Atypical Pupillary Light Reflex and Heart Rate Variability in Children with Autism Spectrum Disorder / Chathuri DALUWATTE in Journal of Autism and Developmental Disorders, 43-8 (August 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1910-1925 Titre : Atypical Pupillary Light Reflex and Heart Rate Variability in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Chathuri DALUWATTE, Auteur ; Judith H. MILES, Auteur ; Shawn E. CHRIST, Auteur ; David Q. BEVERSDORF, Auteur ; T. Nicole TAKAHASHI, Auteur ; Gang YAO, Auteur Article en page(s) : p.1910-1925 Langues : Anglais (eng) Mots-clés : Pupillary light reflex  Heart rate variability  Autism  Autonomic nervous system Index. décimale : PER Périodiques Résumé : We investigated pupillary light reflex (PLR) in 152 children with ASD, 116 typically developing (TD) children, and 36 children with non-ASD neurodevelopmental disorders (NDDs). Heart rate variability (HRV) was measured simultaneously to study potential impairments in the autonomic nervous system (ANS) associated with ASD. The results showed that the ASD group had significantly longer PLR latency, reduced relative constriction amplitude, and shorter constriction/redilation time than those of the TD group. Similar atypical PLR parameters were observed in the NDD group. A significant age effect on PLR latency was observed in children younger than 9 years in the TD group, but not in the ASD and NDD groups. Atypical HRV parameters were observed in the ASD and NDD groups. A significant negative correlation existed between the PLR constriction amplitude and average heart rate in children with an ASD, but not in children with typical development. En ligne : http://dx.doi.org/10.1007/s10803-012-1741-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205 [article] Atypical Pupillary Light Reflex and Heart Rate Variability in Children with Autism Spectrum Disorder [texte imprimé] / Chathuri DALUWATTE, Auteur ; Judith H. MILES, Auteur ; Shawn E. CHRIST, Auteur ; David Q. BEVERSDORF, Auteur ; T. Nicole TAKAHASHI, Auteur ; Gang YAO, Auteur . - p.1910-1925. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1910-1925 Mots-clés : Pupillary light reflex  Heart rate variability  Autism  Autonomic nervous system Index. décimale : PER Périodiques Résumé : We investigated pupillary light reflex (PLR) in 152 children with ASD, 116 typically developing (TD) children, and 36 children with non-ASD neurodevelopmental disorders (NDDs). Heart rate variability (HRV) was measured simultaneously to study potential impairments in the autonomic nervous system (ANS) associated with ASD. The results showed that the ASD group had significantly longer PLR latency, reduced relative constriction amplitude, and shorter constriction/redilation time than those of the TD group. Similar atypical PLR parameters were observed in the NDD group. A significant age effect on PLR latency was observed in children younger than 9 years in the TD group, but not in the ASD and NDD groups. Atypical HRV parameters were observed in the ASD and NDD groups. A significant negative correlation existed between the PLR constriction amplitude and average heart rate in children with an ASD, but not in children with typical development. En ligne : http://dx.doi.org/10.1007/s10803-012-1741-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205

Beta-adrenergic antagonism alters functional connectivity during associative processing in a preliminary study of individuals with and without autism / John P. HEGARTY in Autism, 24-3 (April 2020)  

Public ISBD [article]  inAutism > 24-3 (April 2020) . - p.795-801 Titre : Beta-adrenergic antagonism alters functional connectivity during associative processing in a preliminary study of individuals with and without autism Type de document : texte imprimé Auteurs : John P. HEGARTY, Auteur ; Rachel M. ZAMZOW, Auteur ; Bradley J. FERGUSON, Auteur ; Shawn E. CHRIST, Auteur ; Eric C. PORGES, Auteur ; Jeffrey D. JOHNSON, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.795-801 Langues : Anglais (eng) Mots-clés : beta-blockers  fronto-parietal control network  functional magnetic resonance imaging  noradrenergic  propranolol  semantic fluency Index. décimale : PER Périodiques Résumé : Beta-adrenergic antagonism (e.g. propranolol) has been associated with cognitive/behavioral benefits following stress-induced impairments and for some cognitive/behavioral domains in individuals with autism spectrum disorder. In this preliminary investigation, we examined whether the benefits of propranolol are associated with functional properties in the brain. Adolescents/adults (mean age = 22.54 years) with (n = 13) and without autism spectrum disorder (n = 13) attended