[article]
Titre : |
Stability and change in autism spectrum disorder diagnosis from age 3 to middle childhood in a high-risk sibling cohort |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Jessica BRIAN, Auteur ; Susan E. BRYSON, Auteur ; Isabel M SMITH, Auteur ; Wendy ROBERTS, Auteur ; Caroline RONCADIN, Auteur ; Peter SZATMARI, Auteur ; Lonnie ZWAIGENBAUM, Auteur |
Article en page(s) : |
p.888-892 |
Langues : |
Anglais (eng) |
Mots-clés : |
autism spectrum disorder diagnostic stability middle childhood sibling toddler |
Index. décimale : |
PER Périodiques |
Résumé : |
Considerable evidence on autism spectrum disorder emergence comes from longitudinal high-risk samples (i.e. younger siblings of children with autism spectrum disorder). Diagnostic stability to age 3 is very good when diagnosed as early as 18–24?months, but sensitivity is weaker, and relatively little is known beyond toddlerhood. We examined stability and change in blinded, clinical best-estimate diagnosis from age 3 to middle childhood (mean age?=?9.5?years) in 67 high-risk siblings enrolled in infancy. Good agreement emerged for clinical best-estimate diagnoses (89.6% overall; kappa?=?0.76, p?0.001, 95% confidence interval?=?0.59–0.93). At age 3, 18 cases (26.9%) were classified with “autism spectrum disorder”: 17 retained their autism spectrum disorder diagnosis (94.4%; 13 boys, 4 girls) and 1 no longer met autism spectrum disorder criteria at follow-up. Among “non–autism spectrum disorder” cases at age 3, 43/49 remained non–autism spectrum disorder at follow-up (87.8%; 22 boys, 21 girls) and 6/49 met lower autism symptomatology criteria (“Later-Diagnosed”; 3 boys, 3 girls). Later-diagnosed cases had significantly lower autism spectrum disorder symptomatology and higher receptive language at age 3 and trends toward lower autism symptoms and higher cognitive abilities at follow-up. Emerging developmental concerns were noted in all later-diagnosed cases, by age 3 or 5. High-risk children need to be followed up into middle childhood, particularly when showing differences in autism-related domains. |
En ligne : |
http://dx.doi.org/10.1177/1362361315614979 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 |
in Autism > 20-7 (October 2016) . - p.888-892
[article] Stability and change in autism spectrum disorder diagnosis from age 3 to middle childhood in a high-risk sibling cohort [Texte imprimé et/ou numérique] / Jessica BRIAN, Auteur ; Susan E. BRYSON, Auteur ; Isabel M SMITH, Auteur ; Wendy ROBERTS, Auteur ; Caroline RONCADIN, Auteur ; Peter SZATMARI, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.888-892. Langues : Anglais ( eng) in Autism > 20-7 (October 2016) . - p.888-892
Mots-clés : |
autism spectrum disorder diagnostic stability middle childhood sibling toddler |
Index. décimale : |
PER Périodiques |
Résumé : |
Considerable evidence on autism spectrum disorder emergence comes from longitudinal high-risk samples (i.e. younger siblings of children with autism spectrum disorder). Diagnostic stability to age 3 is very good when diagnosed as early as 18–24?months, but sensitivity is weaker, and relatively little is known beyond toddlerhood. We examined stability and change in blinded, clinical best-estimate diagnosis from age 3 to middle childhood (mean age?=?9.5?years) in 67 high-risk siblings enrolled in infancy. Good agreement emerged for clinical best-estimate diagnoses (89.6% overall; kappa?=?0.76, p?0.001, 95% confidence interval?=?0.59–0.93). At age 3, 18 cases (26.9%) were classified with “autism spectrum disorder”: 17 retained their autism spectrum disorder diagnosis (94.4%; 13 boys, 4 girls) and 1 no longer met autism spectrum disorder criteria at follow-up. Among “non–autism spectrum disorder” cases at age 3, 43/49 remained non–autism spectrum disorder at follow-up (87.8%; 22 boys, 21 girls) and 6/49 met lower autism symptomatology criteria (“Later-Diagnosed”; 3 boys, 3 girls). Later-diagnosed cases had significantly lower autism spectrum disorder symptomatology and higher receptive language at age 3 and trends toward lower autism symptoms and higher cognitive abilities at follow-up. Emerging developmental concerns were noted in all later-diagnosed cases, by age 3 or 5. High-risk children need to be followed up into middle childhood, particularly when showing differences in autism-related domains. |
En ligne : |
http://dx.doi.org/10.1177/1362361315614979 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 |
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