Annual Research Review: Infant development, autism, and ADHD – early pathways to emerging disorders / Mark H. JOHNSON in Journal of Child Psychology and Psychiatry, 56-3 (March 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.228-247 Titre : Annual Research Review: Infant development, autism, and ADHD – early pathways to emerging disorders Type de document : Texte imprimé et/ou numérique Auteurs : Mark H. JOHNSON, Auteur ; Teodora GLIGA, Auteur ; Emily JONES, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.228-247 Langues : Anglais (eng) Mots-clés : Neurodevelopmental disorder  prediction, risk factors  developmental pathways  ADHD  autism spectrum disorders Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) are two of the most common neurodevelopmental disorders, with a high degree of co-occurrence. Methods Prospective longitudinal studies of infants who later meet criteria for ASD or ADHD offer the opportunity to determine whether the two disorders share developmental pathways. Results Prospective studies of younger siblings of children with autism have revealed a range of infant behavioral and neural markers associated with later diagnosis of ASD. Research on infants with later ADHD is less developed, but emerging evidence reveals a number of relations between infant measures and later symptoms of inattention and hyperactivity. Conclusions We review this literature, highlighting points of convergence and divergence in the early pathways to ASD and ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Annual Research Review: Infant development, autism, and ADHD – early pathways to emerging disorders [Texte imprimé et/ou numérique] / Mark H. JOHNSON, Auteur ; Teodora GLIGA, Auteur ; Emily JONES, Auteur ; Tony CHARMAN, Auteur . - p.228-247. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.228-247 Mots-clés : Neurodevelopmental disorder  prediction, risk factors  developmental pathways  ADHD  autism spectrum disorders Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) are two of the most common neurodevelopmental disorders, with a high degree of co-occurrence. Methods Prospective longitudinal studies of infants who later meet criteria for ASD or ADHD offer the opportunity to determine whether the two disorders share developmental pathways. Results Prospective studies of younger siblings of children with autism have revealed a range of infant behavioral and neural markers associated with later diagnosis of ASD. Research on infants with later ADHD is less developed, but emerging evidence reveals a number of relations between infant measures and later symptoms of inattention and hyperactivity. Conclusions We review this literature, highlighting points of convergence and divergence in the early pathways to ASD and ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Attention control in autism: Eye-tracking findings from pre-school children in a low- and middle-income country setting / Luke MASON ; Rashi ARORA ; Supriya BHAVNANI ; Jayashree DASGUPTA ; Sheffali GULATI ; Teodora GLIGA ; Mark H. JOHNSON in Autism, 28-1 (January 2024)  

