Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study / Kun QIN ; Luis R. PATINO ; Maxwell J. TALLMAN ; Du LEI ; Lu LU ; Wenbin LI ; Thomas J. BLOM ; Kaitlyn M. BRUNS ; Jeffrey A. WELGE ; Jeffrey R. STRAWN ; Qiyong GONG ; John A. SWEENEY ; Manpreet K. SINGH ; Melissa P. DELBELLO in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1072-1086 Titre : Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study Type de document : Texte imprimé et/ou numérique Auteurs : Kun QIN, Auteur ; Luis R. PATINO, Auteur ; Maxwell J. TALLMAN, Auteur ; Du LEI, Auteur ; Lu LU, Auteur ; Wenbin LI, Auteur ; Thomas J. BLOM, Auteur ; Kaitlyn M. BRUNS, Auteur ; Jeffrey A. WELGE, Auteur ; Jeffrey R. STRAWN, Auteur ; Qiyong GONG, Auteur ; John A. SWEENEY, Auteur ; Manpreet K. SINGH, Auteur ; Melissa P. DELBELLO, Auteur Article en page(s) : p.1072-1086 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD. Methods Depressed and/or anxious youth (n = 119, age = 14.9?+?1.6?years) with a family history of BD but no prior antidepressant exposure and typically developing controls (n = 57, age = 14.8?+?1.7?years) received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed to compare their brain connectome patterns, followed by machine learning of topological metrics. Results High-risk youth showed weaker connectivity patterns that were mainly located in the default mode network (DMN) (network weight = 50.1%) relative to controls, and connectivity patterns derived from the visual network (VN) constituted the largest proportion of aberrant stronger pairs (network weight = 54.9%). Global local efficiency (Elocal, p = .022) and clustering coefficient (Cp, p = .029) and nodal metrics of the right superior frontal gyrus (SFG) (Elocal: p < .001; Cp: p = .001) in the high-risk group were significantly higher than those in healthy subjects, and similar patterns were also found in the left insula (degree: p = .004; betweenness: p = .005; age-by-group interaction, p = .038) and right hippocampus (degree: p = .003; betweenness: p = .003). The case-control classifier achieved a cross-validation accuracy of 78.4%. Conclusions Our findings of abnormal connectome organization in the DMN and VN may advance mechanistic understanding of risk for BD. Neuroimaging biomarkers of increased network segregation in the SFG and altered topological centrality in the insula and hippocampus in broader limbic systems may be used to target interventions tailored to mitigate the underlying risk of brain abnormalities in these at-risk youth. En ligne : https://doi.org/10.1111/jcpp.13946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study [Texte imprimé et/ou numérique] / Kun QIN, Auteur ; Luis R. PATINO, Auteur ; Maxwell J. TALLMAN, Auteur ; Du LEI, Auteur ; Lu LU, Auteur ; Wenbin LI, Auteur ; Thomas J. BLOM, Auteur ; Kaitlyn M. BRUNS, Auteur ; Jeffrey A. WELGE, Auteur ; Jeffrey R. STRAWN, Auteur ; Qiyong GONG, Auteur ; John A. SWEENEY, Auteur ; Manpreet K. SINGH, Auteur ; Melissa P. DELBELLO, Auteur . - p.1072-1086. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1072-1086 Index. décimale : PER Périodiques Résumé : Background Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD. Methods Depressed and/or anxious youth (n = 119, age = 14.9?+?1.6?years) with a family history of BD but no prior antidepressant exposure and typically developing controls (n = 57, age = 14.8?+?1.7?years) received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed to compare their brain connectome patterns, followed by machine learning of topological metrics. Results High-risk youth showed weaker connectivity patterns that were mainly located in the default mode network (DMN) (network weight = 50.1%) relative to controls, and connectivity patterns derived from the visual network (VN) constituted the largest proportion of aberrant stronger pairs (network weight = 54.9%). Global local efficiency (Elocal, p = .022) and clustering coefficient (Cp, p = .029) and nodal metrics of the right superior frontal gyrus (SFG) (Elocal: p < .001; Cp: p = .001) in the high-risk group were significantly higher than those in healthy subjects, and similar patterns were also found in the left insula (degree: p = .004; betweenness: p = .005; age-by-group interaction, p = .038) and right hippocampus (degree: p = .003; betweenness: p = .003). The case-control classifier achieved a cross-validation accuracy of 78.4%. Conclusions Our findings of abnormal connectome organization in the DMN and VN may advance mechanistic understanding of risk for BD. Neuroimaging biomarkers of increased network segregation in the SFG and altered topological centrality in the insula and hippocampus in broader limbic