three sessions in which propranolol, nadolol (beta-adrenergic antagonist that does not cross the blood-brain barrier), or placebo was administered before a semantic fluency task during functional magnetic resonance imaging. Autonomic nervous system measures and functional connectivity between language/associative processing regions and within the fronto-parietal control, dorsal attention, and default mode networks were examined. Propranolol was associated with improved semantic fluency performance, which was correlated with the baseline resting heart rate. Propranolol also altered network efficiency of regions associated with semantic processing and in an exploratory analysis reduced functional differences in the fronto-parietal control network in individuals with autism spectrum disorder. Thus, the cognitive benefits from beta-adrenergic antagonism may be generally associated with improved information processing in the brain in domain-specific networks, but individuals with autism spectrum disorder may also benefit from additional improvements in domain-general networks. The benefits from propranolol may also be able to be predicted from baseline autonomic nervous system measures, which warrants further investigation. En ligne : http://dx.doi.org/10.1177/1362361319868633 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Beta-adrenergic antagonism alters functional connectivity during associative processing in a preliminary study of individuals with and without autism [texte imprimé] / John P. HEGARTY, Auteur ; Rachel M. ZAMZOW, Auteur ; Bradley J. FERGUSON, Auteur ; Shawn E. CHRIST, Auteur ; Eric C. PORGES, Auteur ; Jeffrey D. JOHNSON, Auteur ; David Q. BEVERSDORF, Auteur . - p.795-801. Langues : Anglais (eng) in Autism > 24-3 (April 2020) . - p.795-801 Mots-clés : beta-blockers  fronto-parietal control network  functional magnetic resonance imaging  noradrenergic  propranolol  semantic fluency Index. décimale : PER Périodiques Résumé : Beta-adrenergic antagonism (e.g. propranolol) has been associated with cognitive/behavioral benefits following stress-induced impairments and for some cognitive/behavioral domains in individuals with autism spectrum disorder. In this preliminary investigation, we examined whether the benefits of propranolol are associated with functional properties in the brain. Adolescents/adults (mean age = 22.54 years) with (n = 13) and without autism spectrum disorder (n = 13) attended three sessions in which propranolol, nadolol (beta-adrenergic antagonist that does not cross the blood-brain barrier), or placebo was administered before a semantic fluency task during functional magnetic resonance imaging. Autonomic nervous system measures and functional connectivity between language/associative processing regions and within the fronto-parietal control, dorsal attention, and default mode networks were examined. Propranolol was associated with improved semantic fluency performance, which was correlated with the baseline resting heart rate. Propranolol also altered network efficiency of regions associated with semantic processing and in an exploratory analysis reduced functional differences in the fronto-parietal control network in individuals with autism spectrum disorder. Thus, the cognitive benefits from beta-adrenergic antagonism may be generally associated with improved information processing in the brain in domain-specific networks, but individuals with autism spectrum disorder may also benefit from additional improvements in domain-general networks. The benefits from propranolol may also be able to be predicted from baseline autonomic nervous system measures, which warrants further investigation. En ligne : http://dx.doi.org/10.1177/1362361319868633 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Brief Report: Flanker Visual Filtering Ability in Older Adolescents with Autism Spectrum Disorder / Kelly M. BOLAND in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.422-428 Titre : Brief Report: Flanker Visual Filtering Ability in Older Adolescents with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Kelly M. BOLAND, Auteur ; Janine P. STICHTER, Auteur ; David Q. BEVERSDORF, Auteur ; Shawn E. CHRIST, Auteur Article en page(s) : p.422-428 Langues : Anglais (eng) Mots-clés : Autism  Development  Executive function  Inhibition  Inhibitory control  Visuoperception Index. décimale : PER Périodiques Résumé : Recent research has documented impaired ability to resist interference from visual distractors in individuals with autism spectrum disorder (ASD) and suggests that this phenomenon may be more pronounced in young versus older children (Christ et al., Neuropsychology 25(6):690-701, 2011). The present study