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in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Titre : The iPSC Technology to Study Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Alysson Renato MUOTRI, Auteur Année de publication : 2016 Importance : p.295-300 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Brain Disease modeling Drug screening Human induced pluripotent stem cells Human neurons Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The inaccessibility of live human brain cells for research has blocked progress toward understanding mechanisms underlying neurodevelopmental disorders. A human model, using reprogrammed patient somatic cells offers an attractive alternative because it captures a patient's genome in a pluripotent stage. Despite current pitfalls, the disease-in-a-dish approach allows dynamic analyses of target cells, offering a unique opportunity to dissect cellular and molecular alterations in a controlled environment. Recent publications have highlighted the use of induced pluripotent stem cells (iPSCs) to model autism spectrum disorders (ASDs). Here, I will discuss the advantages of the iPSC technology to complement and advance the research in ASD. Furthermore, I will review the literature on upcoming innovative technology in tissue engineering and examine how that could be combined with current stem cell practices for a better disease modeling tool and future drug screening. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00018-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 The iPSC Technology to Study Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / Alysson Renato MUOTRI, Auteur . - 2016 . - p.295-300.
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Langues : Anglais (eng)
Mots-clés : Autism spectrum disorders Brain Disease modeling Drug screening Human induced pluripotent stem cells Human neurons Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The inaccessibility of live human brain cells for research has blocked progress toward understanding mechanisms underlying neurodevelopmental disorders. A human model, using reprogrammed patient somatic cells offers an attractive alternative because it captures a patient's genome in a pluripotent stage. Despite current pitfalls, the disease-in-a-dish approach allows dynamic analyses of target cells, offering a unique opportunity to dissect cellular and molecular alterations in a controlled environment. Recent publications have highlighted the use of induced pluripotent stem cells (iPSCs) to model autism spectrum disorders (ASDs). Here, I will discuss the advantages of the iPSC technology to complement and advance the research in ASD. Furthermore, I will review the literature on upcoming innovative technology in tissue engineering and examine how that could be combined with current stem cell practices for a better disease modeling tool and future drug screening. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00018-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Exemplaires
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