Dépouillements

ASD and Preterm Low Birth Weight Infant- A Risk Factor / J.N. CROSS in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 3 p. Titre : ASD and Preterm Low Birth Weight Infant- A Risk Factor Type de document : Texte imprimé et/ou numérique Auteurs : J.N. CROSS, Auteur Article en page(s) : 3 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] ASD and Preterm Low Birth Weight Infant- A Risk Factor [Texte imprimé et/ou numérique] / J.N. CROSS, Auteur . - 3 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 3 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Body image in autism: An exploratory study on the effects of dance movement therapy / Sabine C KOCH in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 7 p. Titre : Body image in autism: An exploratory study on the effects of dance movement therapy Type de document : Texte imprimé et/ou numérique Auteurs : Sabine C KOCH, Auteur ; Jessica GAIDA, Auteur ; Ria KORTUM, Auteur ; Birgitt BODINGBAUER, Auteur ; Elizabeth MANDERS, Auteur ; Elisabeth THOMAS, Auteur ; Maik SIEBER, Auteur ; Angela VON ARNIM, Auteur ; Dusan HIRJAK, Auteur ; Thomas FUCHS, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Young adults with autism  Body image sculpture test (KST)  Body image changes  Dance movement therapy  Mirroring intervention Index. décimale : PER Périodiques Résumé : Body image has rarely been investigated in Autism Spectrum Disorder. Recent advances in embodiment research on nonverbal improvements in Autism Spectrum Disorder have encouraged the investigation of this topic. In the context of the clinical study of autism and schizophrenia in the Heidelberg Node of the TESIS-network, we investigated the effects of dance movement therapy (DMT) on body image in autism with the Body-Image-Sculpture-Test a projective test from clinical body psychotherapy. We applied the Body-Image-Sculpture-Test as a primarily nonverbal test in which the participants’ task was to form a human figure from clay within ten minutes and without visual feedback. Ten young adults with autism spectrum disorder participated in the Body-Image-Sculpture-Test before and after ten weekly sessions of dance movement therapy in a professional rehabilitation and training institution in Southern Germany. The participants in this exploratory study showed a significant improvement at post-test on all five dimensions of the Body-Image-Sculpture-Test: proportions, dimensions, connectedness, completion, and surface quality. The strength of the evidence is limited due to the lack of a control group and the small sample size. Yet, the study yields the first results indicating improvement in body image after dance movement therapy in autism, in the form of individual effects (improvement of body image) and intersubjective aspects (through the interviews) after interactive body-based mirroring exercises and intersubjective experiences in a group context. En ligne : https://dx.doi.org/10.4172/2165-7890.1000175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Body image in autism: An exploratory study on the effects of dance movement therapy [Texte imprimé et/ou numérique] / Sabine C KOCH, Auteur ; Jessica GAIDA, Auteur ; Ria KORTUM, Auteur ; Birgitt BODINGBAUER, Auteur ; Elizabeth MANDERS, Auteur ; Elisabeth THOMAS, Auteur ; Maik SIEBER, Auteur ; Angela VON ARNIM, Auteur ; Dusan HIRJAK, Auteur ; Thomas FUCHS, Auteur . - 7 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 7 p. Mots-clés : Autism spectrum disorder  Young adults with autism  Body image sculpture test (KST)  Body image changes  Dance movement therapy  Mirroring intervention Index. décimale : PER Périodiques Résumé : Body image has rarely been investigated in Autism Spectrum Disorder. Recent advances in embodiment research on nonverbal improvements in Autism Spectrum Disorder have encouraged the investigation of this topic. In the context of the clinical study of autism and schizophrenia in the Heidelberg Node of the TESIS-network, we investigated the effects of dance movement therapy (DMT) on body image in autism with the Body-Image-Sculpture-Test a projective test from clinical body psychotherapy. We applied the Body-Image-Sculpture-Test as a primarily nonverbal test in which the participants’ task was to form a human figure from clay within ten minutes and without visual feedback. Ten young adults with autism spectrum disorder participated in the Body-Image-Sculpture-Test before and after ten weekly sessions of dance movement therapy in a professional rehabilitation and training institution in Southern Germany. The participants in this exploratory study showed a significant improvement at post-test on all five dimensions of the Body-Image-Sculpture-Test: proportions, dimensions, connectedness, completion, and surface quality. The strength of the evidence is limited due to the lack of a control group and the small sample size. Yet, the study yields the first results indicating improvement in body image after dance movement therapy in autism, in the form of individual effects (improvement of body image) and intersubjective