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Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 18 (October 2015)
[article]
Titre : Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Aisha S. DICKERSON, Auteur ; Manouchehr HESSABI, Auteur ; Katherine A. LOVELAND, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.73-82 Langues : Anglais (eng) Mots-clés : Manganese Autism Spectrum Disorder (ASD) Glutathione-S-transferase (GST) genes Oxidative stress Interactions Jamaica Index. décimale : PER Périodiques Résumé : Abstract We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ? 12 ?g/L had about 4 times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ? 12 ?g/L had about six times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268
in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.73-82[article] Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Aisha S. DICKERSON, Auteur ; Manouchehr HESSABI, Auteur ; Katherine A. LOVELAND, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.73-82.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.73-82
Mots-clés : Manganese Autism Spectrum Disorder (ASD) Glutathione-S-transferase (GST) genes Oxidative stress Interactions Jamaica Index. décimale : PER Périodiques Résumé : Abstract We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ? 12 ?g/L had about 4 times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ? 12 ?g/L had about six times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? / Maryam M. ABDULLAH in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
[article]
Titre : Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? Type de document : Texte imprimé et/ou numérique Auteurs : Maryam M. ABDULLAH, Auteur ; Agnes R. LY, Auteur ; Wendy A. GOLDBERG, Auteur ; K. Alison CLARKE-STEWART, Auteur ; John V. DUDGEON, Auteur ; Christopher G. MULL, Auteur ; Tony J. CHAN, Auteur ; Erin E. KENT, Auteur ; Andrew Z. MASON, Auteur ; Jonathon E. ERICSON, Auteur Année de publication : 2012 Article en page(s) : p.929-936 Langues : Anglais (eng) Mots-clés : Autism ADHD Metal Lead Mercury Manganese Index. décimale : PER Périodiques Résumé : To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically developing (TD) children. Using laser ablation inductively coupled plasma mass spectrometry, we found no significant differences in levels of these neurotoxicants for children with ASDs compared with TD children, but there was marginal significance indicating that children with ASDs have lower manganese levels. No significant differences emerged between children with HDB and TD children. The current findings challenge the notion that perinatal heavy metal exposure is a major contributor to the development of ASDs and HDB. En ligne : http://dx.doi.org/10.1007/s10803-011-1318-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.929-936[article] Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? [Texte imprimé et/ou numérique] / Maryam M. ABDULLAH, Auteur ; Agnes R. LY, Auteur ; Wendy A. GOLDBERG, Auteur ; K. Alison CLARKE-STEWART, Auteur ; John V. DUDGEON, Auteur ; Christopher G. MULL, Auteur ; Tony J. CHAN, Auteur ; Erin E. KENT, Auteur ; Andrew Z. MASON, Auteur ; Jonathon E. ERICSON, Auteur . - 2012 . - p.929-936.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.929-936
Mots-clés : Autism ADHD Metal Lead Mercury Manganese Index. décimale : PER Périodiques Résumé : To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically developing (TD) children. Using laser ablation inductively coupled plasma mass spectrometry, we found no significant differences in levels of these neurotoxicants for children with ASDs compared with TD children, but there was marginal significance indicating that children with ASDs have lower manganese levels. No significant differences emerged between children with HDB and TD children. The current findings challenge the notion that perinatal heavy metal exposure is a major contributor to the development of ASDs and HDB. En ligne : http://dx.doi.org/10.1007/s10803-011-1318-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156