Practitioner Review: Current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents / Samuele CORTESE in Journal of Child Psychology and Psychiatry, 54-3 (March 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.227-246 Titre : Practitioner Review: Current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents Type de document : texte imprimé Auteurs : Samuele CORTESE, Auteur ; Martin HOLTMANN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; David COGHILL, Auteur ; Marina DANCKAERTS, Auteur ; Ralf W. DITTMANN, Auteur ; John R. GRAHAM, Auteur ; Eric TAYLOR, Auteur ; Joseph A. SERGEANT, Auteur ; THE EUROPEAN ADHD GUIDELINES GROUP, Auteur Article en page(s) : p.227-246 Mots-clés : ADHD  medication  adverse events  management  recommendations  European Index. décimale : PER Périodiques Résumé : Background: Medication is an important element of therapeutic strategies for ADHD. While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs. The aim of this review is to provide evidence- and expert-based guidance concerning the management of (AEs) with medications for ADHD. Methods: For ease of use by practitioners and clinicians, the article is organized in a simple question and answer format regarding the prevalence and management of the most common AEs. Answers were based on empirical evidence from studies (preferably meta-analyses or systematic reviews) retrieved in PubMed, Ovid, EMBASE and Web of Knowledge through 30 June 2012. When no empirical evidence was available, expert consensus of the members of the European ADHD Guidelines Group is provided. The evidence-level of the management recommendations was based on the SIGN grading system. Results: The review covers monitoring and management strategies of loss of appetite and growth delay, cardiovascular risks, sleep disturbance, tics, substance misuse/abuse, seizures, suicidal thoughts/behaviours and psychotic symptoms. Conclusion: Most AEs during treatment with drugs for ADHD are manageable and most of the times it is not necessary to stop medication, so that patients with ADHD may continue to benefit from the effectiveness of pharmacological treatment. En ligne : http://dx.doi.org/10.1111/jcpp.12036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191 [article] Practitioner Review: Current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents [texte imprimé] / Samuele CORTESE, Auteur ; Martin HOLTMANN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; David COGHILL, Auteur ; Marina DANCKAERTS, Auteur ; Ralf W. DITTMANN, Auteur ; John R. GRAHAM, Auteur ; Eric TAYLOR, Auteur ; Joseph A. SERGEANT, Auteur ; THE EUROPEAN ADHD GUIDELINES GROUP, Auteur . - p.227-246. in Journal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.227-246 Mots-clés : ADHD  medication  adverse events  management  recommendations  European Index. décimale : PER Périodiques Résumé : Background: Medication is an important element of therapeutic strategies for ADHD. While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs. The aim of this review is to provide evidence- and expert-based guidance concerning the management of (AEs) with medications for ADHD. Methods: For ease of use by practitioners and clinicians, the article is organized in a simple question and answer format regarding the prevalence and management of the most common AEs. Answers were based on empirical evidence from studies (preferably meta-analyses or systematic reviews) retrieved in PubMed, Ovid, EMBASE and Web of Knowledge through 30 June 2012. When no empirical evidence was available, expert consensus of the members of the European ADHD Guidelines Group is provided. The evidence-level of the management recommendations was based on the SIGN grading system. Results: The review covers monitoring and management strategies of loss of appetite and growth delay, cardiovascular risks, sleep disturbance, tics, substance misuse/abuse, seizures, suicidal thoughts/behaviours and psychotic symptoms. Conclusion: Most AEs during treatment with drugs for ADHD are manageable and most of the times it is not necessary to stop medication, so that patients with ADHD may continue to benefit from the effectiveness of pharmacological treatment. En ligne : http://dx.doi.org/10.1111/jcpp.12036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191

