Childhood psychopathology predicts development of error-related brain activity across adolescence / Elise M. ADAMS in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2795-2805 Titre : Childhood psychopathology predicts development of error-related brain activity across adolescence Type de document : texte imprimé Auteurs : Elise M. ADAMS, Auteur ; Aline K. SZENCZY, Auteur ; Mariah T. HAWES, Auteur ; Alexandria MEYER, Auteur ; Greg HAJCAK, Auteur ; Brady D. NELSON, Auteur Article en page(s) : p.2795-2805 Langues : Anglais (eng) Mots-clés : Adolescence  anxiety  depression  error-related negativity Index. décimale : PER Périodiques Résumé : Cross-sectional and longitudinal evidence indicates that the error-related negativity (ERN) increases across adolescence. However, there are no longitudinal studies of ERN development which traverse all of adolescence. In addition, anxiety (e.g., generalized and social anxiety) and depression have been associated with a larger and smaller ERN, respectively, but it is unknown whether childhood psychopathology is associated with adolescent development of the ERN. In the present study, 317 8 to 14-year-old girls completed a flanker task at baseline and approximately 2-year and 5-year follow-ups. Multilevel growth modeling was used to examine ERN trajectory across adolescence and test whether self-reported childhood generalized anxiety, social anxiety, and depression symptoms at baseline predicted ERN trajectory. On average, the ERN demonstrated a linear increase from late childhood to early adulthood. Additionally, participants with high baseline anxiety (generalized anxiety, social anxiety) and low depression symptoms had the steepest ERN trajectory across adolescence. The present study provides longitudinal support for an increase in the ERN spanning adolescence and demonstrates that childhood psychopathology is associated with error-related neural development into early adulthood. En ligne : https://dx.doi.org/10.1017/S0954579425100370 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Childhood psychopathology predicts development of error-related brain activity across adolescence [texte imprimé] / Elise M. ADAMS, Auteur ; Aline K. SZENCZY, Auteur ; Mariah T. HAWES, Auteur ; Alexandria MEYER, Auteur ; Greg HAJCAK, Auteur ; Brady D. NELSON, Auteur . - p.2795-2805. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2795-2805 Mots-clés : Adolescence  anxiety  depression  error-related negativity Index. décimale : PER Périodiques Résumé : Cross-sectional and longitudinal evidence indicates that the error-related negativity (ERN) increases across adolescence. However, there are no longitudinal studies of ERN development which traverse all of adolescence. In addition, anxiety (e.g., generalized and social anxiety) and depression have been associated with a larger and smaller ERN, respectively, but it is unknown whether childhood psychopathology is associated with adolescent development of the ERN. In the present study, 317 8 to 14-year-old girls completed a flanker task at baseline and approximately 2-year and 5-year follow-ups. Multilevel growth modeling was used to examine ERN trajectory across adolescence and test whether self-reported childhood generalized anxiety, social anxiety, and depression symptoms at baseline predicted ERN trajectory. On average, the ERN demonstrated a linear increase from late childhood to early adulthood. Additionally, participants with high baseline anxiety (generalized anxiety, social anxiety) and low depression symptoms had the steepest ERN trajectory across adolescence. The present study provides longitudinal support for an increase in the ERN spanning adolescence and demonstrates that childhood psychopathology is associated with error-related neural development into early adulthood. En ligne : https://dx.doi.org/10.1017/S0954579425100370 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

