Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits / Minyoung JUNG in Molecular Autism, (June 2014)  

Public ISBD [article]  inMolecular Autism > (June 2014) . - p.1-11 Titre : Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits Type de document : Texte imprimé et/ou numérique Auteurs : Minyoung JUNG, Auteur ; Hirotaka KOSAKA, Auteur ; Daisuke N. SAITO, Auteur ; Makoto ISHITOBI, Auteur ; Tomoyo MORITA, Auteur ; Keisuke INOHARA, Auteur ; Mizuki ASANO, Auteur ; Sumiyoshi ARAI, Auteur ; Toshio MUNESUE, Auteur ; Akemi TOMODA, Auteur ; Yuji WADA, Auteur ; Norihiro SADATO, Auteur ; Hidehiko OKAZAWA, Auteur ; Tetsuya IIDAKA, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development (TD). Social cognition properties that are deeply associated with autism spectrum traits have been linked to functional connectivity between regions within the brain’s default mode network (DMN). Previous studies have shown that the resting-state functional connectivities (rs-FCs) of DMN are low and show negative correlation with the level of autism spectrum traits in individuals with autism spectrum disorder (ASD). However, it is unclear whether individual differences of autism spectrum traits are associated with the strength of rs-FCs of DMN in participants including the general population. En ligne : http://dx.doi.org/10.1186/2040-2392-5-35 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits [Texte imprimé et/ou numérique] / Minyoung JUNG, Auteur ; Hirotaka KOSAKA, Auteur ; Daisuke N. SAITO, Auteur ; Makoto ISHITOBI, Auteur ; Tomoyo MORITA, Auteur ; Keisuke INOHARA, Auteur ; Mizuki ASANO, Auteur ; Sumiyoshi ARAI, Auteur ; Toshio MUNESUE, Auteur ; Akemi TOMODA, Auteur ; Yuji WADA, Auteur ; Norihiro SADATO, Auteur ; Hidehiko OKAZAWA, Auteur ; Tetsuya IIDAKA, Auteur . - p.1-11. Langues : Anglais (eng) in Molecular Autism > (June 2014) . - p.1-11 Index. décimale : PER Périodiques Résumé : Autism spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development (TD). Social cognition properties that are deeply associated with autism spectrum traits have been linked to functional connectivity between regions within the brain’s default mode network (DMN). Previous studies have shown that the resting-state functional connectivities (rs-FCs) of DMN are low and show negative correlation with the level of autism spectrum traits in individuals with autism spectrum disorder (ASD). However, it is unclear whether individual differences of autism spectrum traits are associated with the strength of rs-FCs of DMN in participants including the general population. En ligne : http://dx.doi.org/10.1186/2040-2392-5-35 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

Episodic memory retrieval for story characters in high-functioning autism / Hidetsugu KOMEDA in Molecular Autism, (June 2013)  

