Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity / Margaret H. SIBLEY in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.655-662 Titre : Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity Type de document : Texte imprimé et/ou numérique Auteurs : Margaret H. SIBLEY, Auteur ; James M. SWANSON, Auteur ; L. Eugene ARNOLD, Auteur ; Lily T. HECHTMAN, Auteur ; Elizabeth B. OWENS, Auteur ; Annamarie STEHLI, Auteur ; Howard B. ABIKOFF, Auteur ; Stephen P. HINSHAW, Auteur ; Brooke S. G. MOLINA, Auteur ; John T. MITCHELL, Auteur ; Peter S. JENSEN, Auteur ; Andrea L. HOWARD, Auteur ; Kimberley D. LAKES, Auteur ; William E. PELHAM, Auteur ; THE M. T. A. COOPERATIVE GROUP,, Auteur Article en page(s) : p.655-662 Langues : Anglais (eng) Mots-clés : Adult ADHD  DSM-5  diagnosis Index. décimale : PER Périodiques Résumé : Objective Longitudinal studies of children diagnosed with ADHD report widely ranging ADHD persistence rates in adulthood (5–75%). This study documents how information source (parent vs. self-report), method (rating scale vs. interview), and symptom threshold (DSM vs. norm-based) influence reported ADHD persistence rates in adulthood. Method Five hundred seventy-nine children were diagnosed with DSM-IV ADHD-Combined Type at baseline (ages 7.0–9.9 years) 289 classmates served as a local normative comparison group (LNCG), 476 and 241 of whom respectively were evaluated in adulthood (Mean Age = 24.7). Parent and self-reports of symptoms and impairment on rating scales and structured interviews were used to investigate ADHD persistence in adulthood. Results Persistence rates were higher when using parent rather than self-reports, structured interviews rather than rating scales (for self-report but not parent report), and a norm-based (NB) threshold of 4 symptoms rather than DSM criteria. Receiver-Operating Characteristics (ROC) analyses revealed that sensitivity and specificity were optimized by combining parent and self-reports on a rating scale and applying a NB threshold. Conclusion The interview format optimizes young adult self-reporting when parent reports are not available. However, the combination of parent and self-reports from rating scales, using an ‘or’ rule and a NB threshold optimized the balance between sensitivity and specificity. With this definition, 60% of the ADHD group demonstrated symptom persistence and 41% met both symptom and impairment criteria in adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.12620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity [Texte imprimé et/ou numérique] / Margaret H. SIBLEY, Auteur ; James M. SWANSON, Auteur ; L. Eugene ARNOLD, Auteur ; Lily T. HECHTMAN, Auteur ; Elizabeth B. OWENS, Auteur ; Annamarie STEHLI, Auteur ; Howard B. ABIKOFF, Auteur ; Stephen P. HINSHAW, Auteur ; Brooke S. G. MOLINA, Auteur ; John T. MITCHELL, Auteur ; Peter S. JENSEN, Auteur ; Andrea L. HOWARD, Auteur ; Kimberley D. LAKES, Auteur ; William E. PELHAM, Auteur ; THE M. T. A. COOPERATIVE GROUP,, Auteur . - p.655-662. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.655-662 Mots-clés : Adult ADHD  DSM-5  diagnosis Index. décimale : PER Périodiques Résumé : Objective Longitudinal studies of children diagnosed with ADHD report widely ranging ADHD persistence rates in adulthood (5–75%). This study documents how information source (parent vs. self-report), method (rating scale vs. interview), and symptom threshold (DSM vs. norm-based) influence reported ADHD persistence rates in adulthood. Method Five hundred seventy-nine children were diagnosed with DSM-IV ADHD-Combined Type at baseline (ages 7.0–9.9 years) 289 classmates served as a local normative comparison group (LNCG), 476 and 241 of whom respectively were evaluated in adulthood (Mean Age = 24.7). Parent and self-reports of symptoms and impairment on rating scales and structured interviews were used to investigate ADHD persistence in adulthood. Results Persistence rates were higher when using parent rather than self-reports, structured