The co-occurrence of autism spectrum disorder and attention-deficit/hyperactivity disorder symptoms in parents of children with ASD or ASD with ADHD / Daphne J. VAN STEIJN in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.954-63 Titre : The co-occurrence of autism spectrum disorder and attention-deficit/hyperactivity disorder symptoms in parents of children with ASD or ASD with ADHD Type de document : texte imprimé Auteurs : Daphne J. VAN STEIJN, Auteur ; Jennifer RICHARDS, Auteur ; Anoek M. OERLEMANS, Auteur ; Saskia W. DE RUITER, Auteur ; Marcel A.G. VAN AKEN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur Année de publication : 2012 Article en page(s) : p.954-63 Langues : Anglais (eng) Mots-clés : Assortative mating  parent-of-origin effect  autism spectrum disorder  attention-deficit/hyperactivity disorder Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share about 50–72% of their genetic factors, which is the most likely explanation for their frequent co-occurrence within the same patient or family. An additional or alternative explanation for the co-occurrence may be (cross-)assortative mating, e.g., the tendency to choose a partner that is similar or dissimilar to oneself. Another issue is that of parent-of-origin effect which refers to the possibility of parents differing in the relative quantity of risk factors they transmit to the offspring. The current study sets out to examine (cross-)assortative mating and (cross-)parent-of-origin effects of ASD and ADHD in parents of children with either ASD or ASD with ADHD diagnosis. Methods:  In total, 121 families were recruited in an ongoing autism-ADHD family genetics project. Participating families consisted of parents and at least one child aged between 2 and 20 years, with either autistic disorder, Asperger disorder or PDD-NOS, and one or more biological siblings. All children and parents were carefully screened for the presence of ASD and ADHD. Results:  No correlations were found between maternal and paternal ASD and ADHD symptoms. Parental ASD and ADHD symptoms were predictive for similar symptoms in the offspring, but with maternal hyperactive-impulsive symptoms, but not paternal symptoms, predicting similar symptoms in daughters. ASD pathology in the parents was not predictive for ADHD pathology in the offspring, but mother’s ADHD pathology was predictive for offspring ASD pathology even when corrected for maternal ASD pathology. Conclusions:  Cross-assortative mating for ASD and ADHD does not form an explanation for the frequent co-occurrence of these disorders within families. Given that parental ADHD is predictive of offspring’ ASD but not vice versa, risk factors underlying ASD may overlap to a larger degree with risk factors underlying ADHD than vice versa. However, future research is needed to clarify this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02556.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] The co-occurrence of autism spectrum disorder and attention-deficit/hyperactivity disorder symptoms in parents of children with ASD or ASD with ADHD [texte imprimé] / Daphne J. VAN STEIJN, Auteur ; Jennifer RICHARDS, Auteur ; Anoek M. OERLEMANS, Auteur ; Saskia W. DE RUITER, Auteur ; Marcel A.G. VAN AKEN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur . - 2012 . - p.954-63. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.954-63 Mots-clés : Assortative mating  parent-of-origin effect  autism spectrum disorder  attention-deficit/hyperactivity disorder Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share about 50–72% of their genetic factors, which is the most likely explanation for their frequent co-occurrence within the same patient or family. An additional or alternative explanation for the co-occurrence may be (cross-)assortative mating, e.g., the tendency to choose a partner that is similar or dissimilar to oneself. Another issue is that of parent-of-origin effect which refers to the possibility of parents differing in the relative quantity of risk factors they transmit to the offspring. The current study sets out to examine (cross-)assortative mating and (cross-)parent-of-origin effects of ASD and ADHD in parents of children with either ASD or ASD with ADHD diagnosis. Methods:  In total, 121 families were recruited in an ongoing autism-ADHD family genetics project. Participating families consisted of parents and at least one child aged between 2 and 20 years, with either autistic disorder, Asperger disorder or PDD-NOS, and one or more biological siblings. All children and parents were carefully screened for the presence of ASD and ADHD. Results:  No correlations were found between maternal and paternal ASD and ADHD symptoms. Parental ASD and ADHD symptoms were predictive for similar symptoms in the offspring, but with maternal hyperactive-impulsive symptoms, but not paternal symptoms, predicting similar symptoms in daughters. ASD pathology in the parents was not predictive for ADHD pathology in the offspring, but mother’s ADHD pathology was predictive for offspring ASD pathology even when corrected for maternal ASD pathology. Conclusions:  Cross-assortative mating for ASD and ADHD does not form an explanation for the frequent co-occurrence of these disorders within families. Given that parental ADHD is predictive of offspring’ ASD but not vice versa, risk factors underlying ASD may overlap to a larger degree with risk factors underlying ADHD than vice versa. However, future research is needed to clarify this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02556.