Adversity in preschool-aged children: Effects on salivary interleukin-1? / Audrey R. TYRKA in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.567-576 Titre : Adversity in preschool-aged children: Effects on salivary interleukin-1? Type de document : Texte imprimé et/ou numérique Auteurs : Audrey R. TYRKA, Auteur ; Stephanie H. PARADE, Auteur ; Thomas R. VALENTINE, Auteur ; Nicole M. ESLINGER, Auteur ; Ronald SEIFER, Auteur Article en page(s) : p.567-576 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Exposure to early life adversity is linked to impaired affective, cognitive, and behavioral functioning and increases risk for various psychiatric and medical conditions. Stress-induced increases in pro-inflammatory cytokines may be a biological mechanism of these effects. Few studies have examined cytokine levels in children experiencing early life adversity, and very little research has investigated cytokines or other markers of inflammation in saliva. In the present study, we examined salivary interleukin (IL)-1? and C-reactive protein (CRP) levels in relation to stress exposure in 40 children aged 3 to 5 years who were enrolled in a larger study of early life adversity. Childhood maltreatment status was assessed via review of child welfare records. Contextual stress exposure, traumatic life event history, and symptoms of psychopathology were assessed via caregiver interviews at a home visit. In a subsequent visit, salivary IL-1? and CRP were obtained before and after participation in four emotion-eliciting tasks. The number of past-month contextual stressors, lifetime contextual stressors, and traumatic life events each demonstrated a significant main effect on IL-1?. Baseline IL-1? was positively associated with each of the significant main-effect adversities. Postchallenge IL-1? displayed positive associations with each adversity variable, but these were not significant. CRP was not significantly associated with any of the adversity variables. Given the evidence suggesting the involvement of IL-1? in the neuropathology of psychiatric conditions, these results may have important implications for developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579415000164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Adversity in preschool-aged children: Effects on salivary interleukin-1? [Texte imprimé et/ou numérique] / Audrey R. TYRKA, Auteur ; Stephanie H. PARADE, Auteur ; Thomas R. VALENTINE, Auteur ; Nicole M. ESLINGER, Auteur ; Ronald SEIFER, Auteur . - p.567-576. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.567-576 Index. décimale : PER Périodiques Résumé : Exposure to early life adversity is linked to impaired affective, cognitive, and behavioral functioning and increases risk for various psychiatric and medical conditions. Stress-induced increases in pro-inflammatory cytokines may be a biological mechanism of these effects. Few studies have examined cytokine levels in children experiencing early life adversity, and very little research has investigated cytokines or other markers of inflammation in saliva. In the present study, we examined salivary interleukin (IL)-1? and C-reactive protein (CRP) levels in relation to stress exposure in 40 children aged 3 to 5 years who were enrolled in a larger study of early life adversity. Childhood maltreatment status was assessed via review of child welfare records. Contextual stress exposure, traumatic life event history, and symptoms of psychopathology were assessed via caregiver interviews at a home visit. In a subsequent visit, salivary IL-1? and CRP were obtained before and after participation in four emotion-eliciting tasks. The number of past-month contextual stressors, lifetime contextual stressors, and traumatic life events each demonstrated a significant main effect on IL-1?. Baseline IL-1? was positively associated with each of the significant main-effect adversities. Postchallenge IL-1? displayed positive associations with each adversity variable, but these were not significant. CRP was not significantly associated with any of the adversity variables. Given the evidence suggesting the involvement of IL-1? in the neuropathology of psychiatric conditions, these results may have important implications for developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579415000164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity / Stephanie H. PARADE in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1627-1634 Titre : Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie H. PARADE, Auteur ; Justin PARENT, Auteur ; Kantoniony RABEMANANJARA, Auteur ; Ronald SEIFER, Auteur ; Carmen J. MARSIT, Auteur ; Bao-Zhu