| Titre : |
The iPSC Technology to Study Neurodevelopmental Disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Alysson Renato MUOTRI, Auteur |
| Année de publication : |
2016 |
| Importance : |
p.295-300 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism spectrum disorders Brain Disease modeling Drug screening Human induced pluripotent stem cells Human neurons |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
The inaccessibility of live human brain cells for research has blocked progress toward understanding mechanisms underlying neurodevelopmental disorders. A human model, using reprogrammed patient somatic cells offers an attractive alternative because it captures a patient's genome in a pluripotent stage. Despite current pitfalls, the disease-in-a-dish approach allows dynamic analyses of target cells, offering a unique opportunity to dissect cellular and molecular alterations in a controlled environment. Recent publications have highlighted the use of induced pluripotent stem cells (iPSCs) to model autism spectrum disorders (ASDs). Here, I will discuss the advantages of the iPSC technology to complement and advance the research in ASD. Furthermore, I will review the literature on upcoming innovative technology in tissue engineering and examine how that could be combined with current stem cell practices for a better disease modeling tool and future drug screening. |
| En ligne : |
http://dx.doi.org/10.1016/B978-0-12-800109-7.00018-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 |
The iPSC Technology to Study Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / Alysson Renato MUOTRI, Auteur . - 2016 . - p.295-300. Langues : Anglais ( eng)
| Mots-clés : |
Autism spectrum disorders Brain Disease modeling Drug screening Human induced pluripotent stem cells Human neurons |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
The inaccessibility of live human brain cells for research has blocked progress toward understanding mechanisms underlying neurodevelopmental disorders. A human model, using reprogrammed patient somatic cells offers an attractive alternative because it captures a patient's genome in a pluripotent stage. Despite current pitfalls, the disease-in-a-dish approach allows dynamic analyses of target cells, offering a unique opportunity to dissect cellular and molecular alterations in a controlled environment. Recent publications have highlighted the use of induced pluripotent stem cells (iPSCs) to model autism spectrum disorders (ASDs). Here, I will discuss the advantages of the iPSC technology to complement and advance the research in ASD. Furthermore, I will review the literature on upcoming innovative technology in tissue engineering and examine how that could be combined with current stem cell practices for a better disease modeling tool and future drug screening. |
| En ligne : |
http://dx.doi.org/10.1016/B978-0-12-800109-7.00018-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 |
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