Brief Report: CANTAB Performance and Brain Structure in Pediatric Patients with Asperger Syndrome / Liane KAUFMANN in Journal of Autism and Developmental Disorders, 43-6 (June 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-6 (June 2013) . - p.1483-1490 Titre : Brief Report: CANTAB Performance and Brain Structure in Pediatric Patients with Asperger Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Liane KAUFMANN, Auteur ; Sibylle ZOTTER, Auteur ; Silvia PIXNER, Auteur ; Marc STARKE, Auteur ; Edda HABERLANDT, Auteur ; Maria STEINMAYR-GENSLUCKNER, Auteur ; Karl EGGER, Auteur ; Michael SCHOCKE, Auteur ; Elisabeth M. WEISS, Auteur ; Josef MARKSTEINER, Auteur Article en page(s) : p.1483-1490 Langues : Anglais (eng) Mots-clés : Asperger syndrome  Structural brain imaging  Neurocognition  CANTAB  Spatial working memory  Executive functions Index. décimale : PER Périodiques Résumé : By merging neuropsychological (CANTAB/Cambridge Neuropsychological Test Automated Battery) and structural brain imaging data (voxel-based-morphometry) the present study sought to identify the neurocognitive correlates of executive functions in individuals with Asperger syndrome (AS) compared to healthy controls. Results disclosed subtle group differences regarding response speed on only one CANTAB subtest that is thought to tap fronto-executive network functions (SWM/spatial working memory). Across all participants, SWM performance was significantly associated with two brain regions (precentral gyrus white matter, precuneus grey matter), thus suggesting a close link between fronto-executive functions (SWM) and circumscribed fronto-parietal brain structures. Finally, symptom severity (ADOS total score) was best predicted by response speed on a set-shifting task (IES) thought to tap fronto-striatal functions (corrected R2 56 %). En ligne : http://dx.doi.org/10.1007/s10803-012-1686-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=201 [article] Brief Report: CANTAB Performance and Brain Structure in Pediatric Patients with Asperger Syndrome [Texte imprimé et/ou numérique] / Liane KAUFMANN, Auteur ; Sibylle ZOTTER, Auteur ; Silvia PIXNER, Auteur ; Marc STARKE, Auteur ; Edda HABERLANDT, Auteur ; Maria STEINMAYR-GENSLUCKNER, Auteur ; Karl EGGER, Auteur ; Michael SCHOCKE, Auteur ; Elisabeth M. WEISS, Auteur ; Josef MARKSTEINER, Auteur . - p.1483-1490. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-6 (June 2013) . - p.1483-1490 Mots-clés : Asperger syndrome  Structural brain imaging  Neurocognition  CANTAB  Spatial working memory  Executive functions Index. décimale : PER Périodiques Résumé : By merging neuropsychological (CANTAB/Cambridge Neuropsychological Test Automated Battery) and structural brain imaging data (voxel-based-morphometry) the present study sought to identify the neurocognitive correlates of executive functions in individuals with Asperger syndrome (AS) compared to healthy controls. Results disclosed subtle group differences regarding response speed on only one CANTAB subtest that is thought to tap fronto-executive network functions (SWM/spatial working memory). Across all participants, SWM performance was significantly associated with two brain regions (precentral gyrus white matter, precuneus grey matter), thus suggesting a close link between fronto-executive functions (SWM) and circumscribed fronto-parietal brain structures. Finally, symptom severity (ADOS total score) was best predicted by response speed on a set-shifting task (IES) thought to tap fronto-striatal functions (corrected R2 56 %). En ligne : http://dx.doi.org/10.1007/s10803-012-1686-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=201

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