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Auteur Joanna D. HOLBROOK |
Documents disponibles écrits par cet auteur (2)
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Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes / Li CHEN in Development and Psychopathology, 27-1 (February 2015)
[article]
Titre : Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes Type de document : Texte imprimé et/ou numérique Auteurs : Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F. P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur Article en page(s) : p.137-150 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257
in Development and Psychopathology > 27-1 (February 2015) . - p.137-150[article] Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes [Texte imprimé et/ou numérique] / Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F. P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur . - p.137-150.
Langues : Anglais (eng)
in Development and Psychopathology > 27-1 (February 2015) . - p.137-150
Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age / Kieran J. O'DONNELL in Development and Psychopathology, 26-4 (Part 2) (November 2014)
[article]
Titre : Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age Type de document : Texte imprimé et/ou numérique Auteurs : Kieran J. O'DONNELL, Auteur ; Vivette GLOVER, Auteur ; Joanna D. HOLBROOK, Auteur ; Thomas G. O'CONNOR, Auteur Année de publication : 2014 Article en page(s) : p.1255-1266 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Multiple behavioral and health outcomes, including internalizing symptoms, may be predicted from prenatal maternal anxiety, depression, or stress. However, not all children are affected, and those that are can be affected in different ways. Here we test the hypothesis that the effects of prenatal anxiety are moderated by genetic variation in the child's brain-derived neurotrophic factor (BDNF) gene, using the Avon Longitudinal Study of Parents and Children population cohort. Internalizing symptoms were assessed from 4 to 13 years of age using the Strengths and Difficulties Questionnaire (n = 8,584); a clinical interview with the adolescents was conducted at age 15 years (n = 4,704). Obstetric and psychosocial risk and postnatal maternal symptoms were included as covariates. Results show that prenatal maternal anxiety predicted internalizing symptoms, including with the diagnostic assessment at 15 years. There was a main effect of two BDNF polymorphisms (rs6265 [val66met] and rs11030104) on internalizing symptoms up to age 13. There was also genetic moderation of the prenatal anxiety effect by different BDNF polymorphisms (rs11030121 and rs7124442), although significant effects were limited to preadolescence. The findings suggest a role for BDNF gene–environment interactions in individual vulnerability to the effects of prenatal anxiety on child internalizing symptoms. En ligne : http://dx.doi.org/10.1017/S095457941400100X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245
in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1255-1266[article] Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age [Texte imprimé et/ou numérique] / Kieran J. O'DONNELL, Auteur ; Vivette GLOVER, Auteur ; Joanna D. HOLBROOK, Auteur ; Thomas G. O'CONNOR, Auteur . - 2014 . - p.1255-1266.
Langues : Anglais (eng)
in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1255-1266
Index. décimale : PER Périodiques Résumé : Multiple behavioral and health outcomes, including internalizing symptoms, may be predicted from prenatal maternal anxiety, depression, or stress. However, not all children are affected, and those that are can be affected in different ways. Here we test the hypothesis that the effects of prenatal anxiety are moderated by genetic variation in the child's brain-derived neurotrophic factor (BDNF) gene, using the Avon Longitudinal Study of Parents and Children population cohort. Internalizing symptoms were assessed from 4 to 13 years of age using the Strengths and Difficulties Questionnaire (n = 8,584); a clinical interview with the adolescents was conducted at age 15 years (n = 4,704). Obstetric and psychosocial risk and postnatal maternal symptoms were included as covariates. Results show that prenatal maternal anxiety predicted internalizing symptoms, including with the diagnostic assessment at 15 years. There was a main effect of two BDNF polymorphisms (rs6265 [val66met] and rs11030104) on internalizing symptoms up to age 13. There was also genetic moderation of the prenatal anxiety effect by different BDNF polymorphisms (rs11030121 and rs7124442), although significant effects were limited to preadolescence. The findings suggest a role for BDNF gene–environment interactions in individual vulnerability to the effects of prenatal anxiety on child internalizing symptoms. En ligne : http://dx.doi.org/10.1017/S095457941400100X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245