Associations between birth weight and attention-deficit/hyperactivity disorder symptom severity: indirect effects via primary neuropsychological functions / Burt HATCH in Journal of Child Psychology and Psychiatry, 55-4 (April 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.384-392 Titre : Associations between birth weight and attention-deficit/hyperactivity disorder symptom severity: indirect effects via primary neuropsychological functions Type de document : Texte imprimé et/ou numérique Auteurs : Burt HATCH, Auteur ; Dione M. HEALEY, Auteur ; Jeffrey M. HALPERIN, Auteur Article en page(s) : p.384-392 Mots-clés : ADHD  neuropsychology  birth weight Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) has a range of aetiological origins which are associated with a number of disruptions in neuropsychological functioning. This study aimed to examine how low birth weight, a proxy measure for a range of environmental complications during gestation, predicted ADHD symptom severity in preschool-aged children indirectly via neuropsychological functioning. Methods A total of 197 preschool-aged children were recruited as part of a larger longitudinal study. Two neuropsychological factors were derived from NEPSY domain scores. One, referred to as ‘Primary Neuropsychological Function,’ was loaded highly with Sensorimotor and Visuospatial scores. The other, termed ‘Higher-Order Function’ was loaded highly with Language and Memory domain scores. Executive functioning split evenly across the two. Analyses examined whether these neuropsychological factors allowed for an indirect association between birth weight and ADHD symptom severity. Results As both factors were associated with symptom severity, only the Primary Neuropsychological Factor was associated with birth weight. Furthermore, birth weight was indirectly associated to symptom severity via this factor. Conclusions These data indicate that birth weight is indirectly associated with ADHD severity via disruption of neuropsychological functions that are more primary in function as opposed to functions that play a higher-order role in utilising and integrating the primary functions. En ligne : http://dx.doi.org/10.1111/jcpp.12168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 [article] Associations between birth weight and attention-deficit/hyperactivity disorder symptom severity: indirect effects via primary neuropsychological functions [Texte imprimé et/ou numérique] / Burt HATCH, Auteur ; Dione M. HEALEY, Auteur ; Jeffrey M. HALPERIN, Auteur . - p.384-392. in Journal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.384-392 Mots-clés : ADHD  neuropsychology  birth weight Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) has a range of aetiological origins which are associated with a number of disruptions in neuropsychological functioning. This study aimed to examine how low birth weight, a proxy measure for a range of environmental complications during gestation, predicted ADHD symptom severity in preschool-aged children indirectly via neuropsychological functioning. Methods A total of 197 preschool-aged children were recruited as part of a larger longitudinal study. Two neuropsychological factors were derived from NEPSY domain scores. One, referred to as ‘Primary Neuropsychological Function,’ was loaded highly with Sensorimotor and Visuospatial scores. The other, termed ‘Higher-Order Function’ was loaded highly with Language and Memory domain scores. Executive functioning split evenly across the two. Analyses examined whether these neuropsychological factors allowed for an indirect association between birth weight and ADHD symptom severity. Results As both factors were associated with symptom severity, only the Primary Neuropsychological Factor was associated with birth weight. Furthermore, birth weight was indirectly associated to symptom severity via this factor. Conclusions These data indicate that birth weight is indirectly associated with ADHD severity via disruption of neuropsychological functions that are more primary in function as opposed to functions that play a higher-order role in utilising and integrating the primary functions. En ligne : http://dx.doi.org/10.1111/jcpp.12168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230

