172 recherche sur le mot-clé 'Autism spectrum disorder (ASD)'

Autism Spectrum Disorder (ASD) and Unlawful Behaviour: Where Do We Go from Here? / Marc WOODBURY-SMITH in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2734-2741 Titre : Autism Spectrum Disorder (ASD) and Unlawful Behaviour: Where Do We Go from Here? Type de document : Texte imprimé et/ou numérique Auteurs : Marc WOODBURY-SMITH, Auteur ; Kalpana DEIN, Auteur Article en page(s) : p.2734-2741 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Adulthood  Outcome  Criminal behaviour Index. décimale : PER Périodiques Résumé : There exists now a body of research that describes case studies of individuals with autism spectrum disorder (ASD) who have engaged, or are alleged to have engaged, in a range of illegal behaviours, and that attempts to estimate the prevalence of ASD at different stages of the criminal justice process. Taken together, this research does suggest that some individuals with ASD will come into contact with the criminal justice system, but many questions regarding this apparent association remain unanswered. The purpose of this review is to propose a direction for research to address some of these unanswered questions and potentially inform the development of treatments and service provision. En ligne : http://dx.doi.org/10.1007/s10803-014-2216-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Autism Spectrum Disorder (ASD) and Unlawful Behaviour: Where Do We Go from Here? [Texte imprimé et/ou numérique] / Marc WOODBURY-SMITH, Auteur ; Kalpana DEIN, Auteur . - p.2734-2741. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2734-2741 Mots-clés : Autism spectrum disorder (ASD)  Adulthood  Outcome  Criminal behaviour Index. décimale : PER Périodiques Résumé : There exists now a body of research that describes case studies of individuals with autism spectrum disorder (ASD) who have engaged, or are alleged to have engaged, in a range of illegal behaviours, and that attempts to estimate the prevalence of ASD at different stages of the criminal justice process. Taken together, this research does suggest that some individuals with ASD will come into contact with the criminal justice system, but many questions regarding this apparent association remain unanswered. The purpose of this review is to propose a direction for research to address some of these unanswered questions and potentially inform the development of treatments and service provision. En ligne : http://dx.doi.org/10.1007/s10803-014-2216-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Autism spectrum disorder (ASD) diagnosis: A biochemical investigation into the diagnostic utility of S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) levels and the SAM/SAH ratio / Zafer YÖNDEN ; Amin DAEMI ; Yusuf DÖ?Ü? ; Hülya BINOKAY ; Perihan Çam RAY ; Ça?lar Charles Daniel JAICKS in Research in Autism Spectrum Disorders, 117 (September 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 117 (September 2024) . - p.102464 Titre : Autism spectrum disorder (ASD) diagnosis: A biochemical investigation into the diagnostic utility of S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) levels and the SAM/SAH ratio Type de document : Texte imprimé et/ou numérique Auteurs : Zafer YÖNDEN, Auteur ; Amin DAEMI, Auteur ; Yusuf DÖ?Ü?, Auteur ; Hülya BINOKAY, Auteur ; Perihan Çam RAY, Auteur ; Ça?lar Charles Daniel JAICKS, Auteur Article en page(s) : p.102464 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  S-Adenosyl Methionine (SAM)  S-adenosyl homocysteine (SAH)  SAM/SAH Ratio  Glycine N-methyltransferase (GNMT)  Methylation Cycle Index. décimale : PER Périodiques Résumé : Background The balance between SAM and SAH ratios is critical for cellular methylation capacity such that a decrease in this ratio signals decrease the methylation potential, impacting cellular functions. In Autism Spectrum Disorder (ASD), impaired methylation processes are prominent, disrupting essential methyl group transfers crucial for DNA methylation, neurotransmitter synthesis, and detoxification. This disturbance affects gene expression and neural function, contributing to ASD development. This paper aims to explore ASD's pathogenesis by investigating biochemical parameters linked to the methylation cycle. For this purpose, some laboratory parameters are employed to aid in the understanding of potential laboratory abnormalities in ASD in children aged 2 to 8 years. Materials and Methods This study included a cohort of 43 children aged 2 to 8 years diagnosed ASD, alongside a control group of 43 age-and gender-matched healthy subjects. The serum of blood samples taken was used to measure biochemical factors. Specimens were processed using ELISA instrumentation and hemogram auto analyzers. The study conducted a statistical comparison between the ASD-diagnosed