Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model / Vanessa BABINEAU in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.21-29 Titre : Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa BABINEAU, Auteur ; Cathryn Gordon GREEN, Auteur ; Alexis JOLICOEUR-MARTINEAU, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Klaus MINDE, Auteur ; Roberto SASSI, Auteur ; Martin ST-ANDRÉ, Auteur ; Normand J. CARREY, Auteur ; Leslie ATKINSON, Auteur ; James L. KENNEDY, Auteur ; John LYDON, Auteur ; Meir STEINER, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Michael MEANEY, Auteur ; Ashley WAZANA, Auteur ; THE MAVAN PROJECT,, Auteur Article en page(s) : p.21-29 Langues : Anglais (eng) Mots-clés : Child development  emotional dysregulation  gene–environment interaction (GxE)  longitudinal studies  maternal depression  Prenatal Index. décimale : PER Périodiques Résumé : Background Childhood dysregulation, which reflects deficits in the capacity to regulate or control one's thoughts, emotions and behaviours, is associated with psychopathology throughout childhood and into adulthood. Exposures to adversity during the prenatal period, including prenatal depression, can influence the development of dysregulation, and a number of candidate genes have been suggested as moderators of prenatal exposure, including polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). We examined whether prenatal depression and child 5-HTTLPR interact to predict childhood dysregulation. Method Sample of N = 213 mother–child pairs from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. Mothers reported the IBQ-R at 3 and 6 months, and the ECBQ at 18 and 36 months, from which measures of dysregulation were extracted. Mothers' self-reported symptoms of depression on the CES-D at 24–36 weeks of gestation, and at 6, 12, 24 and 36 months postnatal. 5-HTTLPR genotype was extracted from buccal swabs. Mixed-model and confirmatory analyses were conducted. Results Prenatal depression and 5-HTTLPR interacted to predict dysregulation from 3 to 36 months, within a model of strong differential susceptibility. Conclusion Children with S or LG alleles, when exposed to prenatal depression, have higher levels of dysregulation, and when exposed to lower or little prenatal depression, have higher capacity for regulation. Our findings support efforts to identify, support and treat prenatal depression. En ligne : http://dx.doi.org/10.1111/jcpp.12246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months – A differential susceptibility model [Texte imprimé et/ou numérique] / Vanessa BABINEAU, Auteur ; Cathryn Gordon GREEN, Auteur ; Alexis JOLICOEUR-MARTINEAU, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Klaus MINDE, Auteur ; Roberto SASSI, Auteur ; Martin ST-ANDRÉ, Auteur ; Normand J. CARREY, Auteur ; Leslie ATKINSON, Auteur ; James L. KENNEDY, Auteur ; John LYDON, Auteur ; Meir STEINER, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Michael MEANEY, Auteur ; Ashley WAZANA, Auteur ; THE MAVAN PROJECT,, Auteur . - p.21-29. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.21-29 Mots-clés : Child development  emotional dysregulation  gene–environment interaction (GxE)  longitudinal studies  maternal depression  Prenatal Index. décimale : PER Périodiques Résumé : Background Childhood dysregulation, which reflects deficits in the capacity to regulate or control one's thoughts, emotions and behaviours, is associated with psychopathology throughout childhood and into adulthood. Exposures to adversity during the prenatal period, including prenatal depression, can influence the development of dysregulation, and a number of candidate genes have been suggested as moderators of prenatal exposure, including polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). We examined whether prenatal depression and child 5-HTTLPR interact to predict childhood dysregulation. Method Sample of N = 213 mother–child pairs from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. Mothers reported the IBQ-R at 3 and 6 months, and the ECBQ at 18 and 36 months, from which measures of dysregulation were extracted. Mothers' self-reported symptoms of depression on the CES-D at 24–36 weeks of gestation, and at 6, 12, 24 and 36 months postnatal. 5-HTTLPR genotype was extracted from buccal swabs. Mixed-model and confirmatory analyses were conducted. Results Prenatal depression and 5-HTTLPR interacted to predict dysregulation from 3 to 36 months, within a model of strong differential susceptibility. Conclusion Children with S or LG alleles, when exposed to prenatal depression, have higher levels of dysregulation, and when exposed to lower or little prenatal depression, have higher capacity for regulation. Our findings support efforts to identify, support and treat prenatal depression. En ligne : http://dx.doi.org/10.1111/jcpp.12246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

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