Atypical mismatch negativity to distressful voices associated with conduct disorder symptoms / An-Yi HUNG in Journal of Child Psychology and Psychiatry, 54-9 (September 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-9 (September 2013) . - p.1016-1027 Titre : Atypical mismatch negativity to distressful voices associated with conduct disorder symptoms Type de document : Texte imprimé et/ou numérique Auteurs : An-Yi HUNG, Auteur ; Jyrki AHVENINEN, Auteur ; Yawei CHENG, Auteur Article en page(s) : p.1016-1027 Langues : Anglais (eng) Mots-clés : Conduct disorder (CD)  distressful voices  impulsivity  juvenile delinquents  mismatch negativity (MMN) Index. décimale : PER Périodiques Résumé : Background Although a general consensus holds that emotional reactivity in youth with conduct disorder (CD) symptoms arises as one of the main causes of successive aggression, it remains to be determined whether automatic emotional processing is altered in this population. Methods We measured auditory event-related potentials (ERP) in 20 young offenders and 20 controls, screened for DSM-IV criteria of CD and evaluated using the youth version of Hare Psychopathy Checklist (PCL:YV), State-Trait Anxiety Inventory (STAI) and Barrett Impulsiveness Scale (BIS-11). In an oddball design, sadly or fearfully spoken ‘deviant’ syllables were randomly presented within a train of emotionally neutral ‘standard’ syllables. Results In young offenders meeting with CD criteria, the ERP component mismatch negativity (MMN), presumed to reflect preattentive auditory change detection, was significantly stronger for fearful than sad syllables. No MMN differences for fearful versus sad syllables were observed in controls. Analyses of nonvocal deviants, matched spectrally with the fearful and sad sounds, supported our interpretation that the MMN abnormalities in juvenile offenders were related to the emotional content of sounds, instead of purely acoustic factors. Further, in the young offenders with CD symptoms, strong MMN amplitudes to fearful syllables were associated with high impulsive tendencies (PCL:YV, Factor 2). Higher trait and state anxiety, assessed by STAI, were positively correlated with P3a amplitudes to fearful and sad syllables, respectively. The differences in group-interaction MMN/P3a patterns to emotional syllables and nonvocal sounds could be speculated to suggest that there is a distinct processing route for preattentive processing of species-specific emotional information in human auditory cortices. Conclusions Our results suggest that youths with CD symptoms may process distressful voices in an atypical fashion already at the preattentive level. This auditory processing abnormality correlated with increased impulsivity and anxiety. Our results may help to shed light on the neural mechanisms of aggression. En ligne : http://dx.doi.org/10.1111/jcpp.12076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Atypical mismatch negativity to distressful voices associated with conduct disorder symptoms [Texte imprimé et/ou numérique] / An-Yi HUNG, Auteur ; Jyrki AHVENINEN, Auteur ; Yawei CHENG, Auteur . - p.1016-1027. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-9 (September 2013) . - p.1016-1027 Mots-clés : Conduct disorder (CD)  distressful voices  impulsivity  juvenile delinquents  mismatch negativity (MMN) Index. décimale : PER Périodiques Résumé : Background Although a general consensus holds that emotional reactivity in youth with conduct disorder (CD) symptoms arises as one of the main causes of successive aggression, it remains to be determined whether automatic emotional processing is altered in this population. Methods We measured auditory event-related potentials (ERP) in 20 young offenders and 20 controls, screened for DSM-IV criteria of CD and evaluated using the youth version of Hare Psychopathy Checklist (PCL:YV), State-Trait Anxiety Inventory (STAI) and Barrett Impulsiveness Scale (BIS-11). In an oddball design, sadly or fearfully spoken ‘deviant’ syllables were randomly presented within a train of emotionally neutral ‘standard’ syllables. Results In young offenders meeting with CD criteria, the ERP component mismatch negativity (MMN), presumed to reflect preattentive auditory change detection, was significantly stronger for fearful than sad syllables. No MMN differences for fearful versus sad syllables were observed in controls. Analyses of nonvocal deviants, matched spectrally with the fearful and sad sounds, supported our interpretation that the MMN abnormalities in juvenile offenders were related to the emotional content of sounds, instead of purely acoustic factors. Further, in the young offenders with CD symptoms, strong MMN amplitudes to fearful syllables were associated with high impulsive tendencies (PCL:YV, Factor 2). Higher trait and state anxiety, assessed by STAI, were positively correlated with P3a amplitudes to fearful and sad syllables, respectively. The differences in group-interaction MMN/P3a patterns to emotional syllables and nonvocal sounds could be speculated to suggest that there is a distinct processing route for preattentive processing of species-specific emotional information in human auditory cortices. Conclusions Our results suggest that youths with CD symptoms may process distressful voices in an atypical fashion already at the preattentive level. This auditory processing abnormality correlated with increased impulsivity and anxiety. Our results may help to shed light on the neural mechanisms of aggression. En ligne : http://dx.doi.org/10.1111/jcpp.12076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces / F. MAMASHLI in Autism Research, 14-6 (June 2021)  

Public ISBD [article]  inAutism Research > 14-6 (June 2021) . - p.1101-1114 Titre : Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces Type de document : Texte imprimé et/ou numérique Auteurs : F. MAMASHLI, Auteur ; N. KOZHEMIAKO, Auteur ; S. KHAN, Auteur ; A. S. NUNES, Auteur ; N. M. MCGUIGGAN, Auteur ; A. LOSH, Auteur ; R. M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; S. M. DOESBURG, Auteur ; M. S. HÄMÄLÄINEN, Auteur ; T. KENET, Auteur Article en page(s) : p.1101-1114 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18?years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces [Texte imprimé et/ou numérique] / F. MAMASHLI, Auteur ; N. KOZHEMIAKO, Auteur ; S. KHAN, Auteur ; A. S. NUNES, Auteur ; N. M. MCGUIGGAN, Auteur ; A. LOSH, Auteur ; R. M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; S. M. DOESBURG, Auteur ; M. S. HÄMÄLÄINEN, Auteur ; T. KENET, Auteur . - p.1101-1114. Langues : Anglais (eng) in Autism Research > 14-6 (June 2021) . - p.1101-1114 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18?years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

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