Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes / Li CHEN in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.137-150 Titre : Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes Type de document : texte imprimé Auteurs : Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur Article en page(s) : p.137-150 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes [texte imprimé] / Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur . - p.137-150. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.137-150 Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

What makes a lonely child: environmental, health, and multimodal neuroimaging correlates of prospective loneliness in the ABCD study / Ting Yat WONG in Journal of Child Psychology and Psychiatry, 67-10 (October 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-10 (October 2026) . - p. 1714-1728 Titre : What makes a lonely child: environmental, health, and multimodal neuroimaging correlates of prospective loneliness in the ABCD study Type de document : texte imprimé Auteurs : Ting Yat WONG, Auteur ; Ting Sam WONG, Auteur ; Wai Kai HOU, Auteur ; Angel Nga Man LEUNG, Auteur ; Jie XIAO, Auteur ; Kenneth S.L. YUEN, Auteur ; Simon S.Y. LUI, Auteur ; Anqi QIU, Auteur ; Tyler M. MOORE, Auteur ; Ruben C. GUR, Auteur Article en page(s) : p. 1714-1728 Langues : Anglais (eng) Mots-clés : Prospective loneliness  late childhood  environmental and health factors  neuroimaging correlates Index. décimale : PER Périodiques Résumé : Background Loneliness in childhood is a growing public health concern, yet early multilevel candidate risk and protective factors remain insufficiently mapped. Systematic investigation is essential to guide prevention and intervention during sensitive developmental periods. This study identifies environmental, health, and neurobiological factors associated with prospective loneliness in children. Methods A population-based longitudinal cohort study used data from children aged 9?10?years and their caregivers enrolled in the Adolescent Brain Cognitive Development (ABCD) Study between 2016 and 2022. A total of 9,602 children with complete baseline and follow-up loneliness and demographic data were included after exclusions for exposure completeness and quality assurance. Baseline measures included 347 environmental exposures, 61 health indicators, and 558 MRI features capturing gray matter volume, white matter microstructure, and resting-state functional connectivity. The primary outcome was prospective loneliness reported from ages 10?14. Linear mixed-effects models assessed associations with environmental and health variables. Linear discriminant analysis was applied to neuroimaging features to distinguish children with and without prospective loneliness. Results Among 9,602 children (mean [SD] age, 119.01 [7.52] months; 48% girls; 55% White, 14% Black, 31% other races/ethnicities), 12% (n?=?1,158) reported loneliness at baseline, and 71.6% (n?=?829) of those re-experienced loneliness over 3?years. Prospective loneliness was significantly associated with 40 environmental variables (|d|?=?0.069?0.388), most strongly parental psychopathology, developmental history, and family income. Twenty-six health indicators were also associated (|d|?=?0.061?0.390), with general mental health showing the largest effect. Neuroimaging features associated with prospective loneliness converged in brain systems involved in socioemotional processing. Conclusions Prospective loneliness was associated with modifiable environmental and health factors, as well as neurobiological differences. Early identification and targeted interventions that support socioemotional development, particularly within family, neighborhood, and school contexts, may help mitigate loneliness and its long-term impact. En ligne : https://doi.org/10.1111/jcpp.70178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] What makes a lonely child: environmental, health, and multimodal neuroimaging correlates of prospective loneliness in the ABCD study [texte imprimé] / Ting Yat WONG, Auteur ; Ting Sam WONG, Auteur ; Wai Kai HOU, Auteur ; Angel Nga Man LEUNG, Auteur ; Jie XIAO, Auteur ; Kenneth S.L. YUEN, Auteur ; Simon S.Y. LUI, Auteur ; Anqi QIU, Auteur ; Tyler M. MOORE, Auteur ; Ruben C. GUR, Auteur . - p. 1714-1728. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-10 (October 2026) . - p. 1714-1728 Mots-clés : Prospective loneliness  late childhood  environmental and health factors  neuroimaging correlates Index. décimale : PER Périodiques Résumé : Background Loneliness in childhood is a growing public health concern, yet early multilevel candidate risk and protective factors remain insufficiently mapped. Systematic investigation is essential to guide prevention and intervention during sensitive developmental periods. This study identifies environmental, health, and neurobiological factors associated with prospective loneliness in children. Methods A population-based longitudinal cohort study used data from children aged 9?10?years and their caregivers enrolled in the Adolescent Brain Cognitive Development (ABCD) Study between 2016 and 2022. A total of 9,602 children with complete baseline and follow-up loneliness and demographic data were included after exclusions for exposure completeness and quality assurance. Baseline measures included 347 environmental exposures, 61 health indicators, and 558 MRI features capturing gray matter volume, white matter microstructure, and resting-state functional connectivity. The primary outcome was prospective loneliness reported from ages 10?14. Linear mixed-effects models assessed associations with environmental and health variables. Linear discriminant analysis was applied to neuroimaging features to distinguish children with and without prospective loneliness. Results Among 9,602 children (mean [SD] age, 119.01 [7.52] months; 48% girls; 55% White, 14% Black, 31% other races/ethnicities), 12% (n?=?1,158) reported loneliness at baseline, and 71.6% (n?=?829) of those re-experienced loneliness over 3?years. Prospective loneliness was significantly associated with 40 environmental variables (|d|?=?0.069?0.388), most strongly parental psychopathology, developmental history, and family income. Twenty-six health indicators were also associated (|d|?=?0.061?0.390), with general mental health showing the largest effect. Neuroimaging features associated with prospective loneliness converged in brain systems involved in socioemotional processing. Conclusions Prospective loneliness was associated with modifiable environmental and health factors, as well as neurobiological differences. Early identification and targeted interventions that support socioemotional development, particularly within family, neighborhood, and school contexts, may help mitigate loneliness and its long-term impact. En ligne : https://doi.org/10.1111/jcpp.70178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

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