YANG, Auteur ; Huiping ZHANG, Auteur ; Audrey R. TYRKA, Auteur Article en page(s) : p.1627-1634 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : FK506 binding protein 5 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate to severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semistructured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization. Methylation of FKBP5 at two CpG sites in intron 7 was measured from saliva DNA at the time of initial study enrollment, and 6 months following enrollment. Child maltreatment was associated with change in FKBP5 methylation over time, but only when children were exposed to high levels of other contextual stressors. Service utilization was associated with increases in methylation over time, but only among children with the FKPB5 rs1360780 protective CC genotype. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579417001286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity [Texte imprimé et/ou numérique] / Stephanie H. PARADE, Auteur ; Justin PARENT, Auteur ; Kantoniony RABEMANANJARA, Auteur ; Ronald SEIFER, Auteur ; Carmen J. MARSIT, Auteur ; Bao-Zhu YANG, Auteur ; Huiping ZHANG, Auteur ; Audrey R. TYRKA, Auteur . - p.1627-1634. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1627-1634 Index. décimale : PER Périodiques Résumé : FK506 binding protein 5 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate to severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semistructured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization. Methylation of FKBP5 at two CpG sites in intron 7 was measured from saliva DNA at the time of initial study enrollment, and 6 months following enrollment. Child maltreatment was associated with change in FKBP5 methylation over time, but only when children were exposed to high levels of other contextual stressors. Service utilization was associated with increases in methylation over time, but only among children with the FKPB5 rs1360780 protective CC genotype. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes. En ligne : http://dx.doi.org/10.1017/S0954579417001286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults / Audrey R. TYRKA in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1319-1331 Titre : Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults Type de document : Texte imprimé et/ou numérique Auteurs : Audrey R. TYRKA, Auteur ; Kathryn K. RIDOUT, Auteur ; Stephanie H. PARADE, Auteur Article en page(s) : p.1319-1331 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early childhood experiences have lasting effects on development, including the risk for psychiatric disorders. Research examining the biologic underpinnings of these associations has revealed the impact of childhood maltreatment on the physiologic stress response and activity of the hypothalamus–pituitary–adrenal axis. A growing body of literature supports the hypothesis that environmental exposures mediate their biological effects via epigenetic mechanisms. Methylation, which is thought to be the most stable form of epigenetic change, is a likely mechanism by which early life exposures have lasting effects. We present recent evidence related to epigenetic regulation of genes involved in hypothalamus–pituitary–adrenal axis regulation, namely, the glucocorticoid receptor gene (nuclear receptor subfamily 3, group C, member 1 [NR3C1]) and FK506 binding protein 51 gene (FKBP5), after childhood adversity and associations with risk for psychiatric disorders. Implications for the development of interventions and future research are discussed. En ligne : http://dx.doi.org/10.1017/s0954579416000870 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults [Texte imprimé et/ou numérique] / Audrey R. TYRKA, Auteur ; Kathryn K. RIDOUT, Auteur ; Stephanie H. PARADE, Auteur . - p.1319-1331. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1319-1331 Index. décimale : PER Périodiques Résumé : Early childhood experiences have lasting effects on development, including the risk for psychiatric disorders. Research examining the biologic underpinnings of these associations has revealed the impact of childhood maltreatment on the physiologic stress response and activity of the hypothalamus–pituitary–adrenal axis. A growing body of literature supports the hypothesis that environmental exposures mediate their biological effects via epigenetic mechanisms. Methylation, which is thought to be the most stable form of epigenetic change, is a likely mechanism by which early life exposures have lasting effects. We present recent evidence related to epigenetic regulation of genes involved in hypothalamus–pituitary–adrenal