aspects (through the interviews) after interactive body-based mirroring exercises and intersubjective experiences in a group context. En ligne : https://dx.doi.org/10.4172/2165-7890.1000175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Clinical Assessment of Pragmatics (CAPs): A Validation Study of a Video-Based Test of Pragmatic Language in Adolescent Students / Adriana LAVI in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 12 p. Titre : Clinical Assessment of Pragmatics (CAPs): A Validation Study of a Video-Based Test of Pragmatic Language in Adolescent Students Type de document : Texte imprimé et/ou numérique Auteurs : Adriana LAVI, Auteur ; Karen J. MAINESS, Auteur ; Noha S. DAHER, Auteur Article en page(s) : 12 p. Langues : Anglais (eng) Mots-clés : Pragmatic language  Assessment  High functioning autism  Specific language delay Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine the validity and reliability of a novel new video-based approach to assessing pragmatic language, namely the Clinical Assessment of Pragmatics (CAPs). This study included students with Language Impairment (LI), High-Functioning Autism (ASD) and non-disabled students. Thirty participants, ages14 to 16 years old, were administered 3 pragmatic judgment and 3 pragmatic performance subtests comprised of 10items each for a total of 60 test items. Expert opinion was solicited for the purpose of obtaining content validity. Study results revealed that this instrument provides a valid and reliable comprehensive measure of pragmatic language skills. Both test-retest and interrater reliability were found to be strong. Experts rated the CAPs highly for both content and clarity. Concurrent validity was obtained on three of the CAPs subtests and was found to correlate to three existing pragmatic language instruments and measures (the Clinical Assessment of Spoken Language –Pragmatic Judgment subtest, the Test of Pragmatic Language and the Social Language Development Test, adolescent). CAPs is a tool which is both valid and reliable and can be used as a means of determining whether school-aged students present with deficits in pragmatic language skills, specifically, high-functioning autism or specific language impairment. En ligne : https://dx.doi.org/10.4172/2165-7890.1000172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Clinical Assessment of Pragmatics (CAPs): A Validation Study of a Video-Based Test of Pragmatic Language in Adolescent Students [Texte imprimé et/ou numérique] / Adriana LAVI, Auteur ; Karen J. MAINESS, Auteur ; Noha S. DAHER, Auteur . - 12 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 12 p. Mots-clés : Pragmatic language  Assessment  High functioning autism  Specific language delay Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine the validity and reliability of a novel new video-based approach to assessing pragmatic language, namely the Clinical Assessment of Pragmatics (CAPs). This study included students with Language Impairment (LI), High-Functioning Autism (ASD) and non-disabled students. Thirty participants, ages14 to 16 years old, were administered 3 pragmatic judgment and 3 pragmatic performance subtests comprised of 10items each for a total of 60 test items. Expert opinion was solicited for the purpose of obtaining content validity. Study results revealed that this instrument provides a valid and reliable comprehensive measure of pragmatic language skills. Both test-retest and interrater reliability were found to be strong. Experts rated the CAPs highly for both content and clarity. Concurrent validity was obtained on three of the CAPs subtests and was found to correlate to three existing pragmatic language instruments and measures (the Clinical Assessment of Spoken Language –Pragmatic Judgment subtest, the Test of Pragmatic Language and the Social Language Development Test, adolescent). CAPs is a tool which is both valid and reliable and can be used as a means of determining whether school-aged students present with deficits in pragmatic language skills, specifically, high-functioning autism or specific language impairment. En ligne : https://dx.doi.org/10.4172/2165-7890.1000172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder / Robert T. SCHULTZ in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 6 p. Titre : Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Robert T. SCHULTZ, Auteur ; Georgianna G. GOULD, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Acetaminophen  Anandamide  Endocannabinoid  Cannabinoid  Fever  Medication Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12-18months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08-33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs. non-ASD children use acetaminophen as a “first choice” compared to “never use” (OR 0.165, 95% CI 0.045, 0.599). We found significantly more children with ASD vs. non-ASD children change to the use of ibuprofen when acetaminophen is not effective at reducing fever (p = 0.033) and theorize this change in use is due to endocannabinoid system