subjects and healthy controls, focusing on levels of S-adenosyl methionine (SAM), S-adenosyl homocysteine (SAH), Glycine N-methyltransferase (GNMT), and platelet counts. RESULTS The levels of SAH and platelets were significantly higher in the case group compared to the control group. Conversely, levels of SAM, as well as the SAM/SAH ratio, were found to be significantly lower in the case group than in the control group (p < 0.05). No statistically significant difference was observed in the levels of GNMT when compared (p > 0.05). Receiver Operating Characteristic (ROC) analysis revealed that the diagnostic performance for SAM had an area under the curve (AUC) of 0.876, with a cut-off point determined at 286.9 ng/mL, yielding a sensitivity of 85 % and a specificity of 75 %. For SAH, the AUC was calculated to be 0.671, with a cut-off point set at 0.49 ng/mL, resulting in a sensitivity and specificity of 64 %. The SAM/SAH ratio demonstrated an AUC of 0.806, with the cut-off point established at 576.3, leading to a sensitivity and specificity of 72 %. A significant negative correlation was detected between the scores of the Modified Checklist for Autism in Toddlers (M-CHAT) and both SAM levels and the SAM/SAH ratio. The analysis indicated that an increase of one unit (1 ng/mL) in SAM levels is associated with a decreased autism risk by a factor of 1/0.914 = 1.1 %, whereas an increase of one unit (1 * 103/uL) in platelet count is associated with an increased autism risk by a factor of 1.019 %. Regarding glycine N-methyltransferase, no significant difference was observed between the two groups. Conclusion Follow-up studies with larger samples will be needed to better understand the potential for SAM, SAH, and SAM/SAH as a potential biomarker, at least for a subset of those with ASD. The correlation between these markers and the total score on the M-Chat raises further interest in this possibility. The correlation between these markers and the total score on the M-Chat further supports their utility as clinical biochemical laboratory parameters that could aid in the diagnosis of ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Autism spectrum disorder (ASD) diagnosis: A biochemical investigation into the diagnostic utility of S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) levels and the SAM/SAH ratio [Texte imprimé et/ou numérique] / Zafer YÖNDEN, Auteur ; Amin DAEMI, Auteur ; Yusuf DÖ?Ü?, Auteur ; Hülya BINOKAY, Auteur ; Perihan Çam RAY, Auteur ; Ça?lar Charles Daniel JAICKS, Auteur . - p.102464. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 117 (September 2024) . - p.102464 Mots-clés : Autism spectrum disorder (ASD)  S-Adenosyl Methionine (SAM)  S-adenosyl homocysteine (SAH)  SAM/SAH Ratio  Glycine N-methyltransferase (GNMT)  Methylation Cycle Index. décimale : PER Périodiques Résumé : Background The balance between SAM and SAH ratios is critical for cellular methylation capacity such that a decrease in this ratio signals decrease the methylation potential, impacting cellular functions. In Autism Spectrum Disorder (ASD), impaired methylation processes are prominent, disrupting essential methyl group transfers crucial for DNA methylation, neurotransmitter synthesis, and detoxification. This disturbance affects gene expression and neural function, contributing to ASD development. This paper aims to explore ASD's pathogenesis by investigating biochemical parameters linked to the methylation cycle. For this purpose, some laboratory parameters are employed to aid in the understanding of potential laboratory abnormalities in ASD in children aged 2 to 8 years. Materials and Methods This study included a cohort of 43 children aged 2 to 8 years diagnosed ASD, alongside a control group of 43 age-and gender-matched healthy subjects. The serum of blood samples taken was used to measure biochemical factors. Specimens were processed using ELISA instrumentation and hemogram auto analyzers. The study conducted a statistical comparison between the ASD-diagnosed subjects and healthy controls, focusing on levels of S-adenosyl methionine (SAM), S-adenosyl homocysteine (SAH), Glycine N-methyltransferase (GNMT), and platelet counts. RESULTS The levels of SAH and platelets were significantly higher in the case group compared to the control group. Conversely, levels of SAM, as well as the SAM/SAH ratio, were found to be significantly lower in the case group than in the control group (p < 0.05). No statistically significant difference was observed in the levels of GNMT when compared (p > 0.05). Receiver Operating Characteristic (ROC) analysis revealed that the diagnostic performance for SAM had an area under the curve (AUC) of 0.876, with a cut-off point determined at 286.9 ng/mL, yielding a sensitivity of 85 % and a specificity of 75 %. For SAH, the AUC was calculated to be 