systems may be used to target interventions tailored to mitigate the underlying risk of brain abnormalities in these at-risk youth. En ligne : https://doi.org/10.1111/jcpp.13946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Information processing in adolescents with bipolar I disorder / Jane WHITNEY in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.937-45 Titre : Information processing in adolescents with bipolar I disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jane WHITNEY, Auteur ; Jutta JOORMANN, Auteur ; Ian H. GOTLIB, Auteur ; Ryan G. KELLEY, Auteur ; Tenah ACQUAYE, Auteur ; Meghan HOWE, Auteur ; Kiki D. CHANG, Auteur ; Manpreet K. SINGH, Auteur Année de publication : 2012 Article en page(s) : p.937-45 Langues : Anglais (eng) Mots-clés : Adolescence  bipolar disorder  information-processing  memory bias  longitudinal Index. décimale : PER Périodiques Résumé : Background:  Cognitive models of bipolar I disorder (BD) may aid in identification of children who are especially vulnerable to chronic mood dysregulation. Information-processing biases related to memory and attention likely play a role in the development and persistence of BD among adolescents; however, these biases have not been extensively studied in youth with BD. Methods:  We administered the self-referent encoding task and the dot-probe task to adolescents with bipolar I disorder (BD, n = 35) and a demographically similar healthy comparison group (HC, n = 25) at baseline, and at a 1-year follow-up in a subset of this cohort (n = 22 per group). Results:  At both baseline and 1-year follow-up, there were significant interactions of group (BD, HC) and valence of stimulus (positive, negative adjective) on endorsement and recall of self-referent adjectives. HC adolescents endorsed and recalled more positive self-referent adjectives at baseline and follow-up while adolescents with BD endorsed and recalled more negative self-referent adjectives at baseline but not follow-up. Over time, depression symptomatology was associated with impaired memory for positive self-referent adjectives. There were no group differences in attentional bias at either time points. Conclusions:  Adolescents with BD exhibit bias away from endorsement and recall of positive adjectives, which remained stable over time and independent of mood state. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02543.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Information processing in adolescents with bipolar I disorder [Texte imprimé et/ou numérique] / Jane WHITNEY, Auteur ; Jutta JOORMANN, Auteur ; Ian H. GOTLIB, Auteur ; Ryan G. KELLEY, Auteur ; Tenah ACQUAYE, Auteur ; Meghan HOWE, Auteur ; Kiki D. CHANG, Auteur ; Manpreet K. SINGH, Auteur . - 2012 . - p.937-45. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.937-45 Mots-clés : Adolescence  bipolar disorder  information-processing  memory bias  longitudinal Index. décimale : PER Périodiques Résumé : Background:  Cognitive models of bipolar I disorder (BD) may aid in identification of children who are especially vulnerable to chronic mood dysregulation. Information-processing biases related to memory and attention likely play a role in the development and persistence of BD among adolescents; however, these biases have not been extensively studied in youth with BD. Methods:  We administered the self-referent encoding task and the dot-probe task to adolescents with bipolar I disorder (BD, n = 35) and a demographically similar healthy comparison group (HC, n = 25) at baseline, and at a 1-year follow-up in a subset of this cohort (n = 22 per group). Results:  At both baseline and 1-year follow-up, there were significant interactions of group (BD, HC) and valence of stimulus (positive, negative adjective) on endorsement and recall of self-referent adjectives. HC adolescents endorsed and recalled more positive self-referent adjectives at baseline and follow-up while adolescents with BD endorsed and recalled more negative self-referent adjectives at baseline but not follow-up. Over time, depression symptomatology was associated with impaired memory for positive self-referent adjectives. There were no group differences in attentional bias at either time points. Conclusions:  Adolescents with BD exhibit bias away from endorsement and recall of positive adjectives, which remained stable over time and independent of mood state. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02543.