A Retrospective Study of Amitriptyline in Youth with Autism Spectrum Disorders / Irfan BHATTI in Journal of Autism and Developmental Disorders, 43-5 (May 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1017-1027 Titre : A Retrospective Study of Amitriptyline in Youth with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Irfan BHATTI, Auteur ; Andrew THOME, Auteur ; Patricia OXLER SMITH, Auteur ; Galen COOK-WIENS, Auteur ; Hung Wen YEH, Auteur ; Gary R. GAFFNEY, Auteur ; Jessica A. HELLINGS, Auteur Article en page(s) : p.1017-1027 Langues : Anglais (eng) Mots-clés : Amitriptyline  Autism Spectrum Disorders  Hyperactivity  Impulsivity Index. décimale : PER Périodiques Résumé : We performed a retrospective chart review of 50 youths with Autism Spectrum Disorder (ASD), prescribed amitriptyline (AMI) for hyperactivity and impulsivity. Data was systematically extracted from 50 outpatient clinic charts, including AMI treatment duration, dose, trough levels and adverse events. Mean age was 9.4 years (4.6–17.9); 40 were males and 10 females. 30 % had failed atomoxetine and 40 % had failed ?3 ADHD medications. Mean dose was 1.3 ± 0.6 mg/kg/day, mean trough level 114.1 ± 50.5 ng/ml, mean duration 3.4 years. Clinical Global Impressions Scale-Improvement (CGI-I) was ?2 in 60 % of patients at the final visit, and in 82 % of patients for at least 50 % of follow-ups. Cautious use of low dose AMI shows promise for treatment-resistant youth with ASD accompanied by hyperactivity, impulsivity, aggression and self injury. En ligne : http://dx.doi.org/10.1007/s10803-012-1647-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195 [article] A Retrospective Study of Amitriptyline in Youth with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Irfan BHATTI, Auteur ; Andrew THOME, Auteur ; Patricia OXLER SMITH, Auteur ; Galen COOK-WIENS, Auteur ; Hung Wen YEH, Auteur ; Gary R. GAFFNEY, Auteur ; Jessica A. HELLINGS, Auteur . - p.1017-1027. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-5 (May 2013) . - p.1017-1027 Mots-clés : Amitriptyline  Autism Spectrum Disorders  Hyperactivity  Impulsivity Index. décimale : PER Périodiques Résumé : We performed a retrospective chart review of 50 youths with Autism Spectrum Disorder (ASD), prescribed amitriptyline (AMI) for hyperactivity and impulsivity. Data was systematically extracted from 50 outpatient clinic charts, including AMI treatment duration, dose, trough levels and adverse events. Mean age was 9.4 years (4.6–17.9); 40 were males and 10 females. 30 % had failed atomoxetine and 40 % had failed ?3 ADHD medications. Mean dose was 1.3 ± 0.6 mg/kg/day, mean trough level 114.1 ± 50.5 ng/ml, mean duration 3.4 years. Clinical Global Impressions Scale-Improvement (CGI-I) was ?2 in 60 % of patients at the final visit, and in 82 % of patients for at least 50 % of follow-ups. Cautious use of low dose AMI shows promise for treatment-resistant youth with ASD accompanied by hyperactivity, impulsivity, aggression and self injury. En ligne : http://dx.doi.org/10.1007/s10803-012-1647-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=195

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