Childhood Maltreatment and Conduct Disorder: Independent Predictors of Adolescent Substance Use Disorders in Youth with Attention Deficit/Hyperactivity Disorder / Virginia A. DE SANCTIS in Journal of Clinical Child & Adolescent Psychology, 37-4 (October-December 2008)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 37-4 (October-December 2008) . - p.785-793 Titre : Childhood Maltreatment and Conduct Disorder: Independent Predictors of Adolescent Substance Use Disorders in Youth with Attention Deficit/Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Virginia A. DE SANCTIS, Auteur ; Jeffrey H. NEWCORN, Auteur ; David J. MARKS, Auteur ; Jeffrey M. HALPERIN, Auteur ; Joey W. TRAMPUSH, Auteur ; Carlin J. MILLER, Auteur ; Seth C. HARTY, Auteur Année de publication : 2008 Article en page(s) : p.785-793 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children with attention deficit/hyperactivity disorder (ADHD) are at heightened risk for maltreatment and later substance use disorders (SUDs). We investigated the relationship of childhood maltreatment and other risk factors to SUDs among adolescents diagnosed with ADHD in childhood. Eighty adolescents diagnosed with ADHD when they were 7 to 11 years old were screened for histories of childhood maltreatment, and SUD diagnoses were formulated in accordance with the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders. Lifetime history of problematic substance use was obtained for each parent at baseline. Childhood maltreatment predicted SUD outcome over and above that accounted for by childhood conduct disorder and problematic parental substance use, two potent predictors of adolescent SUDs. En ligne : http://dx.doi.org/10.1080/15374410802359650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=646 [article] Childhood Maltreatment and Conduct Disorder: Independent Predictors of Adolescent Substance Use Disorders in Youth with Attention Deficit/Hyperactivity Disorder [Texte imprimé et/ou numérique] / Virginia A. DE SANCTIS, Auteur ; Jeffrey H. NEWCORN, Auteur ; David J. MARKS, Auteur ; Jeffrey M. HALPERIN, Auteur ; Joey W. TRAMPUSH, Auteur ; Carlin J. MILLER, Auteur ; Seth C. HARTY, Auteur . - 2008 . - p.785-793. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 37-4 (October-December 2008) . - p.785-793 Index. décimale : PER Périodiques Résumé : Children with attention deficit/hyperactivity disorder (ADHD) are at heightened risk for maltreatment and later substance use disorders (SUDs). We investigated the relationship of childhood maltreatment and other risk factors to SUDs among adolescents diagnosed with ADHD in childhood. Eighty adolescents diagnosed with ADHD when they were 7 to 11 years old were screened for histories of childhood maltreatment, and SUD diagnoses were formulated in accordance with the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders. Lifetime history of problematic substance use was obtained for each parent at baseline. Childhood maltreatment predicted SUD outcome over and above that accounted for by childhood conduct disorder and problematic parental substance use, two potent predictors of adolescent SUDs. En ligne : http://dx.doi.org/10.1080/15374410802359650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=646

Developmental phenotypes and causal pathways in attention deficit/hyperactivity disorder: potential targets for early intervention? / Edmund J. S. SONUGA-BARKE in Journal of Child Psychology and Psychiatry, 51-4 (April 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-4 (April 2010) . - p.368-389 Titre : Developmental phenotypes and causal pathways in attention deficit/hyperactivity disorder: potential targets for early intervention? Type de document : Texte imprimé et/ou numérique Auteurs : Edmund J. S. SONUGA-BARKE, Auteur ; Jeffrey M. HALPERIN, Auteur Année de publication : 2010 Article en page(s) : p.368-389 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity-disorder preschool early-intervention translational development treatment longitudinal-studies Index. décimale : PER Périodiques Résumé : Early intervention approaches have rarely been implemented for the prevention of attention deficit/hyperactivity disorder (ADHD). In this paper we explore whether such an approach may represent an important new direction for therapeutic innovation. We propose that such an approach is most likely to be of value when grounded in and informed by developmental models of the dynamic, complex and heterogeneous nature of the condition. First, we set out a rationale for early intervention grounded in the science of ADHD viewed through developmental models. Second, we re-examine the concept of disorder-onset from the perspective of developmental trajectories and phenotypes. Third, we examine potential causal pathways to ADHD with regard to originating risk, pathophysiological mediators, environmental moderators and developmental continuities. Finally, we explore the potential value of strategies for identifying young children at risk for ADHD, and implementing interventions in ways that can target these underlying pathogenic processes. The utility of such an approach represents an important area for future research but still requires 'proof of concept'. Therefore prior to widespread clinical implementation, far greater knowledge is required of (i) developmental pathways into ADHD, (ii) the value of identifying neuropsychological mediators of these pathways, and (iii) the extent to which targeting mediating mechanisms will improve treatment outcomes for children with ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02195.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=989 [article] Developmental phenotypes and causal pathways in attention deficit/hyperactivity disorder: potential targets for early intervention? [Texte imprimé et/ou numérique] / Edmund J. S. SONUGA-BARKE, Auteur ; Jeffrey M. HALPERIN, Auteur . - 2010 . - p.368-389. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-4 (April 2010) . - p.368-389 Mots-clés : Attention-deficit/hyperactivity-disorder preschool early-intervention translational development treatment longitudinal-studies Index. décimale : PER Périodiques Résumé : Early intervention approaches have rarely been implemented for the prevention of attention deficit/hyperactivity disorder (ADHD). In this paper we explore whether such an approach may represent an important new direction for therapeutic innovation. We propose that such an approach is most likely to be of value when grounded in and informed by developmental models of the dynamic, complex and heterogeneous nature of the condition. First, we set out a rationale for early intervention grounded in the science of ADHD viewed through developmental models. Second, we re-examine the concept of disorder-onset from the perspective of developmental trajectories and phenotypes. Third, we examine potential causal pathways to ADHD with regard to originating risk, pathophysiological mediators, environmental moderators and developmental continuities. Finally, we explore the potential value of strategies for identifying young children at risk for ADHD, and implementing interventions in ways that can target these underlying pathogenic processes. The utility of such an approach represents an important area for future research but still requires 'proof of concept'. Therefore prior to widespread clinical implementation, far greater knowledge is required of (i) developmental pathways into ADHD, (ii) the value of identifying neuropsychological mediators of these pathways, and (iii) the extent to which targeting mediating mechanisms will improve treatment outcomes for children with ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02195.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=989