0.671, with a cut-off point set at 0.49 ng/mL, resulting in a sensitivity and specificity of 64 %. The SAM/SAH ratio demonstrated an AUC of 0.806, with the cut-off point established at 576.3, leading to a sensitivity and specificity of 72 %. A significant negative correlation was detected between the scores of the Modified Checklist for Autism in Toddlers (M-CHAT) and both SAM levels and the SAM/SAH ratio. The analysis indicated that an increase of one unit (1 ng/mL) in SAM levels is associated with a decreased autism risk by a factor of 1/0.914 = 1.1 %, whereas an increase of one unit (1 * 103/uL) in platelet count is associated with an increased autism risk by a factor of 1.019 %. Regarding glycine N-methyltransferase, no significant difference was observed between the two groups. Conclusion Follow-up studies with larger samples will be needed to better understand the potential for SAM, SAH, and SAM/SAH as a potential biomarker, at least for a subset of those with ASD. The correlation between these markers and the total score on the M-Chat raises further interest in this possibility. The correlation between these markers and the total score on the M-Chat further supports their utility as clinical biochemical laboratory parameters that could aid in the diagnosis of ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Brief Report: Associations Between Cognitive Control Processes and Traits of Autism Spectrum Disorder (ASD), attention-Deficit/Hyperactivity Disorder (ADHD) and Anxiety in Children at Elevated and Typical Familial Likelihood for ASD / P. B. G. GODOY in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.3001-3013 Titre : Brief Report: Associations Between Cognitive Control Processes and Traits of Autism Spectrum Disorder (ASD), attention-Deficit/Hyperactivity Disorder (ADHD) and Anxiety in Children at Elevated and Typical Familial Likelihood for ASD Type de document : Texte imprimé et/ou numérique Auteurs : P. B. G. GODOY, Auteur ; E. SHEPHARD, Auteur ; B. MILOSAVLJEVIC, Auteur ; M. H. JOHNSON, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.3001-3013 Langues : Anglais (eng) Mots-clés : Anxiety/complications/psychology  Anxiety Disorders/complications/psychology  Attention Deficit Disorder with Hyperactivity/complications/psychology  Autism Spectrum Disorder/complications/psychology  Child  Cognition  Executive Function/physiology  Female  Humans  Male  Risk Factors  Anxiety  Attention-deficit/hyperactivity disorder (ADHD)  Autism spectrum disorder (ASD)  Cognitive flexibility  Conflict resolution  Inhibitory control Index. décimale : PER Périodiques Résumé : Shared difficulties with cognitive control may play a role in co-occurring mental health problems frequently observed in autistic children. We investigated how different cognitive control processes (inhibitory control, conflict resolution, cognitive flexibility) associated with traits of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD) and anxiety in 7-year-old children at elevated (n = 44) and typical (n = 37) familial likelihood for ASD. Poor inhibitory control was associated with higher ADHD traits. Better inhibitory control and poorer cognitive flexibility predicted higher anxiety traits. Cognitive control processes were not associated dimensionally with autistic traits, though better conflict resolution predicted greater likelihood of meeting diagnostic criteria for ASD in categorical analysis. These findings suggest that different cognitive control alterations are associated with ASD, ADHD and anxiety. En ligne : http://dx.doi.org/10.1007/s10803-020-04732-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Brief Report: Associations Between Cognitive Control Processes and Traits of Autism Spectrum Disorder (ASD), attention-Deficit/Hyperactivity Disorder (ADHD) and Anxiety in Children at Elevated and Typical Familial Likelihood for ASD [Texte imprimé et/ou numérique] / P. B. G. GODOY, Auteur ; E. SHEPHARD, Auteur ; B. MILOSAVLJEVIC, Auteur ; M. H. JOHNSON, Auteur ; Tony CHARMAN, Auteur . - p.3001-3013. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.3001-3013 Mots-clés : Anxiety/complications/psychology  Anxiety Disorders/complications/psychology  Attention Deficit Disorder with Hyperactivity/complications/psychology  Autism Spectrum Disorder/complications/psychology  Child  Cognition  Executive Function/physiology  Female  Humans  Male  Risk Factors  Anxiety  Attention-deficit/hyperactivity disorder (ADHD)  Autism spectrum disorder (ASD)  Cognitive flexibility  Conflict resolution  Inhibitory control Index. décimale : PER Périodiques Résumé : Shared difficulties with cognitive control may play a role in co-occurring mental health problems frequently observed in autistic children. We investigated how different cognitive control processes (inhibitory control, conflict resolution, cognitive