Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders / Leonardo EMBERTI GIALLORETI in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.873-882 Titre : Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Leonardo EMBERTI GIALLORETI, Auteur ; Matteo PARDINI, Auteur ; Francesca BENASSI, Auteur ; Sara MARCIANO, Auteur ; Mario AMORE, Auteur ; Maria Giulia MUTOLO, Auteur ; Maria Cristina PORFIRIO, Auteur ; Paolo CURATOLO, Auteur Année de publication : 2014 Article en page(s) : p.873-882 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Retinal nerve fiber layer thickness  Optical coherence tomography (OCT)  White matter Index. décimale : PER Périodiques Résumé : Recent years have seen an increase in the use of retinal nerve fiber layer (RNFL) evaluation as an easy-to-use, reproducible, proxy-measure of brain structural abnormalities. Here, we evaluated RNFL thickness in a group of subjects with high functioning autism (HFA) or with Asperger Syndrome (AS) to its potential as a tool to study autism pathophysiology. All subjects underwent high-resolution spectral domain optical coherence tomography to evaluate RNFL thickness. HFA subjects presented with reduced global RNFL thickness compared both to AS subjects and controls. AS subjects showed a reduced nasal quadrant RNFL thickness compared to controls. Verbal-IQ/performance-IQ discrepancy correlated with RNFL thickness. Our data suggest that RNFL evaluation could help in the development of biological markers of autism pathophysiology. En ligne : http://dx.doi.org/10.1007/s10803-013-1939-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Leonardo EMBERTI GIALLORETI, Auteur ; Matteo PARDINI, Auteur ; Francesca BENASSI, Auteur ; Sara MARCIANO, Auteur ; Mario AMORE, Auteur ; Maria Giulia MUTOLO, Auteur ; Maria Cristina PORFIRIO, Auteur ; Paolo CURATOLO, Auteur . - 2014 . - p.873-882. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.873-882 Mots-clés : Autism spectrum disorders  Retinal nerve fiber layer thickness  Optical coherence tomography (OCT)  White matter Index. décimale : PER Périodiques Résumé : Recent years have seen an increase in the use of retinal nerve fiber layer (RNFL) evaluation as an easy-to-use, reproducible, proxy-measure of brain structural abnormalities. Here, we evaluated RNFL thickness in a group of subjects with high functioning autism (HFA) or with Asperger Syndrome (AS) to its potential as a tool to study autism pathophysiology. All subjects underwent high-resolution spectral domain optical coherence tomography to evaluate RNFL thickness. HFA subjects presented with reduced global RNFL thickness compared both to AS subjects and controls. AS subjects showed a reduced nasal quadrant RNFL thickness compared to controls. Verbal-IQ/performance-IQ discrepancy correlated with RNFL thickness. Our data suggest that RNFL evaluation could help in the development of biological markers of autism pathophysiology. En ligne : http://dx.doi.org/10.1007/s10803-013-1939-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

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