Age-Related Differences in Restricted Repetitive Behaviors in Autism Spectrum Disorders / Anna J. ESBENSEN in Journal of Autism and Developmental Disorders, 39-1 (January 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.57-66 Titre : Age-Related Differences in Restricted Repetitive Behaviors in Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Anna J. ESBENSEN, Auteur ; Kristen S.L. LAM, Auteur ; Marsha MAILICK SELTZER, Auteur ; James W. BODFISH, Auteur Année de publication : 2009 Article en page(s) : p.57-66 Langues : Anglais (eng) Mots-clés : ASD Repetitive-behaviors Children Adolescents Adults Index. décimale : PER Périodiques Résumé : Restricted repetitive behaviors (RRBs) were examined in a large group of children, adolescents and adults with ASD in order to describe age-related patterns of symptom change and association with specific contextual factors, and to examine if the patterns of change are different for the various types of RRBs. Over 700 individuals with ASD were rated on the Repetitive Behavior Scale-Revised. RRBs were less frequent and less severe among older than younger individuals, corroborating that autism symptoms abate with age. Our findings further suggest that repetitive behaviors are a heterogeneous group of behaviors, with the subtypes of RRBs having their own individual patterns across the lifespan, and in some cases, a differential association with age depending on intellectual functioning. En ligne : http://dx.doi.org/10.1007/s10803-008-0599-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660 [article] Age-Related Differences in Restricted Repetitive Behaviors in Autism Spectrum Disorders [texte imprimé] / Anna J. ESBENSEN, Auteur ; Kristen S.L. LAM, Auteur ; Marsha MAILICK SELTZER, Auteur ; James W. BODFISH, Auteur . - 2009 . - p.57-66. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.57-66 Mots-clés : ASD Repetitive-behaviors Children Adolescents Adults Index. décimale : PER Périodiques Résumé : Restricted repetitive behaviors (RRBs) were examined in a large group of children, adolescents and adults with ASD in order to describe age-related patterns of symptom change and association with specific contextual factors, and to examine if the patterns of change are different for the various types of RRBs. Over 700 individuals with ASD were rated on the Repetitive Behavior Scale-Revised. RRBs were less frequent and less severe among older than younger individuals, corroborating that autism symptoms abate with age. Our findings further suggest that repetitive behaviors are a heterogeneous group of behaviors, with the subtypes of RRBs having their own individual patterns across the lifespan, and in some cases, a differential association with age depending on intellectual functioning. En ligne : http://dx.doi.org/10.1007/s10803-008-0599-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660

