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Détail de l'auteur
Auteur Alysson Renato MUOTRI |
Documents disponibles écrits par cet auteur (2)
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Inducible Pluripotent Stem Cells In Autism Spectrum Disorders / Alysson Renato MUOTRI
Titre : Inducible Pluripotent Stem Cells In Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Alysson Renato MUOTRI, Auteur Année de publication : 2013 Importance : p.391-399 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The generation of human neurons from patients with autism spectrum disorders (ASD) offers a novel and complementary opportunity for basic research and the development of therapeutic compounds aiming to revert or ameliorate this family of conditions. Neurons “in-a-dish” from monogenic and other single locus forms of ASD opened new avenues for the stratification of different subtypes of autism. This chapter covers the conceptual and practical issues related to modeling ASD using induced pluripotent stem cells. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Inducible Pluripotent Stem Cells In Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Alysson Renato MUOTRI, Auteur . - 2013 . - p.391-399.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The generation of human neurons from patients with autism spectrum disorders (ASD) offers a novel and complementary opportunity for basic research and the development of therapeutic compounds aiming to revert or ameliorate this family of conditions. Neurons “in-a-dish” from monogenic and other single locus forms of ASD opened new avenues for the stratification of different subtypes of autism. This chapter covers the conceptual and practical issues related to modeling ASD using induced pluripotent stem cells. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
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in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Titre : The iPSC Technology to Study Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Alysson Renato MUOTRI, Auteur Année de publication : 2016 Importance : p.295-300 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Brain Disease modeling Drug screening Human induced pluripotent stem cells Human neurons Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The inaccessibility of live human brain cells for research has blocked progress toward understanding mechanisms underlying neurodevelopmental disorders. A human model, using reprogrammed patient somatic cells offers an attractive alternative because it captures a patient's genome in a pluripotent stage. Despite current pitfalls, the disease-in-a-dish approach allows dynamic analyses of target cells, offering a unique opportunity to dissect cellular and molecular alterations in a controlled environment. Recent publications have highlighted the use of induced pluripotent stem cells (iPSCs) to model autism spectrum disorders (ASDs). Here, I will discuss the advantages of the iPSC technology to complement and advance the research in ASD. Furthermore, I will review the literature on upcoming innovative technology in tissue engineering and examine how that could be combined with current stem cell practices for a better disease modeling tool and future drug screening. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00018-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 The iPSC Technology to Study Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / Alysson Renato MUOTRI, Auteur . - 2016 . - p.295-300.
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Langues : Anglais (eng)
Mots-clés : Autism spectrum disorders Brain Disease modeling Drug screening Human induced pluripotent stem cells Human neurons Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The inaccessibility of live human brain cells for research has blocked progress toward understanding mechanisms underlying neurodevelopmental disorders. A human model, using reprogrammed patient somatic cells offers an attractive alternative because it captures a patient's genome in a pluripotent stage. Despite current pitfalls, the disease-in-a-dish approach allows dynamic analyses of target cells, offering a unique opportunity to dissect cellular and molecular alterations in a controlled environment. Recent publications have highlighted the use of induced pluripotent stem cells (iPSCs) to model autism spectrum disorders (ASDs). Here, I will discuss the advantages of the iPSC technology to complement and advance the research in ASD. Furthermore, I will review the literature on upcoming innovative technology in tissue engineering and examine how that could be combined with current stem cell practices for a better disease modeling tool and future drug screening. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00018-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Exemplaires
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