Age-Specific Time Trends in Incidence Rates of Autism Spectrum Disorder Following Adaptation of DSM-5 and Other ASD-Related Regulatory Changes in Israel / Michael DAVIDOVITCH in Autism Research, 13-11 (November 2020)  

Public ISBD [article]  inAutism Research > 13-11 (November 2020) . - p.1893-1901 Titre : Age-Specific Time Trends in Incidence Rates of Autism Spectrum Disorder Following Adaptation of DSM-5 and Other ASD-Related Regulatory Changes in Israel Type de document : texte imprimé Auteurs : Michael DAVIDOVITCH, Auteur ; Ortal SLOBODIN, Auteur ; Marc G. WEISSKOPF, Auteur ; Ran S. ROTEM, Auteur Article en page(s) : p.1893-1901 Langues : Anglais (eng) Mots-clés : Dsm  age trends  autism spectrum disorder  incidence  late diagnosis Index. décimale : PER Périodiques Résumé : We analyzed data on 879,029 children born in 1999-2017 from a large Israeli health fund to evaluate time-trends in incidence of autism spectrum disorder (ASD). This included examining possible effects associated with the adaptation of the DSM-5 criteria for ASD, and the implementation of regulatory changes affecting eligibility for ASD-related stipends and services. ASD cases were ascertained based on electronic medical records review, with complete verification of ASD case status. Results indicated a substantial increase in ASD incidence rate (IR) over time that was overall not appreciably affected by the above changes. Cumulative incidence through age 8 rose from 0.46% (boys: 0.73; girls: 0.18) in 2007 to 1.30% (boys: 2.12; girls: 0.45) in 2018. Age-specific analyzes indicated that the largest increase in IR occurred in toddlers and preschool children, with a more modest increase at older age groups. Results suggest that the rise in early diagnosed ASD does not stem from a downward shift in the distribution of ages at first diagnosis, but rather from early detection of cases not previously diagnosed. Findings highlight the need to expand research aimed at identifying exogenous factors that may underlie the rise in incidence, and to evaluate factors that may contribute to late diagnosis of some cases. Autism Res 2020, 13: 1893-1901. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: In an analysis of nearly 900,000 Israeli children born in 1999-2017, we found that the incidence of autism spectrum disorder (ASD) increased significantly over time, especially among toddlers and preschool children but also at older age groups. We additionally observed that changes affecting diagnostic criteria for ASD and eligibility for ASD-related services did not appreciably affect these trends. Results highlight the need to continue research aimed at identifying factors causing this increase and reasons contributing to late diagnosis of some cases. En ligne : http://dx.doi.org/10.1002/aur.2420 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Age-Specific Time Trends in Incidence Rates of Autism Spectrum Disorder Following Adaptation of DSM-5 and Other ASD-Related Regulatory Changes in Israel [texte imprimé] / Michael DAVIDOVITCH, Auteur ; Ortal SLOBODIN, Auteur ; Marc G. WEISSKOPF, Auteur ; Ran S. ROTEM, Auteur . - p.1893-1901. Langues : Anglais (eng) in Autism Research > 13-11 (November 2020) . - p.1893-1901 Mots-clés : Dsm  age trends  autism spectrum disorder  incidence  late diagnosis Index. décimale : PER Périodiques Résumé : We analyzed data on 879,029 children born in 1999-2017 from a large Israeli health fund to evaluate time-trends in incidence of autism spectrum disorder (ASD). This included examining possible effects associated with the adaptation of the DSM-5 criteria for ASD, and the implementation of regulatory changes affecting eligibility for ASD-related stipends and services. ASD cases were ascertained based on electronic medical records review, with complete verification of ASD case status. Results indicated a substantial increase in ASD incidence rate (IR) over time that was overall not appreciably affected by the above changes. Cumulative incidence through age 8 rose from 0.46% (boys: 0.73; girls: 0.18) in 2007 to 1.30% (boys: 2.12; girls: 0.45) in 2018. Age-specific analyzes indicated that the largest increase in IR occurred in toddlers and preschool children, with a more modest increase at older age groups. Results suggest that the rise in early diagnosed ASD does not stem from a downward shift in the distribution of ages at first diagnosis, but rather from early detection of cases not previously diagnosed. Findings highlight the need to expand research aimed at identifying exogenous factors that may underlie the rise in incidence, and to evaluate factors that may contribute to late diagnosis of some cases. Autism Res 2020, 13: 1893-1901. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: In an analysis of nearly 900,000 Israeli children born in 1999-2017, we found that the incidence of autism spectrum disorder (ASD) increased significantly over time, especially among toddlers and preschool children but also at older age groups. We additionally observed that changes affecting diagnostic criteria for ASD and eligibility for ASD-related services did not appreciably affect these trends. Results highlight the need to continue research aimed at identifying factors causing this increase and reasons contributing to late diagnosis of some cases. En ligne : http://dx.doi.org/10.1002/aur.2420 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Congenital muscular torticollis as a potential neonatal marker of autism spectrum disorder and other neurodevelopmental conditions / Michael DAVIDOVITCH in Research in Autism, 132 (April 2026)  