flexibility) associated with traits of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD) and anxiety in 7-year-old children at elevated (n = 44) and typical (n = 37) familial likelihood for ASD. Poor inhibitory control was associated with higher ADHD traits. Better inhibitory control and poorer cognitive flexibility predicted higher anxiety traits. Cognitive control processes were not associated dimensionally with autistic traits, though better conflict resolution predicted greater likelihood of meeting diagnostic criteria for ASD in categorical analysis. These findings suggest that different cognitive control alterations are associated with ASD, ADHD and anxiety. En ligne : http://dx.doi.org/10.1007/s10803-020-04732-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Development and Psychometric Properties of a New Questionnaire to Assess Mental Health and Concerning Behaviors in Children and Young People with Autism Spectrum Disorder (ASD): The Assessment of Concerning Behavior (ACB) Scale / J. TARVER in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2812-2828 Titre : Development and Psychometric Properties of a New Questionnaire to Assess Mental Health and Concerning Behaviors in Children and Young People with Autism Spectrum Disorder (ASD): The Assessment of Concerning Behavior (ACB) Scale Type de document : Texte imprimé et/ou numérique Auteurs : J. TARVER, Auteur ; S. VITORATOU, Auteur ; M. MASTROIANNI, Auteur ; N. HEANEY, Auteur ; E. BENNETT, Auteur ; F. GIBBONS, Auteur ; F. FIORI, Auteur ; M. ABSOUD, Auteur ; L. RAMASUBRAMANIAN, Auteur ; E. SIMONOFF, Auteur ; P. SANTOSH, Auteur Article en page(s) : p.2812-2828 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis/psychology  Behavior Rating Scale  Caregivers/psychology  Child  Female  Humans  Male  Mental Health/trends  Parents/psychology  Problem Behavior/psychology  Psychometrics/methods  Reproducibility of Results  Surveys and Questionnaires  Young Adult  Autism spectrum disorder (ASD)  Emotional and behavioral problems  Instrument development and validation  Risk  F. Fiori is the Chief Technology Officer and shareholder in HealthTracker Ltd. Index. décimale : PER Périodiques Résumé : Although 70% of autistic children and young people meet criteria for co-occurring psychiatric conditions, there are few screening measures specifically for autistic individuals. We describe the development and validation of the Assessment of Concerning Behavior (ACB), an instrument co-developed with the autistic community to assess mental health and problematic/risky behaviors. Items include descriptions to facilitate symptom recognition by autistic people, and carers/professionals. The ACB was completed by 255 parents, 149 autistic children and young people and 30 teachers. Internal consistency, stability and validity was assessed. The ACB parent-version fit a two-factor model (internalizing and externalizing problems) and showed adequate test-retest reliability, internal consistency and construct validity. The ACB is a promising new measure for research and clinical use in autism. En ligne : http://dx.doi.org/10.1007/s10803-020-04748-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Development and Psychometric Properties of a New Questionnaire to Assess Mental Health and Concerning Behaviors in Children and Young People with Autism Spectrum Disorder (ASD): The Assessment of Concerning Behavior (ACB) Scale [Texte imprimé et/ou numérique] / J. TARVER, Auteur ; S. VITORATOU, Auteur ; M. MASTROIANNI, Auteur ; N. HEANEY, Auteur ; E. BENNETT, Auteur ; F. GIBBONS, Auteur ; F. FIORI, Auteur ; M. ABSOUD, Auteur ; L. RAMASUBRAMANIAN, Auteur ; E. SIMONOFF, Auteur ; P. SANTOSH, Auteur . - p.2812-2828. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2812-2828 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis/psychology  Behavior Rating Scale  Caregivers/psychology  Child  Female  Humans  Male  Mental Health/trends  Parents/psychology  Problem Behavior/psychology  Psychometrics/methods  Reproducibility of Results  Surveys and Questionnaires  Young Adult  Autism spectrum disorder (ASD)  Emotional and behavioral problems  Instrument development and validation  Risk  F. Fiori is the Chief Technology Officer and shareholder in HealthTracker Ltd. Index. décimale : PER Périodiques Résumé : Although 70% of autistic children and young people meet criteria for co-occurring psychiatric conditions, there are few screening measures specifically for autistic individuals. We describe the development and validation of the Assessment of Concerning Behavior (ACB), an instrument co-developed with the autistic community to assess mental health and problematic/risky behaviors. Items include descriptions to facilitate symptom recognition by autistic people, and carers/professionals. The ACB was completed by 255 parents, 149 