Autism and the broad autism phenotype: familial patterns and intergenerational transmission / Noah J. SASSON in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 5-1 (December 2013) . - p.11 Titre : Autism and the broad autism phenotype: familial patterns and intergenerational transmission Type de document : texte imprimé Auteurs : Noah J. SASSON, Auteur ; Kristen S.L. LAM, Auteur ; Morgan PARLIER, Auteur ; Julie L. DANIELS, Auteur ; Joseph PIVEN, Auteur Article en page(s) : p.11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Features of the Broad Autism Phenotype (BAP) are disproportionately prevalent in parents of a child with autism, highlighting familial patterns indicative of heritability. It is unclear, however, whether the presence of BAP features in both parents confers an increased liability for autism. The current study explores whether the presence of BAP features in two biological parents occurs more frequently in parents of a child with autism relative to comparison parents, whether parental pairs of a child with autism more commonly consist of one or two parents with BAP features, and whether these features are associated with severity of autism behaviors in probands. METHOD: Seven hundred eleven parents of a child with an autism spectrum disorder and 981 comparison parents completed the Broad Autism Phenotype Questionnaire. Parents of a child with autism also completed the Social Communication Questionnaire. RESULTS: Although parental pairs of a child with autism were more likely than comparison parental pairs to have both parents characterized by the presence of the BAP, they more commonly consisted of a single parent with BAP features. The presence of the BAP in parents was associated with the severity of autism behaviors in probands, with the lowest severity occurring for children of parental pairs in which neither parent exhibited a BAP feature. Severity did not differ between children of two affected parents and those of just one. CONCLUSIONS: Collectively, these findings indicate that parental pairs of children with autism frequently consist of a single parent with BAP characteristics and suggest that future studies searching for implicated genes may benefit from a more narrow focus that identifies the transmitting parent. The evidence of intergenerational transmission reported here also provides further confirmation of the high heritability of autism that is unaccounted for by the contribution of de novo mutations currently emphasized in the field of autism genetics. En ligne : http://dx.doi.org/10.1186/1866-1955-5-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=345 [article] Autism and the broad autism phenotype: familial patterns and intergenerational transmission [texte imprimé] / Noah J. SASSON, Auteur ; Kristen S.L. LAM, Auteur ; Morgan PARLIER, Auteur ; Julie L. DANIELS, Auteur ; Joseph PIVEN, Auteur . - p.11. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 5-1 (December 2013) . - p.11 Index. décimale : PER Périodiques Résumé : BACKGROUND: Features of the Broad Autism Phenotype (BAP) are disproportionately prevalent in parents of a child with autism, highlighting familial patterns indicative of heritability. It is unclear, however, whether the presence of BAP features in both parents confers an increased liability for autism. The current study explores whether the presence of BAP features in two biological parents occurs more frequently in parents of a child with autism relative to comparison parents, whether parental pairs of a child with autism more commonly consist of one or two parents with BAP features, and whether these features are associated with severity of autism behaviors in probands. METHOD: Seven hundred eleven parents of a child with an autism spectrum disorder and 981 comparison parents completed the Broad Autism Phenotype Questionnaire. Parents of a child with autism also completed the Social Communication Questionnaire. RESULTS: Although parental pairs of a child with autism were more likely than comparison parental pairs to have both parents characterized by the presence of the BAP, they more commonly consisted of a single parent with BAP features. The presence of the BAP in parents was associated with the severity of autism behaviors in probands, with the lowest severity occurring for children of parental pairs in which neither parent exhibited a BAP feature. Severity did not differ between children of two affected parents and those of just one. CONCLUSIONS: Collectively, these findings indicate that parental pairs of children with autism frequently consist of a single parent with BAP characteristics and suggest that future studies searching for implicated genes may benefit from a more narrow focus that identifies the transmitting parent. The evidence of intergenerational transmission reported here also provides further confirmation of the high heritability of autism that is unaccounted for by the contribution of de novo mutations currently emphasized in the field of autism genetics. En ligne : http://dx.doi.org/10.1186/1866-1955-5-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=345

Children with autism demonstrate circumscribed attention during passive viewing of complex social and nonsocial picture arrays / Noah J. SASSON in Autism Research, 1-1 (February 2008)  

Public ISBD [article]  inAutism Research > 1-1 (February 2008) . - p.31-42 Titre : Children with autism demonstrate circumscribed attention during passive viewing of complex social and nonsocial picture arrays Type de document : texte imprimé Auteurs : Noah J. SASSON, Auteur ; Kristen S.L. LAM, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Tia N. HOLTZCLAW, Auteur ; James W. BODFISH, Auteur Année de publication : 2008 Article en page(s) : p.31-42 Langues : Anglais (eng) Mots-clés : autism repetitive-behavior circumscribed-interests visual-exploration attention Index. décimale : PER Périodiques Résumé : Although circumscribed interests are a hallmark characteristic of autism spectrum disorders, providing a means for quantifying their functional impairment has proven difficult. We developed a passive viewing task to measure aspects of visual attention in children with autism spectrum disorders and typically developing controls. Task stimuli included picture arrays that were matched for social and nonsocial content. Nonsocial content was balanced to include items related to circumscribed interests (e.g., trains) as well as more commonplace items (e.g., furniture). Discrete aspects of gaze behavior were quantified using eye-tracking technology. Results indicate that visual attention in the autism group was more circumscribed (as indicated by the exploration of fewer images), more perseverative (as indicated by longer fixation times per image explored), and more detail oriented (as indicated by a greater number of discrete fixations on explored images). This pattern of results was similar for both social and object arrays. Within the autism group, overall severity of repetitive behavior symptoms correlated positively with exploration of object pictures and negatively with perseveration on social pictures. Results suggest that children with autism have a domain-general pattern of atypical visual attention that may represent an exaggeration of a typical attentional process and is related to a tendency to perseverate on images of interest and explore them in a more detail-oriented manner. Discrete measures of visual attention may therefore provide a reasonable means of quantifying aspects of the repetitive behavior phenotype in autism. En ligne : http://dx.doi.org/10.1002/aur.4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=929 [article] Children with autism demonstrate circumscribed attention during passive viewing of complex social and nonsocial picture arrays [texte imprimé] / Noah J. SASSON, Auteur ; Kristen S.L. LAM, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Tia N. HOLTZCLAW, Auteur ; James W. BODFISH, Auteur . - 2008 . - p.31-42. Langues : Anglais (eng) in Autism Research > 1-1 (February 2008) . - p.31-42 Mots-clés : autism repetitive-behavior circumscribed-interests visual-exploration attention Index. décimale : PER Périodiques Résumé : Although circumscribed interests are a hallmark characteristic of autism spectrum disorders, providing a means for quantifying their functional impairment has proven difficult. We developed a passive viewing task to measure aspects of visual attention in children with autism spectrum disorders and typically developing controls. Task stimuli included picture arrays that were matched for social and nonsocial content. Nonsocial content was balanced to include items related to circumscribed interests (e.g., trains) as well as more commonplace items (e.g., furniture). Discrete aspects of gaze behavior were quantified using eye-tracking technology. Results indicate that visual attention in the autism group was more circumscribed (as indicated by the exploration of fewer images), more perseverative (as indicated by longer fixation times per image explored), and more detail oriented (as indicated by a greater number of discrete fixations on explored images). This pattern of results was similar for both social and object arrays. Within the autism group, overall severity of repetitive behavior symptoms correlated positively with exploration of object pictures and negatively with perseveration on social pictures. Results suggest that children with autism have a domain-general pattern of atypical visual attention that may represent an exaggeration of a typical attentional process and is related to a tendency to perseverate on images of interest and explore them in a more detail-oriented manner. Discrete measures of visual attention may therefore provide a reasonable means of quantifying aspects of the repetitive behavior phenotype in autism. En ligne : http://dx.doi.org/10.1002/aur.4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=929