Public ISBD [article]  inMolecular Autism > (June 2013) . - 9 p. Titre : Episodic memory retrieval for story characters in high-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Hidetsugu KOMEDA, Auteur ; Hirotaka KOSAKA, Auteur ; Daisuke N. SAITO, Auteur ; Keisuke INOHARA, Auteur ; Toshio MUNESUE, Auteur ; Makoto ISHITOBI, Auteur ; Makoto SATO, Auteur ; Hidehiko OKAZAWA, Auteur Année de publication : 2013 Article en page(s) : 9 p. Langues : Anglais (eng) Mots-clés : High-functioning autism  Narrative comprehension  Recognition  Memory retrieval  Similarity Index. décimale : PER Périodiques Résumé : Background The objective of this study was to examine differences in episodic memory retrieval between individuals with autism spectrum disorder (ASD) and typically developing (TD) individuals. Previous studies have shown that personality similarities between readers and characters facilitated reading comprehension. Highly extraverted participants read stories featuring extraverted protagonists more easily and judged the outcomes of such stories more rapidly than did less extraverted participants. Similarly, highly neurotic participants judged the outcomes of stories with neurotic protagonists more rapidly than did participants with low levels of neuroticism. However, the impact of the similarity effect on memory retrieval remains unclear. This study tested our ‘similarity hypothesis’, namely that memory retrieval is enhanced when readers with ASD and TD readers read stories featuring protagonists with ASD and with characteristics associated with TD individuals, respectively. Methods Eighteen Japanese individuals (one female) with high-functioning ASD (aged 17 to 40 years) and 17 age- and intelligence quotient (IQ)-matched Japanese (one female) TD participants (aged 22 to 40 years) read 24 stories; 12 stories featured protagonists with ASD characteristics, and the other 12 featured TD protagonists. Participants read a single sentence at a time and pressed a spacebar to advance to the next sentence. After reading all 24 stories, they were asked to complete a recognition task about the target sentence in each story. Results To investigate episodic memory in ASD, we analyzed encoding based on the reading times for and readability of the stories and retrieval processes based on the accuracy of and response times for sentence recognition. Although the results showed no differences between ASD and TD groups in encoding processes, they did reveal inter-group differences in memory retrieval. Although individuals with ASD demonstrated the same level of accuracy as did TD individuals, their patterns of memory retrieval differed with respect to response times. Conclusions Individuals with ASD more effectively retrieved ASD-congruent than ASD-incongruent sentences, and TD individuals retrieved stories with TD more effectively than stories with ASD protagonists. Thus, similarity between reader and story character had different effects on memory retrieval in the ASD and TD groups. En ligne : http://dx.doi.org/10.1186/2040-2392-4-20 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Episodic memory retrieval for story characters in high-functioning autism [Texte imprimé et/ou numérique] / Hidetsugu KOMEDA, Auteur ; Hirotaka KOSAKA, Auteur ; Daisuke N. SAITO, Auteur ; Keisuke INOHARA, Auteur ; Toshio MUNESUE, Auteur ; Makoto ISHITOBI, Auteur ; Makoto SATO, Auteur ; Hidehiko OKAZAWA, Auteur . - 2013 . - 9 p. Langues : Anglais (eng) in Molecular Autism > (June 2013) . - 9 p. Mots-clés : High-functioning autism  Narrative comprehension  Recognition  Memory retrieval  Similarity Index. décimale : PER Périodiques Résumé : Background The objective of this study was to examine differences in episodic memory retrieval between individuals with autism spectrum disorder (ASD) and typically developing (TD) individuals. Previous studies have shown that personality similarities between readers and characters facilitated reading comprehension. Highly extraverted participants read stories featuring extraverted protagonists more easily and judged the outcomes of such stories more rapidly than did less extraverted participants. Similarly, highly neurotic participants judged the outcomes of stories with neurotic protagonists more rapidly than did participants with low levels of neuroticism. However, the impact of the similarity effect on memory retrieval remains unclear. This study tested our ‘similarity hypothesis’, namely that memory retrieval is enhanced when readers with ASD and TD readers read stories featuring protagonists with ASD and with characteristics associated with TD individuals, respectively. Methods Eighteen Japanese individuals (one female) with high-functioning ASD (aged 17 to 40 years) and 17 age- and intelligence quotient (IQ)-matched Japanese (one female) TD participants (aged 22 to 40 years) read 24 stories; 12 stories featured protagonists with ASD characteristics, and the other 12 featured TD protagonists. Participants read a single sentence at a time and pressed a spacebar to advance to the next sentence. After reading all 24 stories, they were asked to complete a recognition task about the target sentence in each story. Results To investigate episodic memory in ASD, we analyzed encoding based on the reading times for and readability of the stories and retrieval processes based on the accuracy of and response times for sentence recognition. Although the results showed no differences between ASD and TD groups in encoding processes, they did reveal inter-group differences in memory retrieval. Although individuals with ASD demonstrated the same level of accuracy as did TD individuals, their patterns of memory retrieval differed with respect to response times. Conclusions Individuals with ASD more effectively retrieved ASD-congruent than ASD-incongruent sentences, and TD individuals retrieved stories with TD more effectively than stories with ASD protagonists. Thus, similarity between reader and story character had different effects on memory retrieval in the ASD and TD groups. En ligne : http://dx.doi.org/10.1186/2040-2392-4-20 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

