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Auteur A. LOSH |
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Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces / F. MAMASHLI in Autism Research, 14-6 (June 2021)
[article]
Titre : Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces Type de document : Texte imprimé et/ou numérique Auteurs : F. MAMASHLI, Auteur ; N. KOZHEMIAKO, Auteur ; S. KHAN, Auteur ; A. S. NUNES, Auteur ; N. M. MCGUIGGAN, Auteur ; A. LOSH, Auteur ; R. M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; S. M. DOESBURG, Auteur ; M. S. HÄMÄLÄINEN, Auteur ; T. KENET, Auteur Article en page(s) : p.1101-1114 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/diagnostic imaging Child Gamma Rhythm Humans Magnetic Resonance Imaging Magnetoencephalography Prefrontal Cortex autism spectrum disorder functional connectivity inverted faces phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18?years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-6 (June 2021) . - p.1101-1114[article] Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces [Texte imprimé et/ou numérique] / F. MAMASHLI, Auteur ; N. KOZHEMIAKO, Auteur ; S. KHAN, Auteur ; A. S. NUNES, Auteur ; N. M. MCGUIGGAN, Auteur ; A. LOSH, Auteur ; R. M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; S. M. DOESBURG, Auteur ; M. S. HÄMÄLÄINEN, Auteur ; T. KENET, Auteur . - p.1101-1114.
Langues : Anglais (eng)
in Autism Research > 14-6 (June 2021) . - p.1101-1114
Mots-clés : Adolescent Autism Spectrum Disorder/diagnostic imaging Child Gamma Rhythm Humans Magnetic Resonance Imaging Magnetoencephalography Prefrontal Cortex autism spectrum disorder functional connectivity inverted faces phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18?years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Parenting Behaviors as Predictive of Early Student-Teacher Relationships in ASD / A. LOSH in Journal of Autism and Developmental Disorders, 49-9 (September 2019)
[article]
Titre : Parenting Behaviors as Predictive of Early Student-Teacher Relationships in ASD Type de document : Texte imprimé et/ou numérique Auteurs : A. LOSH, Auteur ; L. A. TIPTON, Auteur ; A. EISENHOWER, Auteur ; Jan BLACHER, Auteur Article en page(s) : p.3582-3591 Langues : Anglais (eng) Mots-clés : Asd Autism Parent behaviors Parent-child interaction Student-teacher relationships Index. décimale : PER Périodiques Résumé : Student-teacher relationship (STR) quality during the early school years has important implications for student adjustment and outcomes. Studies with typically developing (TD) children have identified links between parent behaviors and STRs, but these connections remain unexplored for children with autism spectrum disorder (ASD). The present study investigated relationships between observed parent behaviors during a shared literacy task and STRs one year later for 117 children (ages 4-7) with ASD. Children whose parents displayed more intrusiveness had poorer-quality STRs. Further, parent intrusiveness mediated the predictive relationship between child spoken language skills and STR quality. These results suggest that parent intrusiveness plays an important role in the development of STRs for young children with ASD. Implications for intervention and research are discussed. En ligne : http://dx.doi.org/10.1007/s10803-019-04065-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405
in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3582-3591[article] Parenting Behaviors as Predictive of Early Student-Teacher Relationships in ASD [Texte imprimé et/ou numérique] / A. LOSH, Auteur ; L. A. TIPTON, Auteur ; A. EISENHOWER, Auteur ; Jan BLACHER, Auteur . - p.3582-3591.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3582-3591
Mots-clés : Asd Autism Parent behaviors Parent-child interaction Student-teacher relationships Index. décimale : PER Périodiques Résumé : Student-teacher relationship (STR) quality during the early school years has important implications for student adjustment and outcomes. Studies with typically developing (TD) children have identified links between parent behaviors and STRs, but these connections remain unexplored for children with autism spectrum disorder (ASD). The present study investigated relationships between observed parent behaviors during a shared literacy task and STRs one year later for 117 children (ages 4-7) with ASD. Children whose parents displayed more intrusiveness had poorer-quality STRs. Further, parent intrusiveness mediated the predictive relationship between child spoken language skills and STR quality. These results suggest that parent intrusiveness plays an important role in the development of STRs for young children with ASD. Implications for intervention and research are discussed. En ligne : http://dx.doi.org/10.1007/s10803-019-04065-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405