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White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder / Miriam COOPER in Journal of Autism and Developmental Disorders, 44-11 (November 2014)
[article]
Titre : White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Miriam COOPER, Auteur ; Anita THAPAR, Auteur ; Derek K. JONES, Auteur Article en page(s) : p.2742-2754 Langues : Anglais (eng) Mots-clés : Diffusion MRI ADHD ASD White matter Tract-based spatial statistics RESTORE Index. décimale : PER Périodiques Résumé : Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD. En ligne : http://dx.doi.org/10.1007/s10803-014-2131-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2742-2754[article] White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder [Texte imprimé et/ou numérique] / Miriam COOPER, Auteur ; Anita THAPAR, Auteur ; Derek K. JONES, Auteur . - p.2742-2754.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2742-2754
Mots-clés : Diffusion MRI ADHD ASD White matter Tract-based spatial statistics RESTORE Index. décimale : PER Périodiques Résumé : Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD. En ligne : http://dx.doi.org/10.1007/s10803-014-2131-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241