Asperger syndrome in males over two decades: Quality of life in relation to diagnostic stability and psychiatric comorbidity / Adam HELLES in Autism, 21-4 (May 2017)  

Public ISBD [article]  inAutism > 21-4 (May 2017) . - p.458-469 Titre : Asperger syndrome in males over two decades: Quality of life in relation to diagnostic stability and psychiatric comorbidity Type de document : Texte imprimé et/ou numérique Auteurs : Adam HELLES, Auteur ; I Carina GILLBERG, Auteur ; Christopher GILLBERG, Auteur ; Eva BILLSTEDT, Auteur Article en page(s) : p.458-469 Langues : Anglais (eng) Mots-clés : adults  autism spectrum disorders  development  diagnosis  psychiatric comorbidity  quality of life Index. décimale : PER Périodiques Résumé : This study examined objective quality of life (work, academic success, living situation, relationships, support system) and subjective quality of life (Sense of Coherence and Short-Form Health Survey-36) in an adult sample of males (n?=?50, mean age: 30?years) with Asperger syndrome diagnosed in childhood and followed prospectively over two decades. The association between long-term diagnostic stability of an autism spectrum disorder and/or comorbid psychiatric disorders with quality of life was also examined. The results showed great variability as regards quality of life. The subsample that no longer fulfilled an autism spectrum disorder had full-time jobs or studies (10/11), independent living (100%), and reported having two or more friends (100%). In the stable autism spectrum disorder group, 41% had full-time job or studies, 51% lived independently, and 33% reported two or more friends, and a significant minority had specialized employments, lived with support from the government, or had no friends. Academic success was positively correlated with IQ. A majority of the total group scored average Sense of Coherence scores, and the mean for Short-Form Health Survey-36 was above average regarding psychical health and below average regarding mental health. Stability of autism spectrum disorder diagnosis was associated with objective but not subjective quality of life, while psychiatric comorbidity was associated with subjective but not objective quality of life. En ligne : http://dx.doi.org/10.1177/1362361316650090 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Asperger syndrome in males over two decades: Quality of life in relation to diagnostic stability and psychiatric comorbidity [Texte imprimé et/ou numérique] / Adam HELLES, Auteur ; I Carina GILLBERG, Auteur ; Christopher GILLBERG, Auteur ; Eva BILLSTEDT, Auteur . - p.458-469. Langues : Anglais (eng) in Autism > 21-4 (May 2017) . - p.458-469 Mots-clés : adults  autism spectrum disorders  development  diagnosis  psychiatric comorbidity  quality of life Index. décimale : PER Périodiques Résumé : This study examined objective quality of life (work, academic success, living situation, relationships, support system) and subjective quality of life (Sense of Coherence and Short-Form Health Survey-36) in an adult sample of males (n?=?50, mean age: 30?years) with Asperger syndrome diagnosed in childhood and followed prospectively over two decades. The association between long-term diagnostic stability of an autism spectrum disorder and/or comorbid psychiatric disorders with quality of life was also examined. The results showed great variability as regards quality of life. The subsample that no longer fulfilled an autism spectrum disorder had full-time jobs or studies (10/11), independent living (100%), and reported having two or more friends (100%). In the stable autism spectrum disorder group, 41% had full-time job or studies, 51% lived independently, and 33% reported two or more friends, and a significant minority had specialized employments, lived with support from the government, or had no friends. Academic success was positively correlated with IQ. A majority of the total group scored average Sense of Coherence scores, and the mean for Short-Form Health Survey-36 was above average regarding psychical health and below average regarding mental health. Stability of autism spectrum disorder diagnosis was associated with objective but not subjective quality of life, while psychiatric comorbidity was associated with subjective but not objective quality of life. En ligne : http://dx.doi.org/10.1177/1362361316650090 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Asperger syndrome in males over two decades: stability and predictors of diagnosis / Adam HELLES in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.711-718 Titre : Asperger syndrome in males over two decades: stability and predictors of diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Adam HELLES, Auteur ; Carina I. GILLBERG, Auteur ; Christopher GILLBERG, Auteur ; Eva BILLSTEDT, Auteur Article en page(s) : p.711-718 Langues : Anglais (eng) Mots-clés : Asperger syndrome  diagnostic stability  autism spectrum disorder  pervasive developmental disorder  males  longitudinal study Index. décimale : PER Périodiques Résumé : Objective To examine the diagnostic stability of a childhood diagnosis of Asperger Syndrome (AS) into adulthood in a prospective longitudinal study, and identify the predictors of stability. Methods One hundred males with AS diagnosed in childhood (T0) according to Gillberg's AS criteria, were followed up prospectively into adulthood over an average of 19 years (range 13–26 years). Fifty males (mean age 30 years) participated in this second follow-up (T2) of the cohort. Seventy-six had participated in a previous follow-up (T1) at mean age 22 years (47 participated in both follow-ups). Diagnosis at T2 was assessed using three sets of diagnostic criteria (Gillberg's AS criteria, DSM-IV Pervasive Developmental Disorder (PDD) and DSM-5 Autism Spectrum Disorder (ASD) criteria) and compared to previous assessments. Background predictors of diagnostic stability were analyzed. General functioning at T2 was assessed and compared to T1. Results There was a decline in the stability of AS diagnosis over time, the rate dropping from 82% at T1 to 44% at T2, when using the Gillberg criteria. There was also a significant decrease in the rate of cases fulfilling any PDD diagnosis according to the DSM-IV, from 91% at T1 to 76% at T2 in the 47 cases followed