Auditory-motor rhythm synchronization in children with autism spectrum disorder / Ana TRYFON in Research in Autism Spectrum Disorders, 35 (March 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 35 (March 2017) . - p.51-61 Titre : Auditory-motor rhythm synchronization in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Ana TRYFON, Auteur ; Nicholas E. FOSTER, Auteur ; Tia OUIMET, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Megha SHARDA, Auteur ; Krista L. HYDE, Auteur Article en page(s) : p.51-61 Langues : Anglais (eng) Mots-clés : Autism  Auditory  Motor  Rhythm  Synchronization  Development Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by difficulties in social and communication skills as well as atypical sensory perception and motor skills. Sensorimotor abilities such as auditory-motor integration are essential for social interaction and communication. The goal of this research was to investigate the development of auditory-motor rhythm synchronization for the first time in ASD versus typically-developing (TD) children. Methods Participants were 31 boys with ASD and 23 TD boys that were matched in age and IQ. Participants were tested on an auditory-motor rhythm synchronization task in which they tapped in synchrony with rhythms of varying metrical complexity. Results Both children with ASD and TD performed similarly on this task and both groups performed better with age. This work demonstrates that non-verbal rhythm synchronization is intact in ASD over the course of childhood development. This research serves to better understand sensorimotor interactions in ASD and to better define sensory phenotypes in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Auditory-motor rhythm synchronization in children with autism spectrum disorder [texte imprimé] / Ana TRYFON, Auteur ; Nicholas E. FOSTER, Auteur ; Tia OUIMET, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Megha SHARDA, Auteur ; Krista L. HYDE, Auteur . - p.51-61. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 35 (March 2017) . - p.51-61 Mots-clés : Autism  Auditory  Motor  Rhythm  Synchronization  Development Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by difficulties in social and communication skills as well as atypical sensory perception and motor skills. Sensorimotor abilities such as auditory-motor integration are essential for social interaction and communication. The goal of this research was to investigate the development of auditory-motor rhythm synchronization for the first time in ASD versus typically-developing (TD) children. Methods Participants were 31 boys with ASD and 23 TD boys that were matched in age and IQ. Participants were tested on an auditory-motor rhythm synchronization task in which they tapped in synchrony with rhythms of varying metrical complexity. Results Both children with ASD and TD performed similarly on this task and both groups performed better with age. This work demonstrates that non-verbal rhythm synchronization is intact in ASD over the course of childhood development. This research serves to better understand sensorimotor interactions in ASD and to better define sensory phenotypes in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Effects of Age and Attention on Auditory Global–Local Processing in Children with Autism Spectrum Disorder / Nicholas E. V. FOSTER in Journal of Autism and Developmental Disorders, 46-4 (April 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1415-1428 Titre : Effects of Age and Attention on Auditory Global–Local Processing in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Nicholas E. V. FOSTER, Auteur ; Tia OUIMET, Auteur ; Ana TRYFON, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Krista L. HYDE, Auteur Article en page(s) : p.1415-1428 Langues : Anglais (eng) Mots-clés : Autism  Auditory  Development  Attention Index. décimale : PER Périodiques Résumé : In vision, typically-developing (TD) individuals perceive “global” (whole) before “local” (detailed) features, whereas individuals with autism spectrum disorder (ASD) exhibit a local bias. However, auditory global–local distinctions are less clear in ASD, particularly in terms of age and attention effects. To these aims, here ASD and TD children judged local and global pitch structure in nine-tone melodies. Both groups showed a similar global precedence effect, but ASD children were less sensitive to global interference than TD children at younger ages. There was no effect of attention task. These findings provide novel evidence of developmental differences in auditory perception and may help to refine sensory phenotypes in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2684-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284 [article] Effects of Age and Attention on Auditory Global–Local Processing in Children with Autism Spectrum Disorder [texte imprimé] / Nicholas E. V. FOSTER, Auteur ; Tia OUIMET, Auteur ; Ana TRYFON, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Krista L. HYDE, Auteur . - p.1415-1428. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1415-1428 Mots-clés : Autism  Auditory  Development  Attention Index. décimale : PER Périodiques Résumé : In vision, typically-developing (TD) individuals perceive “global” (whole) before “local” (detailed) features, whereas individuals with autism spectrum disorder (ASD) exhibit a local bias. However, auditory global–local distinctions are less clear in ASD, particularly in terms of age and attention effects. To these aims, here ASD and TD children judged local and global pitch structure in nine-tone melodies. Both groups showed a similar global precedence effect, but ASD children were less sensitive to global interference than TD children at younger ages. There was no effect of attention task. These findings provide novel evidence of developmental differences in auditory perception and may help to refine sensory phenotypes in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2684-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284

Effects of age and symptomatology on cortical thickness in autism spectrum disorders / Krissy DOYLE-THOMAS in Research in Autism Spectrum Disorders, 7-1 (January 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50 Titre : Effects of age and symptomatology on cortical thickness in autism spectrum disorders Type de document : texte imprimé Auteurs : Krissy DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur Année de publication : 2013 Article en page(s) : p.141-50 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Structural MRI  Cortical thickness  Social impairment  Developmental changes Index. décimale : PER Périodiques Résumé : Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Effects of age and symptomatology on cortical thickness in autism spectrum disorders [texte imprimé] / Krissy DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur . - 2013 . - p.141-50. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50 Mots-clés : Autism spectrum disorders  Structural MRI  Cortical thickness  Social impairment  Developmental changes Index. décimale : PER Périodiques Résumé : Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.08.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Is inhibitory control a 'no-go' in adolescents with autism spectrum disorder? / Anji VARA in Molecular Autism, (January 2014)  

