Is there a bit of autism in all of us? Autism spectrum traits are related to cortical thickness differences in both autism and typical development / Line GEBAUER in Research in Autism Spectrum Disorders, 13-14 (May 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 13-14 (May 2015) . - p.8-14 Titre : Is there a bit of autism in all of us? Autism spectrum traits are related to cortical thickness differences in both autism and typical development Type de document : texte imprimé Auteurs : Line GEBAUER, Auteur ; Nicholas E. V. FOSTER, Auteur ; Peter VUUST, Auteur ; Krista L. HYDE, Auteur Article en page(s) : p.8-14 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum quotient  Brain structure  MRI  Cortical thickness Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction, as well as repetitive behaviors and interests. However, these traits are highly variable across individuals with ASD and are also present in the typically developing population. Brain structural correlates of ASD are also heterogeneous. Recent findings have indicated that ASD traits as measured by the autism quotient (AQ) are reflected in white matter structural differences in a continuous way across both typically-developed and ASD individuals. Here, we tested for the first time, how ASD traits are related to gray matter structural differences (and particularly cortical thickness) in both ASD and typically developing adults. The present results show that ASD traits are primarily correlated with reductions in cortical thickness in a continuous fashion across ASD and typically developing adults in social brain areas and the default mode network including the orbitofrontal cortex, postcentral gyrus, and lingual gyrus. These findings provide new evidence that ASD traits are primarily reflected in neural structure that exists along a continuum extending into the typically developing population. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Is there a bit of autism in all of us? Autism spectrum traits are related to cortical thickness differences in both autism and typical development [texte imprimé] / Line GEBAUER, Auteur ; Nicholas E. V. FOSTER, Auteur ; Peter VUUST, Auteur ; Krista L. HYDE, Auteur . - p.8-14. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 13-14 (May 2015) . - p.8-14 Mots-clés : Autism  Autism spectrum quotient  Brain structure  MRI  Cortical thickness Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction, as well as repetitive behaviors and interests. However, these traits are highly variable across individuals with ASD and are also present in the typically developing population. Brain structural correlates of ASD are also heterogeneous. Recent findings have indicated that ASD traits as measured by the autism quotient (AQ) are reflected in white matter structural differences in a continuous way across both typically-developed and ASD individuals. Here, we tested for the first time, how ASD traits are related to gray matter structural differences (and particularly cortical thickness) in both ASD and typically developing adults. The present results show that ASD traits are primarily correlated with reductions in cortical thickness in a continuous fashion across ASD and typically developing adults in social brain areas and the default mode network including the orbitofrontal cortex, postcentral gyrus, and lingual gyrus. These findings provide new evidence that ASD traits are primarily reflected in neural structure that exists along a continuum extending into the typically developing population. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

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