dysfunction. We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children. En ligne : https://dx.doi.org/10.4172/2165-7890.1000170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Robert T. SCHULTZ, Auteur ; Georgianna G. GOULD, Auteur . - 6 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 6 p. Mots-clés : Autism  Autism spectrum disorder  Acetaminophen  Anandamide  Endocannabinoid  Cannabinoid  Fever  Medication Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12-18months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08-33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs. non-ASD children use acetaminophen as a “first choice” compared to “never use” (OR 0.165, 95% CI 0.045, 0.599). We found significantly more children with ASD vs. non-ASD children change to the use of ibuprofen when acetaminophen is not effective at reducing fever (p = 0.033) and theorize this change in use is due to endocannabinoid system dysfunction. We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children. En ligne : https://dx.doi.org/10.4172/2165-7890.1000170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report / Alok SHARMA in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 6 p. Titre : PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report Type de document : Texte imprimé et/ou numérique Auteurs : Alok SHARMA, Auteur ; Hemangi SANE, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Prerna BADHE, Auteur ; Avantika PATIL, Auteur ; Pooja KULKARNI, Auteur ; Amruta PARANJAPE, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Autism  Stem cell therapy  Bone marrow mononuclear cells  Autologous  Childhood autism Rating scale  Functional neuroimaging  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography – Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography – Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre -intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported. En ligne : https://dx.doi.org/10.4172/2165-7890.1000169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report [Texte imprimé et/ou numérique] / Alok SHARMA, Auteur ; Hemangi SANE, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Prerna BADHE, Auteur ; Avantika PATIL, Auteur ; Pooja KULKARNI, Auteur ; Amruta PARANJAPE, Auteur . - 6 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 6 p. Mots-clés : Autism  Stem cell therapy  Bone marrow mononuclear cells  Autologous  Childhood autism Rating scale  Functional neuroimaging  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography – Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography – Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre -intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported. En ligne : https://dx.doi.org/10.4172/2165-7890.1000169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Cortical Synaptogenesis in the Human Brain in Conditions of Prenatal Alcoholization / T.V. SHUSHPANOVA in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 6 p. Titre : Cortical Synaptogenesis in the Human Brain in Conditions of Prenatal Alcoholization Type de document : Texte imprimé et/ou numérique Auteurs : T.V. SHUSHPANOVA, Auteur ; A.V. SOLONSKII, Auteur ; N.A. BOKHAN, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Alcoholism  Prenatal pathology  Brain  Embryos  Fetuses  Ultrastructure  Synapses Index. décimale : PER Périodiques Résumé : Objective: Shaping synaptic contact is one of the leading processes during which largely determine the future integrative brain capabilities. Prenatal exposure to ethanol may have an impact on synaptogenesis in the brain of the embryo and foetus. The purpose of this study - identify the features of synaptogenesis in the brain of embryos and fetuses in conditions of prenatal alcoholization. Materials and Methods: 33 embryos and fetuses were obtained from female alcoholic patients. Alcoholic patients were aged 26–39 years and the duration of illness was 3–13 years. In all cases, grade II alcoholism was diagnosed (ICD - 10 F10.201, F10.202). The control group consisted of embryos and fetuses from healthy women numbering 30 people with no history of neurological or mental illnesses. The method of electron microscopy and morphometry have been used to study peculiarities in formation of the structure of human embryo and fetus brain synapses at early stages (7 to 12 weeks) of development at mother alcoholization. Results: Electron microscopy of material obtained from alcoholic women has shown slowing - down of formation of synaptic structure. Morphometry has revealed that under the influence of prenatal alcoholization the formation of components of synaptic brain contacts slows down at studying stages of development: the area of presynaptic terminals and their perimeter decreases, and the perimeter of postsynaptic densities decreases as well. Conclusions: The data showed a significant effect of prenatal exposure to ethanol on the development of synaptic structures - reduction of morphometric parameters, slowing the formation of synaptic contacts on the background of reduction of their formation in the brain of the fetus in the early