extends previous findings by examining visual filtering inhibitory ability within an older adolescent population. A flanker visual filtering task was administered to 36 adolescents with ASD and 44 adolescents without ASD (age: 11-20 years). Analysis revealed no evidence of group differences in visual filtering performance. Taken together with previous research, these results suggest that during early adolescence the previously observed impairment may resolve or compensatory strategies develop, allowing individuals with ASD to perform as well as their neurotypical peers. En ligne : http://dx.doi.org/10.1007/s10803-018-3755-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Brief Report: Flanker Visual Filtering Ability in Older Adolescents with Autism Spectrum Disorder [texte imprimé] / Kelly M. BOLAND, Auteur ; Janine P. STICHTER, Auteur ; David Q. BEVERSDORF, Auteur ; Shawn E. CHRIST, Auteur . - p.422-428. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.422-428 Mots-clés : Autism  Development  Executive function  Inhibition  Inhibitory control  Visuoperception Index. décimale : PER Périodiques Résumé : Recent research has documented impaired ability to resist interference from visual distractors in individuals with autism spectrum disorder (ASD) and suggests that this phenomenon may be more pronounced in young versus older children (Christ et al., Neuropsychology 25(6):690-701, 2011). The present study extends previous findings by examining visual filtering inhibitory ability within an older adolescent population. A flanker visual filtering task was administered to 36 adolescents with ASD and 44 adolescents without ASD (age: 11-20 years). Analysis revealed no evidence of group differences in visual filtering performance. Taken together with previous research, these results suggest that during early adolescence the previously observed impairment may resolve or compensatory strategies develop, allowing individuals with ASD to perform as well as their neurotypical peers. En ligne : http://dx.doi.org/10.1007/s10803-018-3755-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Brief Report: A Preliminary Study of the Relationship between Repetitive Behaviors and Concurrent Executive Function Demands in Children with Autism Spectrum Disorder / Mackenzie N. CISSNE in Journal of Autism and Developmental Disorders, 52-4 (April 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1896-1902 Titre : Brief Report: A Preliminary Study of the Relationship between Repetitive Behaviors and Concurrent Executive Function Demands in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Mackenzie N. CISSNE, Auteur ; Lindsay E. KESTER, Auteur ; Amanda J. MOFFITT GUNN, Auteur ; Kimberly E. BODNER, Auteur ; Judith H. MILES, Auteur ; Shawn E. CHRIST, Auteur Article en page(s) : p.1896-1902 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Cognition  Executive Function/physiology  Humans  Inhibition, Psychological  Antisaccade  Autism Spectrum Disorder  Cognitive flexibility  Executive function  Inhibitory control  Repetitive behaviors Index. décimale : PER Périodiques Résumé : The present study evaluated the hypothesis that the strength of the relationship between executive function (EF) and repetitive behaviors and restricted interests (RBRI) symptomatology is moderated by the degree to which concurrent demands are placed on multiple aspects of EF. An eye movement task was used to evaluate inhibition and task switching ability (both together and in isolation) in a sample of 22 children with autism spectrum disorder (ASD). The Repetitive Behavior Scale-Revised (RBS-R) was used to assess the severity of RBRI symptoms. Results provide preliminary support for the aforementioned hypothesis. RBS-R scores were significantly correlated with task performance when simultaneous demands were placed on switching and inhibition; however, no such relationship was found for inhibition-only or switching-only task conditions. En ligne : http://dx.doi.org/10.1007/s10803-021-05071-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Brief Report: A Preliminary Study of the Relationship between Repetitive Behaviors and Concurrent Executive Function Demands in Children with Autism Spectrum Disorder [texte imprimé] / Mackenzie N. CISSNE, Auteur ; Lindsay E. KESTER, Auteur ; Amanda J. MOFFITT GUNN, Auteur ; Kimberly E. BODNER, Auteur ; Judith H. MILES, Auteur ; Shawn E. CHRIST, Auteur . - p.1896-1902. