Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm / Alexandra M. URE in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.543-552 Titre : Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm Type de document : texte imprimé Auteurs : Alexandra M. URE, Auteur ; Karli TREYVAUD, Auteur ; Deanne K. THOMPSON, Auteur ; Leona PASCOE, Auteur ; Gehan ROBERTS, Auteur ; Katherine J. LEE, Auteur ; Marc L. SEAL, Auteur ; Elisabeth NORTHAM, Auteur ; Jeanie L. CHEONG, Auteur ; Rod W. HUNT, Auteur ; Terrie E. INDER, Auteur ; Lex W. DOYLE, Auteur ; Peter J. ANDERSON, Auteur Article en page(s) : p.543-552 Langues : Anglais (eng) Mots-clés : preterm birth  brain abnormality  autism spectrum disorder  magnetic resonance imaging  neonatal imaging Index. décimale : PER Périodiques Résumé : Very preterm (VP) survivors are at increased risk of autism spectrum disorder (ASD) compared with term-born children. This study explored whether neonatal magnetic resonance (MR) brain features differed in VP children with and without ASD at 7 years. One hundred and seventy-two VP children (<30 weeks' gestation or <1250 g birth weight) underwent structural brain MR scans at term equivalent age (TEA; 40 weeks' gestation ±2 weeks) and were assessed for ASD at 7 years of age. The presence and severity of white matter, cortical gray matter, deep nuclear gray matter, and cerebellar abnormalities were assessed, and total and regional brain volumes were measured. ASD was diagnosed using a standardized parent report diagnostic interview and confirmed via an independent assessment. Eight VP children (4.7%) were diagnosed with ASD. Children with ASD had more cystic lesions in the cortical white matter at TEA compared with those without ASD (odds ratio [OR] 8.7, 95% confidence interval [CI] 1.5, 51.3, P = 0.02). There was also some evidence for smaller cerebellar volumes in children with ASD compared with those without ASD (OR = 0.82, CI = 0.66, 1.00, P = 0.06). Overall, the results suggest that VP children with ASD have different brain structure in the neonatal period compared with those who do not have ASD. En ligne : http://dx.doi.org/10.1002/aur.1558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm [texte imprimé] / Alexandra M. URE, Auteur ; Karli TREYVAUD, Auteur ; Deanne K. THOMPSON, Auteur ; Leona PASCOE, Auteur ; Gehan ROBERTS, Auteur ; Katherine J. LEE, Auteur ; Marc L. SEAL, Auteur ; Elisabeth NORTHAM, Auteur ; Jeanie L. CHEONG, Auteur ; Rod W. HUNT, Auteur ; Terrie E. INDER, Auteur ; Lex W. DOYLE, Auteur ; Peter J. ANDERSON, Auteur . - p.543-552. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.543-552 Mots-clés : preterm birth  brain abnormality  autism spectrum disorder  magnetic resonance imaging  neonatal imaging Index. décimale : PER Périodiques Résumé : Very preterm (VP) survivors are at increased risk of autism spectrum disorder (ASD) compared with term-born children. This study explored whether neonatal magnetic resonance (MR) brain features differed in VP children with and without ASD at 7 years. One hundred and seventy-two VP children (<30 weeks' gestation or <1250 g birth weight) underwent structural brain MR scans at term equivalent age (TEA; 40 weeks' gestation ±2 weeks) and were assessed for ASD at 7 years of age. The presence and severity of white matter, cortical gray matter, deep nuclear gray matter, and cerebellar abnormalities were assessed, and total and regional brain volumes were measured. ASD was diagnosed using a standardized parent report diagnostic interview and confirmed via an independent assessment. Eight VP children (4.7%) were diagnosed with ASD. Children with ASD had more cystic lesions in the cortical white matter at TEA compared with those without ASD (odds ratio [OR] 8.7, 95% confidence interval [CI] 1.5, 51.3, P = 0.02). There was also some evidence for smaller cerebellar volumes in children with ASD compared with those without ASD (OR = 0.82, CI = 0.66, 1.00, P = 0.06). Overall, the results suggest that VP children with ASD have different brain structure in the neonatal period compared with those who do not have ASD. En ligne : http://dx.doi.org/10.1002/aur.1558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Parenting behavior at 2 years predicts school-age performance at 7 years in very preterm children / Karli TREYVAUD in Journal of Child Psychology and Psychiatry, 57-7 (July 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.814-821 Titre : Parenting behavior at 2 years predicts school-age performance at 7 years in very preterm children Type de document : texte imprimé Auteurs : Karli TREYVAUD, Auteur ; Lex W. DOYLE, Auteur ; Katherine J. LEE, Auteur ; Alexandra URE, Auteur ; Terrie E. INDER, Auteur ; Rod W. HUNT, Auteur ; Peter J. ANDERSON, Auteur Article en page(s) : p.814-821 Langues : Anglais (eng) Mots-clés : Preterm  child development  parent–child relationship  outcomes Index. décimale : PER Périodiques Résumé : Background Parenting influences child development, but it is unclear whether early parenting behavior can influence school-age outcomes in very preterm (VPT) children, and/or if certain groups of VPT children may be more affected