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders / Akua F. NIMARKO in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1037-1052 Titre : Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders Type de document : Texte imprimé et/ou numérique Auteurs : Akua F. NIMARKO, Auteur ; Amy S. GARRETT, Auteur ; Gabrielle A. CARLSON, Auteur ; Manpreet K. SINGH, Auteur Article en page(s) : p.1037-1052 Langues : Anglais (eng) Mots-clés : bipolar disorder  emotion processing  functional connectivity  functional magnetic resonance imaging  major depressive disorder  youth Index. décimale : PER Périodiques Résumé : Aberrant face emotion processing has been demonstrated in youth with and at a familial risk for bipolar and major depressive disorders. However, the neurobiological factors related to emotion processing that underlie resilience from youth-onset mood disorders are not well understood. Functional magnetic resonance imaging data during an implicit emotion processing task were collected at baseline from a sample of 50 youth, ages 8–17, who were healthy but also familially at high risk for either bipolar disorder or major depressive disorder, and 24 healthy controls with no family history of psychopathology (HCL). Participants were reevaluated 3 years later and classified into three groups for analysis: high-risk youth who converted to a psychiatric diagnosis (CVT; N = 23), high-risk youth who were resilient from developing any psychopathology (RES; N = 27), and HCL youth (N = 24) who remained healthy at follow-up. For happy > calm faces, the CVT and RES groups had significantly lower activation in the left inferior parietal lobe (IPL), while the RES group had lower activation in the right supramarginal gyrus. For fear > calm faces, the RES group had lower activation in the right precuneus and inferior frontal gyrus (IFG) compared to the CVT group. Connectivity analyses revealed the RES group exhibited higher left IPL connectivity with visual cortical regions for happy > calm faces, and higher IFG connectivity with frontal, temporal, and limbic regions for fear > calm faces. These connectivities were correlated with improvements in prosocial behaviors and global functioning. Our findings suggest that differential activation and connectivity in the IPL, IFG, and precuneus in response to emotional stimuli may represent distinct resilience and risk markers for youth-onset mood disorders. En ligne : http://dx.doi.org/10.1017/S0954579419000579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders [Texte imprimé et/ou numérique] / Akua F. NIMARKO, Auteur ; Amy S. GARRETT, Auteur ; Gabrielle A. CARLSON, Auteur ; Manpreet K. SINGH, Auteur . - p.1037-1052. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1037-1052 Mots-clés : bipolar disorder  emotion processing  functional connectivity  functional magnetic resonance imaging  major depressive disorder  youth Index. décimale : PER Périodiques Résumé : Aberrant face emotion processing has been demonstrated in youth with and at a familial risk for bipolar and major depressive disorders. However, the neurobiological factors related to emotion processing that underlie resilience from youth-onset mood disorders are not well understood. Functional magnetic resonance imaging data during an implicit emotion processing task were collected at baseline from a sample of 50 youth, ages 8–17, who were healthy but also familially at high risk for either bipolar disorder or major depressive disorder, and 24 healthy controls with no family history of psychopathology (HCL). Participants were reevaluated 3 years later and classified into three groups for analysis: high-risk youth who converted to a psychiatric diagnosis (CVT; N = 23), high-risk youth who were resilient from developing any psychopathology (RES; N = 27), and HCL youth (N = 24) who remained healthy at follow-up. For happy > calm faces, the CVT and RES groups had significantly lower activation in the left inferior parietal lobe (IPL), while the RES group had lower activation in the right supramarginal gyrus. For fear > calm faces, the RES group had lower activation in the right precuneus and inferior frontal gyrus (IFG) compared to the CVT group. Connectivity analyses revealed the RES group exhibited higher left IPL connectivity with visual cortical regions for happy > calm faces, and higher IFG connectivity with frontal, temporal, and limbic regions for fear > calm faces. These connectivities were correlated with improvements in prosocial behaviors and global functioning. Our findings suggest that differential activation and connectivity in the IPL, IFG, and precuneus in response to emotional stimuli may represent distinct resilience and risk markers for youth-onset mood disorders. En ligne : http://dx.doi.org/10.1017/S0954579419000579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

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