Evidence for three subtypes of repetitive behavior in autism that differ in familiality and association with other symptoms / Kristen S.L. LAM in Journal of Child Psychology and Psychiatry, 49-11 (November 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-11 (November 2008) . - p.1193-1200 Titre : Evidence for three subtypes of repetitive behavior in autism that differ in familiality and association with other symptoms Type de document : texte imprimé Auteurs : Kristen S.L. LAM, Auteur ; Joseph PIVEN, Auteur ; James W. BODFISH, Auteur Année de publication : 2008 Article en page(s) : p.1193-1200 Langues : Anglais (eng) Mots-clés : Autism repetitive-behavior factor-analysis Autism-Diagnostic-Interview-Revised Index. décimale : PER Périodiques Résumé : Background: Restricted repetitive behaviors (RRBs) are a core feature of autism and consist of a variety of behaviors, ranging from motor stereotypies to complex circumscribed interests. The objective of the current study was to examine the structure of RRBs in autism using relevant items from the Autism Diagnostic Interview-Revised in a sample of 316 individuals with autistic disorder. Methods/Results: Using exploratory factor analysis, three distinct factors were identified: Repetitive Motor Behaviors (RMB), Insistence on Sameness (IS), and Circumscribed Interests (CI). RMB were found to be associated with a variety of subject characteristics such as IQ, age, social/communication impairments, and the presence of regression. IS was associated with social and communication impairments whereas CI appeared to be independent of subject characteristics, suggesting CI may be particularly useful in subsetting samples. Based on sib-pair correlations, IS and CI (but not RMB) appear to be familial. Analysis of the data at the case level suggests that the presence of multiple forms of RRB in an individual is associated with more impairment in the social and communication domains, suggesting a more severe presentation of autistic disorder. Conclusions: There appears to be considerable structure within repetitive behavior in autism. The finding that these behaviors are differentially related to subject characteristics and familiality adds to their validity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01944.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=633 [article] Evidence for three subtypes of repetitive behavior in autism that differ in familiality and association with other symptoms [texte imprimé] / Kristen S.L. LAM, Auteur ; Joseph PIVEN, Auteur ; James W. BODFISH, Auteur . - 2008 . - p.1193-1200. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-11 (November 2008) . - p.1193-1200 Mots-clés : Autism repetitive-behavior factor-analysis Autism-Diagnostic-Interview-Revised Index. décimale : PER Périodiques Résumé : Background: Restricted repetitive behaviors (RRBs) are a core feature of autism and consist of a variety of behaviors, ranging from motor stereotypies to complex circumscribed interests. The objective of the current study was to examine the structure of RRBs in autism using relevant items from the Autism Diagnostic Interview-Revised in a sample of 316 individuals with autistic disorder. Methods/Results: Using exploratory factor analysis, three distinct factors were identified: Repetitive Motor Behaviors (RMB), Insistence on Sameness (IS), and Circumscribed Interests (CI). RMB were found to be associated with a variety of subject characteristics such as IQ, age, social/communication impairments, and the presence of regression. IS was associated with social and communication impairments whereas CI appeared to be independent of subject characteristics, suggesting CI may be particularly useful in subsetting samples. Based on sib-pair correlations, IS and CI (but not RMB) appear to be familial. Analysis of the data at the case level suggests that the presence of multiple forms of RRB in an individual is associated with more impairment in the social and communication domains, suggesting a more severe presentation of autistic disorder. Conclusions: There appears to be considerable structure within repetitive behavior in autism. The finding that these behaviors are differentially related to subject characteristics and familiality adds to their validity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01944.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=633

