[article] 
inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.73-82

Titre :	Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Aisha S. DICKERSON, Auteur ; Manouchehr HESSABI, Auteur ; Katherine A. LOVELAND, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur
Article en page(s) :	p.73-82
Langues :	Anglais (eng)
Mots-clés :	Manganese  Autism Spectrum Disorder (ASD)  Glutathione-S-transferase (GST) genes  Oxidative stress  Interactions  Jamaica
Index. décimale :	PER Périodiques
Résumé :	Abstract We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ? 12 ?g/L had about 4 times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ? 12 ?g/L had about six times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2015.08.001
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

[article] Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Aisha S. DICKERSON, Auteur ; Manouchehr HESSABI, Auteur ; Katherine A. LOVELAND, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.73-82.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.73-82

Mots-clés :	Manganese  Autism Spectrum Disorder (ASD)  Glutathione-S-transferase (GST) genes  Oxidative stress  Interactions  Jamaica
Index. décimale :	PER Périodiques
Résumé :	Abstract We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ? 12 ?g/L had about 4 times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ? 12 ?g/L had about six times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2015.08.001
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268