by early parenting behavior. These research questions were examined. Methods Participants were 147 children born <30 weeks’ gestation or birth weight <1250 g and their primary caregiver. At term corrected age (CA), magnetic resonance imaging (MRI) was used to determine presence and severity of brain abnormality and medical data collected. High medical risk was defined as the presence of at least one of sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, moderate to severe white matter abnormality on MRI, or postnatal corticosteroids. At 2 years CA, parent–child interaction was assessed, and at 7 years CA, general intelligence (IQ), language, executive function, academic skills, and social-emotional functioning were assessed. Results Higher levels of parent–child synchrony, and parent facilitation, sensitivity and positive affect at 2 years were associated with better child outcomes at 7 years, while higher levels of intrusiveness and negative affect were associated with poorer outcomes. Many of these relationships remained after controlling for early child cognitive development. Interactions between child medical risk (higher/lower) and parenting were limited to child reading, math, and executive functioning outcomes, with stronger relationships for lower medical risk children. Conclusions The contribution of early parenting to VPT children's school-age performance is significant, with stronger effects for lower medical risk children in some outcomes. These findings support the premise that parenting strategies should be included in the NICU and early interventions programs for VPT infants. En ligne : http://dx.doi.org/10.1111/jcpp.12489 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Parenting behavior at 2 years predicts school-age performance at 7 years in very preterm children [texte imprimé] / Karli TREYVAUD, Auteur ; Lex W. DOYLE, Auteur ; Katherine J. LEE, Auteur ; Alexandra URE, Auteur ; Terrie E. INDER, Auteur ; Rod W. HUNT, Auteur ; Peter J. ANDERSON, Auteur . - p.814-821. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.814-821 Mots-clés : Preterm  child development  parent–child relationship  outcomes Index. décimale : PER Périodiques Résumé : Background Parenting influences child development, but it is unclear whether early parenting behavior can influence school-age outcomes in very preterm (VPT) children, and/or if certain groups of VPT children may be more affected by early parenting behavior. These research questions were examined. Methods Participants were 147 children born <30 weeks’ gestation or birth weight <1250 g and their primary caregiver. At term corrected age (CA), magnetic resonance imaging (MRI) was used to determine presence and severity of brain abnormality and medical data collected. High medical risk was defined as the presence of at least one of sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, moderate to severe white matter abnormality on MRI, or postnatal corticosteroids. At 2 years CA, parent–child interaction was assessed, and at 7 years CA, general intelligence (IQ), language, executive function, academic skills, and social-emotional functioning were assessed. Results Higher levels of parent–child synchrony, and parent facilitation, sensitivity and positive affect at 2 years were associated with better child outcomes at 7 years, while higher levels of intrusiveness and negative affect were associated with poorer outcomes. Many of these relationships remained after controlling for early child cognitive development. Interactions between child medical risk (higher/lower) and parenting were limited to child reading, math, and executive functioning outcomes, with stronger relationships for lower medical risk children. Conclusions The contribution of early parenting to VPT children's school-age performance is significant, with stronger effects for lower medical risk children in some outcomes. These findings support the premise that parenting strategies should be included in the NICU and early interventions programs for VPT infants. En ligne : http://dx.doi.org/10.1111/jcpp.12489 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Parenting satisfaction and broader autism phenotype associated with depression, anxiety and stress in caregivers of infants showing early autistic features / Erin O’CONNOR in Research in Autism, 132 (April 2026)  

Public ISBD [article]  inResearch in Autism > 132 (April 2026) . - 202870 Titre : Parenting satisfaction and broader autism phenotype associated with depression, anxiety and stress in caregivers of infants showing early autistic features Type de document : texte imprimé Auteurs : Erin O’CONNOR, Auteur ; Karli TREYVAUD, Auteur ; Cherie C. GREEN, Auteur ; Josephine BARBARO, Auteur ; Murray MAYBERY, Auteur ; Kandice J. VARCIN, Auteur ; Ming Wai WAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur Article en page(s) : 202870 Langues : Anglais (eng) Mots-clés : Caregivers  Supports  Mental health  Parenting  Autism Résumé : While parenting self-efficacy and broader autism phenotype (BAP) have been linked to caregiver depression, anxiety and stress at specific points in time, their