up twice. Severity of autism spectrum symptoms at T1 was the main predictor of diagnostic stability at T2. Twenty percent of those meeting criteria for a PDD diagnosis according to DSM-IV, did not meet DSM-5 ASD criteria although they had marked difficulties in everyday life. Conclusion Asperger Syndrome, when considered as an ASD/PDD diagnosis, was fairly stable into adulthood, but there was a significant increase over time in cases no longer meeting criteria for an ASD diagnosis according to the DSM-IV, or AS according to the Gillberg criteria. Cases with a stable diagnosis showed significantly more core ASD symptoms in adolescence/young adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.12334 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Asperger syndrome in males over two decades: stability and predictors of diagnosis [Texte imprimé et/ou numérique] / Adam HELLES, Auteur ; Carina I. GILLBERG, Auteur ; Christopher GILLBERG, Auteur ; Eva BILLSTEDT, Auteur . - p.711-718. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.711-718 Mots-clés : Asperger syndrome  diagnostic stability  autism spectrum disorder  pervasive developmental disorder  males  longitudinal study Index. décimale : PER Périodiques Résumé : Objective To examine the diagnostic stability of a childhood diagnosis of Asperger Syndrome (AS) into adulthood in a prospective longitudinal study, and identify the predictors of stability. Methods One hundred males with AS diagnosed in childhood (T0) according to Gillberg's AS criteria, were followed up prospectively into adulthood over an average of 19 years (range 13–26 years). Fifty males (mean age 30 years) participated in this second follow-up (T2) of the cohort. Seventy-six had participated in a previous follow-up (T1) at mean age 22 years (47 participated in both follow-ups). Diagnosis at T2 was assessed using three sets of diagnostic criteria (Gillberg's AS criteria, DSM-IV Pervasive Developmental Disorder (PDD) and DSM-5 Autism Spectrum Disorder (ASD) criteria) and compared to previous assessments. Background predictors of diagnostic stability were analyzed. General functioning at T2 was assessed and compared to T1. Results There was a decline in the stability of AS diagnosis over time, the rate dropping from 82% at T1 to 44% at T2, when using the Gillberg criteria. There was also a significant decrease in the rate of cases fulfilling any PDD diagnosis according to the DSM-IV, from 91% at T1 to 76% at T2 in the 47 cases followed up twice. Severity of autism spectrum symptoms at T1 was the main predictor of diagnostic stability at T2. Twenty percent of those meeting criteria for a PDD diagnosis according to DSM-IV, did not meet DSM-5 ASD criteria although they had marked difficulties in everyday life. Conclusion Asperger Syndrome, when considered as an ASD/PDD diagnosis, was fairly stable into adulthood, but there was a significant increase over time in cases no longer meeting criteria for an ASD diagnosis according to the DSM-IV, or AS according to the Gillberg criteria. Cases with a stable diagnosis showed significantly more core ASD symptoms in adolescence/young adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.12334 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20 Years After Initial Diagnosis / I. Carina GILLBERG in Journal of Autism and Developmental Disorders, 46-1 (January 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.74-82 Titre : Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20 Years After Initial Diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : I. Carina GILLBERG, Auteur ; Adam HELLES, Auteur ; Eva BILLSTEDT, Auteur ; Christopher GILLBERG, Auteur Année de publication : 2016 Article en page(s) : p.74-82 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Asperger syndrome  Psychiatric disorder  Depression  ADHD  DCD  Schizophrenia  Neurodevelopmental  Long-term follow-up Index. décimale : PER Périodiques Résumé : We examined comorbid psychiatric and neurodevelopmental disorders in fifty adult males (mean age 30 years) with Asperger syndrome (AS) diagnosed in childhood and followed up prospectively for almost two decades (13–26 years). Only three of the 50 men had never met criteria for an additional psychiatric/neurodevelopmental diagnosis and more than half had ongoing comorbidity (most commonly either ADHD or depression or both). Any psychiatric comorbidity increased the risk of poorer outcome. The minority of the AS group who no longer met criteria for a full diagnosis of an autism spectrum disorder were usually free of current psychiatric comorbidity. The high rate of psychiatric/neurodevelopmental comorbidities underscores the need for a full psychiatric/neurodevelopmental assessment at follow-up of males with AS. En ligne : http://dx.doi.org/10.1007/s10803-015-2544-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20 Years After Initial Diagnosis [Texte imprimé et/ou numérique] / I. Carina GILLBERG, Auteur ; Adam HELLES, Auteur ; Eva BILLSTEDT, Auteur ; Christopher GILLBERG, Auteur . - 2016 . - p.74-82. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.74-82 Mots-clés : Autism spectrum disorder  Asperger syndrome  Psychiatric disorder  Depression  ADHD  DCD  Schizophrenia  Neurodevelopmental  Long-term follow-up Index. décimale : PER Périodiques Résumé : We examined comorbid psychiatric and neurodevelopmental disorders in fifty adult males (mean age 30 years) with Asperger syndrome (AS) diagnosed in childhood and followed up prospectively for almost two decades (13–26 years). Only three of the 50 men had never met criteria for an additional psychiatric/neurodevelopmental diagnosis and more than half had ongoing comorbidity (most commonly either ADHD or depression or both). Any psychiatric comorbidity increased the risk of poorer outcome. The minority of the AS group who no longer met criteria for a full diagnosis of an autism spectrum disorder were usually free of current psychiatric comorbidity. The high rate of psychiatric/neurodevelopmental comorbidities underscores the need for a full psychiatric/neurodevelopmental assessment at follow-up of males with AS. En ligne : http://dx.doi.org/10.1007/s10803-015-2544-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

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