A genetic variant brain-derived neurotrophic factor (BDNF) polymorphism interacts with hostile parenting to predict error-related brain activity and thereby risk for internalizing disorders in children / Alexandria MEYER in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.125-141 Titre : A genetic variant brain-derived neurotrophic factor (BDNF) polymorphism interacts with hostile parenting to predict error-related brain activity and thereby risk for internalizing disorders in children Type de document : texte imprimé Auteurs : Alexandria MEYER, Auteur ; Greg HAJCAK, Auteur ; Elizabeth P. HAYDEN, Auteur ; Haroon I. SHEIKH, Auteur ; Shiva M. SINGH, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.125-141 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The error-related negativity (ERN) is a negative deflection in the event-related potential occurring when individuals make mistakes, and is increased in children with internalizing psychopathology. We recently found that harsh parenting predicts a larger ERN in children, and recent work has suggested that variation in the brain-derived neurotrophic factor (BDNF) gene may moderate the impact of early life adversity. Parents and children completed measures of parenting when children were 3 years old (N = 201); 3 years later, the ERN was measured and diagnostic interviews as well as dimensional symptom measures were completed. We found that harsh parenting predicted an increased ERN only among children with a methionine allele of the BDNF genotype, and evidence of moderated mediation: the ERN mediated the relationship between parenting and internalizing diagnoses and dimensional symptoms only if children had a methionine allele. We tested this model with externalizing disorders, and found that harsh parenting predicted externalizing outcomes, but the ERN did not mediate this association. These findings suggest that harsh parenting predicts both externalizing and internalizing outcomes in children; however, this occurs through different pathways that uniquely implicate error-related brain activity in the development of internalizing disorders. En ligne : https://doi.org/10.1017/S0954579417000517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335 [article] A genetic variant brain-derived neurotrophic factor (BDNF) polymorphism interacts with hostile parenting to predict error-related brain activity and thereby risk for internalizing disorders in children [texte imprimé] / Alexandria MEYER, Auteur ; Greg HAJCAK, Auteur ; Elizabeth P. HAYDEN, Auteur ; Haroon I. SHEIKH, Auteur ; Shiva M. SINGH, Auteur ; Daniel N. KLEIN, Auteur . - p.125-141. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.125-141 Index. décimale : PER Périodiques Résumé : The error-related negativity (ERN) is a negative deflection in the event-related potential occurring when individuals make mistakes, and is increased in children with internalizing psychopathology. We recently found that harsh parenting predicts a larger ERN in children, and recent work has suggested that variation in the brain-derived neurotrophic factor (BDNF) gene may moderate the impact of early life adversity. Parents and children completed measures of parenting when children were 3 years old (N = 201); 3 years later, the ERN was measured and diagnostic interviews as well as dimensional symptom measures were completed. We found that harsh parenting predicted an increased ERN only among children with a methionine allele of the BDNF genotype, and evidence of moderated mediation: the ERN mediated the relationship between parenting and internalizing diagnoses and dimensional symptoms only if children had a methionine allele. We tested this model with externalizing disorders, and found that harsh parenting predicted externalizing outcomes, but the ERN did not mediate this association. These findings suggest that harsh parenting predicts both externalizing and internalizing outcomes in children; however, this occurs through different pathways that uniquely implicate error-related brain activity in the development of internalizing disorders. En ligne : https://doi.org/10.1017/S0954579417000517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335

Intolerance of Uncertainty Predicts Anxiety Outcomes Following CBT in Youth with ASD / Amy KEEFER in Journal of Autism and Developmental Disorders, 47-12 (December 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3949-3958 Titre : Intolerance of Uncertainty Predicts Anxiety Outcomes Following CBT in Youth with ASD Type de document : texte imprimé Auteurs : Amy KEEFER, Auteur ; Nicole L. KREISER, Auteur ; Vini SINGH, Auteur ; Audrey BLAKELEY-SMITH, Auteur ; Amie DUNCAN, Auteur ; Cynthia JOHNSON, Auteur ; Laura G. KLINGER, Auteur ; Alexandria MEYER, Auteur ; Judy REAVEN, Auteur ; Roma A. VASA, Auteur Année de publication : 2017 Article en page(s) : p.3949-3958 Langues : Anglais (eng) Mots-clés : Anxiety  Autism spectrum disorders  Cognitive-behavioral therapy  Intolerance of uncertainty Index. décimale : PER Périodiques Résumé : Modified cognitive-behavioral therapy (MCBT) has been demonstrated to reduce anxiety in youth with autism spectrum disorder (ASD). However, non-response rates are fairly high. Few studies have investigated factors associated with response. Intolerance of uncertainty (IU) is a treatment target for anxiety and worry in neurotypical populations and has been linked to anxiety and ASD. We sought to examine whether IU affects outcomes following MCBT in 43 children, ages 8-14 years, with ASD without intellectual disability. Consistent with prior data, there was a significant reduction in parent reported anxiety following MCBT. Higher levels of pre-intervention IU predicted higher anxiety and worry pre- and post-intervention. These findings suggest that targeting IU may improve outcomes following MCBT in youth with ASD and anxiety. En ligne : http://dx.doi.org/10.1007/s10803-016-2852-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Intolerance of Uncertainty Predicts Anxiety Outcomes Following CBT in Youth with ASD [texte imprimé] / Amy KEEFER, Auteur ; Nicole L. KREISER, Auteur ; Vini SINGH, Auteur ; Audrey BLAKELEY-SMITH, Auteur ; Amie DUNCAN, Auteur ; Cynthia JOHNSON, Auteur ; Laura G. KLINGER, Auteur ; Alexandria MEYER, Auteur ; Judy REAVEN, Auteur ; Roma A. VASA, Auteur . - 2017 . - p.3949-3958. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-12 (December 2017) . - p.3949-3958 Mots-clés : Anxiety  Autism spectrum disorders  Cognitive-behavioral therapy  Intolerance of uncertainty Index. décimale : PER Périodiques Résumé : Modified cognitive-behavioral therapy (MCBT) has been demonstrated to reduce anxiety in youth with autism spectrum disorder (ASD). However, non-response rates are fairly high. Few studies have investigated factors associated with response. Intolerance of uncertainty (IU) is a treatment target for anxiety and worry in neurotypical populations and has been linked to anxiety and ASD. We sought to examine whether IU affects outcomes following MCBT in 43 children, ages 8-14 years, with ASD without intellectual disability. Consistent with prior data, there was a significant reduction in parent reported anxiety following MCBT. Higher levels of pre-intervention IU predicted higher anxiety and worry pre- and post-intervention. These findings suggest that targeting IU may improve outcomes following MCBT in youth with ASD and anxiety. En ligne : http://dx.doi.org/10.1007/s10803-016-2852-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