influence on longer-term mental health trajectories remains unknown, especially for caregivers who participate in support programs for their infants with very-early autistic features. Through secondary analysis of a longitudinal randomized control trial dataset, using latent growth curve analysis we explored the pattern and personal predictors of caregiver depression, anxiety and stress trajectories over a two-year period in a sample of 100 families of infants with early autistic features (when aged 12 months to 3 years) where families had been randomized to receive a parent-mediated support program or community care as usual. While caregivers were estimated to have stable, low-level depression, anxiety and stress on average, for some individuals, stable and high levels of these were associated with low parenting satisfaction, and higher BAP traits of pragmatic language difficulties and rigidity. There was no evidence that participation in the caregiver-mediated support program had predicted caregiver mental health outcomes. Caregivers of infants with early autism features who themselves present with early, sustained mental health symptoms may benefit from additional specific mental health support. En ligne : https://doi.org/10.1016/j.reia.2026.202870 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Parenting satisfaction and broader autism phenotype associated with depression, anxiety and stress in caregivers of infants showing early autistic features [texte imprimé] / Erin O’CONNOR, Auteur ; Karli TREYVAUD, Auteur ; Cherie C. GREEN, Auteur ; Josephine BARBARO, Auteur ; Murray MAYBERY, Auteur ; Kandice J. VARCIN, Auteur ; Ming Wai WAN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur . - 202870. Langues : Anglais (eng) in Research in Autism > 132 (April 2026) . - 202870 Mots-clés : Caregivers  Supports  Mental health  Parenting  Autism Résumé : While parenting self-efficacy and broader autism phenotype (BAP) have been linked to caregiver depression, anxiety and stress at specific points in time, their influence on longer-term mental health trajectories remains unknown, especially for caregivers who participate in support programs for their infants with very-early autistic features. Through secondary analysis of a longitudinal randomized control trial dataset, using latent growth curve analysis we explored the pattern and personal predictors of caregiver depression, anxiety and stress trajectories over a two-year period in a sample of 100 families of infants with early autistic features (when aged 12 months to 3 years) where families had been randomized to receive a parent-mediated support program or community care as usual. While caregivers were estimated to have stable, low-level depression, anxiety and stress on average, for some individuals, stable and high levels of these were associated with low parenting satisfaction, and higher BAP traits of pragmatic language difficulties and rigidity. There was no evidence that participation in the caregiver-mediated support program had predicted caregiver mental health outcomes. Caregivers of infants with early autism features who themselves present with early, sustained mental health symptoms may benefit from additional specific mental health support. En ligne : https://doi.org/10.1016/j.reia.2026.202870 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Prospective Association of Parenting Stress with Later Child Behavior Problems in Early Childhood Autism / Megan GRANT ; Cherie C. GREEN ; Karli TREYVAUD ; Kristelle HUDRY in Journal of Autism and Developmental Disorders, 55-6 (June 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.2021-2026 Titre : Prospective Association of Parenting Stress with Later Child Behavior Problems in Early Childhood Autism Type de document : texte imprimé Auteurs : Megan GRANT, Auteur ; Cherie C. GREEN, Auteur ; Karli TREYVAUD, Auteur ; Kristelle HUDRY, Auteur Article en page(s) : p.2021-2026 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autistic children are reported to display higher levels of externalizing and internalizing behaviors than neurotypical children, and their parents report more stress than parents of neurotypical children. It is unclear whether child behavior difficulties contribute to increased parenting stress, whether parenting stress contributes to child behavior difficulties, or whether the relationship may be bidirectional. En ligne : https://doi.org/10.1007/s10803-023-06177-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Prospective Association of Parenting Stress with Later Child Behavior Problems in Early Childhood Autism [texte imprimé] / Megan GRANT, Auteur ; Cherie C. GREEN, Auteur ; Karli TREYVAUD, Auteur ; Kristelle HUDRY, Auteur . - p.2021-2026. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.2021-2026 Index. décimale : PER Périodiques Résumé : Autistic children are reported to display higher levels of externalizing and internalizing behaviors than neurotypical children, and their parents report more stress than parents of neurotypical children. It is unclear whether child behavior difficulties contribute to increased parenting stress, whether parenting stress contributes to child behavior difficulties, or whether the relationship may be bidirectional. En ligne : https://doi.org/10.1007/s10803-023-06177-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