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1896-1902 Mots-clés : Autism Spectrum Disorder/diagnosis  Child  Cognition  Executive Function/physiology  Humans  Inhibition, Psychological  Antisaccade  Autism Spectrum Disorder  Cognitive flexibility  Executive function  Inhibitory control  Repetitive behaviors Index. décimale : PER Périodiques Résumé : The present study evaluated the hypothesis that the strength of the relationship between executive function (EF) and repetitive behaviors and restricted interests (RBRI) symptomatology is moderated by the degree to which concurrent demands are placed on multiple aspects of EF. An eye movement task was used to evaluate inhibition and task switching ability (both together and in isolation) in a sample of 22 children with autism spectrum disorder (ASD). The Repetitive Behavior Scale-Revised (RBS-R) was used to assess the severity of RBRI symptoms. Results provide preliminary support for the aforementioned hypothesis. RBS-R scores were significantly correlated with task performance when simultaneous demands were placed on switching and inhibition; however, no such relationship was found for inhibition-only or switching-only task conditions. En ligne : http://dx.doi.org/10.1007/s10803-021-05071-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Inhibitory Control in Children with Autism Spectrum Disorder / Shawn E. CHRIST in Journal of Autism and Developmental Disorders, 37-6 (July 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-6 (July 2007) . - p.1155-1165 Titre : Inhibitory Control in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Shawn E. CHRIST, Auteur ; Daniel D. HOLT, Auteur ; Desirée A. WHITE, Auteur ; Leonard GREEN, Auteur Année de publication : 2007 Article en page(s) : p.1155-1165 Langues : Anglais (eng) Mots-clés : Inhibitory-control Autism Children Development Executive-abilities Index. décimale : PER Périodiques Résumé : Impairments in executive abilities such as cognitive flexibility have been identified in individuals with autism spectrum disorder (ASD). It remains unclear, however, whether such individuals also experience impairments in another executive ability: inhibitory control. In the present study, we administered three inhibitory tasks to 18 children with ASD, 23 siblings of children with ASD, and 25 typically developing children. After controlling for individual differences in age, overall IQ, and processing speed, children with ASD demonstrated impaired performance on two of the three inhibitory tasks. Results suggest that children with ASD experience circumscribed deficits in some but not all aspects of inhibitory control. More generally, the findings underscore the importance of using multiple measures to assess a putative single cognitive ability. En ligne : http://dx.doi.org/10.1007/s10803-006-0259-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 [article] Inhibitory Control in Children with Autism Spectrum Disorder [texte imprimé] / Shawn E. CHRIST, Auteur ; Daniel D. HOLT, Auteur ; Desirée A. WHITE, Auteur ; Leonard GREEN, Auteur . - 2007 . - p.1155-1165. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-6 (July 2007) . - p.1155-1165 Mots-clés : Inhibitory-control Autism Children Development Executive-abilities Index. décimale : PER Périodiques Résumé : Impairments in executive abilities such as cognitive flexibility have been identified in individuals with autism spectrum disorder (ASD). It remains unclear, however, whether such individuals also experience impairments in another executive ability: inhibitory control. In the present study, we administered three inhibitory tasks to 18 children with ASD, 23 siblings of children with ASD, and 25 typically developing children. After controlling for individual differences in age, overall IQ, and processing speed, children with ASD demonstrated impaired performance on two of the three inhibitory tasks. Results suggest that children with ASD experience circumscribed deficits in some but not all aspects of inhibitory control. More generally, the findings underscore the importance of using multiple measures to assess a putative single cognitive ability. En ligne : http://dx.doi.org/10.1007/s10803-006-0259-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155

Psychiatric Symptoms and Psychosocial Difficulties in Young Adults with Autistic Traits / Stephen M. KANNE in Journal of Autism and Developmental Disorders, 39-6 (June 2009)  

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Social Skills Intervention Participation and Associated Improvements in Executive Function Performance / Shawn E. CHRIST in Autism Research and Treatment, 2017 (2017)  

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The Subthreshold Autism Trait Questionnaire (SATQ): Development of a Brief Self-Report Measure of Subthreshold Autism Traits / Stephen M. KANNE in Journal of Autism and Developmental Disorders, 42-5 (May 2012)  

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