A neural biomarker, the error-related negativity, predicts the first onset of generalized anxiety disorder in a large sample of adolescent females / Alexandria MEYER in Journal of Child Psychology and Psychiatry, 59-11 (November 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-11 (November 2018) . - p.1162-1170 Titre : A neural biomarker, the error-related negativity, predicts the first onset of generalized anxiety disorder in a large sample of adolescent females Type de document : texte imprimé Auteurs : Alexandria MEYER, Auteur ; Brady D. NELSON, Auteur ; Greg PERLMAN, Auteur ; Daniel N. KLEIN, Auteur ; Roman KOTOV, Auteur Article en page(s) : p.1162-1170 Langues : Anglais (eng) Mots-clés : Adolescence  anxiety  biomarkers  event-related potential Index. décimale : PER Périodiques Résumé : OBJECTIVE: An increased neural response to making mistakes has emerged as a potential biomarker of anxiety across development. The error-related negativity (ERN) is an event-related potential elicited when people make mistakes on simple laboratory-based reaction time tasks that has been associated with risk for anxiety. This study examined whether the ERN prospectively predicted the first onset of generalized anxiety disorder (GAD) over 1.5 years in adolescent girls. METHODS: The sample included 457 girls between the ages of 13.5 and 15.5 years, with no history of GAD. At baseline, the ERN was measured using a flankers task. Psychiatric history of the adolescent and biological parent was assessed with diagnostic interviews, and the adolescent completed a self-report questionnaire regarding anxiety symptoms. Approximately 1.5 years later, adolescents completed the same interview. RESULTS: An increased neural response to errors at baseline predicted first-onset GAD over 1.5 years. The ERN was a significant predictor independent of other prominent risk factors, including baseline anxiety and depression symptoms and parental lifetime psychiatric history. Jointly the ERN and social anxiety symptoms provided the greatest power for predicting first-onset GAD. CONCLUSIONS: This study provides evidence for the utility of the ERN as a biomarker of risk for GAD during a key developmental period. En ligne : http://dx.doi.org/10.1111/jcpp.12922 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] A neural biomarker, the error-related negativity, predicts the first onset of generalized anxiety disorder in a large sample of adolescent females [texte imprimé] / Alexandria MEYER, Auteur ; Brady D. NELSON, Auteur ; Greg PERLMAN, Auteur ; Daniel N. KLEIN, Auteur ; Roman KOTOV, Auteur . - p.1162-1170. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-11 (November 2018) . - p.1162-1170 Mots-clés : Adolescence  anxiety  biomarkers  event-related potential Index. décimale : PER Périodiques Résumé : OBJECTIVE: An increased neural response to making mistakes has emerged as a potential biomarker of anxiety across development. The error-related negativity (ERN) is an event-related potential elicited when people make mistakes on simple laboratory-based reaction time tasks that has been associated with risk for anxiety. This study examined whether the ERN prospectively predicted the first onset of generalized anxiety disorder (GAD) over 1.5 years in adolescent girls. METHODS: The sample included 457 girls between the ages of 13.5 and 15.5 years, with no history of GAD. At baseline, the ERN was measured using a flankers task. Psychiatric history of the adolescent and biological parent was assessed with diagnostic interviews, and the adolescent completed a self-report questionnaire regarding anxiety symptoms. Approximately 1.5 years later, adolescents completed the same interview. RESULTS: An increased neural response to errors at baseline predicted first-onset GAD over 1.5 years. The ERN was a significant predictor independent of other prominent risk factors, including baseline anxiety and depression symptoms and parental lifetime psychiatric history. Jointly the ERN and social anxiety symptoms provided the greatest power for predicting first-onset GAD. CONCLUSIONS: This study provides evidence for the utility of the ERN as a biomarker of risk for GAD during a key developmental period. En ligne : http://dx.doi.org/10.1111/jcpp.12922 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children / Ellen M. KESSEL in Development and Psychopathology, 31-4 (October 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-4 (October 2019) . - p.1589-1598 Titre : Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children Type de document : texte imprimé Auteurs : Ellen M. KESSEL, Auteur ; Brady D. NELSON, Auteur ; Megan FINSAAS, Auteur ; Autumn KUJAWA, Auteur ; Alexandria MEYER, Auteur ; Evelyn BROMET, Auteur ; Gabrielle A. CARLSON, Auteur ; Greg