Psychiatric outcomes at age seven for very preterm children: rates and predictors / Karli TREYVAUD in Journal of Child Psychology and Psychiatry, 54-7 (July 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-7 (July 2013) . - p.772-779 Titre : Psychiatric outcomes at age seven for very preterm children: rates and predictors Type de document : texte imprimé Auteurs : Karli TREYVAUD, Auteur ; Alexandra URE, Auteur ; Lex W. DOYLE, Auteur ; Katherine J. LEE, Auteur ; Cynthia E. ROGERS, Auteur ; Hiroyuki KIDOKORO, Auteur ; Terrie E. INDER, Auteur ; Peter J. ANDERSON, Auteur Article en page(s) : p.772-779 Langues : Anglais (eng) Mots-clés : Preterm  psychiatric disorder  brain abnormality  predictor  mental health Index. décimale : PER Périodiques Résumé : Background: Uncertainty remains about the rate of specific psychiatric disorders and associated predictive factors for very preterm (VPT) children. The aims of this study were to document rates of psychiatric disorders in VPT children aged 7 years compared with term born children, and to examine potential predictive factors for psychiatric diagnoses in VPT children. Methods: Participants were 177 VPT and 65 term born children. Perinatal medical data were collected, which included brain abnormalities detected using magnetic resonance imaging. The Infant-Toddler Social-Emotional Assessment (ITSEA) and Strengths and Difficulties Questionnaire (SDQ) were administered at 2 and 5 years respectively. At 7 years of age, the Developmental and Well-being Assessment (DAWBA) was used to indicate psychiatric diagnoses. Results: Compared with term born children, VPT children had three times the odds of meeting criteria for any psychiatric diagnosis at age 7 years (odds ratio 3.03; 95% confidence interval 1.23, 7.47, p = .02). The most common diagnoses were anxiety disorders (11% VPT, 8% term), attention-deficit/hyperactivity disorder (10% VPT, 3% term) and autism spectrum disorder (4.5% VPT, 0% term). For VPT children, those with severe global brain abnormalities (p = .02), those who displayed social-emotional problems at age 5 (p = .000) and those with higher social risk at age 7 (p = .001) were more likely to meet criteria for a psychiatric illness at age 7. Conclusions: Compared with term born children, VPT children have higher rates of psychiatric diagnoses at early school age, predicted by neonatal brain abnormalities, prior social-emotional problems and social factors. En ligne : http://dx.doi.org/10.1111/jcpp.12040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=203 [article] Psychiatric outcomes at age seven for very preterm children: rates and predictors [texte imprimé] / Karli TREYVAUD, Auteur ; Alexandra URE, Auteur ; Lex W. DOYLE, Auteur ; Katherine J. LEE, Auteur ; Cynthia E. ROGERS, Auteur ; Hiroyuki KIDOKORO, Auteur ; Terrie E. INDER, Auteur ; Peter J. ANDERSON, Auteur . - p.772-779. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-7 (July 2013) . - p.772-779 Mots-clés : Preterm  psychiatric disorder  brain abnormality  predictor  mental health Index. décimale : PER Périodiques Résumé : Background: Uncertainty remains about the rate of specific psychiatric disorders and associated predictive factors for very preterm (VPT) children. The aims of this study were to document rates of psychiatric disorders in VPT children aged 7 years compared with term born children, and to examine potential predictive factors for psychiatric diagnoses in VPT children. Methods: Participants were 177 VPT and 65 term born children. Perinatal medical data were collected, which included brain abnormalities detected using magnetic resonance imaging. The Infant-Toddler Social-Emotional Assessment (ITSEA) and Strengths and Difficulties Questionnaire (SDQ) were administered at 2 and 5 years respectively. At 7 years of age, the Developmental and Well-being Assessment (DAWBA) was used to indicate psychiatric diagnoses. Results: Compared with term born children, VPT children had three times the odds of meeting criteria for any psychiatric diagnosis at age 7 years (odds ratio 3.03; 95% confidence interval 1.23, 7.47, p = .02). The most common diagnoses were anxiety disorders (11% VPT, 8% term), attention-deficit/hyperactivity disorder (10% VPT, 3% term) and autism spectrum disorder (4.5% VPT, 0% term). For VPT children, those with severe global brain abnormalities (p = .02), those who displayed social-emotional problems at age 5 (p = .000) and those with higher social risk at age 7 (p = .001) were more likely to meet criteria for a psychiatric illness at age 7. Conclusions: Compared with term born children, VPT children have higher rates of psychiatric diagnoses at early school age, predicted by neonatal brain abnormalities, prior social-emotional problems and social factors. En ligne : http://dx.doi.org/10.1111/jcpp.12040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=203

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