Bullying and Autism / Alisa G. WOODS in Autism - Open Access, 3-3 (December 2013)  

Public ISBD [article]  inAutism - Open Access > 3-3 (December 2013) . - 2 p. Titre : Bullying and Autism Type de document : Texte imprimé et/ou numérique Auteurs : Alisa G. WOODS, Auteur Année de publication : 2013 Article en page(s) : 2 p. Langues : Anglais (eng) Mots-clés : Bullying  Neurodevelopmental  Autism  ADHD  Victimization Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Bullying and Autism [Texte imprimé et/ou numérique] / Alisa G. WOODS, Auteur . - 2013 . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 3-3 (December 2013) . - 2 p. Mots-clés : Bullying  Neurodevelopmental  Autism  ADHD  Victimization Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

Environmental Influences on Biochemistry in Autism Spectrum Disorder / Kelly L. WORMWOOD in Autism - Open Access, 4-3 ([01/06/2014])  

Public ISBD [article]  inAutism - Open Access > 4-3 [01/06/2014] . - 2 p. Titre : Environmental Influences on Biochemistry in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kelly L. WORMWOOD, Auteur ; Emmalyn J. DUPREE, Auteur ; Costel C. DARIE, Auteur ; Alisa G. WOODS, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Mass spectrometry  Proteomics  Proteins Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Environmental Influences on Biochemistry in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kelly L. WORMWOOD, Auteur ; Emmalyn J. DUPREE, Auteur ; Costel C. DARIE, Auteur ; Alisa G. WOODS, Auteur . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 4-3 [01/06/2014] . - 2 p. Mots-clés : Autism spectrum disorder  Mass spectrometry  Proteomics  Proteins Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder / Armand G. NGOUNOU WETIE in Autism Research, 8-3 (June 2015)  

Public ISBD [article]  inAutism Research > 8-3 (June 2015) . - p.338-350 Titre : A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Armand G. NGOUNOU WETIE, Auteur ; Kelly L. WORMWOOD, Auteur ; Stefanie RUSSELL, Auteur ; Jeanne P. RYAN, Auteur ; Costel C. DARIE, Auteur ; Alisa G. WOODS, Auteur Article en page(s) : p.338-350 Langues : Anglais (eng) Mots-clés : ASD  proteomics  biomarker signature  early detection  diagnosis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) prevalence is increasing, with current estimates at 1/68–1/50 individuals diagnosed with an ASD. Diagnosis is based on behavioral assessments. Early diagnosis and intervention is known to greatly improve functional outcomes in people with ASD. Diagnosis, treatment monitoring and prognosis of ASD symptoms could be facilitated with biomarkers to complement behavioral assessments. Mass spectrometry (MS) based proteomics may help reveal biomarkers for ASD. In this pilot study, we have analyzed the salivary proteome in individuals with ASD compared to neurotypical control subjects, using MS-based proteomics. Our goal is to optimize methods for salivary proteomic biomarker discovery and to identify initial putative biomarkers in people with ASDs. The salivary proteome is virtually unstudied in ASD, and saliva could provide an easily accessible biomaterial for analysis. Using nano liquid chromatography-tandem mass spectrometry, we found statistically significant differences in several salivary proteins, including elevated prolactin-inducible protein, lactotransferrin, Ig kappa chain C region, Ig gamma-1 chain C region, Ig lambda-2 chain C regions, neutrophil elastase, polymeric immunoglobulin receptor and deleted in malignant brain tumors 1. Our results indicate that this is an effective method for identification of salivary protein biomarkers, support the concept that immune system and gastrointestinal disturbances may be present in individuals with ASDs and point toward the need for larger studies in behaviorally-characterized individuals. En ligne : http://dx.doi.org/10.1002/aur.1450 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=262 [article] A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Armand G. NGOUNOU WETIE, Auteur ; Kelly L. WORMWOOD, Auteur ; Stefanie RUSSELL, Auteur ; Jeanne P. RYAN, Auteur ; Costel C. DARIE, Auteur ; Alisa G. WOODS, Auteur . - p.338-350. Langues : Anglais (eng) in Autism Research > 8-3 (June 2015) . - p.338-350 Mots-clés : ASD  proteomics  biomarker signature  early detection  diagnosis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) prevalence is increasing, with current estimates at 1/68–1/50 individuals diagnosed with an ASD. Diagnosis is based on behavioral assessments. Early diagnosis and intervention is known to greatly improve functional outcomes in people with ASD. Diagnosis, treatment monitoring and prognosis of ASD symptoms could be facilitated with biomarkers to complement behavioral assessments. Mass spectrometry (MS) based proteomics may help reveal biomarkers for ASD. In this pilot study, we have analyzed the salivary proteome in individuals with ASD compared to neurotypical control subjects, using MS-based proteomics. Our goal is to optimize methods for salivary proteomic biomarker discovery and to identify initial putative biomarkers in people with ASDs. The salivary proteome is virtually unstudied in ASD, and saliva could provide an easily accessible biomaterial for analysis. Using nano liquid chromatography-tandem mass spectrometry, we found statistically significant differences in several salivary proteins, including elevated prolactin-inducible protein, lactotransferrin, Ig kappa chain C region, Ig gamma-1 chain C region, Ig lambda-2 chain C regions, neutrophil elastase, polymeric immunoglobulin receptor and deleted in malignant brain tumors 1. Our results indicate that this is an effective method for identification of salivary protein biomarkers, support the concept that immune system and gastrointestinal disturbances may be present in individuals with ASDs and point toward the need for larger studies in behaviorally-characterized individuals. En ligne : http://dx.doi.org/10.1002/aur.1450 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=262

Proteomics and Cholesterol in Autism / Alisa G. WOODS in Autism - Open Access, 3-2 (September 2013)  

Public ISBD [article]  inAutism - Open Access > 3-2 (September 2013) . - 4 p. Titre : Proteomics and Cholesterol in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Alisa G. WOODS, Auteur ; Kelly L. WORMWOOD, Auteur ; Armand G. NGOUNOU WETIE, Auteur ; Jeanne P. RYAN, Auteur ; Costel C. DARIE, Auteur Année de publication : 2013 Article en page(s) : 4 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) diagnosis is increasing worldwide. ASDs are characterized by impaired social function, stereotyped behaviors/interests and communication deficits. ASD causes are poorly understood and treatments are largely limited to behavioral interventions once problems have developed and been detected. Here we discuss the potential use of mass spectrometry and proteomics in early diagnosis of ASD. The potential link between at least some subtypes of ASD, the cholesterol system and proteins that interact with cholesterol is also discussed. En ligne : http://dx.doi.org/10.4172/2165-7890.1000112 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Proteomics and Cholesterol in Autism [Texte imprimé et/ou numérique] / Alisa G. WOODS, Auteur ; Kelly L. WORMWOOD, Auteur ; Armand G. NGOUNOU WETIE, Auteur ; Jeanne P. RYAN, Auteur ; Costel C. DARIE, Auteur . - 2013 . - 4 p. Langues : Anglais (eng) in Autism - Open Access > 3-2 (September 2013) . - 4 p. Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) diagnosis is increasing worldwide. ASDs are characterized by impaired social function, stereotyped behaviors/interests and communication deficits. ASD causes are poorly understood and treatments are largely limited to behavioral interventions once problems have developed and been detected. Here we discuss the potential use of mass spectrometry and proteomics in early diagnosis of ASD. The potential link between at least some subtypes of ASD, the cholesterol system and proteins that interact with cholesterol is also discussed. En ligne : http://dx.doi.org/10.4172/2165-7890.1000112 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

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