axis regulation, namely, the glucocorticoid receptor gene (nuclear receptor subfamily 3, group C, member 1 [NR3C1]) and FK506 binding protein 51 gene (FKBP5), after childhood adversity and associations with risk for psychiatric disorders. Implications for the development of interventions and future research are discussed. En ligne : http://dx.doi.org/10.1017/s0954579416000870 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5) / Audrey R. TYRKA in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1637-1645 Titre : Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5) Type de document : Texte imprimé et/ou numérique Auteurs : Audrey R. TYRKA, Auteur ; Kathryn K. RIDOUT, Auteur ; Stephanie H. PARADE, Auteur ; Alison PAQUETTE, Auteur ; Carmen J. MARSIT, Auteur ; Ronald SEIFER, Auteur Article en page(s) : p.1637-1645 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A growing body of evidence suggests that alterations of the stress response system may be a mechanism by which childhood maltreatment alters risk for psychopathology. FK506 binding protein 51 (FKBP5) binds to the glucocorticoid receptor and alters its ability to respond to stress signaling. The aim of the present study was to examine methylation of the FKBP5 gene (FKBP5), and the role of an FKBP5 genetic variant, in relation to childhood maltreatment in a sample of impoverished preschool-aged children. One hundred seventy-four families participated in this study, including 69 with child welfare documentation of moderate to severe maltreatment in the past 6 months. The children, who ranged in age from 3 to 5 years, were racially and ethnically diverse. Structured record review and interviews in the home were used to assess a history of maltreatment, other traumas, and contextual life stressors; and a composite variable assessed the number exposures to these adversities. Methylation of two sites in intron 7 of FKBP5 was measured via sodium bisulfite pyrosequencing. Maltreated children had significantly lower levels of methylation at both CpG sites (p < .05). Lifetime contextual stress exposure showed a trend for lower levels of methylation at one of the sites, and a trend for an interaction with the FKBP5 polymorphism. A composite adversity variable was associated with lower levels of methylation at one of the sites as well (p < .05). FKBP5 alters glucocorticoid receptor responsiveness, and FKBP5 gene methylation may be a mechanism of the biobehavioral effects of adverse exposures in young children. En ligne : http://dx.doi.org/10.1017/S0954579415000991 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5) [Texte imprimé et/ou numérique] / Audrey R. TYRKA, Auteur ; Kathryn K. RIDOUT, Auteur ; Stephanie H. PARADE, Auteur ; Alison PAQUETTE, Auteur ; Carmen J. MARSIT, Auteur ; Ronald SEIFER, Auteur . - p.1637-1645. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1637-1645 Index. décimale : PER Périodiques Résumé : A growing body of evidence suggests that alterations of the stress response system may be a mechanism by which childhood maltreatment alters risk for psychopathology. FK506 binding protein 51 (FKBP5) binds to the glucocorticoid receptor and alters its ability to respond to stress signaling. The aim of the present study was to examine methylation of the FKBP5 gene (FKBP5), and the role of an FKBP5 genetic variant, in relation to childhood maltreatment in a sample of impoverished preschool-aged children. One hundred seventy-four families participated in this study, including 69 with child welfare documentation of moderate to severe maltreatment in the past 6 months. The children, who ranged in age from 3 to 5 years, were racially and ethnically diverse. Structured record review and interviews in the home were used to assess a history of maltreatment, other traumas, and contextual life stressors; and a composite variable assessed the number exposures to these adversities. Methylation of two sites in intron 7 of FKBP5 was measured via sodium bisulfite pyrosequencing. Maltreated children had significantly lower levels of methylation at both CpG sites (p < .05). Lifetime contextual stress exposure showed a trend for lower levels of methylation at one of the sites, and a trend for an interaction with the FKBP5 polymorphism. A composite adversity variable was associated with lower levels of methylation at one of the sites as well (p < .05). FKBP5 alters glucocorticoid receptor responsiveness, and FKBP5 gene methylation may be a mechanism of the biobehavioral effects of adverse exposures in young children. En ligne : http://dx.doi.org/10.1017/S0954579415000991 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