interviews rather than rating scales (for self-report but not parent report), and a norm-based (NB) threshold of 4 symptoms rather than DSM criteria. Receiver-Operating Characteristics (ROC) analyses revealed that sensitivity and specificity were optimized by combining parent and self-reports on a rating scale and applying a NB threshold. Conclusion The interview format optimizes young adult self-reporting when parent reports are not available. However, the combination of parent and self-reports from rating scales, using an ‘or’ rule and a NB threshold optimized the balance between sensitivity and specificity. With this definition, 60% of the ADHD group demonstrated symptom persistence and 41% met both symptom and impairment criteria in adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.12620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

The Relationship of Asperger’s Characteristics and Schizotypal Personality Traits in a Non-clinical Adult Sample / Ruth M. HURST in Journal of Autism and Developmental Disorders, 37-9 (October 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-9 (October 2007) . - p.1711-1720 Titre : The Relationship of Asperger’s Characteristics and Schizotypal Personality Traits in a Non-clinical Adult Sample Type de document : Texte imprimé et/ou numérique Auteurs : Ruth M. HURST, Auteur ; Rosemery O. NELSON-GRAY, Auteur ; John T. MITCHELL, Auteur ; Thomas R. KWAPIL, Auteur Année de publication : 2007 Article en page(s) : p.1711-1720 Langues : Anglais (eng) Mots-clés : Asperger’s-Disorder Schizotypal-Personality-Disorder Autism-Spectrum-Quotient Schizotypal-Personality-Questionnaire autism-spectrum-disorders Schizophrenia-spectrum-Disorders Index. décimale : PER Périodiques Résumé : The study examines the relationship between Asperger’s Disorder (AD) and Schizotypal Personality Disorder (SPD), mutually exclusive but similar diagnoses [DSM-IV-TR; American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders. Washington, DC: Author]. The literature and comparison of diagnostic criteria suggest that the two disorders may overlap: AD social impairment with SPD interpersonal problems and AD communication deficits with SPD disorganized features. Questionnaire measures of AD and SPD were administered to a large non-clinical adult sample. Consistent with expectations, the Asperger’s and Schizotypal questionnaires were positively correlated. Further, the social-interpersonal and communication-disorganized areas were positively correlated, though the relationship between social-interpersonal areas is particularly strong. Future research should continue to explore the relationship between AD and schizotypy to confirm current findings and improve understanding of distinctions between the disorders. En ligne : http://dx.doi.org/10.1007/s10803-006-0302-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=175 [article] The Relationship of Asperger’s Characteristics and Schizotypal Personality Traits in a Non-clinical Adult Sample [Texte imprimé et/ou numérique] / Ruth M. HURST, Auteur ; Rosemery O. NELSON-GRAY, Auteur ; John T. MITCHELL, Auteur ; Thomas R. KWAPIL, Auteur . - 2007 . - p.1711-1720. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-9 (October 2007) . - p.1711-1720 Mots-clés : Asperger’s-Disorder Schizotypal-Personality-Disorder Autism-Spectrum-Quotient Schizotypal-Personality-Questionnaire autism-spectrum-disorders Schizophrenia-spectrum-Disorders Index. décimale : PER Périodiques Résumé : The study examines the relationship between Asperger’s Disorder (AD) and Schizotypal Personality Disorder (SPD), mutually exclusive but similar diagnoses [DSM-IV-TR; American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders. Washington, DC: Author]. The literature and comparison of diagnostic criteria suggest that the two disorders may overlap: AD social impairment with SPD interpersonal problems and AD communication deficits with SPD disorganized features. Questionnaire measures of AD and SPD were