinoid system  Gene expression  PBMCs Index. décimale : PER Périodiques Résumé : Autistic disorders (ADs) are heterogeneous neurodevelopmental disorders arised by the interaction of genes and environmental factors. Dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and non-verbal behaviours are common features of ADs. There are no defined mechanisms of pathogenesis, rendering curative therapy very difficult. Indeed, the treatments for autism presently available can be divided into behavioural, nutritional and medical approaches, although no defined standard approach exists. Autistic children display immune system dysregulation and show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the involvement of cannabinoid system in PBMCs from autistic children compared to age-matched normal healthy developing controls (age ranging 3–9 years; mean age: 6.06 ± 1.52 vs. 6.14 ± 1.39 in autistic children and healthy subjects, respectively). The mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in AD-PBMCs as compared to healthy subjects (mean ± SE of arbitrary units: 0.34 ± 0.03 vs. 0.23 ± 0.02 in autistic children and healthy subjects, respectively), whereas CB1 and fatty acid amide hydrolase mRNA levels were unchanged. mRNA levels of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D gene were slightly decreased. Protein levels of CB-2 were also significantly increased in autistic children (mean ± SE of arbitrary units: 33.5 ± 1.32 vs. 6.70 ± 1.25 in autistic children and healthy subjects, respectively). Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care. En ligne : http://dx.doi.org/10.1007/s10803-013-1824-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Anna SAPONE, Auteur ; Catia GIORDANO, Auteur ; Alessandra CIRILLO, Auteur ; Laura MAGISTRIS, Auteur ; Francesco ROSSI, Auteur ; Alessio FASANO, Auteur ; James Jeffrey BRADSTREET, Auteur ; Sabatino MAIONE, Auteur ; Nicola ANTONUCCI, Auteur . - p.2686-2695. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2686-2695 Mots-clés : Autistic disorders  Cannabinoid system  Gene expression  PBMCs Index. décimale : PER Périodiques Résumé : Autistic disorders (ADs) are heterogeneous neurodevelopmental disorders arised by the interaction of genes and environmental factors. Dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and non-verbal behaviours are common features of ADs. There are no defined mechanisms of pathogenesis, rendering curative therapy very difficult. Indeed, the treatments for autism presently available can be divided into behavioural, nutritional and medical approaches, although no defined standard approach exists. Autistic children display immune system dysregulation and show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the involvement of cannabinoid system in PBMCs from autistic children compared to age-matched normal healthy developing controls (age ranging 3–9 years; mean age: 6.06 ± 1.52 vs. 6.14 ± 1.39 in autistic children and healthy subjects, respectively). The mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in AD-PBMCs as compared to healthy subjects (mean ± SE of arbitrary units: 0.34 ± 0.03 vs. 0.23 ± 0.02 in autistic children and healthy subjects, respectively), whereas CB1 and fatty acid amide hydrolase mRNA levels were unchanged. mRNA levels of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D gene were slightly decreased. Protein levels of CB-2 were also significantly increased in autistic children (mean ± SE of arbitrary units: 33.5 ± 1.32 vs. 6.70 ± 1.25 in autistic children and healthy subjects, respectively). Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care. En ligne : http://dx.doi.org/10.1007/s10803-013-1824-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

Ethics in Autism Care / Dario SINISCALCO in Autism - Open Access, 3-3 (December 2013)  

Public ISBD [article]  inAutism - Open Access > 3-3 (December 2013) . - 1 p. Titre : Ethics in Autism Care Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Angela DI MARSILIO, Auteur ; Nicola ANTONUCCI, Auteur Année de publication : 2013 Article en page(s) : 1 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e119 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Ethics in Autism Care [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Angela DI MARSILIO, Auteur ; Nicola ANTONUCCI, Auteur . - 2013 . - 1 p. Langues : Anglais (eng) in Autism - Open Access > 3-3 (December 2013) . - 1 p. Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e119 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Melatonin for Autism Spectrum Disorder: Beyond Sleep Disturbances? / Dario SINISCALCO in Autism - Open Access, 8-2 ([01/03/2018])  

Public ISBD [article]  inAutism - Open Access > 8-2 [01/03/2018] . - 2 p. Titre : Melatonin for Autism Spectrum Disorder: Beyond Sleep Disturbances? Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Nicola ANTONUCCI, Auteur ; Rita REZZANI, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Melatonin for Autism Spectrum Disorder: Beyond Sleep Disturbances? [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Nicola ANTONUCCI, Auteur ; Rita REZZANI, Auteur . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 8-2 [01/03/2018] . - 2 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients / Dario SINISCALCO in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1403-1410 Titre : The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Anna SAPONE, Auteur ; Catia GIORDANO, Auteur ; Alessandra CIRILLO, Auteur ; Vito DE NOVELLIS, Auteur ; Laura DE MAGISTRIS, Auteur ; Francesco ROSSI, Auteur ; Alessio FASANO, Auteur ; Sabatino SABATINO, Auteur ; Nicola ANTONUCCI, Auteur Année de publication : 2012 Article en page(s) : p.1403-1410 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Caspases  Gene expression  PBMCs Index. décimale : PER Périodiques Résumé : Autism and autism spectrum disorders (ASDs) are heterogeneous complex neuro-developmental disorders characterized by dysfunctions in social interaction and communication skills. Their pathogenesis has been linked to interactions between genes and environmental factors. Consistent with the evidence of certain similarities between immune cells and neurons, autistic children also show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the activation of caspases, cysteinyl aspartate-specific proteases involved in apoptosis and several other cell functions in PBMCs from 15 ASD children compared to age-matched normal healthy developing controls. The mRNA levels for caspase-1, -2, -4, -5 were significantly increased in ASD children as compared to healthy subjects. Protein levels of Caspase-3, -7, -12 were also increased in ASD patients. Our data are suggestive of a possible role of the capsase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management. En ligne : http://dx.doi.org/10.1007/s10803-011-1373-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] The Expression of Caspases is Enhanced in Peripheral Blood Mononuclear Cells of Autism Spectrum Disorder Patients [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Anna SAPONE, Auteur ; Catia GIORDANO, Auteur ; Alessandra CIRILLO, Auteur ; Vito DE NOVELLIS, Auteur ; Laura DE MAGISTRIS, Auteur ; Francesco ROSSI, Auteur ; Alessio FASANO, Auteur ; Sabatino SABATINO, Auteur ; Nicola ANTONUCCI, Auteur . - 2012 . - p.1403-1410. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1403-1410 Mots-clés : Autism spectrum disorders  Caspases  Gene expression  PBMCs Index. décimale : PER Périodiques Résumé : Autism and autism spectrum disorders (ASDs) are heterogeneous complex neuro-developmental disorders characterized by dysfunctions in social interaction and communication skills. Their pathogenesis has been linked to interactions between genes and environmental factors. Consistent with the evidence of certain similarities between immune cells and neurons, autistic children also show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the activation of caspases, cysteinyl aspartate-specific proteases involved in apoptosis and several other cell functions in PBMCs from 15 ASD children compared to age-matched normal healthy developing controls. The mRNA levels for caspase-1, -2, -4, -5 were significantly increased in ASD children as compared to healthy subjects. Protein levels of Caspase-3, -7, -12 were also increased in ASD patients. Our data are suggestive of a possible role of the capsase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management. En ligne : http://dx.doi.org/10.1007/s10803-011-1373-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

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