Research Review: The role of diet in the treatment of attention-deficit/hyperactivity disorder – an appraisal of the evidence on efficacy and recommendations on the design of future studies / Jim STEVENSON in Journal of Child Psychology and Psychiatry, 55-5 (May 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-5 (May 2014) . - p.416-427 Titre : Research Review: The role of diet in the treatment of attention-deficit/hyperactivity disorder – an appraisal of the evidence on efficacy and recommendations on the design of future studies Type de document : texte imprimé Auteurs : Jim STEVENSON, Auteur ; Jan K. BUITELAAR, Auteur ; Samuele CORTESE, Auteur ; Maite FERRIN, Auteur ; Eric KONOFAL, Auteur ; Michel LECENDREUX, Auteur ; Emily SIMONOFF, Auteur ; Ian C.K. WONG, Auteur ; Edmund J.S. SONUGA-BARKE, Auteur ; THE EUROPEAN ADHD GUIDELINES GROUP, Auteur Article en page(s) : p.416-427 Mots-clés : ADHD  meta-analysis  food colours  fatty acid  elimination diet  food supplements Index. décimale : PER Périodiques Résumé : Background The efficacy of three dietary treatments for ADHD has been repeatedly tested in randomized controlled trials (RCTs). These interventions are restricted elimination diets (RED), artificial food colour elimination (AFCE) and supplementation with free fatty acids (SFFA). There have been three systematic reviews and associated meta-analyses of the RCTs for each of these treatments. Scope The aim of this review is to critically appraise the studies on the dietary treatments of ADHD, to compare the various meta-analyses of their efficacy that have been published and to identify where the design of such RCTs could be improved and where further investigations are needed. Findings The meta-analyses differ in the inclusion and exclusion criteria applied to potentially eligible studies. The range of average effect sizes in standard deviation units is RED (0.29–1.2), AFCE (0.18–0.42) and SFFA (0.17–0.31). The methodology of many of the trials on which the meta-analyses are based is weak. Conclusions Nevertheless, there is evidence from well-conducted studies for a small effect of SFFA. Restricted elimination diets may be beneficial, but large-scale studies are needed on unselected children, using blind assessment and including assessment of long-term outcome. Artificial food colour elimination is a potentially valuable treatment but its effect size remains uncertain, as does the type of child for whom it is likely to be efficacious. There are additional dietary supplements that have been used with children with ADHD. A systematic search identified 11 RCTs that investigated the effects of these food supplements. Despite positive results for some individual trials, more studies are required before conclusions can be reached on the value in reducing ADHD symptoms of any of these additional supplements. En ligne : http://dx.doi.org/10.1111/jcpp.12215 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231 [article] Research Review: The role of diet in the treatment of attention-deficit/hyperactivity disorder – an appraisal of the evidence on efficacy and recommendations on the design of future studies [texte imprimé] / Jim STEVENSON, Auteur ; Jan K. BUITELAAR, Auteur ; Samuele CORTESE, Auteur ; Maite FERRIN, Auteur ; Eric KONOFAL, Auteur ; Michel LECENDREUX, Auteur ; Emily SIMONOFF, Auteur ; Ian C.K. WONG, Auteur ; Edmund J.S. SONUGA-BARKE, Auteur ; THE EUROPEAN ADHD GUIDELINES GROUP, Auteur . - p.416-427. in Journal of Child Psychology and Psychiatry > 55-5 (May 2014) . - p.416-427 Mots-clés : ADHD  meta-analysis  food colours  fatty acid  elimination diet  food supplements Index. décimale : PER Périodiques Résumé : Background The efficacy of three dietary treatments for ADHD has been repeatedly tested in randomized controlled trials (RCTs). These interventions are restricted elimination diets (RED), artificial food colour elimination (AFCE) and supplementation with free fatty acids (SFFA). There have been three systematic reviews and associated meta-analyses of the RCTs for each of these treatments. Scope The aim of this review is to critically appraise the studies on the dietary treatments of ADHD, to compare the various meta-analyses of their efficacy that have been published and to identify where the design of such RCTs could be improved and where further investigations are needed. Findings The meta-analyses differ in the inclusion and exclusion criteria applied to potentially eligible studies. The range of average effect sizes in standard deviation units is RED (0.29–1.2), AFCE (0.18–0.42) and SFFA (0.17–0.31). The methodology of many of the trials on which the meta-analyses are based is weak. Conclusions Nevertheless, there is evidence from well-conducted studies for a small effect of SFFA. Restricted elimination diets may be beneficial, but large-scale studies are needed on unselected children, using blind assessment and including assessment of long-term outcome. Artificial food colour elimination is a potentially valuable treatment but its effect size remains uncertain, as does the type of child for whom it is likely to be efficacious. There are additional dietary supplements that have been used with children with ADHD. A systematic search identified 11 RCTs that investigated the effects of these food supplements. Despite positive results for some individual trials, more studies are required before conclusions can be reached on the value in reducing ADHD symptoms of any of these additional supplements. En ligne : http://dx.doi.org/10.1111/jcpp.12215 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231

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