Initially intact neural responses to pain in autism are diminished during sustained pain / Michelle D. FAILLA in Autism, 22-6 (August 2018)  

Public ISBD [article]  inAutism > 22-6 (August 2018) . - p.669-683 Titre : Initially intact neural responses to pain in autism are diminished during sustained pain Type de document : texte imprimé Auteurs : Michelle D. FAILLA, Auteur ; Estephan J. MOANA-FILHO, Auteur ; G.K. ESSICK, Auteur ; Grace T. BARANEK, Auteur ; Baxter P. ROGERS, Auteur ; Carissa J. CASCIO, Auteur Article en page(s) : p.669-683 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  functional magnetic resonance imaging  pain  repetitive behaviors  self-injury  sensory Index. décimale : PER Périodiques Résumé : Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience. In this first functional magnetic resonance imaging study of pain in autism spectrum disorder, we investigated neural responses to pain in 15 adults with autism spectrum disorder relative to a typical comparison group (n = 16). We explored temporal and spatial properties of the neural pain signature and its modulators during sustained heat pain. The two groups had indistinguishable pain ratings and neural pain signature responses during acute pain; yet, we observed strikingly reduced neural pain signature response in autism spectrum disorder during sustained pain and after stimulus offset. The posterior cingulate cortex, a neural pain signature modulating region, mirrored this late signal reduction in autism spectrum disorder. Intact early responses, followed by diminished late responses to sustained pain, may reflect altered pain coping or evaluation in autism spectrum disorder. Evidence of a dichotomous neural response to initial versus protracted pain may clarify the coexistence of both hypo- and hyperresponsiveness to pain in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361317696043 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Initially intact neural responses to pain in autism are diminished during sustained pain [texte imprimé] / Michelle D. FAILLA, Auteur ; Estephan J. MOANA-FILHO, Auteur ; G.K. ESSICK, Auteur ; Grace T. BARANEK, Auteur ; Baxter P. ROGERS, Auteur ; Carissa J. CASCIO, Auteur . - p.669-683. Langues : Anglais (eng) in Autism > 22-6 (August 2018) . - p.669-683 Mots-clés : autism spectrum disorder  functional magnetic resonance imaging  pain  repetitive behaviors  self-injury  sensory Index. décimale : PER Périodiques Résumé : Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience. In this first functional magnetic resonance imaging study of pain in autism spectrum disorder, we investigated neural responses to pain in 15 adults with autism spectrum disorder relative to a typical comparison group (n = 16). We explored temporal and spatial properties of the neural pain signature and its modulators during sustained heat pain. The two groups had indistinguishable pain ratings and neural pain signature responses during acute pain; yet, we observed strikingly reduced neural pain signature response in autism spectrum disorder during sustained pain and after stimulus offset. The posterior cingulate cortex, a neural pain signature modulating region, mirrored this late signal reduction in autism spectrum disorder. Intact early responses, followed by diminished late responses to sustained pain, may reflect altered pain coping or evaluation in autism spectrum disorder. Evidence of a dichotomous neural response to initial versus protracted pain may clarify the coexistence of both hypo- and hyperresponsiveness to pain in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361317696043 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Perceptual and Neural Response to Affective Tactile Texture Stimulation in Adults with Autism Spectrum Disorders / Carissa J. CASCIO in Autism Research, 5-4 (August 2012)  

Public ISBD [article]  inAutism Research > 5-4 (August 2012) . - p.231-44 Titre : Perceptual and Neural Response to Affective Tactile Texture Stimulation in Adults with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Carissa J. CASCIO, Auteur ; Estephan J. MOANA-FILHO, Auteur ; Steve GUEST, Auteur ; Mary Beth NEBEL, Auteur ; Jonathan WEISNER, Auteur ; Grace T. BARANEK, Auteur ; Gregory ESSICK, Auteur Année de publication : 2012 Article en page(s) : p.231-44 Langues : Anglais (eng) Mots-clés : touch  fMRI  sensory  adults  psychophysics  affective Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with differences in sensory sensitivity and affective response to sensory stimuli, the neural basis of which is still largely unknown. We used psychophysics and functional magnetic resonance imaging (fMRI) to investigate responses to somatosensory stimulation with three textured surfaces that spanned a range of roughness and pleasantness in a sample of adults with ASD and a control group. While psychophysical ratings of roughness and pleasantness were largely similar across the two groups, the ASD group gave pleasant and unpleasant textures more extreme average ratings than did controls. In addition, their ratings for a neutral texture were more variable than controls, indicating they are less consistent in evaluating a stimulus that is affectively ambiguous. Changes in brain blood oxygenation level-dependent (BOLD) signal in response to stimulation with these textures differed substantially between the groups, with the ASD group exhibiting diminished responses compared to the control group, particularly for pleasant and neutral textures. For the most unpleasant texture, the ASD group exhibited greater BOLD response than controls in affective somatosensory processing areas such as the posterior cingulate cortex and the insula. The amplitude of response in the insula in response to the unpleasant texture was positively correlated with social impairment as measured by the Autism Diagnostic Interview-Revised (ADI-R). These results suggest that people with ASD tend to show diminished response to pleasant and neutral stimuli, and exaggerated limbic responses to unpleasant stimuli, which may contribute to diminished social reward associated with touch, perpetuating social withdrawal, and aberrant social development. En ligne : http://dx.doi.org/10.1002/aur.1224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Perceptual and Neural Response to Affective Tactile Texture Stimulation in Adults with Autism Spectrum Disorders [texte imprimé] / Carissa J. CASCIO, Auteur ; Estephan J. MOANA-FILHO, Auteur ; Steve GUEST, Auteur ; Mary Beth NEBEL, Auteur ; Jonathan WEISNER, Auteur ; Grace T. BARANEK, Auteur ; Gregory ESSICK, Auteur . - 2012 . - p.231-44. Langues : Anglais (eng) in Autism Research > 5-4 (August 2012) . - p.231-44 Mots-clés : touch  fMRI  sensory  adults  psychophysics  affective Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with differences in sensory sensitivity and affective response to sensory stimuli, the neural basis of which is still largely unknown. We used psychophysics and functional magnetic resonance imaging (fMRI) to investigate responses to somatosensory stimulation with three textured surfaces that spanned a range of roughness and pleasantness in a sample of adults with ASD and a control group. While psychophysical ratings of roughness and pleasantness were largely similar across the two groups, the ASD group gave pleasant and unpleasant textures more extreme average ratings than did controls. In addition, their ratings for a neutral texture were more variable than controls, indicating they are less consistent in evaluating a stimulus that is affectively ambiguous. Changes in brain blood oxygenation level-dependent (BOLD) signal in response to stimulation with these textures differed substantially between the groups, with the ASD group exhibiting diminished responses compared to the control group, particularly for pleasant and neutral textures. For the most unpleasant texture, the ASD group exhibited greater BOLD response than controls in affective somatosensory processing areas such as the posterior cingulate cortex and the insula. The amplitude of response in the insula in response to the unpleasant texture was positively correlated with social impairment as measured by the Autism Diagnostic Interview-Revised (ADI-R). These results suggest that people with ASD tend to show diminished response to pleasant and neutral stimuli, and exaggerated limbic responses to unpleasant stimuli, which may contribute to diminished social reward associated with touch, perpetuating social withdrawal, and aberrant social development. En ligne : http://dx.doi.org/10.1002/aur.1224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

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