Generativity Abilities Predict Communication Deficits but not Repetitive Behaviors in Autism Spectrum Disorders / Gabriel S. DICHTER in Journal of Autism and Developmental Disorders, 39-9 (September 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-9 (September 2009) . - p.1298-1304 Titre : Generativity Abilities Predict Communication Deficits but not Repetitive Behaviors in Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Gabriel S. DICHTER, Auteur ; Kristen S.L. LAM, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Tia N. HOLTZCLAW, Auteur ; James W. BODFISH, Auteur Année de publication : 2009 Article en page(s) : p.1298-1304 Langues : Anglais (eng) Mots-clés : Autism Generativity Repetitive-behaviors Communication Severity-of-symptoms Children Index. décimale : PER Périodiques Résumé : Individuals with Autism Spectrum Disorders (ASD) often demonstrate impaired generativity that is thought to mediate repetitive behaviors in autism (Turner in J Child Psychol Psychiatry, 40(6):839–849, 1999a). The present study evaluated generativity in children with and without ASD via the use-of-objects task (Turner in J Child Psychol Psychiatry, 40(2):189–201, 1999b) and an Animals Fluency Task (Lezak in Neuropsychological assessment. Oxford University Press, Oxford, 1995). Groups differed significantly on two of four metrics from the Animals Fluency Task and two of seven metrics from the Use of Objects task. In the ASD sample, no significant relations were found between generativity and repetitive behaviors. Significant relations were found, however, between performance on the Animals Fluency Task and communication symptoms. Results replicate reports of generativity deficits in ASD and suggest that impaired generativity may reflect communication deficits that are characteristic of the disorder. En ligne : http://dx.doi.org/10.1007/s10803-009-0742-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=814 [article] Generativity Abilities Predict Communication Deficits but not Repetitive Behaviors in Autism Spectrum Disorders [texte imprimé] / Gabriel S. DICHTER, Auteur ; Kristen S.L. LAM, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Tia N. HOLTZCLAW, Auteur ; James W. BODFISH, Auteur . - 2009 . - p.1298-1304. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-9 (September 2009) . - p.1298-1304 Mots-clés : Autism Generativity Repetitive-behaviors Communication Severity-of-symptoms Children Index. décimale : PER Périodiques Résumé : Individuals with Autism Spectrum Disorders (ASD) often demonstrate impaired generativity that is thought to mediate repetitive behaviors in autism (Turner in J Child Psychol Psychiatry, 40(6):839–849, 1999a). The present study evaluated generativity in children with and without ASD via the use-of-objects task (Turner in J Child Psychol Psychiatry, 40(2):189–201, 1999b) and an Animals Fluency Task (Lezak in Neuropsychological assessment. Oxford University Press, Oxford, 1995). Groups differed significantly on two of four metrics from the Animals Fluency Task and two of seven metrics from the Use of Objects task. In the ASD sample, no significant relations were found between generativity and repetitive behaviors. Significant relations were found, however, between performance on the Animals Fluency Task and communication symptoms. Results replicate reports of generativity deficits in ASD and suggest that impaired generativity may reflect communication deficits that are characteristic of the disorder. En ligne : http://dx.doi.org/10.1007/s10803-009-0742-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=814

Performance of Children with Autism Spectrum Disorders on the Dimension-Change Card Sort Task / Gabriel S. DICHTER in Journal of Autism and Developmental Disorders, 40-4 (April 2010)  

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Phenomenology and measurement of circumscribed interests in autism spectrum disorders / Lauren M. TURNER-BROWN in Autism, 15-4 (July 2011)  

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The Broad Autism Phenotype Questionnaire: Prevalence and Diagnostic Classification / Noah J. SASSON in Autism Research, 6-2 (April 2013)  

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The Repetitive Behavior Scale-Revised: Independent Validation in Individuals with Autism Spectrum Disorders / Kristen S.L. LAM in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

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