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder / Dennis VAN DER MEER in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1363-1371 Titre : The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Dennis VAN DER MEER, Auteur ; Catharina A. HARTMAN, Auteur ; Jennifer RICHARDS, Auteur ; Janita B. BRALTEN, Auteur ; Barbara FRANKE, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Stephen V. FARAONE, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur Article en page(s) : p.1363-1371 Langues : Anglais (eng) Mots-clés : ADHD  gene–environment interaction (GxE)  stress  serotonin transporter (5-HTTLPR) Index. décimale : PER Périodiques Résumé : Introduction The role of the serotonin transporter gene polymorphism 5-HTTLPR in attention-deficit/hyperactivity disorder (ADHD) is unclear. Heterogeneity of findings may be explained by gene–environment interactions (GxE), as it has been suggested that S-allele carriers are more reactive to psychosocial stress than L-allele homozygotes. This study aimed to investigate whether 5-HTTLPR genotype moderates the effects of stress on ADHD in a multisite prospective ADHD cohort study. Methods 5-HTTLPR genotype, as well as the number of stressful life events in the past 5 years and ongoing long-term difficulties, was determined in 671 adolescents and young adults with ADHD, their siblings, and healthy controls (57.4% male, average age 17.3 years). Linear mixed models, accounting for family relatedness, were applied to investigate the effects of genotype, experienced stress, and their interaction on ADHD severity at time point T2, while controlling for ADHD severity at T1 (mean follow-up time 5.9 years) and for comorbid internalizing problems at T2. Results The interaction between genotype and stress significantly predicted ADHD severity at T2 (p = .006), which was driven by the effect on hyperactivity–impulsivity (p = .004). Probing of the interaction effect made clear that S-allele carriers had a significantly more positive correlation between stress and ADHD severity than L-allele homozygotes. Conclusion The results show that the interaction between 5-HTTLPR and stress is a mechanism involved particularly in the hyperactivity/impulsivity dimension of ADHD, and that this is independent of comorbid internalizing problems. Further research into the neurobiological mechanisms underlying this interaction effect is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] The serotonin transporter gene polymorphism 5-HTTLPR moderates the effects of stress on attention-deficit/hyperactivity disorder [texte imprimé] / Dennis VAN DER MEER, Auteur ; Catharina A. HARTMAN, Auteur ; Jennifer RICHARDS, Auteur ; Janita B. BRALTEN, Auteur ; Barbara FRANKE, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Stephen V. FARAONE, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur . - p.1363-1371. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1363-1371 Mots-clés : ADHD  gene–environment interaction (GxE)  stress  serotonin transporter (5-HTTLPR) Index. décimale : PER Périodiques Résumé : Introduction The role of the serotonin transporter gene polymorphism 5-HTTLPR in attention-deficit/hyperactivity disorder (ADHD) is unclear. Heterogeneity of findings may be explained by gene–environment interactions (GxE), as it has been suggested that S-allele carriers are more reactive to psychosocial stress than L-allele homozygotes. This study aimed to investigate whether 5-HTTLPR genotype moderates the effects of stress on ADHD in a multisite prospective ADHD cohort study. Methods 5-HTTLPR genotype, as well as the number of stressful life events in the past 5 years and ongoing long-term difficulties, was determined in 671 adolescents and young adults with ADHD, their siblings, and healthy controls (57.4% male, average age 17.3 years). Linear mixed models, accounting for family relatedness, were applied to investigate the effects of genotype, experienced stress, and their interaction on ADHD severity at time point T2, while controlling for ADHD severity at T1 (mean follow-up time 5.9 years) and for comorbid internalizing problems at T2. Results The interaction between genotype and stress significantly predicted ADHD severity at T2 (p = .006), which was driven by the effect on hyperactivity–impulsivity (p = .004). Probing of the interaction effect made clear that S-allele carriers had a significantly more positive correlation between stress and ADHD severity than L-allele homozygotes. Conclusion The results show that the interaction between 5-HTTLPR and stress is a mechanism involved particularly in the hyperactivity/impulsivity dimension of ADHD, and that this is independent of comorbid internalizing problems. Further research into the neurobiological mechanisms underlying this interaction effect is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12240 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