Neural correlates of emotion processing during observed self-face recognition in individuals with autism spectrum disorders / Tomoyo MORITA in Research in Autism Spectrum Disorders, 26 (June 2016)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 26 (June 2016) . - p.16-32 Titre : Neural correlates of emotion processing during observed self-face recognition in individuals with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Tomoyo MORITA, Auteur ; Hirotaka KOSAKA, Auteur ; Daisuke N. SAITO, Auteur ; Takeshi FUJII, Auteur ; Makoto ISHITOBI, Auteur ; Toshio MUNESUE, Auteur ; Keisuke INOHARA, Auteur ; Hidehiko OKAZAWA, Auteur ; Ryusuke KAKIGI, Auteur ; Norihiro SADATO, Auteur Article en page(s) : p.16-32 Langues : Anglais (eng) Mots-clés : Anterior cingulate cortex  Anterior insula  Autism spectrum disorder (ASD)  Being observed  Embarrassment  Functional magnetic resonance imaging  Self-face Index. décimale : PER Périodiques Résumé : When exposed to self-face images, individuals often experience embarrassment, which is enhanced by being observed. This self-evaluative emotion is related to activity in the right anterior insula and the functional connectivity between the anterior cingulate and prefrontal cortices. Coupling between cognitive evaluation of self-face images and emotional response to them (cognitive–emotional coupling) is weaker in individuals with autism spectrum disorder (ASD), in parallel with reduced activity of the right insula. To determine whether self-evaluative emotions of individuals with ASD are less strongly impacted by observation, we conducted functional MRI in 14 adult men with ASD and 18 age-matched control men while the participants viewed self-face images. Increased embarrassment upon observation was positively correlated with increased activity in the right anterior insula in the control group, but not in the ASD group. In addition, awareness of being observed enhanced cognitive–emotional coupling in the controls but not in the ASD group. The coupling was correlated with the functional connectivity between the anterior cingulate and medial prefrontal cortices. These results suggest that the reduced impact of observation on embarrassment induced by self-face images in individuals with ASD is related to impairment in the right anterior insula, which is involved in creating subjective feelings, and the anterior cingulate cortex, which acts as a hub for integrating information from others during self-face evaluation. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] Neural correlates of emotion processing during observed self-face recognition in individuals with autism spectrum disorders [Texte imprimé et/ou numérique] / Tomoyo MORITA, Auteur ; Hirotaka KOSAKA, Auteur ; Daisuke N. SAITO, Auteur ; Takeshi FUJII, Auteur ; Makoto ISHITOBI, Auteur ; Toshio MUNESUE, Auteur ; Keisuke INOHARA, Auteur ; Hidehiko OKAZAWA, Auteur ; Ryusuke KAKIGI, Auteur ; Norihiro SADATO, Auteur . - p.16-32. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 26 (June 2016) . - p.16-32 Mots-clés : Anterior cingulate cortex  Anterior insula  Autism spectrum disorder (ASD)  Being observed  Embarrassment  Functional magnetic resonance imaging  Self-face Index. décimale : PER Périodiques Résumé : When exposed to self-face images, individuals often experience embarrassment, which is enhanced by being observed. This self-evaluative emotion is related to activity in the right anterior insula and the functional connectivity between the anterior cingulate and prefrontal cortices. Coupling between cognitive evaluation of self-face images and emotional response to them (cognitive–emotional coupling) is weaker in individuals with autism spectrum disorder (ASD), in parallel with reduced activity of the right insula. To determine whether self-evaluative emotions of individuals with ASD are less strongly impacted by observation, we conducted functional MRI in 14 adult men with ASD and 18 age-matched control men while the participants viewed self-face images. Increased embarrassment upon observation was positively correlated with increased activity in the right anterior insula in the control group, but not in the ASD group. In addition, awareness of being observed enhanced cognitive–emotional coupling in the controls but not in the ASD group. The coupling was correlated with the functional connectivity between the anterior cingulate and medial prefrontal cortices. These results suggest that the reduced impact of observation on embarrassment induced by self-face images in individuals with ASD is related to impairment in the right anterior insula, which is involved in creating subjective feelings, and the anterior cingulate cortex, which acts as a hub for integrating information from others during self-face evaluation. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders / Yasuhiro MASUYA in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-10 Titre : Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Yasuhiro MASUYA, Auteur ; Yuko OKAMOTO, Auteur ; Keisuke INOHARA, Auteur ; Yukiko MATSUMURA, Auteur ; Toru FUJIOKA, Auteur ; Yuji WADA, Auteur ; Hirotaka KOSAKA, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The prevalence of autism spectrum disorders (ASDs) is higher in men than in women. The extreme male brain theory proposes that excessive prenatal testosterone activity could be a risk factor for ASDs. However, it is unclear whether prenatal sex hormone activity is a risk factor for women. The ratio of the length of the second to fourth digits (2D:4D) is considered to be a biomarker of the prenatal ratio of testosterone to estrogen. Therefore, this study compared the 2D:4D ratios of women with and without ASDs to determine if prenatal sex hormone activity could be a risk factor for ASDs in women. En ligne : http://dx.doi.org/10.1186/s13229-015-0028-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders [Texte imprimé et/ou numérique] / Yasuhiro MASUYA, Auteur ; Yuko OKAMOTO, Auteur ; Keisuke INOHARA, Auteur ; Yukiko MATSUMURA, Auteur ; Toru FUJIOKA, Auteur ; Yuji WADA, Auteur ; Hirotaka KOSAKA, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-10 Index. décimale : PER Périodiques Résumé : The prevalence of autism spectrum disorders (ASDs) is higher in men than in women. The extreme male brain theory proposes that excessive prenatal testosterone activity could be a risk factor for ASDs. However, it is unclear whether prenatal sex hormone activity is a risk factor for women. The ratio of the length of the second to fourth digits (2D:4D) is considered to be a biomarker of the prenatal ratio of testosterone to estrogen. Therefore, this study compared the 2D:4D ratios of women with and without ASDs to determine if prenatal sex hormone activity could be a risk factor for ASDs in women. En ligne : http://dx.doi.org/10.1186/s13229-015-0028-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

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