Developmental psychopathology in the post-genomics era – substantial challenges but reasons for hope / Jeffrey M. HALPERIN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.219-221 Titre : Developmental psychopathology in the post-genomics era – substantial challenges but reasons for hope Type de document : Texte imprimé et/ou numérique Auteurs : Jeffrey M. HALPERIN, Auteur Article en page(s) : p.219-221 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : One only has to quickly look through the Table of Contents for this issue of JCPP to gain an appreciation of the ever-increasing influence of genetic research in the field of developmental psychopathology. Among the 13 articles in this issue that follow this editorial: two employ large family and/or twin studies to provide compelling behavioral genetic findings bolstering the importance of genes in the emergence of ADHD (Chen, Brikell, Lichtenstein, Serlachius, Kuja-Halkola, Sandin, and Larsson) and level of educational achievement in adolescents (Lewis, Asbury, and Plomin); one paper focuses on cortical development in patients with 22q11.2 deletion syndrome and its association with positive symptoms of psychosis (Radoeva, Bansal, Antshel, Fremont, Peterson, and Kates); a Commentary (Border and Keller) and Response to Commentary (Moore) debate the relative advantages and disadvantages of candidate gene versus genome-wide approaches to detecting certain genetic markers, particularly in relation to interactions with the environment; and two more focus on the identification of endophenotypes for autism spectrum disorders which will presumably facilitate the identification of genes for this complex disorder (Jones, Venema, Earl, Lowy, and Webb; Van Eylen, Boets, Cosemans, Peeters, Steyaert, Wagemans, and Noens). En ligne : http://dx.doi.org/10.1111/jcpp.12708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Developmental psychopathology in the post-genomics era – substantial challenges but reasons for hope [Texte imprimé et/ou numérique] / Jeffrey M. HALPERIN, Auteur . - p.219-221. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.219-221 Index. décimale : PER Périodiques Résumé : One only has to quickly look through the Table of Contents for this issue of JCPP to gain an appreciation of the ever-increasing influence of genetic research in the field of developmental psychopathology. Among the 13 articles in this issue that follow this editorial: two employ large family and/or twin studies to provide compelling behavioral genetic findings bolstering the importance of genes in the emergence of ADHD (Chen, Brikell, Lichtenstein, Serlachius, Kuja-Halkola, Sandin, and Larsson) and level of educational achievement in adolescents (Lewis, Asbury, and Plomin); one paper focuses on cortical development in patients with 22q11.2 deletion syndrome and its association with positive symptoms of psychosis (Radoeva, Bansal, Antshel, Fremont, Peterson, and Kates); a Commentary (Border and Keller) and Response to Commentary (Moore) debate the relative advantages and disadvantages of candidate gene versus genome-wide approaches to detecting certain genetic markers, particularly in relation to interactions with the environment; and two more focus on the identification of endophenotypes for autism spectrum disorders which will presumably facilitate the identification of genes for this complex disorder (Jones, Venema, Earl, Lowy, and Webb; Van Eylen, Boets, Cosemans, Peeters, Steyaert, Wagemans, and Noens). En ligne : http://dx.doi.org/10.1111/jcpp.12708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder / Anne-Claude V. BÉDARD in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.40-48 Titre : Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Anne-Claude V. BÉDARD, Auteur ; Mark A. STEIN, Auteur ; Jeffrey M. HALPERIN, Auteur ; Beth KRONE, Auteur ; Estrella RAJWAN, Auteur ; Jeffrey H. NEWCORN, Auteur Article en page(s) : p.40-48 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  atomoxetine  methylphenidate  attention  vigilance Index. décimale : PER Périodiques Résumé : Background This study examined the effects of atomoxetine (ATX) and OROS methylphenidate (MPH) on laboratory measures of inhibitory control and attention in youth with attention-deficit/hyperactivity disorder (ADHD). It was hypothesized that performance would be improved by both treatments, but response profiles would differ because the medications work via different mechanisms. Methods One hundred and two youth (77 male; mean age = 10.5 ± 2.7 years) with ADHD received ATX (1.4 ± 0.5 mg/kg) and MPH (52.4 ± 16.6 mg) in a randomized, double-blind, crossover design. Medication was titrated in 4–6-week blocks separated by a 2-week placebo washout. Inhibitory control and attention measures were obtained at baseline, following washout, and at the end of each treatment using Conners' Continuous Performance Test II (CPT-II), which provided age-adjusted T-scores for reaction time (RT), reaction time variability (RT variability), and errors. Repeated-measures analyses of variance were performed, with Time (premedication, postmedication) and