HAJCAK, Auteur ; Roman KOTOV, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.1589-1598 Langues : Anglais (eng) Mots-clés : brain development  event-related potentials  natural disaster  parenting Index. décimale : PER Périodiques Résumé : Little is known about the effect of natural disasters on children's neural development. Additionally, despite evidence that stress and parenting may both influence the development of neural systems underlying reward and threat processing, few studies have brought together these areas of research. The current investigation examined the effect of parenting styles and hurricane-related stress on the development of neural reactivity to reward and threat in children. Approximately 8 months before and 9 months after Hurricane Sandy, 74 children experiencing high and low levels of hurricane-related stress completed tasks that elicited the reward positivity and error-related negativity, event-related potentials indexing sensitivity to reward and threat, respectively. At the post-Hurricane assessment, children completed a self-report questionnaire to measure promotion- and prevention-focused parenting styles. Among children exposed to high levels of hurricane-related stress, lower levels of promotion-focused, but not prevention-focused, parenting were associated with a reduced post-Sandy reward positivity. In addition, in children with high stress exposure, greater prevention-focused, but not promotion-focused, parenting was associated with a larger error-related negativity after Hurricane Sandy. These findings highlight the need to consider contextual variables such as parenting when examining how exposure to stress alters the development of neural reactivity to reward and threat in children. En ligne : http://dx.doi.org/10.1017/s0954579418001347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children [texte imprimé] / Ellen M. KESSEL, Auteur ; Brady D. NELSON, Auteur ; Megan FINSAAS, Auteur ; Autumn KUJAWA, Auteur ; Alexandria MEYER, Auteur ; Evelyn BROMET, Auteur ; Gabrielle A. CARLSON, Auteur ; Greg HAJCAK, Auteur ; Roman KOTOV, Auteur ; Daniel N. KLEIN, Auteur . - p.1589-1598. Langues : Anglais (eng) in Development and Psychopathology > 31-4 (October 2019) . - p.1589-1598 Mots-clés : brain development  event-related potentials  natural disaster  parenting Index. décimale : PER Périodiques Résumé : Little is known about the effect of natural disasters on children's neural development. Additionally, despite evidence that stress and parenting may both influence the development of neural systems underlying reward and threat processing, few studies have brought together these areas of research. The current investigation examined the effect of parenting styles and hurricane-related stress on the development of neural reactivity to reward and threat in children. Approximately 8 months before and 9 months after Hurricane Sandy, 74 children experiencing high and low levels of hurricane-related stress completed tasks that elicited the reward positivity and error-related negativity, event-related potentials indexing sensitivity to reward and threat, respectively. At the post-Hurricane assessment, children completed a self-report questionnaire to measure promotion- and prevention-focused parenting styles. Among children exposed to high levels of hurricane-related stress, lower levels of promotion-focused, but not prevention-focused, parenting were associated with a reduced post-Sandy reward positivity. In addition, in children with high stress exposure, greater prevention-focused, but not promotion-focused, parenting was associated with a larger error-related negativity after Hurricane Sandy. These findings highlight the need to consider contextual variables such as parenting when examining how exposure to stress alters the development of neural reactivity to reward and threat in children. En ligne : http://dx.doi.org/10.1017/s0954579418001347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

The stability of the feedback negativity and its relationship with depression during childhood and adolescence / Jennifer N. BRESS in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

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Transdiagnostic factors and pathways to multifinality: The error-related negativity predicts whether preschool irritability is associated with internalizing versus externalizing symptoms at age 9 / Ellen M. KESSEL in Development and Psychopathology, 28-4 pt1 (November 2016)  

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Understanding Service Usage and Needs for Adults with ASD: The Importance of Living Situation / Katerina DUDLEY in Journal of Autism and Developmental Disorders, 49-2 (February 2019)  

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