stages of development compared with the norm, which is reflected on during synaptogenesis in the developing brain and can lie the basis of severe disorders in the unborn child. En ligne : https://dx.doi.org/10.4172/2165-7890.1000173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Cortical Synaptogenesis in the Human Brain in Conditions of Prenatal Alcoholization [Texte imprimé et/ou numérique] / T.V. SHUSHPANOVA, Auteur ; A.V. SOLONSKII, Auteur ; N.A. BOKHAN, Auteur . - 6 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 6 p. Mots-clés : Alcoholism  Prenatal pathology  Brain  Embryos  Fetuses  Ultrastructure  Synapses Index. décimale : PER Périodiques Résumé : Objective: Shaping synaptic contact is one of the leading processes during which largely determine the future integrative brain capabilities. Prenatal exposure to ethanol may have an impact on synaptogenesis in the brain of the embryo and foetus. The purpose of this study - identify the features of synaptogenesis in the brain of embryos and fetuses in conditions of prenatal alcoholization. Materials and Methods: 33 embryos and fetuses were obtained from female alcoholic patients. Alcoholic patients were aged 26–39 years and the duration of illness was 3–13 years. In all cases, grade II alcoholism was diagnosed (ICD - 10 F10.201, F10.202). The control group consisted of embryos and fetuses from healthy women numbering 30 people with no history of neurological or mental illnesses. The method of electron microscopy and morphometry have been used to study peculiarities in formation of the structure of human embryo and fetus brain synapses at early stages (7 to 12 weeks) of development at mother alcoholization. Results: Electron microscopy of material obtained from alcoholic women has shown slowing - down of formation of synaptic structure. Morphometry has revealed that under the influence of prenatal alcoholization the formation of components of synaptic brain contacts slows down at studying stages of development: the area of presynaptic terminals and their perimeter decreases, and the perimeter of postsynaptic densities decreases as well. Conclusions: The data showed a significant effect of prenatal exposure to ethanol on the development of synaptic structures - reduction of morphometric parameters, slowing the formation of synaptic contacts on the background of reduction of their formation in the brain of the fetus in the early stages of development compared with the norm, which is reflected on during synaptogenesis in the developing brain and can lie the basis of severe disorders in the unborn child. En ligne : https://dx.doi.org/10.4172/2165-7890.1000173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism / Anthony TORRES in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 8 p. Titre : A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Anthony TORRES, Auteur ; Jonna WESTOVER, Auteur ; Michael BENSON, Auteur ; Randall JOHNSON, Auteur ; Annelise DYKES, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : Autism  Killer - cell immunoglobulin - like receptors(KIR)  Human leukocyte antigen (HLA) alleles  Transmission disequilibrium test (TDT)  KIR gene Index. décimale : PER Périodiques Résumé : The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte antigen cognate ligands. It has been suggested in previous publications that activating human leukocyte antigen / killer - cell immunoglobulin - like receptor complexes are increased in people with autism. We present data, which suggests that an activating cB01 / tA01 killer cell immunoglobulin – like receptor gene - content haplotype and the cognate ligand human leukocyte antigen - C1k that activates this haplotype is significantly increased in autism. This is an important observation suggesting that the interaction between two proteins encoded on different chromosomes increases natural killer cell killing in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism [Texte imprimé et/ou numérique] / Anthony TORRES, Auteur ; Jonna WESTOVER, Auteur ; Michael BENSON, Auteur ; Randall JOHNSON, Auteur ; Annelise DYKES, Auteur . - 8 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 8 p. Mots-clés : Autism  Killer - cell immunoglobulin - like receptors(KIR)  Human leukocyte antigen (HLA) alleles  Transmission disequilibrium test (TDT)  KIR gene Index. décimale : PER Périodiques Résumé : The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte antigen cognate ligands. It has been suggested in previous publications that activating human leukocyte antigen / killer - cell immunoglobulin - like receptor complexes are increased in people with autism. We present data, which suggests that an activating cB01 / tA01 killer cell immunoglobulin – like receptor gene - content haplotype and the cognate ligand human leukocyte antigen - C1k that activates this haplotype is significantly increased in autism. This is an important observation suggesting that the interaction between two proteins encoded on different chromosomes increases natural killer cell killing in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410