[article]
| Titre : |
White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Miriam COOPER, Auteur ; Anita THAPAR, Auteur ; Derek K. JONES, Auteur |
| Article en page(s) : |
p.2742-2754 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Diffusion MRI ADHD ASD White matter Tract-based spatial statistics RESTORE |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-014-2131-9 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 |
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2742-2754
[article] White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder [Texte imprimé et/ou numérique] / Miriam COOPER, Auteur ; Anita THAPAR, Auteur ; Derek K. JONES, Auteur . - p.2742-2754. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2742-2754
| Mots-clés : |
Diffusion MRI ADHD ASD White matter Tract-based spatial statistics RESTORE |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-014-2131-9 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 |
|
White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder in Journal of Autism and Developmental Disorders, 44-11 (November 2014)