Public ISBD [article]  inAutism > 28-1 (January 2024) . - p.43?57 Titre : Attention control in autism: Eye-tracking findings from pre-school children in a low- and middle-income country setting Type de document : Texte imprimé et/ou numérique Auteurs : Luke MASON, Auteur ; Rashi ARORA, Auteur ; Supriya BHAVNANI, Auteur ; Jayashree DASGUPTA, Auteur ; Sheffali GULATI, Auteur ; Teodora GLIGA, Auteur ; Mark H. JOHNSON, Auteur Article en page(s) : p.43?57 Mots-clés : autism spectrum disorders  cognition (attention  learning  memory)  development  pre-school children Index. décimale : PER Périodiques Résumé : Alterations in the development of attention control and learning have been associated with autism and can be measured using the ?antisaccade task?, which assesses a child?s ability to make an oculomotor response away from a distracting stimulus, and learn to instead anticipate a later reward. We aimed to assess these cognitive processes using portable eye-tracking in an understudied population of pre-school children with and without a diagnosis of autism spectrum disorder in community settings in New Delhi, India. The eye-tracking antisaccade task was presented to children in three groups (n?=?104) (children with a clinical diagnosis of autism spectrum disorder or intellectual disability and children meeting developmental milestones). In accordance with findings from high-income, laboratory-based environments, children learnt to anticipate looks towards a reward, as well as inhibit eye-movements towards a distractor stimulus. We also provide novel evidence that while differences in inhibition responses might be applicable to multiple developmental conditions, a reduced learning to anticipate looks towards a target in this age group may be specific to autism. This eye-tracking task may, therefore, have the potential to identify and assess autism specific traits across development, and be used in longitudinal research studies such as investigating response to intervention in low-resource settings. Lay abstract The development of cognitive processes, such as attention control and learning, has been suggested to be altered in children with a diagnosis of autism spectrum disorder. However, nearly all of our understanding of the development of these cognitive processes comes from studies with school-aged or older children in high-income countries, and from research conducted in a controlled laboratory environment, thereby restricting the potential generalisability of results and away from the majority of the world?s population. We need to expand our research to investigate abilities beyond these limited settings. We address shortcomings in the literature by (1) studying attention control and learning in an understudied population of children in a low- and middle-income country setting in India, (2) focusing research on a critical younger age group of children and (3) using portable eye-tracking technology that can be taken into communities and healthcare settings to increase the accessibility of research in hard-to-reach populations. Our results provide novel evidence on differences in attention control and learning responses in groups of children with and without a diagnosis of autism spectrum disorder. We show that learning responses in children that we assessed through a portable eye-tracking task, called the ?antisaccade task?, may be specific to autism. This suggests that the methods we use may have the potential to identify and assess autism-specific traits across development, and be used in research in low-resource settings. En ligne : https://dx.doi.org/10.1177/13623613221149541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Attention control in autism: Eye-tracking findings from pre-school children in a low- and middle-income country setting [Texte imprimé et/ou numérique] / Luke MASON, Auteur ; Rashi ARORA, Auteur ; Supriya BHAVNANI, Auteur ; Jayashree DASGUPTA, Auteur ; Sheffali GULATI, Auteur ; Teodora GLIGA, Auteur ; Mark H. JOHNSON, Auteur . - p.43?57. in Autism > 28-1 (January 2024) . - p.43?57 Mots-clés : autism spectrum disorders  cognition (attention  learning  memory)  development  pre-school children Index. décimale : PER Périodiques Résumé : Alterations in the development of attention control and learning have been associated with autism and can be measured using the ?antisaccade task?, which assesses a child?s ability to make an oculomotor response away from a distracting stimulus, and learn to instead anticipate a later reward. We aimed to assess these cognitive processes using portable eye-tracking in an understudied population of pre-school children with and without a diagnosis of autism spectrum disorder in community settings in New Delhi, India. The eye-tracking antisaccade task was presented to children in three groups (n?=?104) (children with a clinical diagnosis of autism spectrum disorder or intellectual disability and children meeting developmental milestones). In accordance with findings from high-income, laboratory-based environments, children learnt to anticipate looks towards a reward, as well as inhibit eye-movements towards a distractor stimulus. We also provide novel evidence that while differences in inhibition responses might be applicable to multiple developmental conditions, a reduced learning to anticipate looks towards a target in this age group may be specific to autism. This eye-tracking task may, therefore, have the potential to identify and assess autism specific traits across development, and be used in longitudinal research studies such as investigating response to intervention in low-resource settings. Lay abstract The development of cognitive processes, such as attention control and learning, has been suggested to be altered in children with a diagnosis of autism spectrum disorder. However, nearly all of our understanding of the development of these cognitive processes comes from studies with school-aged or older children in high-income countries, and from research conducted in a controlled laboratory environment, thereby restricting the potential generalisability of results and away from the majority of the world?s population. We need to expand our research to investigate abilities beyond these limited settings. We address shortcomings in the literature by (1) studying attention control and learning in an understudied population of children in a low- and middle-income country setting in India, (2) focusing research on a critical younger age group of children and (3) using