Public ISBD [article]  inMolecular Autism > (January 2014) Titre : Is inhibitory control a 'no-go' in adolescents with autism spectrum disorder? Type de document : texte imprimé Auteurs : Anji VARA, Auteur ; Elizabeth W. PANG, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Julie VIDAL, Auteur ; Margot J. TAYLOR, Auteur ; Evdokia ANAGNOSTOU, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) refers to a range of neurodevelopmental conditions characterized by social communication deficits, repetitive behaviours, and restrictive interests. Impaired inhibition has been suggested to exacerbate the core symptoms of ASD. This is particularly critical during adolescence when social skills are maturing to adult levels. Using magnetoencephalography (MEG), we identified the location and timing pattern of neural activity associated with inhibition in adolescents with autism, compared to typically developing adolescents. The MEG data from 15 adolescents with ASD and 15 age-matched controls (13 to 17 years) were collected during a go/no-go task with inverse ratios of go/no-go trials in two conditions: an inhibition condition (1:2) and a baseline condition (2:1). No-go trials from the two conditions were analyzed using beamformer source localizations from 200ms to 400ms post-stimulus onset. Significant activations were determined using permutation testing. Adolescents with ASD recruited first the right middle frontal gyrus (200 to 250ms) followed by the left postcentral gyrus (250 to 300ms) and finally the left middle frontal and right medial frontal gyri (300 to 400ms). Typically developing adolescents recruited first the left middle frontal gyrus (200 to 250ms), followed by the left superior and inferior frontal gyri (250 to 300ms), then the right middle temporal gyrus (300 to 350ms), and finally the superior and precentral gyri and right inferior lobule (300 to 400ms). Adolescents with ASD showed recruitment limited largely to the frontal cortex unlike typically developing adolescents who recruited parietal and temporal regions as well. These findings support the presence of an atypical, restricted inhibitory network in adolescents with ASD compared to controls. En ligne : http://dx.doi.org/10.1186/2040-2392-5-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Is inhibitory control a 'no-go' in adolescents with autism spectrum disorder? [texte imprimé] / Anji VARA, Auteur ; Elizabeth W. PANG, Auteur ; Krissy DOYLE-THOMAS, Auteur ; Julie VIDAL, Auteur ; Margot J. TAYLOR, Auteur ; Evdokia ANAGNOSTOU, Auteur. Langues : Anglais (eng) in Molecular Autism > (January 2014) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) refers to a range of neurodevelopmental conditions characterized by social communication deficits, repetitive behaviours, and restrictive interests. Impaired inhibition has been suggested to exacerbate the core symptoms of ASD. This is particularly critical during adolescence when social skills are maturing to adult levels. Using magnetoencephalography (MEG), we identified the location and timing pattern of neural activity associated with inhibition in adolescents with autism, compared to typically developing adolescents. The MEG data from 15 adolescents with ASD and 15 age-matched controls (13 to 17 years) were collected during a go/no-go task with inverse ratios of go/no-go trials in two conditions: an inhibition condition (1:2) and a baseline condition (2:1). No-go trials from the two conditions were analyzed using beamformer source localizations from 200ms to 400ms post-stimulus onset. Significant activations were determined using permutation testing. Adolescents with ASD recruited first the right middle frontal gyrus (200 to 250ms) followed by the left postcentral gyrus (250 to 300ms) and finally the left middle frontal and right medial frontal gyri (300 to 400ms). Typically developing adolescents recruited first the left middle frontal gyrus (200 to 250ms), followed by the left superior and inferior frontal gyri (250 to 300ms), then the right middle temporal gyrus (300 to 350ms), and finally the superior and precentral gyri and right inferior lobule (300 to 400ms). Adolescents with ASD showed recruitment limited largely to the frontal cortex unlike typically developing adolescents who recruited parietal and temporal regions as well. These findings support the presence of an atypical, restricted inhibitory network in adolescents with ASD compared to controls. En ligne : http://dx.doi.org/10.1186/2040-2392-5-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders / Krissy DOYLE-THOMAS in Research in Autism Spectrum Disorders, 8-1 (January 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-1 (January 2014) . - p.44-51 Titre : Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders Type de document : texte imprimé Auteurs : Krissy DOYLE-THOMAS, Auteur ; Dallas CARD, Auteur ; Latha V. SOORYA, Auteur ; A. TING WANG, Auteur ; Jin FAN, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Magnetic resonance spectroscopy  Autism spectrum disorders  Deep gray matter  Caudate nucleus  Putamen  Thalamus and social cognition Index. décimale : PER Périodiques Résumé : Abstract Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7–18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 [article] Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders [texte imprimé] / Krissy DOYLE-THOMAS, Auteur ; Dallas CARD, Auteur ; Latha V. SOORYA, Auteur ; A. TING WANG, Auteur ; Jin FAN, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.44-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-1 (January 2014) . - p.44-51 Mots-clés : Magnetic resonance spectroscopy  Autism spectrum disorders  Deep gray matter  Caudate nucleus  Putamen  Thalamus and social cognition Index. décimale : PER Périodiques Résumé : Abstract Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7–18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220

Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder / V. M. VOGAN in Journal of Autism and Developmental Disorders, 46-6 (June 2016)  

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