Public ISBD [article]  inResearch in Autism > 132 (April 2026) . - 202831 Titre : Congenital muscular torticollis as a potential neonatal marker of autism spectrum disorder and other neurodevelopmental conditions Type de document : texte imprimé Auteurs : Michael DAVIDOVITCH, Auteur ; Limor ADLER, Auteur ; Mervatte SHUKHA, Auteur ; Sonia HERNANDEZ-DIAZ, Auteur ; Marc G. WEISSKOPF, Auteur ; Ran S. ROTEM, Auteur Article en page(s) : 202831 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neurodevelopment  Torticollis  Early detection  Congenital Résumé : Background Early intervention consistently improves developmental outcomes in children with autism spectrum disorder (ASD) and related conditions, underscoring the importance for timely recognition. Identifying early markers of atypical neurodevelopment is therefore critical. Congenital muscular torticollis (CMT), unilateral shortening of the sternocleidomastoid muscle causing infant head tilt, shares prenatal and perinatal risk factors with ASD and other developmental abnormalities. This overlap suggests that CMT may signal early disruption in neural development, potentially enabling earlier surveillance and intervention. However, large-scale evidence is scarce. Methods We used electronic records (live births 2005–2018; follow-up through 2024) from a large Israeli Health Maintenance Organization (HMO) to match 14,150 infants diagnosed with CMT by six months of age with unexposed peers. ASD and related conditions were ascertained via validated algorithms. Upper-respiratory and gastroenteritis infections served as negative control outcomes. Early physical therapy was examined as a potential effect modifier. Results Children with CMT had increased odds of ASD (odds ratio [OR]=1.25, 95 % CI: 1.08–1.45) and developmental language disorder (1.25, 1.16–1.34), relative to unexposed peers. These associations persisted after accounting for maternal and perinatal factors, were absent for the negative control outcomes, and were stronger, though less precise, in infants who received physical therapy. Conclusion CMT is associated with elevated risks for later atypical neurodevelopment. The results suggest a possible etiological link between abnormal neural circuit maturation and musculoskeletal development. Although CMT is often considered benign in infancy, it may represent an early clinical marker of neurodevelopmental vulnerability, highlighting an opportunity for earlier recognition and intervention. En ligne : https://doi.org/10.1016/j.reia.2026.202831 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Congenital muscular torticollis as a potential neonatal marker of autism spectrum disorder and other neurodevelopmental conditions [texte imprimé] / Michael DAVIDOVITCH, Auteur ; Limor ADLER, Auteur ; Mervatte SHUKHA, Auteur ; Sonia HERNANDEZ-DIAZ, Auteur ; Marc G. WEISSKOPF, Auteur ; Ran S. ROTEM, Auteur . - 202831. Langues : Anglais (eng) in Research in Autism > 132 (April 2026) . - 202831 Mots-clés : Autism spectrum disorder  Neurodevelopment  Torticollis  Early detection  Congenital Résumé : Background Early intervention consistently improves developmental outcomes in children with autism spectrum disorder (ASD) and related conditions, underscoring the importance for timely recognition. Identifying early markers of atypical neurodevelopment is therefore critical. Congenital muscular torticollis (CMT), unilateral shortening of the sternocleidomastoid muscle causing infant head tilt, shares prenatal and perinatal risk factors with ASD and other developmental abnormalities. This overlap suggests that CMT may signal early disruption in neural development, potentially enabling earlier surveillance and intervention. However, large-scale evidence is scarce. Methods We used electronic records (live births 2005–2018; follow-up through 2024) from a large Israeli Health Maintenance Organization (HMO) to match 14,150 infants diagnosed with CMT by six months of age with unexposed peers. ASD and related conditions were ascertained via validated algorithms. Upper-respiratory and gastroenteritis infections served as negative control outcomes. Early physical therapy was examined as a potential effect modifier. Results Children with CMT had increased odds of ASD (odds ratio [OR]=1.25, 95 % CI: 1.08–1.45) and developmental language