autistic children and young people and 30 teachers. Internal consistency, stability and validity was assessed. The ACB parent-version fit a two-factor model (internalizing and externalizing problems) and showed adequate test-retest reliability, internal consistency and construct validity. The ACB is a promising new measure for research and clinical use in autism. En ligne : http://dx.doi.org/10.1007/s10803-020-04748-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Exploring Predictors of Bullying and Victimization of Students with Autism Spectrum Disorder (ASD): Findings from NLTS 2012 / C. MATTHIAS in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4632-4643 Titre : Exploring Predictors of Bullying and Victimization of Students with Autism Spectrum Disorder (ASD): Findings from NLTS 2012 Type de document : Texte imprimé et/ou numérique Auteurs : C. MATTHIAS, Auteur ; J. M. LAVELLE, Auteur ; D. R. JOHNSON, Auteur ; Y. C. WU, Auteur ; M. L. THURLOW, Auteur Article en page(s) : p.4632-4643 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Bullying  Crime Victims  Humans  Peer Group  Students  Autism spectrum disorder (ASD)  Student and family predictors  Victimization Index. décimale : PER Périodiques Résumé : Research suggests that bullying victimization occurs at higher rates among students with autism spectrum disorder (ASD) than among their typically-developing peers. This study used data from the National Longitudinal Transition Study 2012 to explore differences in student and family characteristics between students with ASD and students with all other special education disability categories. The study also examined characteristics serve as predictors of bullying and victimization. Students with ASD were found to have greater difficulties with communication and social skills, as well as less-robust sense of themselves and their abilities than students with all other disabilities. Race, household income, social and communication skills, and self-concept were found to be associated with higher rates of bullying and victimization. En ligne : http://dx.doi.org/10.1007/s10803-021-04907-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Exploring Predictors of Bullying and Victimization of Students with Autism Spectrum Disorder (ASD): Findings from NLTS 2012 [Texte imprimé et/ou numérique] / C. MATTHIAS, Auteur ; J. M. LAVELLE, Auteur ; D. R. JOHNSON, Auteur ; Y. C. WU, Auteur ; M. L. THURLOW, Auteur . - p.4632-4643. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4632-4643 Mots-clés : Autism Spectrum Disorder/epidemiology  Bullying  Crime Victims  Humans  Peer Group  Students  Autism spectrum disorder (ASD)  Student and family predictors  Victimization Index. décimale : PER Périodiques Résumé : Research suggests that bullying victimization occurs at higher rates among students with autism spectrum disorder (ASD) than among their typically-developing peers. This study used data from the National Longitudinal Transition Study 2012 to explore differences in student and family characteristics between students with ASD and students with all other special education disability categories. The study also examined characteristics serve as predictors of bullying and victimization. Students with ASD were found to have greater difficulties with communication and social skills, as well as less-robust sense of themselves and their abilities than students with all other disabilities. Race, household income, social and communication skills, and self-concept were found to be associated with higher rates of bullying and victimization. En ligne : http://dx.doi.org/10.1007/s10803-021-04907-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Parent-reported and clinician-observed autism spectrum disorder (ASD) symptoms in children with attention deficit/hyperactivity disorder (ADHD): implications for practice under DSM-5 / R. GRZADZINSKI in Molecular Autism, 7 (2016)  

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Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder / Lei WANG in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

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Brief Report: Sex/Gender Differences in Symptomology and Camouflaging in Adults with Autism Spectrum Disorder / R. K. SCHUCK in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

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Development of a cell-based metabolic test for the identification of individuals with autism spectrum disorder / Rini PAULY in Research in Autism Spectrum Disorders, 85 (July 2021)  

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Is there a role for routinely screening children with autism spectrum disorder for creatine deficiency syndrome? / Lv WANG in Autism Research, 3-5 (October 2010)  

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