The social withdrawal and social anxiety feedback loop and the role of peer victimization and acceptance in the pathways / Stefania A. BARZEVA in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1402-1417 Titre : The social withdrawal and social anxiety feedback loop and the role of peer victimization and acceptance in the pathways Type de document : texte imprimé Auteurs : Stefania A. BARZEVA, Auteur ; Jennifer RICHARDS, Auteur ; Wim H.J. MEEUS, Auteur ; Albertine J. OLDEHINKEL, Auteur Article en page(s) : p.1402-1417 Langues : Anglais (eng) Mots-clés : peer acceptance  peer victimization  random intercept cross-lagged panel model  social anxiety  social withdrawal Index. décimale : PER Périodiques Résumé : Social withdrawal and social anxiety are believed to have a bidirectional influence on one another, but it is unknown if their relationship is bidirectional, especially within person, and if peer experiences influence this relationship. We investigated temporal sequencing and the strength of effects between social withdrawal and social anxiety, and the roles of peer victimization and acceptance in the pathways. Participants were 2,772 adolescents from the population-based and clinically referred cohorts of the Tracking Adolescents' Individual Lives Survey. Self- and parent-reported withdrawal, and self-reported social anxiety, peer victimization, and perceived peer acceptance were assessed at 11, 13, and 16 years. Random-intercept cross-lagged panel models were used to investigate within-person associations between these variables. There was no feedback loop between withdrawal and social anxiety. Social withdrawal did not predict social anxiety at any age. Social anxiety at 11 years predicted increased self-reported withdrawal at 13 years. Negative peer experiences predicted increased self- and parent-reported withdrawal at 13 years and increased parent-reported withdrawal at 16 years. In turn, self-reported withdrawal at 13 years predicted negative peer experiences at 16 years. In conclusion, adolescents became more withdrawn when they became more socially anxious or experienced greater peer problems, and increasing withdrawal predicted greater victimization and lower acceptance. En ligne : http://dx.doi.org/10.1017/s0954579419001354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] The social withdrawal and social anxiety feedback loop and the role of peer victimization and acceptance in the pathways [texte imprimé] / Stefania A. BARZEVA, Auteur ; Jennifer RICHARDS, Auteur ; Wim H.J. MEEUS, Auteur ; Albertine J. OLDEHINKEL, Auteur . - p.1402-1417. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1402-1417 Mots-clés : peer acceptance  peer victimization  random intercept cross-lagged panel model  social anxiety  social withdrawal Index. décimale : PER Périodiques Résumé : Social withdrawal and social anxiety are believed to have a bidirectional influence on one another, but it is unknown if their relationship is bidirectional, especially within person, and if peer experiences influence this relationship. We investigated temporal sequencing and the strength of effects between social withdrawal and social anxiety, and the roles of peer victimization and acceptance in the pathways. Participants were 2,772 adolescents from the population-based and clinically referred cohorts of the Tracking Adolescents' Individual Lives Survey. Self- and parent-reported withdrawal, and self-reported social anxiety, peer victimization, and perceived peer acceptance were assessed at 11, 13, and 16 years. Random-intercept cross-lagged panel models were used to investigate within-person associations between these variables. There was no feedback loop between withdrawal and social anxiety. Social withdrawal did not predict social anxiety at any age. Social anxiety at 11 years predicted increased self-reported withdrawal at 13 years. Negative peer experiences predicted increased self- and parent-reported withdrawal at 13 years and increased parent-reported withdrawal at 16 years. In turn, self-reported withdrawal at 13 years predicted negative peer experiences at 16 years. In conclusion, adolescents became more withdrawn when they became more socially anxious or experienced greater peer problems, and increasing withdrawal predicted greater victimization and lower acceptance. En ligne : http://dx.doi.org/10.1017/s0954579419001354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

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