Community-engaged research: Bringing the science of developmental psychopathology into the real world / Stephanie H. PARADE ; Ernestine Jennings ; Lindsay Huffhines ; Darlynn M. Rojo-Wissar ; Colleen Caron ; Blythe Berger ; Laura R. STROUD ; Audrey R. TYRKA in Development and Psychopathology, 36-5 (December 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-5 (December 2024) . - p.2349-2356 Titre : Community-engaged research: Bringing the science of developmental psychopathology into the real world : Development and Psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie H. PARADE, Auteur ; Ernestine Jennings, Auteur ; Lindsay Huffhines, Auteur ; Darlynn M. Rojo-Wissar, Auteur ; Colleen Caron, Auteur ; Blythe Berger, Auteur ; Laura R. STROUD, Auteur ; Audrey R. TYRKA, Auteur Année de publication : 2024 Article en page(s) : p.2349-2356 Langues : Anglais (eng) Mots-clés : Academic-community partnerships  community collaboration  community engagement  community-engaged research  research-community partnerships Index. décimale : PER Périodiques Résumé : The science of developmental psychopathology has made outstanding progress over the past 40 years in understanding adaptive and maladaptive developmental processes across the life span. Yet most of this work has been researcher driven with little involvement of community partners in the research process, limiting the potential public health significance of our work. To continue to advance the field we must move beyond the physical and conceptual walls of our research laboratories and into the real world. In this article, we define and describe the importance of community-engaged research, and present our overarching principles for engaging the community including practicing respect, shared power and decision-making, prioritizing the needs of the community, and engaging in consistent and transparent communication. We present several associated recommendations for best practice and highlight examples from our own research that is grounded in a developmental psychopathology perspective to illustrate these practices. Recommendations for the future of the discipline of development and psychopathology, with emphasis on training and continuing education, are described. En ligne : https://dx.doi.org/10.1017/S0954579424001020 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Community-engaged research: Bringing the science of developmental psychopathology into the real world : Development and Psychopathology [Texte imprimé et/ou numérique] / Stephanie H. PARADE, Auteur ; Ernestine Jennings, Auteur ; Lindsay Huffhines, Auteur ; Darlynn M. Rojo-Wissar, Auteur ; Colleen Caron, Auteur ; Blythe Berger, Auteur ; Laura R. STROUD, Auteur ; Audrey R. TYRKA, Auteur . - 2024 . - p.2349-2356. Langues : Anglais (eng) in Development and Psychopathology > 36-5 (December 2024) . - p.2349-2356 Mots-clés : Academic-community partnerships  community collaboration  community engagement  community-engaged research  research-community partnerships Index. décimale : PER Périodiques Résumé : The science of developmental psychopathology has made outstanding progress over the past 40 years in understanding adaptive and maladaptive developmental processes across the life span. Yet most of this work has been researcher driven with little involvement of community partners in the research process, limiting the potential public health significance of our work. To continue to advance the field we must move beyond the physical and conceptual walls of our research laboratories and into the real world. In this article, we define and describe the importance of community-engaged research, and present our overarching principles for engaging the community including practicing respect, shared power and decision-making, prioritizing the needs of the community, and engaging in consistent and transparent communication. We present several associated recommendations for best practice and highlight examples from our own research that is grounded in a developmental psychopathology perspective to illustrate these practices. Recommendations for the future of the discipline of development and psychopathology, with emphasis on training and continuing education, are described. En ligne : https://dx.doi.org/10.1017/S0954579424001020 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

Dynamic stress-related epigenetic regulation of the glucocorticoid receptor gene promoter during early development: The role of child maltreatment / Justin PARENT in Development and Psychopathology, 29-5 (December 2017)  

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Early childhood trauma exposure and neurocognitive and emotional processes: Associations in young children in a partial hospital program / Lindsay Huffhines in Development and Psychopathology, 37-2 (May 2025)  

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Interleukin 1B gene (IL1B) variation and internalizing symptoms in maltreated preschoolers / Kathryn K. RIDOUT in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

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Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children / Audrey R. TYRKA in Development and Psychopathology, 27-2 (May 2015)  

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Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers / Stephanie H. PARADE in Development and Psychopathology, 29-5 (December 2017)  

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