portable eye-tracking technology that can be taken into communities and healthcare settings to increase the accessibility of research in hard-to-reach populations. Our results provide novel evidence on differences in attention control and learning responses in groups of children with and without a diagnosis of autism spectrum disorder. We show that learning responses in children that we assessed through a portable eye-tracking task, called the ?antisaccade task?, may be specific to autism. This suggests that the methods we use may have the potential to identify and assess autism-specific traits across development, and be used in research in low-resource settings. En ligne : https://dx.doi.org/10.1177/13623613221149541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Brain adaptation and alternative developmental trajectories / Mark H. JOHNSON in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.425-442 Titre : Brain adaptation and alternative developmental trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Teodora GLIGA, Auteur Article en page(s) : p.425-442 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Resilience and adaptation in the face of early genetic or environmental risk has become a major interest in child psychiatry over recent years. However, we still remain far from an understanding of how developing human brains as a whole adapt to the diffuse and widespread atypical synaptic function that may be characteristic of some common developmental disorders. The first part of this paper discusses four types of whole-brain adaptation in the face of early risk: redundancy, reorganization, niche construction, and adjustment of developmental rate. The second part of the paper applies these adaptation processes specifically to autism. We speculate that key features of autism may be the end result of processes of early brain adaptation, rather than the direct consequences of ongoing neural pathology. En ligne : http://dx.doi.org/10.1017/S0954579415000073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Brain adaptation and alternative developmental trajectories [Texte imprimé et/ou numérique] / Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Teodora GLIGA, Auteur . - p.425-442. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.425-442 Index. décimale : PER Périodiques Résumé : Resilience and adaptation in the face of early genetic or environmental risk has become a major interest in child psychiatry over recent years. However, we still remain far from an understanding of how developing human brains as a whole adapt to the diffuse and widespread atypical synaptic function that may be characteristic of some common developmental disorders. The first part of this paper discusses four types of whole-brain adaptation in the face of early risk: redundancy, reorganization, niche construction, and adjustment of developmental rate. The second part of the paper applies these adaptation processes specifically to autism. We speculate that key features of autism may be the end result of processes of early brain adaptation, rather than the direct consequences of ongoing neural pathology. En ligne : http://dx.doi.org/10.1017/S0954579415000073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Early Language Profiles in Infants at High-Risk for Autism Spectrum Disorders / Kristelle HUDRY in Journal of Autism and Developmental Disorders, 44-1 (January 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.154-167 Titre : Early Language Profiles in Infants at High-Risk for Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Kristelle HUDRY, Auteur ; Susie CHANDLER, Auteur ; Rachael BEDFORD, Auteur ; Greg PASCO, Auteur ; Teodora GLIGA, Auteur ; Mayada ELSABBAGH, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.154-167 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Broader autism phenotype  High-risk siblings  Receptive language  Expressive language  Language profiles Index. décimale : PER Périodiques Résumé : Many preschoolers with autism spectrum disorders (ASD) present relative lack of receptive advantage over concurrent expressive language. Such profile emergence was investigated longitudinally in 54 infants at high-risk (HR) for ASD and 50 low-risk controls, with three language measures taken across four visits (around 7, 14, 24, 38 months). HR infants presented three outcome subgroups: ASD, other atypicality, and typical development. Reduced receptive vocabulary advantage was observed in HR infants by 14 months, but was maintained to 24 months only in ASD/other atypicality outcome subgroups while typically-developing HR infants regained a more normative profile. Few group differences appeared on a direct assessment of language and parent-reported functional communication. Processes of early development toward ASD outcome and in intermediate phenotypes are discussed. En ligne : http://dx.doi.org/10.1007/s10803-013-1861-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 [article] Early Language Profiles in Infants at High-Risk for Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Kristelle HUDRY, Auteur ; Susie CHANDLER, Auteur ; Rachael BEDFORD, Auteur ; Greg PASCO, Auteur ; Teodora GLIGA, Auteur ; Mayada ELSABBAGH, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur . - p.154-167. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.154-167 Mots-clés : Autism spectrum disorder  Broader autism phenotype  High-risk siblings  Receptive language  Expressive language  Language profiles Index. décimale : PER Périodiques Résumé : Many preschoolers with autism spectrum disorders (ASD) present relative lack of receptive advantage over concurrent expressive language. Such profile emergence was investigated longitudinally in 54 infants at high-risk (HR) for ASD and 50 low-risk controls, with three language measures taken across four visits (around 7, 14, 24, 38 months). HR infants presented three outcome subgroups: ASD, other atypicality, and typical development. Reduced receptive vocabulary advantage was observed in HR infants by 14 months, but was maintained to 24 months only in ASD/other atypicality outcome subgroups while typically-developing HR infants regained a more normative profile. Few group differences appeared on a direct assessment of language and parent-reported functional communication. Processes of early development toward ASD outcome and in intermediate phenotypes are discussed. En ligne : http://dx.doi.org/10.1007/s10803-013-1861-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220

Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD / Anna GUI in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1303-1322 Titre : Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Anna GUI, Auteur ; Luke MASON, Auteur ; Teodora GLIGA, Auteur ; Alexandra HENDRY, Auteur ; Jannath BEGUM ALI, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Charles CURTIS, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emma MEABURN, Auteur ; Emily J. H. JONES, Auteur Article en page(s) : p.1303-1322 Langues : Anglais (eng) Mots-clés : attention  endophenotypes  eye-tracking  infant siblings  polygenic score Index. décimale : PER Périodiques Résumé : Identifying developmental endophenotypes on the pathway between genetics and behavior is critical to uncovering the mechanisms underlying neurodevelopmental conditions. In this proof-of-principle study, we explored whether early disruptions in visual attention are a unique or shared candidate endophenotype of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). We calculated the duration of the longest look (i.e., peak look) to faces in an array-based eye-tracking task for 335 14-month-old infants with and without first-degree relatives with ASD and/or ADHD. We leveraged parent-report and genotype data available for a proportion of these infants to evaluate the relation of looking behavior to familial (n = 285) and genetic liability (using polygenic scores, n = 185) as well as ASD and ADHD-relevant temperament traits at 2 years of age (shyness and inhibitory control, respectively, n = 272) and ASD and ADHD clinical traits at 6 years of age (n = 94).Results showed that longer peak looks at the face were associated with elevated polygenic scores for ADHD (? = 0.078, p = .023), but not ASD (? = 0.002, p = .944), and with elevated ADHD traits in mid-childhood (F(1,88) = 6.401, p = .013, $\eta _p^2$=0.068; ASD: F (1,88) = 3.218, p = .076), but not in toddlerhood (ps > 0.2). This pattern of results did not emerge when considering mean peak look duration across face and nonface stimuli. Thus, alterations in attention to faces during spontaneous visual exploration may be more consistent with a developmental endophenotype of ADHD than ASD. Our work shows that dissecting paths to neurodevelopmental conditions requires longitudinal data incorporating polygenic contribution, early neurocognitive function, and clinical phenotypic variation. En ligne : http://dx.doi.org/10.1017/s0954579420000930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD [Texte imprimé et/ou numérique] / Anna GUI, Auteur ; Luke MASON, Auteur ; Teodora GLIGA, Auteur ; Alexandra HENDRY, Auteur ; Jannath BEGUM ALI, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Charles CURTIS, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emma MEABURN, Auteur ; Emily J. H. JONES, Auteur . - p.1303-1322. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1303-1322 Mots-clés : attention  endophenotypes  eye-tracking  infant siblings  polygenic score Index. décimale : PER Périodiques Résumé : Identifying developmental endophenotypes on the pathway between genetics and behavior is critical to uncovering the mechanisms underlying neurodevelopmental conditions. In this proof-of-principle study, we explored whether early disruptions in visual attention are a unique or shared candidate endophenotype of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). We calculated the duration of the longest look (i.e., peak look) to faces in an array-based eye-tracking task for 335 14-month-old infants with and without first-degree relatives with ASD and/or ADHD. We leveraged parent-report and genotype data available for a proportion of these infants to evaluate the relation of looking behavior to familial (n = 285) and genetic liability (using polygenic scores, n = 185) as well as ASD and ADHD-relevant temperament traits at 2 years of age (shyness and inhibitory control, respectively, n = 272) and ASD and ADHD clinical traits at 6 years of age (n = 94).Results showed that longer peak looks at the face were associated with elevated polygenic scores for ADHD (? = 0.078, p = .023), but not ASD (? = 0.002, p = .944), and with elevated ADHD traits in mid-childhood (F(1,88) = 6.401, p = .013, $\eta _p^2$=0.068; ASD: F (1,88) = 3.218, p = .076), but not in toddlerhood (ps > 0.2). This pattern of results did not emerge when considering mean peak look duration across face and nonface stimuli. Thus, alterations in attention to faces during spontaneous visual exploration may be more consistent with a developmental endophenotype of ADHD than ASD. Our work shows that dissecting paths to neurodevelopmental conditions requires longitudinal data incorporating polygenic contribution, early neurocognitive function, and clinical phenotypic variation. En ligne : http://dx.doi.org/10.1017/s0954579420000930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Low noise in autism: Cause or consequence? / Teodora GLIGA in Autism, 19-3 (April 2015)  

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Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder / Elizabeth SHEPHARD in Autism Research, 10-3 (March 2017)  

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Parent-mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a gaze-following task / Rachael BEDFORD in Autism Research, 17-11 (November 2024)  

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Precursors to Social and Communication Difficulties in Infants At-Risk for Autism: Gaze Following and Attentional Engagement / Rachael BEDFORD in Journal of Autism and Developmental Disorders, 42-10 (October 2012)  

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Using mobile health technology to assess childhood autism in low-resource community settings in India: An innovation to address the detection gap / Indu DUBEY in Autism, 28-3 (March 2024)  

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