administered to a large non-clinical adult sample. Consistent with expectations, the Asperger’s and Schizotypal questionnaires were positively correlated. Further, the social-interpersonal and communication-disorganized areas were positively correlated, though the relationship between social-interpersonal areas is particularly strong. Future research should continue to explore the relationship between AD and schizotypy to confirm current findings and improve understanding of distinctions between the disorders. En ligne : http://dx.doi.org/10.1007/s10803-006-0302-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=175

Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression / James M. SWANSON in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.663-678 Titre : Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression Type de document : Texte imprimé et/ou numérique Auteurs : James M. SWANSON, Auteur ; L. Eugene ARNOLD, Auteur ; Brooke S. G. MOLINA, Auteur ; Margaret H. SIBLEY, Auteur ; Lily T. HECHTMAN, Auteur ; Stephen P. HINSHAW, Auteur ; Howard B. ABIKOFF, Auteur ; Annamarie STEHLI, Auteur ; Elizabeth B. OWENS, Auteur ; John T. MITCHELL, Auteur ; Quyen NICHOLS, Auteur ; Andrea HOWARD, Auteur ; Laurence L. GREENHILL, Auteur ; Betsy HOZA, Auteur ; Jeffrey H. NEWCORN, Auteur ; Peter S. JENSEN, Auteur ; Benedetto VITIELLO, Auteur ; Timothy WIGAL, Auteur ; Jeffery N. EPSTEIN, Auteur ; Leanne TAMM, Auteur ; Kimberly D. LAKES, Auteur ; James WAXMONSKY, Auteur ; Marc LERNER, Auteur ; Joy ETCOVITCH, Auteur ; Desiree W. MURRAY, Auteur ; Maximilian MUENKE, Auteur ; Maria T. ACOSTA, Auteur ; Mauricio ARCOS-BURGOS, Auteur ; William E. PELHAM, Auteur ; Helena C. KRAEMER, Auteur ; THE M. T. A. COOPERATIVE GROUP,, Auteur Article en page(s) : p.663-678 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  follow-up studies  growth  longitudinal studies  treatment trials  medication effects Index. décimale : PER Périodiques Résumé : Background The Multimodal Treatment Study (MTA) began as a 14-month randomized clinical trial of behavioral and pharmacological treatments of 579 children (7–10 years of age) diagnosed with attention-deficit/hyperactivity disorder (ADHD)-combined type. It transitioned into an observational long-term follow-up of 515 cases consented for continuation and 289 classmates (258 without ADHD) added as a local normative comparison group (LNCG), with assessments 2–16 years after baseline. Methods Primary (symptom severity) and secondary (adult height) outcomes in adulthood were specified. Treatment was monitored to age 18, and naturalistic subgroups were formed based on three patterns of long-term use of stimulant medication (Consistent, Inconsistent, and Negligible). For the follow-up, hypothesis-generating analyses were performed on outcomes in early adulthood (at 25 years of age). Planned comparisons were used to estimate ADHD-LNCG differences reflecting persistence of symptoms and naturalistic subgroup differences reflecting benefit (symptom reduction) and cost (height suppression) associated with extended use of medication. Results For ratings of symptom severity, the ADHD-LNCG comparison was statistically significant for the parent/self-report average (0.51 ± 0.04, p < .0001, d = 1.11), documenting symptom persistence, and for the parent/self-report difference (0.21 ± 0.04, p < .0001, d = .60), documenting source discrepancy, but the comparisons of naturalistic subgroups reflecting medication effects were not significant. For adult height, the ADHD group was 1.29 ± 0.55 cm shorter than the LNCG (p < .01, d = .21), and the comparisons of the naturalistic subgroups were significant: the treated group with the Consistent or Inconsistent pattern was 2.55 ± 0.73 cm shorter than the subgroup with the Negligible pattern (p < .0005, d = .42), and within the treated group, the subgroup with the Consistent pattern was 2.36 ± 1.13 cm shorter than the subgroup with the Inconsistent pattern (p < .04, d = .38). Conclusions In the MTA