Treatment type (ATX, MPH) entered as within-subject factors. Data from the two treatment blocks were checked for order effects and combined if order effects were not present. Clinical trial registration: Clinicaltrials.gov: NCT00183391. Results Main effects for Time on RT (p = .03), RTSD (p = .001), and omission errors (p = .01) were significant. A significant Drug × Time interaction indicated that MPH improved RT, RTSD, and omission errors more than ATX (p < .05). Changes in performance with treatment did not correlate with changes in ADHD symptoms. Conclusions MPH has greater effects than ATX on CPT measures of sustained attention in youth with ADHD. However, the dissociation of cognitive and behavioral change with treatment indicates that CPT measures cannot be considered proxies for symptomatic improvement. Further research on the dissociation of cognitive and behavioral endpoints for ADHD is indicated. En ligne : http://dx.doi.org/10.1111/jcpp.12272 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Anne-Claude V. BÉDARD, Auteur ; Mark A. STEIN, Auteur ; Jeffrey M. HALPERIN, Auteur ; Beth KRONE, Auteur ; Estrella RAJWAN, Auteur ; Jeffrey H. NEWCORN, Auteur . - p.40-48. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.40-48 Mots-clés : Attention-deficit/hyperactivity disorder  atomoxetine  methylphenidate  attention  vigilance Index. décimale : PER Périodiques Résumé : Background This study examined the effects of atomoxetine (ATX) and OROS methylphenidate (MPH) on laboratory measures of inhibitory control and attention in youth with attention-deficit/hyperactivity disorder (ADHD). It was hypothesized that performance would be improved by both treatments, but response profiles would differ because the medications work via different mechanisms. Methods One hundred and two youth (77 male; mean age = 10.5 ± 2.7 years) with ADHD received ATX (1.4 ± 0.5 mg/kg) and MPH (52.4 ± 16.6 mg) in a randomized, double-blind, crossover design. Medication was titrated in 4–6-week blocks separated by a 2-week placebo washout. Inhibitory control and attention measures were obtained at baseline, following washout, and at the end of each treatment using Conners' Continuous Performance Test II (CPT-II), which provided age-adjusted T-scores for reaction time (RT), reaction time variability (RT variability), and errors. Repeated-measures analyses of variance were performed, with Time (premedication, postmedication) and Treatment type (ATX, MPH) entered as within-subject factors. Data from the two treatment blocks were checked for order effects and combined if order effects were not present. Clinical trial registration: Clinicaltrials.gov: NCT00183391. Results Main effects for Time on RT (p = .03), RTSD (p = .001), and omission errors (p = .01) were significant. A significant Drug × Time interaction indicated that MPH improved RT, RTSD, and omission errors more than ATX (p < .05). Changes in performance with treatment did not correlate with changes in ADHD symptoms. Conclusions MPH has greater effects than ATX on CPT measures of sustained attention in youth with ADHD. However, the dissociation of cognitive and behavioral change with treatment indicates that CPT measures cannot be considered proxies for symptomatic improvement. Further research on the dissociation of cognitive and behavioral endpoints for ADHD is indicated. En ligne : http://dx.doi.org/10.1111/jcpp.12272 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Executive functioning – a key construct for understanding developmental psychopathology or a ‘catch-all’ term in need of some rethinking? / Jeffrey M. HALPERIN in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

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Latent profile analysis of neuropsychological measures to determine preschoolers' risk for ADHD / Khushmand RAJENDRAN in Journal of Child Psychology and Psychiatry, 56-9 (September 2015)  

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Mother–child dyadic synchrony is associated with better functioning in hyperactive/inattentive preschool children / Dione M. HEALEY in Journal of Child Psychology and Psychiatry, 51-9 (September 2010)  

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Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls / Jeffrey M. HALPERIN in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

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Parenting style influences bullying: a longitudinal study comparing children with and without behavioral problems / Khushmand RAJENDRAN in Journal of Child Psychology and Psychiatry, 57-2 (February 2016)  

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Pragmatic deficits and social impairment in children with ADHD / Ekaterina STAIKOVA in Journal of Child Psychology and Psychiatry, 54-12 (December 2013)  

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Psychometric Properties of the Alabama Parenting Questionnaire-Preschool Revision / Suzanne M. CLERKIN in Journal of Clinical Child & Adolescent Psychology, 36-1 (January-March 2007)  

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