disorder (1.25, 1.16–1.34), relative to unexposed peers. These associations persisted after accounting for maternal and perinatal factors, were absent for the negative control outcomes, and were stronger, though less precise, in infants who received physical therapy. Conclusion CMT is associated with elevated risks for later atypical neurodevelopment. The results suggest a possible etiological link between abnormal neural circuit maturation and musculoskeletal development. Although CMT is often considered benign in infancy, it may represent an early clinical marker of neurodevelopmental vulnerability, highlighting an opportunity for earlier recognition and intervention. En ligne : https://doi.org/10.1016/j.reia.2026.202831 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Deviations from Typical Developmental Trajectories Detectable at 9 Months of Age in Low Risk Children Later Diagnosed with Autism Spectrum Disorder / Michael DAVIDOVITCH in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2854-2869 Titre : Deviations from Typical Developmental Trajectories Detectable at 9 Months of Age in Low Risk Children Later Diagnosed with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Michael DAVIDOVITCH, Auteur ; Nataly STEIN, Auteur ; Gideon KOREN, Auteur ; Bat Chen FRIEDMAN, Auteur Article en page(s) : p.2854-2869 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Developmental trajectories  Early development  Low risk Index. décimale : PER Périodiques Résumé : This study was designed to track the developmental trajectory, during the first 24 months of life, of 335 low-risk infants later diagnosed with Autism Spectrum Disorder and identify early deviations observed in routine Well Care checkups. We compared their achievements to typically developing children and to children later diagnosed with non-autistic developmental impairments. The results show that in the first 6 months, the children with autism showed normal acquisition of milestones, whereas by 9 months of age they began to fail the language/communication, as well as motor items when compared to typical and delayed non-autistic children. Regular check-up visits may be useful in detecting early failure in achieving milestones, leading to earlier referral for further evaluation and treatment. En ligne : http://dx.doi.org/10.1007/s10803-018-3549-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Deviations from Typical Developmental Trajectories Detectable at 9 Months of Age in Low Risk Children Later Diagnosed with Autism Spectrum Disorder [texte imprimé] / Michael DAVIDOVITCH, Auteur ; Nataly STEIN, Auteur ; Gideon KOREN, Auteur ; Bat Chen FRIEDMAN, Auteur . - p.2854-2869. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2854-2869 Mots-clés : Autism spectrum disorder  Developmental trajectories  Early development  Low risk Index. décimale : PER Périodiques Résumé : This study was designed to track the developmental trajectory, during the first 24 months of life, of 335 low-risk infants later diagnosed with Autism Spectrum Disorder and identify early deviations observed in routine Well Care checkups. We compared their achievements to typically developing children and to children later diagnosed with non-autistic developmental impairments. The results show that in the first 6 months, the children with autism showed normal acquisition of milestones, whereas by 9 months of age they began to fail the language/communication, as well as motor items when compared to typical and delayed non-autistic children. Regular check-up visits may be useful in detecting early failure in achieving milestones, leading to earlier referral for further evaluation and treatment. En ligne : http://dx.doi.org/10.1007/s10803-018-3549-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Differences in Autism Spectrum Disorders Incidence by Sub-Populations in Israel 1992–2009: A Total Population Study / Raanan RAZ in Journal of Autism and Developmental Disorders, 45-4 (April 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1062-1069 Titre : Differences in Autism Spectrum Disorders Incidence by Sub-Populations in Israel 1992–2009: A Total Population Study Type de document : texte imprimé Auteurs : Raanan RAZ, Auteur ; Marc G. WEISSKOPF, Auteur ; Michael DAVIDOVITCH, Auteur ; Ofir PINTO, Auteur ; Hagai LEVINE, Auteur Article en page(s) : p.1062-1069 Langues : Anglais (eng) Mots-clés : Autism  Incidence  Prevalence  Israel  Sub-populations Index. décimale : PER Périodiques Résumé : We analyzed data from the Israeli National Insurance Institute (NII). Autism Spectrum Disorder (ASD) incidence was calculated for all children born in Israel 1992–2009, and by population groups. Overall, 9,109 ASD cases among 2,431,649 children were identified. ASD cumulative incidence by age 8 years increased 10-fold during 2000–2011, from 0.49 % to 0.49 %, while other child disabilities in NII increased only 1.65-fold. There was a consistent increase in ASD incidence with advancing birth cohorts born 1992–2004, stabilizing among those born 2005–2009. ASD rates among Israeli Arabs were substantially lower, and increased about 10 years later than the general population. The findings suggest a role for ASD awareness, accessing of the government benefit, or the way the concept of ASD is perceived. En ligne : http://dx.doi.org/10.1007/s10803-014-2262-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Differences in Autism Spectrum Disorders Incidence by Sub-Populations in Israel 1992–2009: A Total Population Study [texte imprimé] / Raanan RAZ, Auteur ; Marc G. WEISSKOPF, Auteur ; Michael DAVIDOVITCH, Auteur ; Ofir PINTO, Auteur ; Hagai LEVINE, Auteur . - p.1062-1069. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1062-1069 Mots-clés : Autism  Incidence  Prevalence  Israel  Sub-populations Index. décimale : PER Périodiques Résumé : We analyzed data from the Israeli National Insurance Institute (NII). Autism Spectrum Disorder (ASD) incidence was calculated for all children born in Israel 1992–2009, and by population groups. Overall, 9,109 ASD cases among 2,431,649 children were identified. ASD cumulative incidence by age 8 years increased 10-fold during 2000–2011, from 0.49 % to 0.49 %, while other child disabilities in NII increased only 1.65-fold. There was a consistent increase in ASD incidence with advancing birth cohorts born 1992–2004, stabilizing among those born 2005–2009. ASD rates among Israeli Arabs were substantially lower, and increased about 10 years later than the general population. The findings suggest a role for ASD awareness, accessing of the government benefit, or the way the concept of ASD is perceived. En ligne : http://dx.doi.org/10.1007/s10803-014-2262-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Prevalence and Incidence of Autism Spectrum Disorder in an Israeli Population / Michael DAVIDOVITCH in Journal of Autism and Developmental Disorders, 43-4 (April 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-4 (April 2013) . - p.785-793 Titre : Prevalence and Incidence of Autism Spectrum Disorder in an Israeli Population Type de document : texte imprimé Auteurs : Michael DAVIDOVITCH, Auteur ; Beatriz HEMO, Auteur ; Patricia MANNING-COURTNEY, Auteur ; Eric FOMBONNE, Auteur Article en page(s) : p.785-793 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Incidence  Prevalence  Israel Index. décimale : PER Périodiques Résumé : The prevalence of autism spectrum disorders has been steadily rising. In most parts of the world, rates as high as 1 % are reported, including in the United States. In Israel, previously reported prevalence rates have been in the 0.2 % range, and were based on parental reporting of diagnosis. In this study, records from one of the largest Israeli Health Maintenance organizations were used to calculate both incidence and prevalence of autism spectrum disorder (ASD) in Israel. Israeli prevalence of ASD was calculated at 0.48 % for 1–12 years olds and 0.65 % for 8 year old children in 2010, higher than previous Israeli reports, but still lower than prevalence estimates for the US. Incidence calculations ranged from 0.65 to 0.84 per 1,000 children for children 1–12 year olds. Reasons for these differences are suggested and discussed. En ligne : http://dx.doi.org/10.1007/s10803-012-1611-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=193 [article] Prevalence and Incidence of Autism Spectrum Disorder in an Israeli Population [texte imprimé] / Michael DAVIDOVITCH, Auteur ; Beatriz HEMO, Auteur ; Patricia MANNING-COURTNEY, Auteur ; Eric FOMBONNE, Auteur . - p.785-793. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-4 (April 2013) . - p.785-793 Mots-clés : Autism spectrum disorder (ASD)  Incidence  Prevalence  Israel Index. décimale : PER Périodiques Résumé : The prevalence of autism spectrum disorders has been steadily rising. In most parts of the world, rates as high as 1 % are reported, including in the United States. In Israel, previously reported prevalence rates have been in the 0.2 % range, and were based on parental reporting of diagnosis. In this study, records from one of the largest Israeli Health Maintenance organizations were used to calculate both incidence and prevalence of autism spectrum disorder (ASD) in Israel. Israeli prevalence of ASD was calculated at 0.48 % for 1–12 years olds and 0.65 % for 8 year old children in 2010, higher than previous Israeli reports, but still lower than prevalence estimates for the US. Incidence calculations ranged from 0.65 to 0.84 per 1,000 children for children 1–12 year olds. Reasons for these differences are suggested and discussed. En ligne : http://dx.doi.org/10.1007/s10803-012-1611-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=193

Sensory and motor secondary symptoms as indicators of brain vulnerability / Nava LEVIT-BINNUN in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

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