follow-up into adulthood, the ADHD group showed symptom persistence compared to local norms from the LNCG. Within naturalistic subgroups of ADHD cases, extended use of medication was associated with suppression of adult height but not with reduction of symptom severity. En ligne : http://dx.doi.org/10.1111/jcpp.12684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression [Texte imprimé et/ou numérique] / James M. SWANSON, Auteur ; L. Eugene ARNOLD, Auteur ; Brooke S. G. MOLINA, Auteur ; Margaret H. SIBLEY, Auteur ; Lily T. HECHTMAN, Auteur ; Stephen P. HINSHAW, Auteur ; Howard B. ABIKOFF, Auteur ; Annamarie STEHLI, Auteur ; Elizabeth B. OWENS, Auteur ; John T. MITCHELL, Auteur ; Quyen NICHOLS, Auteur ; Andrea HOWARD, Auteur ; Laurence L. GREENHILL, Auteur ; Betsy HOZA, Auteur ; Jeffrey H. NEWCORN, Auteur ; Peter S. JENSEN, Auteur ; Benedetto VITIELLO, Auteur ; Timothy WIGAL, Auteur ; Jeffery N. EPSTEIN, Auteur ; Leanne TAMM, Auteur ; Kimberly D. LAKES, Auteur ; James WAXMONSKY, Auteur ; Marc LERNER, Auteur ; Joy ETCOVITCH, Auteur ; Desiree W. MURRAY, Auteur ; Maximilian MUENKE, Auteur ; Maria T. ACOSTA, Auteur ; Mauricio ARCOS-BURGOS, Auteur ; William E. PELHAM, Auteur ; Helena C. KRAEMER, Auteur ; THE M. T. A. COOPERATIVE GROUP,, Auteur . - p.663-678. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-6 (June 2017) . - p.663-678 Mots-clés : Attention-deficit/hyperactivity disorder  follow-up studies  growth  longitudinal studies  treatment trials  medication effects Index. décimale : PER Périodiques Résumé : Background The Multimodal Treatment Study (MTA) began as a 14-month randomized clinical trial of behavioral and pharmacological treatments of 579 children (7–10 years of age) diagnosed with attention-deficit/hyperactivity disorder (ADHD)-combined type. It transitioned into an observational long-term follow-up of 515 cases consented for continuation and 289 classmates (258 without ADHD) added as a local normative comparison group (LNCG), with assessments 2–16 years after baseline. Methods Primary (symptom severity) and secondary (adult height) outcomes in adulthood were specified. Treatment was monitored to age 18, and naturalistic subgroups were formed based on three patterns of long-term use of stimulant medication (Consistent, Inconsistent, and Negligible). For the follow-up, hypothesis-generating analyses were performed on outcomes in early adulthood (at 25 years of age). Planned comparisons were used to estimate ADHD-LNCG differences reflecting persistence of symptoms and naturalistic subgroup differences reflecting benefit (symptom reduction) and cost (height suppression) associated with extended use of medication. Results For ratings of symptom severity, the ADHD-LNCG comparison was statistically significant for the parent/self-report average (0.51 ± 0.04, p < .0001, d = 1.11), documenting symptom persistence, and for the parent/self-report difference (0.21 ± 0.04, p < .0001, d = .60), documenting source discrepancy, but the comparisons of naturalistic subgroups reflecting medication effects were not significant. For adult height, the ADHD group was 1.29 ± 0.55 cm shorter than the LNCG (p < .01, d = .21), and the comparisons of the naturalistic subgroups were significant: the treated group with the Consistent or Inconsistent pattern was 2.55 ± 0.73 cm shorter than the subgroup with the Negligible pattern (p < .0005, d = .42), and within the treated group, the subgroup with the Consistent pattern was 2.36 ± 1.13 cm shorter than the subgroup with the Inconsistent pattern (p < .04, d = .38). Conclusions In the MTA follow-up into adulthood, the ADHD group showed symptom persistence compared to local norms from the LNCG. Within naturalistic subgroups of ADHD cases, extended use of medication was associated with suppression of adult height but not with reduction of symptom severity. En ligne : http://dx.doi.org/10.1111/jcpp.12684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

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